Desyrel

Insomnia, Schizophrenia, Alzheimer's Disease + 8 more
Treatment
1 FDA approval
20 Active Studies for Desyrel

What is Desyrel

TrazodoneThe Generic name of this drug
Treatment SummaryTrazodone is an antidepressant medication that belongs to a class of drugs called serotonin receptor antagonists and reuptake inhibitors (SARIs). It is prescribed to adults to treat depression and is as effective as other drugs such as tricyclic antidepressants, selective serotonin reuptake inhibitors, and serotonin-norepinephrine receptor inhibitors. Unlike these other medications, trazodone does not cause anxiety, sexual problems, or insomnia. It works differently by affecting various receptors in the brain, including histamine, serotonin, and adrenergic receptors. Trazodone was first approved by the FDA in 1981.
Trazodone Hydrochlorideis the brand name
image of different drug pills on a surface
Desyrel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trazodone Hydrochloride
Trazodone
1987
344

Approved as Treatment by the FDA

Trazodone, otherwise called Trazodone Hydrochloride, is approved by the FDA for 1 uses which include Depression .
Depression

Effectiveness

How Desyrel Affects PatientsTrazodone helps with depression and can make it easier to sleep. However, it can cause memory, alertness, and cognitive problems in elderly people. It is also important to note that trazodone can lead to a rare but serious condition called priapism, which is a long-lasting and painful erection of the penis. If this occurs, patients should seek medical help immediately.
How Desyrel works in the bodyThe exact way trazodone works is still not completely understood, but it is known to stop the reuptake of serotonin and also block certain receptors. This means that it stops serotonin from being taken back up by the cells, which helps to fight depression. It also blocks histamine and alpha-1-adrenergic receptors, which can help to reduce anxiety. Trazodone's strongest effects come from blocking serotonin 5-HT2 receptors, which stop serotonin uptake. This is the main way it helps reduce depressive symptoms.

When to interrupt dosage

The advocated measure of Desyrel is dependent on the detected condition, such as Insomnia, Schizophrenia and Pain. The quantity of dosage differs as per the method of delivery (e.g. Tablet, extended release - Oral or Tablet - Oral) noted in the table hereunder.
Condition
Dosage
Administration
Insomnia
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Schizophrenia
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Generalized Anxiety Disorder
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Pain
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Alzheimer's Disease
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Eating Disorders
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Depression
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Pain
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Alzheimer's Disease
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Fibromyalgia
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Alcoholism
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit

Warnings

Desyrel Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Desyrel.
Common Desyrel Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be decreased when it is combined with Trazodone.
Abexinostat
Major
The risk or severity of QTc prolongation can be increased when Trazodone is combined with Abexinostat.
Acebutolol
Major
The risk or severity of QTc prolongation can be increased when Trazodone is combined with Acebutolol.
Acepromazine
Major
Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aceprometazine
Major
The risk or severity of QTc prolongation can be increased when Trazodone is combined with Aceprometazine.
Desyrel Toxicity & Overdose RiskThe safest amount of trazodone to take is 690mg/kg in rats. Too much trazodone can cause difficulty breathing, slow heart rate, low blood pressure, confusion, lack of coordination, and even coma. It can also cause an unrelenting erection of the penis that can result in permanent damage if not treated quickly. There is no known antidote for a trazodone overdose, so contact a poison control center for advice on how to treat it. Dialysis does not speed up the clearance of trazodone from the body.
image of a doctor in a lab doing drug, clinical research

Desyrel Novel Uses: Which Conditions Have a Clinical Trial Featuring Desyrel?

948 active clinical trials are being conducted to assess the potential of Desyrel in treating Schizophrenia, Alzheimer's Disease and Painful conditions.
Condition
Clinical Trials
Trial Phases
Alzheimer's Disease
135 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Schizophrenia
106 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 2, Phase 1
Generalized Anxiety Disorder
204 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Early Phase 1, Phase 4, Phase 1
Depression
195 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Pain
0 Actively Recruiting
Alzheimer's Disease
34 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1
Pain
0 Actively Recruiting
Insomnia
1 Actively Recruiting
Not Applicable
Alcoholism
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Eating Disorders
1 Actively Recruiting
Not Applicable
Fibromyalgia
0 Actively Recruiting

Desyrel Reviews: What are patients saying about Desyrel?

5Patient Review
5/1/2014
Desyrel for Chronic Trouble Sleeping
Trazadone is the only drug that has ever really worked for me in terms of sleep. I've tried Ambien, Lunesta, Benadryl, and a host of others but none of them compare to Trazadone. The effects last around 4-5 hours before I have to take another dose, but it's worth it to get a good night's sleep.
5Patient Review
2/21/2014
Desyrel for Chronic Trouble Sleeping
This drug has been incredibly effective for me in treating my insomnia and anxiety. I've been taking it for over three years with no negative side effects.
5Patient Review
12/17/2015
Desyrel for Major Depressive Disorder
This medication has been hugely beneficial for me. Not only does it help with my depression, but it also helps me get to sleep. I've been on a 300mg dose for 8 years now and have had zero problems.
5Patient Review
2/16/2015
Desyrel for Depression
This treatment has been really effective for me with few side effects.
4.7Patient Review
7/20/2014
Desyrel for Chronic Trouble Sleeping
I've been taking this medication for 11 years to help with my insomnia. It worked great at first, but after a few years, I began to build up a tolerance. My doctor upped the dosage, and it helped for a while, but eventually stopped working altogether. I decided to try weaning myself off of it, but that was a mistake. After many sleepless nights, I increased the dosage back to 150ml and finally got some relief.
View All Reviews
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Patient Q&A Section about desyrel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Desyrel a sleeping pill?

"Although trazodone was not designed to be a sedative or hypnotic to address sleep disorders, it is now being prescribed by doctors to help with insomnia. Trazodone was first approved by the FDA in 1981 and is now available as a generic medication from several different drug companies."

Answered by AI

What type of drug is Desyrel?

"This is a prescription medicine used to treat depression in adults. It is in a class of medicines known as SSRIs (or selective serotonin reuptake inhibitors)."

Answered by AI

Is Desyrel and trazodone the same thing?

"Trazodone, also known by the brand name Desyrel, is a medication that was approved by the U.S. Food and Drug Administration in 1981 for the treatment of major depressive disorder."

Answered by AI

What are the side effects of Desyrel?

"The following side effects may occur: feeling nauseous, throwing up, having diarrhea, feeling sleepy, feeling dizzy, feeling tired, blurry vision, changes in weight, headaches, muscle pain, having a dry mouth, bad taste in mouth, stuffy nose, constipation, or changes in sexual interest/ ability."

Answered by AI

Clinical Trials for Desyrel

Have you considered Desyrel clinical trials? We made a collection of clinical trials featuring Desyrel, we think they might fit your search criteria.
Have you considered Desyrel clinical trials? We made a collection of clinical trials featuring Desyrel, we think they might fit your search criteria.
Have you considered Desyrel clinical trials? We made a collection of clinical trials featuring Desyrel, we think they might fit your search criteria.
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