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TJA for Osteoarthritis and Weight Loss

Boston Medical Center, Boston, MA
Targeting 3 different conditionsMedical weight loss +4 moreN/ARecruitingLed by David M Freccero, MDResearch Sponsored by Boston Medical Center

Study Summary

This trial will compare bariatric surgery, medical weight loss, and usual standard of care to optimize morbidly obese patients with end-stage osteoarthritis of the hip or knee joint for total joint arthroplasty.

Eligible Conditions
  • Morbid Obesity
  • Osteoarthritis

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
You must be willing to consider TJA as a treatment option.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Bariatric surgery to achieve a BMI ≤ 40 kg/m2
Medical weight loss to achieve a BMI ≤ 40 kg/m2
Secondary outcome measures
24 month reoperation rate
24 month revision rate
90 day postoperative readmission rate
+11 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Group I: Medical weight loss groupExperimental Treatment3 Interventions
Participants randomized to the medical weight loss study arm will attempt to lose weight through diet, exercise, and potentially pharmacotherapy an effort to lower their BMI to ≤ 40 kg/m2.
Group II: Bariatric surgery groupExperimental Treatment3 Interventions
Participants randomized to the bariatric surgery arm will undergo either a laparoscopic sleeve gastrectomy or a laparoscopic gastric bypass to achieve a BMI ≤ 40 kg/m2.
Group III: "Usual Standard of Care"Experimental Treatment2 Interventions
Patients randomized to the "usual standard of care" study arm will be counseled on the importance of losing weight to optimize their BMI and will be provided with referral information (name and clinic number) to either the bariatric surgery or medical weight loss clinics.
First Studied
Drug Approval Stage
How many patients have taken this drug
Bariatric surgery
Completed Phase 4

Find a Location

Who is running the clinical trial?

Boston Medical CenterLead Sponsor
379 Previous Clinical Trials
869,471 Total Patients Enrolled
16 Trials studying Obesity
67,591 Patients Enrolled for Obesity
David M Freccero, MDPrincipal InvestigatorBoston Medical Center

Media Library

Bariatric Surgery (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT05156762 — N/A
Obesity Research Study Groups: "Usual Standard of Care", Bariatric surgery group, Medical weight loss group
Obesity Clinical Trial 2023: Bariatric Surgery Highlights & Side Effects. Trial Name: NCT05156762 — N/A
Bariatric Surgery (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05156762 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the highest possible participant count for this experiment?

"Correct. All information available from clinicaltrials.gov indicates that this medical study is currently recruiting volunteers, having been first posted on October 3rd 2022 and recently updated on the 28th of the same month. This trial requires 138 participants to be recruited at a single location."

Answered by AI

What is the primary aim of this investigation?

"The primary aim of this year-long trial is to attain a BMI ≤ 40 kg/m2 through bariatric surgery. Secondary endpoints being evaluated include prosthetic joint infection rate, total TJA operative time, and the percentage change in body weight from baseline to postoperative results."

Answered by AI

Is there still an opportunity for people to volunteer for this experiment?

"Clinicaltrials.gov divulges that this research, which was first posted on October 3rd 2022, is actively looking for participants. The trial's particulars were last revised on the 28th of October in the same year."

Answered by AI
~92 spots leftby Nov 2026