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Discharge Antibiotic Stewardship for Pediatric Infections (DISCO Trial)
N/A
Waitlist Available
Led By Jeffrey S Gerber, MD, PhD
Research Sponsored by Children's Hospital of Philadelphia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 3 years
Awards & highlights
DISCO Trial Summary
This trial tests if a discharge stewardship bundle can reduce inappropriate antibiotic prescribing for kids with 3 common infections. It will involve surveys, interviews and feedback reports.
Who is the study for?
This trial is for children under 18 with common infections like pneumonia, UTIs, or skin infections who are being discharged from the hospital. It's also for their parents and healthcare providers over 18 working at the hospital. Children who stayed in the hospital longer than a week or needed intensive care are not eligible.Check my eligibility
What is being tested?
The study tests a 'discharge stewardship bundle' to see if it helps reduce unnecessary antibiotic prescriptions when kids leave the hospital after treatment for pneumonia, UTI, or skin infections. The intervention will be adapted and implemented across four children's hospitals.See study design
What are the potential side effects?
Since this trial focuses on improving antibiotic prescribing practices rather than testing new medications, side effects are not a primary concern of this study. However, antibiotics can typically cause digestive issues or allergic reactions.
DISCO Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 3 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 3 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Rate of suboptimal prescribing
Secondary outcome measures
Impact of the discharge stewardship intervention on adverse drug events
Impact of the discharge stewardship intervention on post-discharge treatment failure
DISCO Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Pediatric HospitalistsExperimental Treatment1 Intervention
Prescribing physicians and hospital employees will be recruited during regularly held staff meetings prior to the data collection period. The study team will briefly introduce the study aims and methods and let the hospitalists know that the study team will be emailing them separately to ask permission for Dr. Szymczak to shadow them. Only those who have agreed will participate in the ethnographic observations. For the interviews and surveys, the study team will recruit respondents via contact made during ethnographic observations. The study team will also utilize a snowball approach by asking respondents if they know of any other staff who might be interested in participating in an interview. Approximately 120 clinicians will participate in the interviews and surveys.
Group II: Families of hospitalized childrenActive Control1 Intervention
Families of children who were hospitalized at one of the four participating sites will be approached for consent to participate in the study. Families who consent will complete 2 brief REDCap surveys and a wellness tracker after their child is discharged from the hospital.
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Who is running the clinical trial?
Agency for Healthcare Research and Quality (AHRQ)FED
399 Previous Clinical Trials
6,816,628 Total Patients Enrolled
Children's Hospital of PhiladelphiaLead Sponsor
708 Previous Clinical Trials
8,575,583 Total Patients Enrolled
Seattle Children's HospitalOTHER
301 Previous Clinical Trials
5,211,257 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I am over 18, have been in the hospital for more than 7 days, and need intensive care.I am under 18 and do not work for the hospital.I am under 18 and have pneumonia, a UTI, or a skin infection, treated and released.I am over 18 and work in the hospital as a healthcare professional.
Research Study Groups:
This trial has the following groups:- Group 1: Families of hospitalized children
- Group 2: Pediatric Hospitalists
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is the research team searching for volunteers at this time?
"Based on the clinicaltrials.gov data, this particular medical study is not currently accepting patients; it was initially posted June 10th 2020 and last updated May 9th 2023. Nevertheless, there are a plethora of other trials that may be seeking participants at this time: specifically, 987 studies are actively recruiting individuals."
Answered by AI
Am I eligible to participate in this experimental study?
"Qualified participants for this trial must have bacterial pneumonia with ages ranging from 28 days to 18 years old. In total, 5720 people are eligible for enrolment."
Answered by AI
Is this research endeavor available to those aged 20 or greater?
"The criteria for participation in this clinical trial stipulates that patients must be between 28 days and 18 years old. There are 221 trials available to younger participants, while those 65+ have access to 795 separate studies."
Answered by AI
To what extent are hospitals in Canada facilitating this clinical trial?
"Five medical centres are running this clinical trial, including the Children's Hospital of Philadelphia in Philadelphia, Seattle Children's Hospital in Seattle, and University of Pennsylvania in Salt Lake City."
Answered by AI
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