Combipatch

Endometriosis, Low Testosterone, Osteoporosis + 16 more

Treatment

20 Active Studies for Combipatch

What is Combipatch

Norethisterone

The Generic name of this drug

Treatment Summary

Estradiol is a hormone naturally produced in female bodies. It is used in hormone therapy to treat symptoms related to low estrogen levels, such as hot flashes and vaginal dryness. Estradiol is available as a pill, injection, vaginal ring, patch, spray, gel, or cream. It is also often used as a pro-drug ester, like Ethinyl Estradiol (EE), which is the estrogenic component of most combination birth control pills. EE is more bioavailable and more resistant to metabolism than regular estradiol, making it better suited for oral administration.

Necon

is the brand name

image of different drug pills on a surface

Combipatch Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Necon

Norethisterone

1967

347

Effectiveness

How Combipatch Affects Patients

Estradiol is used to reduce hot flashes and other menopausal symptoms, as well as improve vaginal dryness and pain during sex. It also helps increase bone density and affects the levels of certain proteins in the liver. However, it can also cause an increased risk of cardiovascular disease, deep vein thrombosis, and stroke, so it is not recommended for patients at high risk of these conditions. Estrogen can also cause an increase in the body's ability to form blood clots, which is associated with taking oral contraceptives or being pregnant. It is believed that estrogen increases levels of sodium in the body, which is

How Combipatch works in the body

Estrogen is a hormone found in many parts of the body, including the breasts, uterus, ovaries, skin, prostate, bones, and brain. In young women, the main source of estrogen is from the ovaries. After menopause, however, most of the estrogen produced in the body comes from the adrenal glands. Estrogen binds to two types of receptors in the body, ER-alpha and ER-beta. When estrogen binds to these receptors, it enters the target cell's nucleus and triggers gene transcription, which then produces proteins that cause estrogenic effects. These effects can include hot flashes, chills, vaginal

When to interrupt dosage

The suggested dosage of Combipatch is contingent upon the determined condition, for example, Premature Menopause, Pharmaceutical Preparations and Postmenopause. The measure of dosage shifts, in light of the administration technique laid out in the accompanying table.

Condition

Dosage

Administration

Fracture

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Osteoporosis

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Atrophic

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

hypoestrogenism

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Hot flashes

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Birth Control

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Therapeutic procedure

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Endometriosis

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Menopause

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Estrogen Deprivation Symptoms

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Oral Contraceptives

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Low Testosterone

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Osteoporosis, Postmenopausal

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Endometriosis

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Primary Ovarian Insufficiency

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Hormonal Contraception

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

female castration

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Hormone Replacement Therapy

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Vasomotor System

0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg

, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch - Transdermal, Patch, Tablet, chewable, Tablet, chewable - Oral, Capsule, Capsule - Oral, Intramuscular; Oral; Topical

Warnings

Combipatch Contraindications

Condition

Risk Level

Notes

Liver Diseases

Do Not Combine

Thrombophilia

Do Not Combine

Vaginal Hemorrhage

Do Not Combine

Malignant Neoplasms

Do Not Combine

Benign hepatic neoplasm

Do Not Combine

Breast Cancer

Do Not Combine

Thromboembolism

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Norethisterone may interact with Pulse Frequency

There are 20 known major drug interactions with Combipatch.

Common Combipatch Drug Interactions

Drug Name

Risk Level

Description

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Norethisterone.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Norethisterone.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Norethisterone.

Clomipramine

Major

The metabolism of Clomipramine can be increased when combined with Norethisterone.

Copanlisib

Major

The metabolism of Copanlisib can be decreased when combined with Norethisterone.

Combipatch Toxicity & Overdose Risk

After 90 days of testing, the highest safe dose of estradiol in rats was found to be 0.003 mg/kg per day. The lowest toxic dose of ethinyl estradiol is 21 mg/kg per day for women, with an LD50 of 960 mg/kg in rats. Symptoms of an overdose on estradiol may include nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. If an overdose occurs, it is recommended to stop the treatment and offer supportive care.

image of a doctor in a lab doing drug, clinical research

Combipatch Novel Uses: Which Conditions Have a Clinical Trial Featuring Combipatch?

867 active clinical trials are currently evaluating the potential of Combipatch in providing relief from Osteoporosis, Polymenorrhea and Urogenital Atrophy.

