Combipatch

Postmenopausal Osteoporosis, Hypogonadism, Prostate Cancer + 27 more
Treatment
4 FDA approvals
20 Active Studies for Combipatch

What is Combipatch

EstradiolThe Generic name of this drug
Treatment SummaryEstradiol is a hormone naturally produced in female bodies. It is used in hormone therapy to treat symptoms related to low estrogen levels, such as hot flashes and vaginal dryness. Estradiol is available as a pill, injection, vaginal ring, patch, spray, gel, or cream. It is also often used as a pro-drug ester, like Ethinyl Estradiol (EE), which is the estrogenic component of most combination birth control pills. EE is more bioavailable and more resistant to metabolism than regular estradiol, making it better suited for oral administration.
Estradermis the brand name
Combipatch Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Estraderm
Estradiol
1986
373

Approved as Treatment by the FDA

Estradiol, also known as Estraderm, is approved by the FDA for 4 uses like Birth Control and Palliative Treatment .
Birth Control
Used to treat Contraception in combination with Levonorgestrel
Palliative Treatment
Hormonal Contraception
Used to treat Hormonal Contraception therapy in combination with Levonorgestrel
Breast Cancer

Effectiveness

How Combipatch Affects PatientsEstradiol is used to reduce hot flashes and other menopausal symptoms, as well as improve vaginal dryness and pain during sex. It also helps increase bone density and affects the levels of certain proteins in the liver. However, it can also cause an increased risk of cardiovascular disease, deep vein thrombosis, and stroke, so it is not recommended for patients at high risk of these conditions. Estrogen can also cause an increase in the body's ability to form blood clots, which is associated with taking oral contraceptives or being pregnant. It is believed that estrogen increases levels of sodium in the body, which is
How Combipatch works in the bodyEstrogen is a hormone found in many parts of the body, including the breasts, uterus, ovaries, skin, prostate, bones, and brain. In young women, the main source of estrogen is from the ovaries. After menopause, however, most of the estrogen produced in the body comes from the adrenal glands. Estrogen binds to two types of receptors in the body, ER-alpha and ER-beta. When estrogen binds to these receptors, it enters the target cell's nucleus and triggers gene transcription, which then produces proteins that cause estrogenic effects. These effects can include hot flashes, chills, vaginal

When to interrupt dosage

The suggested dosage of Combipatch is contingent upon the determined condition, for example, Premature Menopause, Pharmaceutical Preparations and Postmenopause. The measure of dosage shifts, in light of the administration technique laid out in the accompanying table.
Condition
Dosage
Administration
Metastatic Breast Cancer
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Therapeutic procedure
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Postmenopausal Osteoporosis
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Hypogonadism
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
hypoestrogenism
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
advanced androgen dependent Prostate cancer
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Birth Control
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Pharmaceutical Preparations
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Low Testosterone
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Atrophic Vaginitis
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Palliation
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Vasomotor Symptoms Associated With Menopause
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Hot flashes
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Atrophic
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Vasomotor System
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
female castration
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
no menstrual period in previous 6 months
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
estradiol
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
moderate to severe symptoms
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Urogenital atrophy
0.005 mg/hour, 0.00025 mg/mg, , 0.06 %, 0.001 mg/mg, 3.28 mg, 0.0025 mg/mg, 0.0025 mg/hour, 2.0 mg, 2.17 mg, 0.5 mg, 0.00375 mg/hour, 0.01 mg/hour, 0.0075 mg/hour, 1.0 mg, 6.0 mg, 12.5 mg, 18.0 mg, 20.0 mg, 15.0 mg, 25.0 mg, 10.0 mg, 22.0 mg, 0.005 mg/mg, 6.57 mg, 0.00125 mg/mg, 0.0075 mg/mg, 0.025 mg, 0.00075 mg/mg, 8.0 mg, 0.097 mg/[USP'U], 0.01 mg/[USP'U], 4.0 mg, 0.0001 mg/mg, 0.00005 mg/mg, 5.0 mg, 1.5 mg, 0.00052 mg/mg, 0.004 mg, 0.01 mg, 0.0005 mg/mg, 0.0006 mg/mg, 0.006 mg/hour, 1.53 mg, 0.1 %, 20.0 mg/mL, 8.66 mg, 4.33 mg, 6.56 mg, 0.146 mg/[USP'U], 4.4 mg, 5.0 mg/mL, 0.0014 mg/hour, 0.62 mg, 40.0 mg/mL, 0.194 mg/[USP'U], 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 10.0 mg/mL, 0.51 mg, 0.45 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable

