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What is Darvocet A500
DextropropoxypheneThe Generic name of this drug
Treatment SummaryAcetaminophen (also known as Tylenol) is an over-the-counter pain reliever and fever reducer that is widely used all over the world. It comes in many forms, including syrup, tablets, effervescent tablets, injections, and suppositories. It is often found in combination with other drugs in more than 600 over-the-counter medications for allergies, colds, sleep, and pain relief. It is important to follow the recommended dosage instructions for this medication since taking too much of it can lead to fatal overdose or liver failure.
Propoxypheneis the brand name
Darvocet A500 Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Propoxyphene
Dextropropoxyphene
1973
64
Approved as Treatment by the FDA
Dextropropoxyphene, also known as Propoxyphene, is approved by the FDA for 1 uses like Chronic Pain .Chronic Pain
Helps manage Pain
Effectiveness
How Darvocet A500 Affects PatientsAcetaminophen is a drug used to reduce fever and pain. It does not cause inflammation, nor does it interfere with how the body produces uric acid or affects acid-base balance when taken in the recommended doses. It is also unlikely to cause allergic reactions. It does not interfere with blood clotting or prevent platelets from clumping together.
How Darvocet A500 works in the bodyAcetaminophen works to reduce pain by blocking the body's ability to create pain-causing chemicals. It does this by inhibiting two types of proteins called cyclooxygenases, which are involved in the production of prostaglandins. Acetaminophen does not affect these proteins in other parts of the body, so it does not have anti-inflammatory effects. It is also thought to work on heat regulating centers in the brain, which helps the body to cool down and lose excess body heat. While we don't fully understand how acetaminophen works, more research may help us better understand its mechanism of action.
When to interrupt dosage
The prescribed dosage of Darvocet A500 is reliant upon the identified condition, including Pain, Spasm and Inflammation. The amount of dosage fluctuates, depending on the technique of administration as stated in the table beneath.Condition
Dosage
Administration
Chronic Pain
, 65.0 mg, 100.0 mg, 50.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral
Warnings
Darvocet A500 has three contraindications and should not be administered together with the circumstances enumerated in the following table.Darvocet A500 ContraindicationsCondition
Risk Level
Notes
Hypercarbia
Do Not Combine
Asthma
Do Not Combine
Mental Depression
Do Not Combine
Paralytic Ileus
Do Not Combine
Asthma Acute
Do Not Combine
Common Darvocet A500 Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Dextropropoxyphene.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Dextropropoxyphene.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Dextropropoxyphene.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Dextropropoxyphene.
Darvocet A500 Toxicity & Overdose RiskAcetaminophen has a toxic dose of 338mg/kg in mice and 1944mg/kg in rats. Symptoms of an overdose include kidney damage, hypoglycemia, low blood platelets, and liver damage which can lead to death or the need for a liver transplant. Long term use has been linked to cancer in female rats. Mutagenic effects have been observed in some studies, but the relevance to humans is unknown. Fertility tests have shown no effects, but pregnant and nursing women should exercise caution when taking the drug.
Darvocet A500 Novel Uses: Which Conditions Have a Clinical Trial Featuring Darvocet A500?
698 active clinical trials are currently assessing the utility of Darvocet A500 in treating Chronic Pain, Rheumatoid Arthritis and Allergic Conditions.Condition
Clinical Trials
Trial Phases
Chronic Pain
175 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Darvocet A500 Reviews: What are patients saying about Darvocet A500?
5Patient Review
8/3/2011 This drug has been around for a while, and it's really helped me manage my chronic back pain. I haven't had any negative side effects from using it long-term.
5Patient Review
4/6/2010 I had shoulder surgery and took a drug containing codine that made me really sick. This drug has no side affect and works, but you need to use it every four hours or pain returns and it takes awhile to cut the pain again.
5Patient Review
12/23/2011 I'm allergic to most pain medication, but Darvocet was the only thing that helped me. As long as you don't overuse it, it's a great drug.
4.7Patient Review
3/20/2010 This was really effective in providing comfort.
4.7Patient Review
3/5/20094.7Patient Review
12/16/2009 While this medication didn't completely remove my pain, it also didn't make me sick like other pain medications have in the past. Not sure what else to do, but my doctor just thinks I want more drugs.
4.7Patient Review
11/2/2009 I didn't love this treatment, but it was effective. I didn't like the way it made me feel, though.
4.7Patient Review
8/16/2010 I almost never take anything stronger than Tylenol because I'm worried about the side effects, but this weekend my back pain was so bad that I decided to give it a try. It worked really well with hardly any noticeable side effects (just a little drowsiness).
4.3Patient Review
10/23/2009 I've been on Darvocet for a while now and haven't experienced any constipation. If you're struggling with this issue, I recommend trying a couple tablespoons of ground flaxseed with breakfast and drinking a few glasses of water each day. It helped me a lot!
3.7Patient Review
5/12/20093.3Patient Review
1/3/2010 The Vicodin didn't help much with my pain, and it made my anxiety levels spike. The Darvocet was a marked improvement in that it helped with the pain while also keeping me calm. I recommend this for anyone struggling with both pain and anxiety.
3Patient Review
5/16/20093Patient Review
5/22/20092Patient Review
4/11/20091.7Patient Review
10/12/2009 I generally have had good results with this medication, so long as I stick to the white pills and not the pink generic ones. However, since I started taking B12 vitamins (1500mg), I've been getting headaches constantly and feeling lightheaded sometimes. Not sure what's going on there.
1.7Patient Review
10/14/2009 I tried Darvocet instead of Vicodin because I was experiencing extreme nausea. Unfortunately, this led to serious mental side effects that forced me to discontinue use. When I went back to half doses of Vicodin, the results were much better. Overall, I would not recommend using this drug.
Patient Q&A Section about darvocet a500
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Darvocet A500?
"Darvocet A500 is a prescription medicine containing the two active ingredients propoxyphene and acetaminophen. Darvocet A500 is used to relieve mild to moderate pain."
Answered by AI
Did they stop making Darvocet?
"- The FDA has finally banned Darvon, Darvocet and other brand / generic drugs containing propoxyphene, a painkiller with a long history of safety issues."
Answered by AI
Why was Darvocet withdrawn from the market?
"The Food and Drug Administration announced today that propoxyphene, a painkiller, is being taken off the market. This is because the drug has been linked to a deadly heart-rhythm abnormality, even when taken as recommended."
Answered by AI