Cold Vest Exposure for Obesity
Trial Summary
Will I have to stop taking my current medications?
Yes, you will need to stop taking any prescribed medications other than oral contraceptives. Treatments for weight loss or supplements that may alter weight or metabolism are not allowed, but vitamins are okay.
How does the Cold Vest Exposure treatment for obesity differ from other treatments?
What is the purpose of this trial?
A promising approach to correct the metabolic dysfunction associated with obesity is to activate brown fat non-shivering thermogenesis (NST). A critical limitation with NST as a therapeutic option, however, is that this beneficial process is silenced under human physiological temperature conditions and the mechanisms of how this occurs is unknown. This study will be the first to identify human NST silencing factors that may be targeted for the treatment of obesity and metabolic disorders.
Research Team
Paul Cohen, Ph.D., M.D.
Principal Investigator
The Rockefeller University
Joeva Barrow, Ph.D., R.D.
Principal Investigator
The Rockefeller University and Cornell University
Eligibility Criteria
This trial is for adults aged 18-35 who are either obese with a BMI over 30 and HgA1c levels below 5.7%, or those with Type II diabetes having higher HgA1c levels but possibly on certain medications. A lean group with BMI between 18.5 and 24.9 and low HgA1c is also included.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Nutritional assessments, BMI, and body composition measurements are conducted
Cold Exposure and Rewarming
Participants undergo a 3-hour cold exposure followed by a 3-hour rewarming period to assess metabolome, proteome, and transcriptome changes
Follow-up
Participants are monitored for safety and effectiveness after the cold exposure and rewarming interventions
Treatment Details
Interventions
- Cold Vest Exposure Period
- Fasting
- Rewarming Exposure Period
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rockefeller University
Lead Sponsor
Cornell University
Collaborator