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What is Dalfampridine
DalfampridineThe Generic name of this drug
Treatment SummaryDalfampridine is a drug used to help people with multiple sclerosis walk more easily. It works by blocking potassium channels in the body. It is the first medication approved by the FDA specifically to improve mobility in people with multiple sclerosis and was approved in 2010.
Ampyrais the brand name
Dalfampridine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ampyra
Dalfampridine
2010
13
Approved as Treatment by the FDA
Dalfampridine, also known as Ampyra, is approved by the FDA for 1 uses including Multiple Sclerosis .Multiple Sclerosis
Helps manage Multiple Sclerosis
Effectiveness
How Dalfampridine Affects PatientsDalfampridine is a drug that blocks certain potassium channels in the central nervous system, which are more common in people with Multiple Sclerosis. It does not affect the QTc interval.
How Dalfampridine works in the bodyIn people with Multiple Sclerosis, damage to the protective coating around nerve cells makes it harder for nerve signals to travel. Dalfampridine works to fix this by helping to keep the electric charge within the cells high enough for signals to be sent. This helps make sure that nerve signals can still be sent, even in cells that don't have a full protective coating.
When to interrupt dosage
The measure of Dalfampridine relies upon the diagnosed condition. The amount of dosage is also contingent upon the method of delivery (e.g. Tablet, extended release - Oral or Tablet, film coated, extended release) featured in the table below.Condition
Dosage
Administration
Multiple Sclerosis
, 10.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Warnings
Dalfampridine has two contraindications, and it should be avoided in instances of the conditions specified in the below table.Dalfampridine ContraindicationsCondition
Risk Level
Notes
History of Seizures
Do Not Combine
moderate to severe renal dysfunction
Do Not Combine
Common Dalfampridine Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Minor
Dalfampridine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Dalfampridine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Dalfampridine may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Almasilate
Minor
Dalfampridine may decrease the excretion rate of Almasilate which could result in a higher serum level.
Ammonium chloride
Minor
Dalfampridine may decrease the excretion rate of Ammonium chloride which could result in a higher serum level.
Dalfampridine Toxicity & Overdose RiskThe toxic dose of this drug for mice is 19mg/kg and for rats is 21mg/kg when taken orally.
Dalfampridine Novel Uses: Which Conditions Have a Clinical Trial Featuring Dalfampridine?
193 active studies are currently being conducted to ascertain the potential of Dalfampridine to mitigate symptoms of Multiple Sclerosis.Condition
Clinical Trials
Trial Phases
Multiple Sclerosis
195 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4, Early Phase 1
Dalfampridine Reviews: What are patients saying about Dalfampridine?
5Patient Review
11/22/2010 I had been in a wheelchair for about seven years, but within six days of taking this medication, I was able to take my first steps unassisted. It's been 10 days now and I'm walking everywhere!
5Patient Review
5/19/2021 This medication has been crucial in maintaining my mobility. I've delayed getting a wheelchair for as long as possible and will continue to take this medication for as long as it's working.
3Patient Review
2/12/2013 I was originally hesitant to start this medication because of possible side effects, like seizures. However, I decided to give it a try by only taking one pill per day. Almost immediately, I noticed more strength in my right leg. So far, there have been no negative side effects that I can mention.
2.7Patient Review
3/7/2019 AMPYRA is more effective than this treatment
2.3Patient Review
12/3/2010 I've been on this medication for six months without the results I was hoping for. It's frustrating, but hopefully my doctor will have some answers when I see him next month.
Patient Q&A Section about dalfampridine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is dalfampridine used for?
"Dalfampridine is a medication used to improve walking speed in people with multiple sclerosis. MS is a disease which can cause problems with movement, sensation, vision, and bladder control."
Answered by AI
What is the generic name for dalfampridine?
"A generic form of Ampyra (dalfampridine) which is used to improve walking in adults with MS, has been approved by the U.S. Food and Drug Administration and launched by Mylan NV."
Answered by AI
Is dalfampridine the same as Ampyra?
"Dalfampridine is a medication that was approved by the FDA on January 22nd, 2010 to help improve walking in patients who have MS. Dalfampridine is a symptomatic therapy, which means it can be used in combination with disease modifying agents. Dalfampridine is an extended release form of 4-aminopyridine (4-AP, also known as fampridine)."
Answered by AI
What type of drug is dalfampridine?
"In chemistry, organic compounds are chemicals that have both carbon and hydrogen. There are millions of different organic compounds because carbon can create long chains."
Answered by AI