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What is Diazepam
DiazepamThe Generic name of this drug
Treatment SummaryDiazepam is a powerful medication used to treat severe anxiety, insomnia, seizures, muscle spasms, and alcohol withdrawal. It works by increasing the activity of a neurotransmitter called gamma-aminobutyric acid. Recently, a new auto-injectable form of diazepam was approved by the FDA to treat seizures quickly and easily. This new form of the medication is a useful tool for treating epilepsy.
Valiumis the brand name
Diazepam Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Valium
Diazepam
1963
289
Effectiveness
How Diazepam Affects PatientsDiazepam is a benzodiazepine that helps with anxiety, sedation, muscle relaxation, seizure prevention, and memory loss. It works by assisting the neurotransmitter GABA in the brain, which helps to slow down the nervous system.
How Diazepam works in the bodyDiazepam is a medication that can reduce anxiety, muscle tension, and seizures. It works by connecting to receptors in the brain and spinal cord, which helps increase the calming effects of a chemical called GABA. This chemical can help with sleep, memory, anxiety, epilepsy, and controlling how sensitive the nerves are.
When to interrupt dosage
The suggested measure of Diazepam is contingent upon the determined condition, including Muscle Tissue, Seizures and Anger Management Therapy. The magnitude of dosage is contingent on the technique of delivery outlined in the table below.Condition
Dosage
Administration
Seizures
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Sedation therapy
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Syndrome
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Sedation
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Anxiety Disorders
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Muscle Tissue
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Anger Management Therapy
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Athetosis
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Lockjaw
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Motor Neuron Disease, Upper
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Stiff Man Syndrome
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Generalized Anxiety Disorder
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Drug Resistant Epilepsy
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Status Epilepticus (Convulsive)
5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL
Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray
Warnings
Diazepam ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Obstructive Sleep Apnea (OSA)
Do Not Combine
Glaucoma
Do Not Combine
Myasthenia Gravis
Do Not Combine
severe hepatic insufficiency
Do Not Combine
Respiratory Insufficiency
Do Not Combine
Common Diazepam Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Diazepam.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Diazepam.
Azelastine
Major
Diazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Diazepam.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Diazepam.
Diazepam Toxicity & Overdose RiskTaking too much diazepam can cause increased effects of the drug, like clumsiness, sleepiness, difficulty speaking, weak muscles, deep sleep, low blood pressure, slow heart rate, and eye twitching. In some cases, it can even lead to a coma. It can be especially dangerous when taken with other medications that can cause drowsiness. Diazepam should not be taken by pregnant women or while breastfeeding. It may cause harm to babies if taken while pregnant or during labor. It should not be used in children younger than six months old. Elderly people should use the lowest effective dose and have their kidney function
Diazepam Novel Uses: Which Conditions Have a Clinical Trial Featuring Diazepam?
409 active trials are presently assessing the suitability of Diazepam for use in treating Anxiety Disorders, Generalized Anxiety Disorder and Stiff Man Syndrome.Condition
Clinical Trials
Trial Phases
Generalized Anxiety Disorder
243 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4
Anxiety Disorders
205 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1
Sedation therapy
0 Actively Recruiting
Motor Neuron Disease, Upper
0 Actively Recruiting
Lockjaw
2 Actively Recruiting
Phase 2
Syndrome
3 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Drug Resistant Epilepsy
1 Actively Recruiting
Not Applicable
Muscle Tissue
0 Actively Recruiting
Anger Management Therapy
0 Actively Recruiting
Stiff Man Syndrome
0 Actively Recruiting
Sedation
2 Actively Recruiting
Phase 3
Status Epilepticus (Convulsive)
0 Actively Recruiting
Seizures
0 Actively Recruiting
Athetosis
0 Actively Recruiting
Diazepam Reviews: What are patients saying about Diazepam?
5Patient Review
8/10/2019 I find that this medication works very well for me when I am feeling anxious. It helps to take the edge off and makes me feel more relaxed.
5Patient Review
5/2/2016 I've been taking this for four years now for my panic disorder. I definitely think that ROCHE is the best brand out there--Watson's a close second. If you're given the knockoff brand (teva), it's like taking nothing.
5Patient Review
10/24/2017 I've used this medication for years to combat my motion sickness when traveling and it works like a charm every time. I'm very grateful for its existence!
5Patient Review
12/1/2017 I was in a lot of pain and went to the ER. I tried various treatments at home, but nothing worked as well as this medication.
5Patient Review
3/8/2018 This is the best anti-anxiety medication that I have tried. I would recommend it to others who suffer from anxiety.
5Patient Review
10/5/2018 I've had 10 heart attacks and 7 stents put in, plus a stroke that affected my right side. These drugs help me to relax and calm down. They're effective!
5Patient Review
8/12/2022 This medication was very effective for treating both my PTSD and muscle spasms from gunshot wounds. I would definitely recommend it to others with similar problems. Just be careful not to mix it with alcohol or other depressants/sedatives.
5Patient Review
8/30/2017 This treatment is better than xanax.
1Patient Review
9/6/2017 I used this medication for two years in an attempt to relieve my muscle spasms. Not only did it not help, but I actually developed more spasms after stopping the medication. Additionally, it was very hard to sleep and I became irritable. Overall, I wish I had never started taking this medication.
Patient Q&A Section about diazepam
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How quickly do diazepam work?
"How long after taking diazepam will it start to work?"
Answered by AI
What are the side effects of diazepam?
"The side effects of the medication include feeling drowsy, dizzy, or tired, as well as muscle weakness, headaches, a dry mouth, nausea, and constipation."
Answered by AI
What are diazepam drugs used for?
"Diazepam is a medication used to relieve symptoms of anxiety and alcohol withdrawal, as well as treat certain seizure disorders. It works by relaxing muscles and relieving muscle spasms. Diazepam is a type of benzodiazepine."
Answered by AI