Diastat

Athetosis, Lockjaw, Syndrome + 11 more

Treatment

20 Active Studies for Diastat

Treatment for

Athetosis

What is Diastat

DiazepamThe Generic name of this drug

Treatment SummaryDiazepam is a medicine used to treat a variety of conditions, including severe anxiety, insomnia, seizures, muscle spasms, and alcohol withdrawal. It works by increasing the activity of a brain chemical called gamma-aminobutyric acid. There is also an auto-injectable form of diazepam which is designed to be injected under the skin quickly and easily, offering faster results in cases of uncontrolled seizures. This has become an important treatment option for people with epilepsy.

Valiumis the brand name

Diastat Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Valium

Diazepam

1963

289

Effectiveness

How Diastat Affects PatientsDiazepam is a type of medication that helps reduce anxiety and causes sedation, muscle relaxation, and memory loss. It works by increasing the action of a neurotransmitter called GABA, which helps to quiet down the activity in the brain.

How Diastat works in the bodyDiazepam is a drug that helps reduce anxiety, muscle tension, and seizures. It works by increasing the effects of a calming chemical in the brain called GABA. This helps with sleep, memory, relaxation, and controlling nerve activity.

When to interrupt dosage

The proposed measure of Diastat is contingent upon the diagnosed condition, including Muscle Tissue, Seizures and Anger Management Therapy. The magnitude of dosage is determined by the approach of administration noted in the table below.

Condition

Dosage

Administration

Lockjaw

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Motor Neuron Disease, Upper

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Sedation therapy

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Sedation

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Stiff Man Syndrome

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Drug Resistant Epilepsy

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Muscle Tissue

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Syndrome

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Anxiety Disorders

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Status Epilepticus (Convulsive)

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Athetosis

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Generalized Anxiety Disorder

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Seizures

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Anger Management Therapy

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

Solution, Solution - Oral, , Oral, Rectal, Gel, Gel - Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Kit, Liquid, Liquid - Intramuscular; Intravenous, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Intramuscular, Injection, Injection - Intramuscular, Liquid - Intramuscular, Topical, Cream, Cream - Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Warnings

Diastat has six contraindications, so it should not be administered when living with any of the ailments presented in the following table.Diastat Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Obstructive Sleep Apnea (OSA)

Do Not Combine

Glaucoma

Do Not Combine

Myasthenia Gravis

Do Not Combine

severe hepatic insufficiency

Do Not Combine

Respiratory Insufficiency

Do Not Combine

There are 20 known major drug interactions with Diastat.

Common Diastat Drug Interactions

Drug Name

Risk Level

Description

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Diazepam.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Diazepam.

Azelastine

Major

Diazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Diazepam.

Copanlisib

Major

The metabolism of Copanlisib can be decreased when combined with Diazepam.

Diastat Toxicity & Overdose RiskOverdosing on diazepam can lead to increased intensity of its regular effects, like unsteadiness, sleepiness, trouble speaking, muscle weakness, deep sleep, low blood pressure, slow heart rate, and eye twitching. In more serious cases, it can result in a coma, lack of reflexes, problems breathing, and no breathing at all. It can also cause the breakdown of muscle tissue and lower body temperature. Pregnant women should be aware of the potential risk to the fetus if taking diazepam. It is not recommended for breastfeeding mothers and safety and effectiveness have not been established in pediatric patients under 6 months

Diastat Novel Uses: Which Conditions Have a Clinical Trial Featuring Diastat?

409 active studies are assessing the potential of Diastat in alleviating Anxiety Disorders, Generalized Anxiety Disorder and Stiff Man Syndrome.

Condition

Clinical Trials

Trial Phases

Anxiety Disorders

206 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1

Generalized Anxiety Disorder

243 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4

Sedation therapy

0 Actively Recruiting

Motor Neuron Disease, Upper

0 Actively Recruiting

Lockjaw

2 Actively Recruiting

Phase 2

Syndrome

3 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Drug Resistant Epilepsy

1 Actively Recruiting

Not Applicable

Muscle Tissue

0 Actively Recruiting

Anger Management Therapy

0 Actively Recruiting

Stiff Man Syndrome

0 Actively Recruiting

Sedation

2 Actively Recruiting

Phase 3

Status Epilepticus (Convulsive)

0 Actively Recruiting

Seizures

0 Actively Recruiting

Athetosis

0 Actively Recruiting

Diastat Reviews: What are patients saying about Diastat?

4.3Patient Review

11/24/2007

Diastat for Epileptic Seizure

This treatment works great, but unfortunately our school district won't allow it because they say the results are unpredictable.

4Patient Review

8/1/2009

Diastat for Epileptic Seizure

This treatment is effective if you can give it the time it needs.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about diastat

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Diastat?

"Tiredness, drowsiness, dizziness, headache, nausea, and vomiting are all common symptoms of sleepiness."

Answered by AI

How quickly does Diastat work?

"How long does it Diastat take to work? It is absorbed quickly from the rectum and seizures may stop within 15 minutes of administering the medicine; however, it will continue to work for a much longer duration. Diastat reaches a peak level in the bloodstream in approximately 1.5 hours but can last up to almost 2 days."

