Cortef

Scleritis, Iridocyclitis, Iritis + 47 more

Treatment

22 FDA approvals

20 Active Studies for Cortef

What is Cortef

Hydrocortisone acetate

The Generic name of this drug

Treatment Summary

Hydrocortisone, also known as cortisol, is a steroid hormone produced by the adrenal cortex. It is used to treat various conditions related to the immune system, inflammation, and cancer. It was first discovered in the 1930s by Edward Kendall and was approved for medical use by the FDA in 1952.

Cortisporin

is the brand name

image of different drug pills on a surface

Cortef Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Cortisporin

Hydrocortisone acetate

1963

43

Approved as Treatment by the FDA

Hydrocortisone acetate, commonly known as Cortisporin, is approved by the FDA for 22 uses which include Hypersensitivity and Neoplastic Disease .

Hypersensitivity

Neoplastic Disease

Collagen Diseases

Rheumatoid Arthritis

Helps manage Rheumatoid Arthritis

Skin Diseases

Androgenital syndrome

Helps manage Androgenital syndrome

Haemorrhoids

Thyroiditis

Helps manage Thyroiditis

Thyroiditis

Helps manage Thyroiditis

Dermatological Disease

Itching

Ulcerative Colitis

Used in combination with other therapies

Pruritus

hormonal disorder

Proctitis

Helps manage Proctitis

Atopic Dermatitis

Skin Irritation

Adrenal Insufficiency

Helps manage Adrenal cortical hypofunctions

Ulcerative Colitis

Used in combination with other therapies

Adrenal cortical hypofunctions

Helps manage Adrenal cortical hypofunctions

Proctitis

Helps manage Proctitis

cryptitis

Helps manage cryptitis

Effectiveness

How Cortef Affects Patients

Hydrocortisone works by attaching to a receptor in the body that helps reduce inflammation. It is usually considered a safe drug, with long-lasting effects. However, if the patient experiences any irritation or allergic reactions, they should stop taking the medication.

How Cortef works in the body

Corticosteroids reduce inflammation by narrowing blood vessels and stopping white blood cells from flowing to the site of inflammation. They also work on a genetic level, blocking substances that cause inflammation and promoting substances that reduce it. Low doses are anti-inflammatory, while high doses are immunosuppressive. High doses over a long period of time also increase sodium levels and decrease potassium levels.

When to interrupt dosage

The advised dosage of Cortef is contingent upon the diagnosed condition, such as Ophthalmia, Sympathetic, Drug Allergy and Sarcoidosis. The quantity of dosage alters, in concurrence with the technique of delivery (e.g. Topical or Auricular (otic)) presented in the table beneath.

Condition

Dosage

Administration

Acute, Inflammatory Superficial Cutaneous Lesions caused by susceptible bacteria

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Thyroiditis

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Itching

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Blepharitis

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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ocular bacterial infections

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Adrenal Insufficiency

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Communicable Diseases

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Adrenal Cortex Hormones

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Collagen Diseases

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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hormonal disorder

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Ulcerative Colitis

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Anorectal Surgeries

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Fissure in Ano

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Anal inflammation

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Proctitis

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Postoperative

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Allergic Conjunctivitis (AC)

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Dermatitis

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

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Hemorrhoids

, 0.01 mg/mg, 0.15 mg/mg, 20.0 mg/mL, 0.025 mg/mg, 25.0 mg/mL, 10.0 mg/mL, 25.0 mg, 30.0 mg, 0.005 mg/mg, 0.02 mg/mg, 0.0088 mL/mL, 100.0 mg/mL, 0.0185 mg/mg, 0.019 mg/mg, 0.0055 mg/mg, 0.0112 mg/mg, 5.0 mg/mL, 0.5 %, 10.0 mg, 1.0 %, 40.0 mg, 1.5 %, 0.028 mg/mg, 1.0 mg/mg, 5.0 mg, 2.0 %, 2.5 %, 10.0 %, 23.5 mg/mL, 18.5 mg/mL, 0.9 mg/mg, 15.0 mg/mL, 0.0705 mg/mg, 0.25 mg/mg, 0.001 mg/mg, 11.2 mg/mL, 0.04 mg/mg, 0.0235 mg/mg, 0.0075 mg/mg

