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What is Desipramine Hydrochloride
DesipramineThe Generic name of this drug
Treatment SummaryDesipramine hydrochloride is an antidepressant drug belonging to a group of medications called tricyclic antidepressants. It works by increasing the levels of serotonin and norepinephrine in the brain, which helps to improve mood. It is used to treat depression and other conditions such as neuropathic pain, agitation, and insomnia. Desipramine is generally considered to have fewer side effects than other tricyclic antidepressants, such as amitriptyline and clomipramine, but it can still cause sedation, blurred vision, dry mouth, constipation, and urinary retention.
Norpraminis the brand name
Desipramine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norpramin
Desipramine
1964
122
Approved as Treatment by the FDA
Desipramine, also called Norpramin, is approved by the FDA for 1 uses including Depression .Depression
Effectiveness
How Desipramine Hydrochloride Affects PatientsDesipramine is a type of antidepressant used to treat depression. It works by blocking the reuptake of noradrenaline and serotonin, two chemical messengers in the brain, and by making serotonin receptors more sensitive. It usually takes 2-4 weeks for the antidepressant effects to be felt, although some people may need up to 8 weeks. People with more severe depression may start feeling the effects sooner than those with mild depression.
How Desipramine Hydrochloride works in the bodyDesipramine is a medication used to treat depression. It works by blocking the brain from reabsorbing norepinephrine and serotonin, which are chemicals that normally help regulate mood. Desipramine can also make serotonin receptors inside the brain more sensitive, which helps increase the amount of serotonin available. It also has a minor effect on other receptors in the brain, called muscarinic receptors. All of these effects together help to improve mood and reduce depression symptoms.
When to interrupt dosage
The advised dose of Desipramine Hydrochloride is contingent upon the established condition, including Irritable Bowel Syndrome (IBS), Neuropathic Pain and Chronic Pain. The measure of dosage is subject to the technique of delivery listed in the table beneath.Condition
Dosage
Administration
Panic Disorder
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Diabetic Neuropathy
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Bulimia Nervosa
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Depression
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Insomnia
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Postherpetic Neuralgia
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Chronic Pain
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Irritable Bowel Syndrome (IBS)
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Neuropathic Pain
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Anorexia Nervosa
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Ophthalmic, Ophthalmic
Warnings
Desipramine Hydrochloride ContraindicationsCondition
Risk Level
Notes
Myocardial Infarction
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Desipramine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Desipramine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Desipramine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Desipramine is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Desipramine.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Desipramine.
Desipramine Hydrochloride Toxicity & Overdose RiskDesipramine can be toxic at a dose of 290mg/kg in male mice and 320mg/kg in female rats. Side effects may include drowsiness, low blood pressure, blurred vision, dry mouth, constipation, and difficulty urinating. Higher doses can cause changes in blood pressure, heart rate, or electrical activity in the heart. Memory problems, confusion, or manic episodes may occur and withdrawal symptoms may include nausea, vomiting, abdominal pain, diarrhea, anxiety, insomnia, headache, and general discomfort.
Desipramine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Desipramine Hydrochloride?
Presently, 791 active trials are examining the potential of Desipramine Hydrochloride to mitigate Anorexia Nervosa, Irritable Bowel Syndrome (IBS) and Depressive symptoms.Condition
Clinical Trials
Trial Phases
Insomnia
91 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Depression
696 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
Chronic Pain
31 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Neuropathic Pain
27 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Postherpetic Neuralgia
0 Actively Recruiting
Bulimia Nervosa
15 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1
Panic Disorder
17 Actively Recruiting
Not Applicable, Phase 2
Anorexia Nervosa
0 Actively Recruiting
Irritable Bowel Syndrome (IBS)
9 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Diabetic Neuropathy
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1
Desipramine Hydrochloride Reviews: What are patients saying about Desipramine Hydrochloride?
5Patient Review
1/6/2014 After my car accident, I was dealing with some really intense pain from Fibromyalgia. This drug helped to reduce that pain by 80%, which made a world of difference.
5Patient Review
2/23/20135Patient Review
5/6/20135Patient Review
9/13/2022 This treatment is really effective for people suffering from PTSD.
4.7Patient Review
2/4/2014 Dr. Ackerman prescribed this medication to help with my depression, and it's done wonders in restoring my quality of life.
3.7Patient Review
2/23/2014 Amongst the SSRIs and SNRIs I've tried, this one is most effective for with fewest side effects. The only complaint I have is that if I forget to take it, I become very energetic (manic?) the next morning and vomit shortly after lunch.
2.3Patient Review
6/27/2020 My psychiatrist had me start with 150 milligrams, and after only five days I had to go to the emergency room. I was in so much pain I could barely walk or eat, urinating was agony, and my heart raced just from walking up the stairs. If I didn't know him, I would have thought he was trying to kill me!
2.3Patient Review
8/20/2014 My depression has decreased since taking this medication, but I've noticed some memory loss or confusion. I'm also sleepier and have less energy than before.
1.3Patient Review
8/4/2017 I would not recommend this drug to anyone. I experienced terrible constipation and pelvic pain as a result of the 100 mg dosage. This medication did nothing to ease my neuropathic pain, and if anything made it worse.
1Patient Review
2/3/2015 I took the recommended dosage of 50mg for pain relief, but unfortunately woke up in more pain than before. This might work better for other people, but I didn't have a great experience with it.
1Patient Review
8/4/2017 This medication was an complete nightmare for me. I developed such severe constipation that I ended up with a painful UTI, which then led to burning pain and pelvic cramps. Lowering my dosage did nothing to help ease these symptoms, so I would advise anyone thinking of taking this drug to steer clear.
1Patient Review
3/10/2013Patient Q&A Section about desipramine hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does desipramine cause weight gain?
"Desipramine (Norpramin) can cause weight gain, though some people have lost weight while taking the medication. If you have experienced a significant change in weight while taking desipramine (Norpramin), speak to your provider."
Answered by AI
What is desipramine hydrochloride used for?
"Desipramine is a medication used to treat depression that belongs to a class of medications called tricyclic antidepressants. These drugs work by increasing the levels of natural substances in the brain that are needed for mental balance."
Answered by AI
How does desipramine make you feel?
"If you experience any of the following effects for an extended period of time, or if they worsen, notify your doctor or pharmacist. These effects include: headache, nausea, dizziness, drowsiness, nervousness, trouble sleeping, blurred vision, increased appetite, weight gain, constipation, and dry mouth."
Answered by AI
Is desipramine used for pain?
"Desipramine is a type of antidepressant medication known as a tricyclic antidepressant (TCA). It is sometimes used to treat chronic neuropathic pain (pain due to nerve damage or changes in the central nervous system (CNS))."
Answered by AI