Warnings

Combipatch Contraindications
Condition
Risk Level
Notes
Deep Vein Thrombosis
Do Not Combine
Thromboembolism
Do Not Combine
Pulmonary Embolism
Do Not Combine
Thromboembolism
Do Not Combine
Neoplasms, Hormone-Dependent
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Liver Dysfunction
Do Not Combine
Thrombophilia
Do Not Combine
Breast
Do Not Combine
Breast
Do Not Combine
Angioedema
Do Not Combine
Breast Cancer
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Pulmonary Embolism
Do Not Combine
Angioedema
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
suspected pregnancy
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Estradiol may interact with Toxoplasma Infections
There are 20 known major drug interactions with Combipatch.
Common Combipatch Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Estradiol.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Estradiol.
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Estradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Estradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Estradiol.
Combipatch Toxicity & Overdose RiskAfter 90 days of testing, the highest safe dose of estradiol in rats was found to be 0.003 mg/kg per day. The lowest toxic dose of ethinyl estradiol is 21 mg/kg per day for women, with an LD50 of 960 mg/kg in rats. Symptoms of an overdose on estradiol may include nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. If an overdose occurs, it is recommended to stop the treatment and offer supportive care.

Combipatch Novel Uses: Which Conditions Have a Clinical Trial Featuring Combipatch?

867 active clinical trials are currently evaluating the potential of Combipatch in providing relief from Osteoporosis, Polymenorrhea and Urogenital Atrophy.
Condition
Clinical Trials
Trial Phases
Osteoporosis
44 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3
Birth Control
37 Actively Recruiting
Phase 4, Not Applicable, Phase 3, Phase 2, Early Phase 1
Metastatic Breast Cancer
84 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4
Urogenital atrophy
0 Actively Recruiting
Postmenopausal Osteoporosis
4 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Hot flashes
18 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Hypogonadism
0 Actively Recruiting
Hormone Replacement Therapy
0 Actively Recruiting
Atrophic
3 Actively Recruiting
Phase 4, Phase 2
no menstrual period in previous 6 months
0 Actively Recruiting
Postmenopause
7 Actively Recruiting
Phase 2, Not Applicable, Phase 3
moderate to severe symptoms
0 Actively Recruiting
Low Testosterone
20 Actively Recruiting
Phase 1, Phase 2, Phase 4, Not Applicable
Hysterectomy
2 Actively Recruiting
Not Applicable, Phase 4
Vasomotor Symptoms Associated With Menopause
8 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Hormonal Contraception
0 Actively Recruiting
Kraurosis Vulvae
0 Actively Recruiting
Breast Cancer
724 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Premature Menopause
0 Actively Recruiting
Breast
0 Actively Recruiting

Combipatch Reviews: What are patients saying about Combipatch?

