What is Crinone
ProgesteroneThe Generic name of this drug
Treatment SummaryProgesterone is a naturally-occurring hormone in women that helps with fertility and pregnancy. Low levels of progesterone or a lack of a response to progesterone can lead to infertility or pregnancy loss. Progesterone is also used in various contraceptive preparations to stop ovulation and fertilization. It is available in different forms, such as capsules, gel, tablets, inserts, and injections. Progesterone can be made from plants and is chemically identical to the progesterone found in the human body.
Progesteroneis the brand name
Crinone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Progesterone
Progesterone
1978
124
Effectiveness
How Crinone Affects PatientsProgesterone has many different effects, depending on the concentration and delivery form of the drug. Generally, it helps to transition the uterus from the growth phase to the preparation phase needed for pregnancy. It also helps to provide a supportive environment for a fertilized egg and maintain a pregnancy. Progesterone can also be used as a contraceptive, as it suppresses ovulation, thickens cervical mucus to prevent sperm movement, and lowers the levels of hormones that trigger ovulation. Injections of progesterone are used to help prevent overgrowth of endometrial tissue due to unopposed estrogen, which can
How Crinone works in the bodyProgesterone helps prepare the uterus for pregnancy. It works by activating a special protein, called Progesterone Receptor (PR), which is found in female reproductive tissue and the central nervous system. This protein helps control the growth and development of target tissues. Progesterone can also help prevent pregnancy by thickening cervical mucus and stopping ovulation. When taken perfectly, it has a failure rate of 0.5%. However, when taken regularly, the failure rate is estimated to be 5%.
When to interrupt dosage
The suggested dosage of Crinone is contingent upon the determined condition, such as hormonal imbalance, Female Infertility and Postmenopause. The amount of dosage is contingent upon the method of administration noted in the table beneath.Condition
Dosage
Administration
Postmenopause
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
Endometrial hyperplasia caused by conjugated estrogen
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
Gel
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
hormonal imbalance
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
Female Infertility
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
Uterine hemorrhage
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
Amenorrhea
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
prophylaxis of recurrent spontaneous preterm birth
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
recurrent spontaneous preterm birth
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
Secondary Amenorrhea
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
Pregnancy
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
Assisted Reproductive Techniques (ART)
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
Reproductive Technology
8.0 %, 100.0 mg, 0.001 mg/mg, , 0.0025 mg/mg, 1.0 mg/mg, 50.0 mg, 50.0 mg/mL, 0.045 mg/mg, 200.0 mg, 1.1 mg/hour, 0.09 mg/mg, 16.9 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 25.0 mg/mL
Capsule, , Capsule - Oral, Gel - Vaginal, Solution, Oral; Transdermal, Topical, Vaginal, Capsule; Spray, metered - Oral; Transdermal, Subcutaneous, Insert - Vaginal, Cream - Transdermal, Capsule, liquid filled - Oral, Intramuscular, Oral, Insert, Cream - Vaginal, Solution - Topical, Injection - Intramuscular, Cream, Capsule; Spray, metered, Gel, Capsule - Vaginal, Transdermal, Liquid - Intramuscular, Solution - Intramuscular, Injection, Ring, Injection, solution - Intramuscular, Cream - Topical, Injection, solution, Ring - Vaginal, Capsule, liquid filled, Liquid, Solution - Subcutaneous
Warnings
Crinone ContraindicationsCondition
Risk Level
Notes
liver dysfunction or disease
Do Not Combine
Pulmonary Embolism
Do Not Combine
Breast Cancer
Do Not Combine
Breast
Do Not Combine
Liver Dysfunction
Do Not Combine
Breast
Do Not Combine
suspected pregnancy
Do Not Combine
Pulmonary Embolism
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Malignant Neoplasms
Do Not Combine
Thromboembolism
Do Not Combine
suspected pregnancy
Do Not Combine
Missed Abortion
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
active thrombophlebitis
Do Not Combine
Breast
Do Not Combine
Heart Attack
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Thromboembolism
Do Not Combine
Thrombophlebitis
Do Not Combine
undiagnosed vaginal bleeding
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Pulmonary Embolism
Do Not Combine
Cerebrovascular accident
Do Not Combine
Thromboembolism
Do Not Combine
cerebral apoplexy
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Progesterone may interact with Toxoplasma Infections
Severe Hypersensitivity Reactions
Do Not Combine
Progesterone may interact with Toxoplasma Infections
Common Crinone Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Progesterone.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Progesterone.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Progesterone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Progesterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Progesterone.
