Cortrosyn

Iritis, Ophthalmia, Sympathetic, Pemphigus + 22 more

Treatment

25 FDA approvals

20 Active Studies for Cortrosyn

Treatment for

Iritis

What is Cortrosyn

TetracosactideThe Generic name of this drug

Treatment SummaryTetracosactide (also known as Cosyntropin) is a synthetic hormone that is identical to a segment of the natural hormone adrenocorticotropic hormone (ACTH). This peptide works in the same way as natural ACTH, stimulating the production of corticosteroids in the adrenal cortex. Tetracosactide is absorbed over a longer period of time than natural ACTH, so treatment can be continued with less frequent doses.

Cortrosynis the brand name

image of different drug pills on a surface

Cortrosyn Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Cortrosyn

Tetracosactide

2003

Approved as Treatment by the FDA

Tetracosactide, also known as Cortrosyn, is approved by the FDA for 25 uses which include Adrenal Insufficiency and Panhypopituitarism .

Adrenal Insufficiency

Panhypopituitarism

Helps manage Panhypopituitarism

Lupus Erythematosus

Helps manage Lupus Erythematosus

Rheumatoid Arthritis

Helps manage Rheumatoid Arthritis

exfoliative erythroderma

Helps manage exfoliative erythroderma

Acute Rheumatic Fever

Helps manage Acute Rheumatic Fever

Jaundice, Hemolytic

Helps manage acquired hemolytic jaundice

Nephrotic Syndrome

Helps manage Nephrotic Syndrome

Still's Disease

Helps manage Still's Disease

Multiple Sclerosis

Helps manage Multiple sclerosis exacerbation

Ophthalmia, Sympathetic

Helps manage Ophthalmia, Sympathetic

Psoriatic Arthritis

Helps manage Psoriatic Arthritis

Ankylosing Spondylitis

Helps manage Ankylosing Spondylitis (AS)

Dermatomyositis (DM)

Helps manage Dermatomyositis (DM)

Periarteritis nodosa

Helps manage Periarteritis nodosa

Uveitis

Helps manage Uveitis

Arthritis, Gouty

Iritis

Helps manage Iritis

Pemphigus

Helps manage Pemphigus

Bell's Palsy

Helps manage Bell's Palsy

Scleroderma

Helps manage Scleroderma

Pink Eye

Helps manage Conjunctivitis

Optic Neuritis

Helps manage Optic Neuritis

Choroiditis

Helps manage Choroiditis

Ulcerative Colitis

Helps manage Ulcerative Colitis

Effectiveness

How Cortrosyn Affects PatientsCosyntropin is a synthetic form of ACTH (adrenocorticotropic hormone) that has similar effects to natural ACTH, with the potential to stimulate the adrenal cortex. The effects of Cosyntropin are maximized at 0.25 milligrams (mg) and are comparable to the effects of 25 units of natural ACTH. Cosyntropin is less likely to cause an allergic reaction than natural ACTH, as it lacks part of the amino acid sequence that is responsible for causing an immune response. In addition to stimulating the adrenal cortex, Cosyntropin may also increase melanin production and

How Cortrosyn works in the bodyCosyntropin connects to a receptor on the cells in the adrenal gland. This connection stimulates the production of hormones, like cortisol and aldosterone, from cholesterol. In people with healthy adrenal glands, cosyntropin increases the amount of hormones produced. However, it won't have much effect on those with adrenal insufficiency.

When to interrupt dosage

The endorsed portion of Cortrosyn is contingent upon the diagnosed condition, including Exfoliative dermatitis, Arthritis, Gouty and Uveitis. The dosage fluctuates based on the method of administration (e.g. Injection, powder, lyophilized, for solution - Intramuscular; Intravenous; Parenteral or Injection, solution) as seen in the table below.

Condition

Dosage

Administration

Panhypopituitarism