Dibenzyline

Urinary Retention, Dysuria, Pheochromocytoma
Treatment
2 FDA approvals
9 Active Studies for Dibenzyline

What is Dibenzyline

PhenoxybenzamineThe Generic name of this drug
Treatment SummaryAn alpha-adrenergic antagonist is a type of drug used to lower high blood pressure and widen the blood vessels to improve blood flow. It works over a long period of time.
Dibenzylineis the brand name
Dibenzyline Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dibenzyline
Phenoxybenzamine
1953
8

Approved as Treatment by the FDA

Phenoxybenzamine, also known as Dibenzyline, is approved by the FDA for 2 uses which include Pheochromocytomas and Pheochromocytoma .
Pheochromocytomas
Pheochromocytoma

Effectiveness

How Dibenzyline Affects PatientsPhenoxybenzamine is used to treat high blood pressure and excessive sweating caused by a disease called pheochromocytoma. It works by blocking certain alpha receptors in the body, which relaxes the muscles in the walls of the blood vessels and widens them. This helps to lower blood pressure. If the heart rate is too high, a beta-blocking agent may be used along with Phenoxybenzamine.
How Dibenzyline works in the bodyPhenoxybenzamine relaxes muscles and lowers blood pressure by blocking certain receptors in the body. This helps widen the blood vessels, allowing more blood to flow more freely.

When to interrupt dosage

The dosage of Dibenzyline is contingent upon the determined malady, including Dysuria, Pheochromocytomas and Urinary Retention. The measure of dosage is contingent upon the technique of administration referenced in the table below.
Condition
Dosage
Administration
Dysuria
, 10.0 mg
, Oral, Capsule, Capsule - Oral
Pheochromocytoma
, 10.0 mg
, Oral, Capsule, Capsule - Oral
Urinary Retention
, 10.0 mg
, Oral, Capsule, Capsule - Oral

Warnings

Dibenzyline has one contraindication. If you have any of the conditions given in the table below, Dibenzyline should not be utilized.Dibenzyline Contraindications
Condition
Risk Level
Notes
Hypotension
Do Not Combine
There are 20 known major drug interactions with Dibenzyline.
Common Dibenzyline Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Phenoxybenzamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Alfuzosin
Major
Phenoxybenzamine may increase the hypotensive activities of Alfuzosin.
Amifostine
Major
Phenoxybenzamine may increase the hypotensive activities of Amifostine.
Aripiprazole
Major
Phenoxybenzamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Aripiprazole lauroxil
Major
Phenoxybenzamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Dibenzyline Toxicity & Overdose RiskSymptoms of an overdose of Atropine may include fainting or dizziness from low blood pressure, a faster than normal heart rate, vomiting, tiredness, and shock. These symptoms are typically caused by blockage of the sympathetic nervous system and epinephrine.
image of a doctor in a lab doing drug, clinical research

Dibenzyline Novel Uses: Which Conditions Have a Clinical Trial Featuring Dibenzyline?

19 active investigations are presently examining the potential of Dibenzyline to mitigate Urinary Retention, Dysuria and Pheochromocytomas.
Condition
Clinical Trials
Trial Phases
Urinary Retention
8 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3
Dysuria
0 Actively Recruiting
Pheochromocytoma
0 Actively Recruiting

Dibenzyline Reviews: What are patients saying about Dibenzyline?

4Patient Review
2/21/2012
Dibenzyline for Tumor of Adrenal Gland Causing High Blood Pressure
This medication does help to ease my symptoms, but I have to take a larger dose than recommended for it to be completely effective. The downside to this is that I feel very lightheaded and dizzy.
4Patient Review
10/8/2007
Dibenzyline for Tumor of Adrenal Gland Causing High Blood Pressure
This medication is helping me to get ready for surgery.
3.7Patient Review
10/26/2008
Dibenzyline for Tumor of Adrenal Gland Causing High Blood Pressure
I am currently taking this treatment leading up to my surgery on 11/3. I have found it difficult to breathe; the constant stuffed nose is very unpleasant. However, there are some benefits: my blood pressure has lowered and I don't sweat as much anymore.
2.7Patient Review
2/16/2011
Dibenzyline for Tumor of Adrenal Gland Causing High Blood Pressure
My blood pressure is under control now, but I still have a really bad sweating problem all over my body. I've seen several doctors about this, but no one has been able to help me.

Patient Q&A Section about dibenzyline

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Phenoxybenzamine used for?

"Phenoxybenzamine is used to treat high blood pressure (hypertension) caused by a disease called pheochromocytoma. By blocking the effects of certain chemicals in the body, phenoxybenzamine helps to control blood pressure."

Answered by AI

What class of drug is Dibenzyline?

"Dibenzyline is an Alpha Blocker and Antihypertensive."

Answered by AI

What is Dibenzyline used for?

"This medication is used to treat high blood pressure caused by a certain tumor of the adrenal glands (pheochromocytoma). Phenoxybenzamine belongs to a class of drugs known as alpha blockers. It relaxes and widens blood vessels so that blood can flow more easily."

Answered by AI

Clinical Trials for Dibenzyline

Have you considered Dibenzyline clinical trials? We made a collection of clinical trials featuring Dibenzyline, we think they might fit your search criteria.
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