Crinone Toxicity & Overdose RiskThe toxic dose of progesterone in rats is 327mg/kg. It is not recommended to use progesterone while pregnant and it may decrease fertility until it is stopped. Studies have found that progesterone may cause tumors in animals, but it is not yet known if this applies to humans. Using combined oral contraceptives has been linked to an increased risk of breast cancer, but it is not clear if progestin-only contraceptives have the same effect. Progesterone can be found in the milk of nursing mothers, but there have been no reports of negative effects on the baby. In rare cases, there have been reports
Crinone Novel Uses: Which Conditions Have a Clinical Trial Featuring Crinone?
Presently, there are 56 active clinical trials assessing the ability of Crinone Gel to aid Assisted Reproductive Techniques (ART) and Reproductive Technology.Condition
Clinical Trials
Trial Phases
Gel
0 Actively Recruiting
Assisted Reproductive Techniques (ART)
0 Actively Recruiting
hormonal imbalance
0 Actively Recruiting
recurrent spontaneous preterm birth
0 Actively Recruiting
Postmenopause
7 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Reproductive Technology
0 Actively Recruiting
prophylaxis of recurrent spontaneous preterm birth
0 Actively Recruiting
Pregnancy
43 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4
Female Infertility
2 Actively Recruiting
Not Applicable
Secondary Amenorrhea
0 Actively Recruiting
Amenorrhea
2 Actively Recruiting
Phase 1, Not Applicable
Uterine hemorrhage
2 Actively Recruiting
Phase 3, Phase 2
Endometrial hyperplasia caused by conjugated estrogen
0 Actively Recruiting
Crinone Reviews: What are patients saying about Crinone?
5Patient Review
10/15/20074.3Patient Review
3/13/2012 I've been using this for a little over a week and have experienced fatigue and some breast tenderness. I also have mild cramping in my vaginal area, but it's not too bad. I'm unsure if it's okay to have intercourse while taking this drug because of the discharge.
4.3Patient Review
5/24/2010 I had some uncomfortable side effects while taking this medication, including breast tenderness, cramping, heartburn and acne.
4Patient Review
7/28/2010 I've had good results with this progesterone supplement, and it has far fewer side effects than other brands. The discharge can be a bit icky, and my breasts are sometimes sore, but that's it.
4Patient Review
1/7/2010 The side effects for me were really bad. I had headaches, was dizzy, and got cramps in my stomach.
3.7Patient Review
5/30/2009 I'm very drug sensitive, and this unfortunately did not work for me. The side effects weren't worth it either.
3Patient Review
1/16/2010 I'm just starting out with this treatment, but I'm already seeing some positive results. My monthly cycles have become more regular, and I haven't experienced any terrible side effects. Just some minor headaches, breast tenderness, and discharge.
Patient Q&A Section about crinone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Crinone gel help implantation?
"The study found that the use of Crinone 8% vaginal progesterone gel was associated with a lower implantation rate than the use of IM progesterone-in-oil."
Answered by AI
What is the purpose of Crinone gel?
"This medication is used to treat infertility by increasing the levels of progesterone in the body. Progesterone is a hormone essential for maintaining pregnancy. This medication can also be used to restore menstrual cycles in women whose cycles have stopped."
Answered by AI
What is Crinone used for in IVF?
"Crinone is a medication used to treat infertility by providing extra progesterone. This is necessary when the body does not produce the correct levels of progesterone during the menstrual cycle, or when undergoing assisted fertility procedures. Crinone may also be used during pregnancy to support the new pregnancy."
Answered by AI
How long do you take Crinone during pregnancy?
"Crinone 8% is given vaginally as two 90 mg doses per day to women with partial or complete ovarian failure who need progesterone replacement. If pregnancy happens, treatment may continue until the placenta can function on its own, for up to 10 to 12 weeks."
Answered by AI