Topical, , Aerosol, foam, Aerosol, foam - Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Ointment, Ointment - Topical, Kit, Suppository - Rectal, Rectal, Suppository, Cream - Rectal, Gel - Rectal, Gel, Gel - Topical, Aerosol, foam - Rectal, Auricular (otic); Ophthalmic, Ointment - Auricular (otic); Ophthalmic, Suspension - Auricular (otic); Ophthalmic, Suspension, Rectal; Topical, Ointment - Rectal; Topical, Ointment - Rectal, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Aerosol, Aerosol - Rectal, Soap, Soap - Topical, Powder - Topical, Powder, for solution - Topical, Powder, for solution, Powder, Cream - Rectal; Topical, Lotion / shampoo, Lotion / shampoo - Topical, Ointment - Ophthalmic, Shampoo - Topical, Shampoo, Kit - Topical, Solution, Solution - Topical, Auricular (otic), Solution / drops - Auricular (otic), Suspension - Ophthalmic, Suspension - Auricular (otic), Kit - Oral, Oral, Kit - Irrigation; Ophthalmic; Topical, Irrigation; Ophthalmic; Topical, Kit - Irrigation; Ophthalmic; Respiratory (inhalation); Topical, Oral; Rectal, Kit - Ophthalmic; Respiratory (inhalation); Topical, Ophthalmic; Topical, Kit - Respiratory (inhalation); Topical, Kit - Ophthalmic; Topical, Ophthalmic; Respiratory (inhalation); Topical, Irrigation; Ophthalmic; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Respiratory (inhalation); Topical

Androgenital syndrome

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Warnings

There are 20 known major drug interactions with Cortef.

Common Cortef Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Hydrocortisone acetate.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Hydrocortisone acetate.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Hydrocortisone acetate.

Alpelisib

Major

The metabolism of Alpelisib can be increased when combined with Hydrocortisone acetate.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Hydrocortisone acetate.

Cortef Toxicity & Overdose Risk

Taking too much of a glucocorticoid drug can cause long-term health issues like cataracts, glaucoma, high blood pressure, and water retention. There may also be short-term problems such as ulcers, muscle weakness, and changes in mood or behavior. To treat an overdose, doctors may reduce the dose or stop the drug and provide supportive treatment.

image of a doctor in a lab doing drug, clinical research

Cortef Novel Uses: Which Conditions Have a Clinical Trial Featuring Cortef?

525 active clinical trials are currently evaluating the potential of Cortef in ameliorating Ulcerative Colitis, Inflammation and Trichinosis.

Condition

Clinical Trials

Trial Phases

Rheumatoid Arthritis

55 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Open-angle glaucoma

45 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1, Phase 1

Thyroiditis

0 Actively Recruiting

Adrenal Insufficiency

0 Actively Recruiting

Fluorophotometry

0 Actively Recruiting

Eczema

0 Actively Recruiting

Ulcerative Colitis

14 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1

Anorectal Surgeries

0 Actively Recruiting

Defecation

0 Actively Recruiting

Iritis

0 Actively Recruiting

Proctitis

0 Actively Recruiting

Hypersensitivity

1 Actively Recruiting

Phase 4

Allergic Conjunctivitis (AC)

1 Actively Recruiting

Phase 2

Dermatologic disorders

0 Actively Recruiting

Scleritis

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Androgenital syndrome

0 Actively Recruiting

Haemorrhoids

1 Actively Recruiting

Not Applicable

Neoplastic Disease

1 Actively Recruiting

Phase 1

Dermatitis

1 Actively Recruiting

Not Applicable

Cortef Reviews: What are patients saying about Cortef?

5

Patient Review

7/14/2014

Cortef for Decreased Function of the Adrenal Gland

Cortef has been a life-saving medication for me. I have congenital adrenal hyperplasia and when my levels are regulated, it makes a world of difference. I know other people who struggle with weight issues due to this condition, but Cortef has helped me maintain a healthy weight. I've been on the medication for many years now, so I'm not sure what other side effects there may be.

5

Patient Review

7/18/2015

Cortef for Addison's Disease

I was diagnosed with Addison's disease in the 1950s, and at that time I weighed just 90 pounds. Thanks to modern medicine and treatments like Cortef, I'm now up to 190 pounds and have lived a fairly normal life despite having had a few crises over the years. I'm 81 now and still going strong!

