Dibenzyline

Urinary Retention, Dysuria, Pheochromocytoma

Treatment

2 FDA approvals

6 Active Studies for Dibenzyline

What is Dibenzyline

Phenoxybenzamine

The Generic name of this drug

Treatment Summary

An alpha-adrenergic antagonist is a type of drug used to lower high blood pressure and widen the blood vessels to improve blood flow. It works over a long period of time.

Dibenzyline

is the brand name

Dibenzyline Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Dibenzyline

Phenoxybenzamine

1953

8

Approved as Treatment by the FDA

Phenoxybenzamine, also known as Dibenzyline, is approved by the FDA for 2 uses which include Pheochromocytomas and Pheochromocytoma .

Pheochromocytomas

Pheochromocytoma

Effectiveness

How Dibenzyline Affects Patients

Phenoxybenzamine is used to treat high blood pressure and excessive sweating caused by a disease called pheochromocytoma. It works by blocking certain alpha receptors in the body, which relaxes the muscles in the walls of the blood vessels and widens them. This helps to lower blood pressure. If the heart rate is too high, a beta-blocking agent may be used along with Phenoxybenzamine.

How Dibenzyline works in the body

Phenoxybenzamine relaxes muscles and lowers blood pressure by blocking certain receptors in the body. This helps widen the blood vessels, allowing more blood to flow more freely.

When to interrupt dosage

The dosage of Dibenzyline is contingent upon the determined malady, including Dysuria, Pheochromocytomas and Urinary Retention. The measure of dosage is contingent upon the technique of administration referenced in the table below.

Condition

Dosage

Administration

Dysuria

, 10.0 mg

Capsule - Oral, , Oral, Capsule

Urinary Retention

, 10.0 mg

Capsule - Oral, , Oral, Capsule

Pheochromocytoma

, 10.0 mg

Capsule - Oral, , Oral, Capsule

Warnings

Dibenzyline has one contraindication. If you have any of the conditions given in the table below, Dibenzyline should not be utilized.

Dibenzyline Contraindications

Condition

Risk Level

Notes

Hypotension

Do Not Combine

There are 20 known major drug interactions with Dibenzyline.

Common Dibenzyline Drug Interactions

Drug Name

Risk Level

Description

Acepromazine

Major

Phenoxybenzamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.

Alfuzosin

Major

Phenoxybenzamine may increase the hypotensive activities of Alfuzosin.

Amifostine

Major

Phenoxybenzamine may increase the hypotensive activities of Amifostine.

Aripiprazole

Major

Phenoxybenzamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.

Aripiprazole lauroxil

Major

Phenoxybenzamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.

Dibenzyline Toxicity & Overdose Risk

Symptoms of an overdose of Atropine may include fainting or dizziness from low blood pressure, a faster than normal heart rate, vomiting, tiredness, and shock. These symptoms are typically caused by blockage of the sympathetic nervous system and epinephrine.

image of a doctor in a lab doing drug, clinical research

Dibenzyline Novel Uses: Which Conditions Have a Clinical Trial Featuring Dibenzyline?

19 active investigations are presently examining the potential of Dibenzyline to mitigate Urinary Retention, Dysuria and Pheochromocytomas.

Condition

Clinical Trials

Trial Phases

Urinary Retention

8 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Early Phase 1

Dysuria

0 Actively Recruiting

Pheochromocytoma

0 Actively Recruiting

Dibenzyline Reviews: What are patients saying about Dibenzyline?

4

Patient Review

2/21/2012

Dibenzyline for Tumor of Adrenal Gland Causing High Blood Pressure

This medication does help to ease my symptoms, but I have to take a larger dose than recommended for it to be completely effective. The downside to this is that I feel very lightheaded and dizzy.

4

Patient Review

10/8/2007

Dibenzyline for Tumor of Adrenal Gland Causing High Blood Pressure

This medication is helping me to get ready for surgery.

3.7

Patient Review

10/26/2008

Dibenzyline for Tumor of Adrenal Gland Causing High Blood Pressure

I am currently taking this treatment leading up to my surgery on 11/3. I have found it difficult to breathe; the constant stuffed nose is very unpleasant. However, there are some benefits: my blood pressure has lowered and I don't sweat as much anymore.

2.7

Patient Review

2/16/2011

Dibenzyline for Tumor of Adrenal Gland Causing High Blood Pressure

My blood pressure is under control now, but I still have a really bad sweating problem all over my body. I've seen several doctors about this, but no one has been able to help me.

Patient Q&A Section about dibenzyline

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Phenoxybenzamine used for?

"Phenoxybenzamine is used to treat high blood pressure (hypertension) caused by a disease called pheochromocytoma. By blocking the effects of certain chemicals in the body, phenoxybenzamine helps to control blood pressure."

Answered by AI

What class of drug is Dibenzyline?

"Dibenzyline is an Alpha Blocker and Antihypertensive."

Answered by AI

What is Dibenzyline used for?

"This medication is used to treat high blood pressure caused by a certain tumor of the adrenal glands (pheochromocytoma). Phenoxybenzamine belongs to a class of drugs known as alpha blockers. It relaxes and widens blood vessels so that blood can flow more easily."

Answered by AI

Clinical Trials for Dibenzyline

Image of UPMC Magee-Womens Hospital in Pittsburgh, United States.

Catheterization Methods for Postpartum Urinary Problems

18+
All Sexes
Pittsburgh, PA

At least ten percent of patients have postpartum urinary retention or difficulty urinating after birth, which can cause incontinence and other urinary problems long-term. After getting an epidural placed, patients should be numb in their pelvic region. This numbness makes it difficult to feel the need to urinate, so patients need a urinary catheter placed to empty the bladder. Some patients have one catheter placed throughout their labor and others have a catheter placed to empty the bladder then removed every few hours. The investigators are studying whether placing a catheter once or catheterizing multiple times affects the rate of postpartum urinary problems and infection.

Recruiting
Has No Placebo

UPMC Magee-Womens Hospital

Anna Binstock, MD

Image of Cleveland Clinic in Cleveland, United States.

Pelvic Floor Physical Therapy for Stress Urinary Incontinence

18+
Male
Cleveland, OH

The purpose of this study is to allow us to assess the effectiveness (or success) of starting pelvic floor physical therapy (i.e. exercises for your pelvic muscles) prior to HoLEP (holmium laser enucleation of the prostate) surgery for enlarged prostates in order to manage or prevent urinary incontinence (i.e. leaking) after surgery (i.e. post-operatively). Your pelvic floor refers to the muscles under your bladder along your pelvic bones that prevent you from leaking urine or stool. Traditionally, pelvic floor physical therapy is started after surgery and continued until urinary continence (i.e. no leaking of urine) is regained. We want to assess if beginning pelvic floor physical therapy prior to surgery (and continuing afterwards) reduces the time required to regain urinary continence following HoLEP.

Recruiting
Has No Placebo

Cleveland Clinic

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