5Patient Review
11/28/2018
Combipatch for "Change of Life" Signs
I've been using this treatment for 15 years to effectively manage hot flashes. I don't have any issues with the patches staying on, and they last me an entire week. The only downside is that they're quite expensive; however, given how well they work, I think they're worth the price.
5Patient Review
3/13/2019
Combipatch for Wasting of Tissues of the Vulva
I was pleased to find quick relief from hot flashes and irritability within a week of using this patch. I have noticed increased appetite and consequent weight gain; however, I am confident that I can manage this through diet changes. All in all, this is a great product!
5Patient Review
1/6/2020
Combipatch for "Change of Life" Signs
I've been using this patch for 11 years and it's really helped me. I never took it at full strength because even one patch a week caused bloating and breast pain, so I tapered over the years. Now I'm down to half a patch every 10 days, and I tried tapering to zero last year but my hot flashes returned after 3-4 weeks. Hopefully I can continue tapering successfully over the next few years.
5Patient Review
6/27/2021
Combipatch for "Change of Life" Signs
I've been using this product for over 20 years without any issues. I just found out that Medicare won't cover it anymore, which is a bummer because it's really helped me maintain my quality of life.
5Patient Review
2/10/2022
Combipatch for "Change of Life" Signs
I started seeing results from this patch within two weeks of starting it, and now three years post-menopause, I haven't had a hot flash since. If you're on the fence about trying it, just go for it!
5Patient Review
2/10/2022
Combipatch for "Change of Life" Signs
I had some spotting during weeks three and five, but it wasn't too bad.
4.7Patient Review
1/20/2021
Combipatch for "Change of Life" Signs
I've used combipatch for over a year and it's been great in regards to managing my menopausal symptoms. However, the most recent batch I received is definitely different; the disk is more rigid as opposed to pliable like before. Additionally, I'm now experiencing pretty significant irritation from this new patch but had no issue with the prior patches. Trying to tough it out but its very uncomfortable. Wondering why
4.7Patient Review
6/21/2022
Combipatch for "Change of Life" Signs
I've been really happy with this patch overall, but the itching is a serious problem. I often end up scratching my skin raw because of it. Please improve the adhesive! Thank you for your time.
4.3Patient Review
7/18/2018
Combipatch for "Change of Life" Signs
I was given this to help with hot flashes, mood changes, irritability etc. and it's been working great so far! I would recommend applying the patch immediately after bathing when skin is clean and dry. Otherwise, use alcohol to swab the area clean and make sure it's completely dry before applying the patch.
4.3Patient Review
4/28/2021
Combipatch for "Change of Life" Signs
I had great results with this treatment until the manufacturer changed the adhesive. Now, I'm having terrible reactions, as are others who have discovered the same thing. We're all experiencing extreme itching, burning, dried red skin, and the patch falls off before it's time to change it out. This new adhesive is really causing problems for a lot of people. PLEASE go back to using the original adhesive!
4Patient Review
5/25/2022
Combipatch for "Change of Life" Signs
I really love this patch! It's helped me a lot. However, the adhesive is very itchy on my skin. I've tried putting it on different parts of my body, but it always ends up being itchy and red. Please change the adhesive!
4Patient Review
11/22/2021
Combipatch for "Change of Life" Signs
I was on this for a couple years and it really improved my quality of life by preventing hot flashes and night sweats. However, I stopped using it recently because the adhesive they switched to was incredibly itchy and caused redness that would last for days after taking the patch off.
3.7Patient Review
11/4/2019
Combipatch for "Change of Life" Signs
I've been using this patch for almost nine months now. It's effectively stopped hot flashes, night sweats, and moodiness; however, I have experienced irregular spotting that lasts a few days each month. My doctor suggested trying half a patch; hopefully, this will work.
3.7Patient Review
11/16/2021
Combipatch for "Change of Life" Signs
I've found that this treatment really helps with hot flashes. I was having them every 15 minutes prior to using the patch, but now they're much more manageable. However, I have noticed that the patch does come off easily if you sweat or shower, so I put a sterile transparent film over it to keep it in place. This has saved me a lot of money and hassle.

Patient Q&A Section about combipatch

What is the CombiPatch used for?

"This medication is taken by women to help reduce menopause symptoms such as hot flashes and vaginal dryness. These symptoms are caused by the body producing less estrogen. The progestin in this medication helps lower the risk of cancer of the uterus, which can be caused by using estrogen." - Anonymous Online Contributor

Unverified Answer

What is equivalent to CombiPatch?

"As of August 10th, 2022, there is no therapeutically equivalent version of CombiPatch available in the United States. It is important to note that there are many fraudulent online pharmacies that may try to sell an illegal generic version of CombiPatch. These medications can be counterfeit and potentially unsafe." - Anonymous Online Contributor

Unverified Answer

Does CombiPatch make you gain weight?

"The use of progestin in addition to other treatments helps to prevent cancer of the uterus. It is important to discuss treatment options with a doctor to see what is best based on individual needs. There is no evidence to suggest that hormone therapy causes weight gain." - Anonymous Online Contributor

Unverified Answer

How long does it take for CombiPatch to start working?

"COMBIPATCH is an effective combination hormone therapy that results in estrogen levels in your blood similar to what you would see in the early phase of your usual menstrual cycle during your premenopausal years. These levels are achieved within 12 to 24 hours after applying COMBIPATCH." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Combipatch

Have you considered Combipatch clinical trials? We made a collection of clinical trials featuring Combipatch, we think they might fit your search criteria.
Have you considered Combipatch clinical trials? We made a collection of clinical trials featuring Combipatch, we think they might fit your search criteria.
Have you considered Combipatch clinical trials? We made a collection of clinical trials featuring Combipatch, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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