5

Patient Review

8/24/2014

Cortef for Addison's Disease

Cortef has been a game-changer for me. I was originally on the generic form of this drug, but it didn't work nearly as well. I have more energy and just feel overall better on this medication.

5

Patient Review

8/31/2010

Cortef for Fluid Accumulation in the Brain

5

Patient Review

9/27/2012

Cortef for Addison's Disease

I have CAH and this medication has been a lifesaver. I've been taking it since childhood.

4.7

Patient Review

7/20/2011

Cortef for Addison's Disease

This medication unfortunately makes my stomach upset; however, it is otherwise very effective.

4.3

Patient Review

6/6/2011

Cortef for Addison's Disease

I gained 20 pounds in less than two months on this treatment.

4.3

Patient Review

12/3/2011

Cortef for Condition caused by Excess Secretion of Male Hormones

I just started taking this drug yesterday and my blood sugar was 80 points higher today than it was yesterday.

4.3

Patient Review

2/10/2021

Cortef for Increase in Cell Growth of Adrenal Gland Present at Birth

This treatment from 1980 really helped me. It's called "hippo pituitary" and it uses cortef.

4

Patient Review

4/14/2013

Cortef for Addison's Disease

I saw some good results from this treatment.

3.7

Patient Review

10/24/2011

Cortef for Underdevelopment of the Pituitary Gland Since Birth

This medication was a lifesaver for me nine years ago. I have graves disease and pernicious anemia, so cortef and florinef cause really bad water retention.

3.7

Patient Review

11/30/2010

Cortef for Addison's Disease

3

Patient Review

12/14/2010

Cortef for Diagnostic Test For Cushing's Syndrome

I've been on this medication for five months now. The biggest side effect I've experienced is the opposite of what most people report; instead of insatiable hunger, I have to make a concerted effort to eat. If I don't remind myself, it's easy to forget meals entirely.

2

Patient Review

9/27/2011

Cortef for Systemic Lupus Erythematosus

Unfortunately, I now have to get surgery for cataracts in both eyes because of the side effects from this medication. In addition to that, it's made my symptoms from Addison's disease worse.

1

Patient Review

2/27/2011

Cortef for Addison's Disease

This medication is effective; however, I have found it difficult to lose weight while taking it.

Patient Q&A Section about cortef

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug Cortef used to treat?

"This medication is used to treat a variety of conditions, including arthritis, disorders of the blood/hormone/immune system, skin and eye conditions, breathing problems, cancer, and severe allergies. It works by suppressing the immune system's response to diseases, which reduces symptoms such as pain, swelling, and reactions similar to allergies."

Answered by AI

Is Cortef the same as prednisone?

"The brands of prednisone are Prednisone Intensol and Rayos, while the brands of hydrocortisone are A-Hydrocort, Solu-CORTEE, and Cortef."

Answered by AI

Is Cortef an immunosuppressant?

"If you are using hydrocortisone, be aware that it may weaken your body's response to infection and make it harder for you to know that you have an infection."

Answered by AI

Is Cortef a steroid?

"Cortef is a low-strength corticosteroid medication that is man-made and mimics the natural hormone cortisol that is produced by the body. This medication works by reducing the amount of certain chemicals in the body that are responsible for causing symptoms like itching, redness, swelling or pain."

Answered by AI

Clinical Trials for Cortef

Image of University Center for Ambulatory Surgery in Somerset, United States.

Infusion Pump for Postoperative Pain

18+
All Sexes
Somerset, NJ

This study will be a pragmatic, prospective cluster randomized trial, where clusters will formed based on sequential 2 week time increments across the study recruitment period.. Patients 18 years or older undergoing ACL reconstruction, open shoulder labrum or rotator cuff surgery, arthroscopic rotator cuff repair, proximal or distal patellar realignment surgery, open knee arthrotomy cases (i.e. inside out meniscus repair, osteochondral allograft transplantation (OCA), meniscal allograft transplantation (MAT)) at University Center for Ambulatory Surgery, LLC (UOA) will be reviewed for eligibility. Once identified, potential study subjects will be asked whether they are interested in participating in the project. If the patient agrees, the subject will be given the informed consent to read and sign. Objectives: The primary objective is to compare the effectiveness of postoperative infusion pain pump versus preoperative nerve block in reducing visual analog pain scores/numerical pain rating scale (VAS/NPRS) in the postoperative period. The second objective is to evaluate the requirement of narcotic and non-narcotic analgesic medications between the two groups. Hypotheses: Use of continuous infusion pain pump or single shot peripheral block will result in similar post-operative pain control after outpatient sports medicine surgical cases.