Answered by AI

Is Diastat the same as diazepam?

"Diazepam rectal gel, marketed as Diastat in the US and Canada, is an anticonvulsant used to stop cluster seizures. It is inserted into the rectum."

Answered by AI

What is Diastat used for?

"DIASTAT can be used to treat infrequent, unusual episodes of increased seizures in patients with epilepsy who are 2 years of age or older. DIASTAT can cause potentially fatal effects if it is used with opioids, including problems with breathing and extreme sedation."

Answered by AI

Clinical Trials for Diastat

Image of Emma Jones in Boston, United States.

Connectomic Targeted TMS for Mental Illness

This trial will test a new treatment called aiTBS on patients with anxiety-related disorders like panic disorder or OCD. 80 participants will receive either active or fake treatments over 5 days. The main

Waitlist Available

Emma JonesShan Siddiqi, MD

Image of University of Tennessee Medical Center in Knoxville, United States.

Med AAAction intervention for Congestive Heart Failure

This trial aims to help low-income individuals with multiple chronic conditions improve their medication adherence after being discharged from the hospital. The study will test a new pharmacy-led intervention that includes providing medications with zero copay

University of Tennessee Medical Center (+1 Sites)Satya Surbhi, PhD

Image of Stanford University in Stanford, United States.

Teleo for Mood Disorders

This trial will look at how children undergoing psychotherapy engage with telehealth services. They will enroll 42 families in a pilot randomized trial to compare patient engagement in Teleo, a virtual therapy platform,

Waitlist Available

Stanford UniversityDavid S Hong, MD

Image of St. Mary's Research Centre in Montreal, Canada.

TEMPO for Prostate Cancer

Montreal, Canada

"This trial focuses on helping men with prostate cancer and their caregivers cope with the physical and emotional challenges that come with the disease and its treatment. The research team developed a program called TEMPO, which is

Waitlist Available

St. Mary's Research Centre (+1 Sites)Sylvie Lambert, PhD

Have you considered Diastat clinical trials? We made a collection of clinical trials featuring Diastat, we think they might fit your search criteria.

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Image of Massachusetts General Hospital in Charlestown, United States.

Resilience Training for Psychosis

Charlestown, MA

This trial aimed to see if teaching resilience skills using virtual reality technology is practical and well-received by participants.

Massachusetts General Hospital

Image of Ann & Robert H Lurie Children's Hospital of Chicago in Chicago, United States.

Project YES for Depression

This trial will test a one-time intervention for teenagers and young adults who show signs of depression or anxiety. Participants will choose from three different digital interventions and will fill out questionnaires before, immediately after,

Waitlist Available

Ann & Robert H Lurie Children's Hospital of Chicago

Image of Vistagen Clinical Site in Oceanside, United States.

Fasedienol Nasal Spray for Social Anxiety Disorder

"This trial will test the effectiveness, safety, and tolerance of a nasal spray called Fasedienol in reducing anxiety symptoms in adults aged 18-65 with Social Anxiety Disorder. The study will also

Vistagen Clinical Site (+4 Sites)Michael Liebowitz, MDVistaGen Therapeutics, Inc.

Image of Columbia University Irving Medical Center in New York, United States.

Self-Distancing for Obsessive-Compulsive Disorder

This trial is looking at a technique called Self-Distancing, which involves changing your perspective to a more objective view in emotionally charged situations. The study wants to see if using self-distancing can help

Waitlist Available

Columbia University Irving Medical CenterKate D Fitzgerald, MD

Have you considered Diastat clinical trials? We made a collection of clinical trials featuring Diastat, we think they might fit your search criteria.

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Image of Wake Forest University Health Sciences in Winston-Salem, United States.

Lavender aromatherapy sticker for Anxiety

Winston-Salem, NC

This trial aims to see if creating a relaxing environment using lavender aromatherapy, calming music, dim lighting, and modest positioning during bladder injections can reduce anxiety and pain in women with urge urinary incontin

Waitlist Available

Wake Forest University Health SciencesMegan Tarr, MD

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Lavender Aromatherapy for Procedural Pain

Gainesville, FL

This trial showed that using lavender aromatherapy during office hysteroscopy can help reduce stress and anxiety levels in patients compared to using a placebo.

Waitlist Available

University of FloridaTiffani-Amber Miller, MD

Image of Massachusetts General Hospital in Boston, United States.

Video Intervention 1 +2 More for Depression

"This trial aims to test a self-administered video-based program to reduce stigma and mistrust among Black adults with moderate to severe depression or anxiety."

Massachusetts General HospitalAderonke Pederson, MD

Image of Memorial Sloan Kettering at Basking Ridge (All Protocol Activities) in Basking Ridge, United States.

Managing Anxiety from Cancer (MAC) for Caregiver

Basking Ridge, NJ

"This trial aims to determine if an anxiety treatment program is both feasible and helpful for Latino older adults with cancer and their caregivers."

Memorial Sloan Kettering at Basking Ridge (All Protocol Activities) (+6 Sites)Kelly McConnell, PhD

Have you considered Diastat clinical trials? We made a collection of clinical trials featuring Diastat, we think they might fit your search criteria.

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