Smart Reminders for Treatment Compliance

Overseen By Walter Boot, PhD

Age: 65+

Sex: Any

Trial Phase: Academic

Sponsor: Florida State University

Disqualifiers: Parkinson's, Alzheimer's, Neurodegenerative, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 6 months

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how well a smart reminder system can help older adults stick to their at-home brain training exercises. It compares regular text message reminders with a new system, the Adherence Promotion With Person-centered Technology (APPT) System, which tailors reminders based on personal habits and preferences. The trial seeks participants who are 65 or older, have clear vision, and have passed a dementia screening. Those with conditions like Parkinson's or Alzheimer's, or who will not reside in Tallahassee for the next six months, are not eligible. As an unphased trial, this study offers participants the opportunity to contribute to innovative research that could enhance daily life for older adults.

Do I need to stop my current medications to join the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that this reminder system is safe for older adults?

Research shows that the Adherence Promotion With Person-centered Technology (APPT) system helps people remember to take their medication by sending personalized reminders. It uses custom messages and smart technology to encourage users.

Studies on the APPT system emphasize its ability to tailor reminders to each person's needs and preferences, aiming to help them follow their treatment plans better.

Since the APPT system is a reminder tool and not a medication or medical device, it poses no safety concerns like side effects. It focuses on helping people remember tasks, such as taking medication or doing cognitive exercises. Therefore, the main concern is the effectiveness of the reminders, not safety.

In summary, the APPT system is easy to use because it simply sends reminders to help people keep up with their treatment schedules. There are no known safety risks associated with using it. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores innovative ways to boost treatment compliance using technology. Unlike standard reminder systems that send generic messages, the "Smart Adherence Support Condition" uses dynamic algorithms to tailor reminders based on personal preferences, past successes, and other factors. This personalized approach aims to engage participants more effectively by delivering reminders at the times they are most likely to respond. By adapting to individual needs, this system could significantly improve adherence to home-based cognitive training, potentially leading to better treatment outcomes.

What evidence suggests that this trial's reminder systems could be effective for treatment compliance?

Research has shown that the Adherence Promotion With Person-centered Technology (APPT) System, which participants in this trial may receive, uses personalized and flexible smart reminders. This system sends text reminders tailored to each person, considering their past responses and preferences. Studies have found that these personalized reminders can greatly improve adherence, meaning sticking to a treatment or routine. By customizing reminders, the APPT System aims to help individuals consistently follow their home-based cognitive training. Early findings suggest this method could assist older adults in better managing their cognitive exercises. Meanwhile, another group in this trial will receive a Standard Reminder System, which provides generic reminders to promote adherence. ^{1 6 7 8 9}

Are You a Good Fit for This Trial?

This trial is for older adults who are at least 65 years old with normal or corrected vision and can pass a dementia screening. It's not suitable for those with blindness, deafness, reading difficulties below the 6th-grade level, Parkinson's, Alzheimer's, other neurodegenerative diseases, terminal illness, severe motor issues or those not in Tallahassee for 6 months.

Inclusion Criteria

Normal or corrected to normal visual acuity

Must pass a dementia screening

I am 65 years old or older.

Exclusion Criteria

Terminal illness

Not living in the Tallahassee area for the entire 6 month study period

I have a history of Parkinson's, Alzheimer's, or another neurodegenerative disease.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in home-based cognitive training with either generic or adaptive reminders over a 6-month period

6 months

Multiple sessions each week

Follow-up

Participants are monitored for adherence and effectiveness of the reminder systems

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Adherence Promotion With Person-centered Technology (APPT) System
• Standard Reminder System

Trial Overview The study is testing if an adaptive and personalized reminder system (APPT) can improve adherence to home-based cognitive training compared to standard reminders among older adults. The goal is to see which method better supports regular participation in the training.

How Is the Trial Designed?

Group I: Smart Adherence Support Condition Experimental Treatment 1 Intervention

To promote adherence, participants will receive reminders when home-based cognitive training has not been completed. This will be in the form of a text message to participants' smart phone. In this condition, participants will receive adaptive and tailored reminders based on dynamic algorithms that deploy reminders in a way that considers participant preferences, days and times of previous successful assessments, the success of previous reminder attempts, and answers to brief questions contained within reminder prompts. Parameter weights for these variables will be adjusted dynamically over a 6-month assessment period to ensure that reminders are deployed when they are most likely to be acted upon.

Group II: Reminder Only Condition Active Control 1 Intervention

To promote adherence, participants will receive generic reminders when home-based cognitive training has not been completed. This will be in the form of a text message to participants' smart phone.

Who Is Running the Clinical Trial?

Florida State University

Lead Sponsor

Trials

234

Recruited

41,100+

Citations

1. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/40850371/

Introducing the adherence promotion with person-centered ... Adherence rate will be the primary outcome measure, calculated and compared across conditions. Findings from this study will have implications ...

2. researchgate.net researchgate.net/publication/357143321_Aims_of_the_Adherence_Promotion_With_Person-Centered_Technology_APPT_Project

Aims of the Adherence Promotion With Person-Centered ... These studies will provide insight into the benefits of adherence support, and individual difference factors that should shape the adherence ...

3. clinicaltrials.gov clinicaltrials.gov/study/NCT05016856

Smart Reminders to Promote Home-based Cognitive ... Intervention/Treatment, Behavioral : Adherence Promotion With Person-centered Technology (APPT) System. A personalized and adaptive text message reminder system ...

4. iadrp.nia.nih.gov iadrp.nia.nih.gov/project/adherence-promotion-person-centered-technology-appt-project-promoting-adherence-enhance-2

Promoting Adherence to Enhance the Early Detection and ... The Adherence Promotion with Person-centered Technology (APPT) Project: Promoting Adherence to Enhance the Early Detection and Treatment of Cognitive Decline.

5. sciencedirect.com sciencedirect.com/science/article/pii/S1098301515051311

Patient-Centered Outcomes of Medication Adherence ... Modest but significant improvements in patient-centered outcomes were observed after medication adherence interventions.

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11908691/

New Opportunities for the Early Detection and Treatment of ... Specifically, we highlight prior and ongoing work conducted as part of the Adherence Promotion with Person-centered Technology (APPT) project, ...

7. bmcdigitalhealth.biomedcentral.com bmcdigitalhealth.biomedcentral.com/articles/10.1186/s44247-023-00008-1

New opportunities for the early detection and treatment of ... Specifically, we highlight prior and ongoing work conducted as part of the Adherence Promotion with Person-centered Technology (APPT) project, ...

8. drug-dev.com drug-dev.com/patient-centric-technology-how-technology-can-impact-patient-adherence-increasing-patient-engagement-education-to-save-the-healthcare-industry-billions/

How Technology Can Impact Patient Adherence Mobile adherence applications enable pharmaceutical brands and HCPs to gather this valuable data. The technology utilizes commercial programs that involve data ...

9. frontiersin.org frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2020.604183/full

A Digital Innovation for the Personalized Management of ... This study suggests that digital solutions have the potential to facilitate high-quality medication management and improve adherence to medications.