Phase 4
Recruiting

University Center for Ambulatory Surgery

Image of University of Waterloo, School of Optometry and Vision Science in Waterloo, Canada.

Brain Stimulation for Vision Impairment

18+
All Sexes
Waterloo, Canada

This pilot clinical trial evaluates whether non-invasive brain stimulation improves the orientation and mobility (O\&M) skills of individuals with constricted visual fields in both eyes. The study is composed of three visits. The first visit is meant to confirm eligibility by performing a few clinical tests. Eligible participants will then complete two additional visits, one in which they receive active stimulation, and one in which they receive placebo (sham) stimulation. Stimulation will be administered in a randomized, double-blind order. To evaluate improvement, various measures of O\&M performance will be assessed on a standardized obstacle course featuring static natural and artificial obstacles at defined intervals after the intervention. We hypothesize that the application of brain stimulation to region of the brain responsible for visual processing will improve the orientation and mobility skills of individuals with binocular constricted visual fields immediately following stimulation, and the results will inform the design of a future, larger-scale study.

Waitlist Available
Device

University of Waterloo, School of Optometry and Vision Science

Benjamin Thompson, PhD

Image of McMaster Children's Hospital - Digestive Diseases Clinic in Hamilton, Canada.

Vancomycin for Ulcerative Colitis

18+
All Sexes
Hamilton, Canada

This clinical trial tests if oral vancomycin can safely treat active ulcerative colitis (UC) in adults who also have primary sclerosing cholangitis (PSC), a liver condition. The main questions it aims to answer are: * Can oral vancomycin improve UC symptoms as measured by Mayo score at 4 weeks? * Is oral vancomycin safe and tolerable in this patient group? Participants will be compared to see if vancomycin works better than placebo. Participants will: * Take oral vancomycin (250 mg twice daily) or identical placebo capsules for 4 weeks * Have the option for 4 more weeks of open-label vancomycin after the blinded phase * Attend clinic visits at baseline, week 4, and follow-up for Mayo scoring, endoscopy, blood/stool tests, and safety checks * Track treatment adherence and side effects The study primarily assesses if the trial can recruit 14 participants, retain them, achieve good adherence, and follow protocol procedures (feasibility). Secondary goals include safety (adverse events) and early signs of benefit in UC activity, liver tests, and gut bacteria balance. This pilot will guide larger future studies.

Phase 2
Waitlist Available

McMaster Children's Hospital - Digestive Diseases Clinic

Neeraj Narula, MD

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Image of Johns Hopkins Bayview Medical Center in Baltimore, United States.

VR-Enhanced PMR for Post-Burn Symptoms

18+
All Sexes
Baltimore, MD

The goal of this clinical trial is to learn whether progressive muscle relaxation (PMR), delivered either alone or enhanced with virtual reality (VR), can help treat chronic symptom, such as pain, itch, anxiety, sleep disturbances, and fatigue, in adult burn survivors. The main questions it aims to answer are: * Does VR-enhanced PMR (VR-PMR) reduce chronic pain, anxiety, itch, sleep disturbances, and fatigue more effectively than standard PMR? * Is VR-PMR a feasible and acceptable self-administered home-based intervention for burn survivors? Researchers will compare two self-administered intervention conditions, VR-enhanced PMR and standard PMR, using a randomized to sequence crossover design to see if VR technology enhances the therapeutic effects of PMR on chronic symptom management in burn survivors. Participants will: * Complete home-based sessions of VR-enhanced PMR * Complete home-based sessions of standard PMR * Report symptoms such as pain, itch, anxiety, sleep disturbances, and fatigue throughout the study * Use VR equipment provided for the intervention period (during the VR-PMR arm)

Recruiting
Has No Placebo

Johns Hopkins Bayview Medical Center

Sheera Lerman Zohar, PhD

Image of MUHC - Montreal General Hospital in Montreal, Canada.

Ustekinumab for Crohn's Disease and Ulcerative Colitis

18+
All Sexes
Montreal, Canada

The goal of this clinical trial is to evaluate whether disease remission can be maintained when biologic therapy is reduced in patients with Crohn"s disease (CD) and ulcerative colitis (UC) taking ustekinumab (UST). The main question it aims to answer is: Can we de-escalate UST subcutaneous dose either from every 4 weeks (Q4) to every 8 weeks (Q8) or every 8 weeks (Q8) to every 12 weeks (Q12) in CD or UC patients in deep remission without loosing their response? Researchers will follow UST blood levels, inflammation markers and intestinal mucosa integrity and to see if UST dose can be reduced while maintaining clinical remission. Participants will: Change UST dosing from Q4 to Q8 or from Q8 to Q12. Visit the clinic once every 12 weeks for checkups and tests.

Phase 4
Recruiting

MUHC - Montreal General Hospital

Janssen Inc.

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Image of The Royal Alexandra Hospital in Edmonton, Canada.

Graft Selection for Glaucoma Surgery

18 - 110
All Sexes
Edmonton, Canada

Glaucoma refers to a group of progressive optic neuropathies that lead to permanent vision loss. Glaucoma is the leading cause of irreversible blindness globally. In 2020, it was estimated to affect 76 million individuals worldwide, with projections indicating this number will rise to 111.8 million by 2040. In Canada, glaucoma affects an estimated 2.7-7.5% of individuals over the age of 50, contributing substantially to the national disease burden. This condition is linked to damage of the optic nerve due to elevated intraocular pressure (IOP; raised eye pressure), which results in the loss of retinal ganglion cells. Therefore, most of the treatments are guided towards reducing the IOP either via using laser, medications or surgery. Glaucoma surgery is typically reserved for cases where IOP remains uncontrolled while on maximum tolerated medical therapy and/or where glaucoma progression warrants surgery. The goal of many glaucoma surgeries is to divert aqueous humor from the anterior chamber to the subconjunctival space, therefore reducing intraocular pressure. The device used for this purpose are the PRESERFLO™ MicroShunt (Glaukos Corporation, Laguna Hills, CA, USA) (the documents will interchangeably use terms "stent" and "shunt" to refer to these devices in the text below). The device is implanted using the ab externo approach to channel fluid from the anterior chamber to the subconjunctival/subtenon space. To reduce postoperative fibrosis and inhibit fibroblast activity that could obstruct flow and lead to device failure, 5-fluorouracil (5-FU) or mitomycin C (MMC) are administered. Additionally, a double-layered closure of conjunctiva and Tenon's is performed to minimize Tenon's migration and blockage of tenon the stents. Despite these measures, stent encapsulation and failure are still too common requiring revisions and bleb needling in 2-20% of cases within the first 12 months of follow-up. This project will involve a series of studies evaluating graft selection in PreserFlo MicroShunt implantation, focusing on donor sclera, cornea, and pericardium as patch graft materials. First, the investigators will conduct a prospective, randomized study comparing clinical outcomes between these graft types. Outcomes of interest will include surgical success rates, post-operative hypotony, tube erosion, conjunctival complications, infection, and overall device longevity. Donor sclera has long been used as a patch graft in glaucoma drainage device surgery and is associated with low erosion rates and reliable long-term results. Corneal tissue is increasingly used due to its transparency and availability through eye banks, with demonstrated safety in ocular surface reconstruction and tube coverage. Pericardium is another durable, biocompatible option, historically applied in both cardiovascular and ocular surgery, and has shown effectiveness as a patch graft in glaucoma drainage implants. This comparison will extend to both primary implantation and revision surgeries, recognizing the high clinical relevance of graft performance in complex cases. Building on these results, the investigators will then perform a cost-effectiveness analysis of graft strategies, incorporating surgical time, post-operative management, complication rates, and need for re-operation. An economic model will be developed to evaluate costs and resource utilization associated with each material, providing valuable data for policy and surgical decision-making. Finally, the investigators will conduct a patient-reported outcome (PRO) study to assess patient comfort and satisfaction with different grafts. Surveys will evaluate domains such as foreign body sensation, cosmesis, and overall satisfaction at key time points (immediate post-operative period, 1 week, 3 weeks, and 3 months). These results will highlight the patient perspective, an often underrepresented but critical factor in surgical innovation. Together, these studies will comprehensively assess graft selection from surgical, economic, and patient-centered perspectives, informing evidence-based practice in glaucoma care.

Waitlist Available
Has No Placebo

The Royal Alexandra Hospital

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