Condition

Clinical Trials

Trial Phases

Birth Control

19 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2

Oral Contraceptives

1 Actively Recruiting

Not Applicable

Endometriosis

30 Actively Recruiting

Early Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4

Osteoporosis

28 Actively Recruiting

Not Applicable, Phase 4, Phase 1, Phase 3, Phase 2

Low Testosterone

5 Actively Recruiting

Phase 4, Phase 2, Phase 1

Endometriosis

2 Actively Recruiting

Phase 4, Not Applicable

Hot flashes

19 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Early Phase 1, Phase 3

Estrogen Deprivation Symptoms

0 Actively Recruiting

Osteoporosis, Postmenopausal

0 Actively Recruiting

female castration

0 Actively Recruiting

Atrophic

5 Actively Recruiting

Phase 4, Not Applicable

Hormone Replacement Therapy

0 Actively Recruiting

Hormonal Contraception

0 Actively Recruiting

hypoestrogenism

1 Actively Recruiting

Phase 4

Fracture

0 Actively Recruiting

Vasomotor System

0 Actively Recruiting

Primary Ovarian Insufficiency

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

Menopause

0 Actively Recruiting

Combipatch Reviews: What are patients saying about Combipatch?

5

Patient Review

11/28/2018

Combipatch for "Change of Life" Signs

I've been using this treatment for 15 years to effectively manage hot flashes. I don't have any issues with the patches staying on, and they last me an entire week. The only downside is that they're quite expensive; however, given how well they work, I think they're worth the price.

5

Patient Review

3/13/2019

Combipatch for Wasting of Tissues of the Vulva

I was pleased to find quick relief from hot flashes and irritability within a week of using this patch. I have noticed increased appetite and consequent weight gain; however, I am confident that I can manage this through diet changes. All in all, this is a great product!

5

Patient Review

1/6/2020

Combipatch for "Change of Life" Signs

I've been using this patch for 11 years and it's really helped me. I never took it at full strength because even one patch a week caused bloating and breast pain, so I tapered over the years. Now I'm down to half a patch every 10 days, and I tried tapering to zero last year but my hot flashes returned after 3-4 weeks. Hopefully I can continue tapering successfully over the next few years.

5

Patient Review

6/27/2021

Combipatch for "Change of Life" Signs

I've been using this product for over 20 years without any issues. I just found out that Medicare won't cover it anymore, which is a bummer because it's really helped me maintain my quality of life.

5

Patient Review

2/10/2022

Combipatch for "Change of Life" Signs

I started seeing results from this patch within two weeks of starting it, and now three years post-menopause, I haven't had a hot flash since. If you're on the fence about trying it, just go for it!

5

Patient Review

2/10/2022

Combipatch for "Change of Life" Signs

I had some spotting during weeks three and five, but it wasn't too bad.

4.7

Patient Review

1/20/2021

Combipatch for "Change of Life" Signs

I've used combipatch for over a year and it's been great in regards to managing my menopausal symptoms. However, the most recent batch I received is definitely different; the disk is more rigid as opposed to pliable like before. Additionally, I'm now experiencing pretty significant irritation from this new patch but had no issue with the prior patches. Trying to tough it out but its very uncomfortable. Wondering why

4.7

Patient Review

6/21/2022

Combipatch for "Change of Life" Signs

I've been really happy with this patch overall, but the itching is a serious problem. I often end up scratching my skin raw because of it. Please improve the adhesive! Thank you for your time.

4.3

Patient Review

7/18/2018

Combipatch for "Change of Life" Signs

I was given this to help with hot flashes, mood changes, irritability etc. and it's been working great so far! I would recommend applying the patch immediately after bathing when skin is clean and dry. Otherwise, use alcohol to swab the area clean and make sure it's completely dry before applying the patch.

4.3

Patient Review

4/28/2021

Combipatch for "Change of Life" Signs

I had great results with this treatment until the manufacturer changed the adhesive. Now, I'm having terrible reactions, as are others who have discovered the same thing. We're all experiencing extreme itching, burning, dried red skin, and the patch falls off before it's time to change it out. This new adhesive is really causing problems for a lot of people. PLEASE go back to using the original adhesive!

4

Patient Review

5/25/2022

Combipatch for "Change of Life" Signs

I really love this patch! It's helped me a lot. However, the adhesive is very itchy on my skin. I've tried putting it on different parts of my body, but it always ends up being itchy and red. Please change the adhesive!

4

Patient Review

11/22/2021

Combipatch for "Change of Life" Signs

I was on this for a couple years and it really improved my quality of life by preventing hot flashes and night sweats. However, I stopped using it recently because the adhesive they switched to was incredibly itchy and caused redness that would last for days after taking the patch off.

3.7

Patient Review

11/4/2019

Combipatch for "Change of Life" Signs

I've been using this patch for almost nine months now. It's effectively stopped hot flashes, night sweats, and moodiness; however, I have experienced irregular spotting that lasts a few days each month. My doctor suggested trying half a patch; hopefully, this will work.

3.7

Patient Review

11/16/2021

Combipatch for "Change of Life" Signs

I've found that this treatment really helps with hot flashes. I was having them every 15 minutes prior to using the patch, but now they're much more manageable. However, I have noticed that the patch does come off easily if you sweat or shower, so I put a sterile transparent film over it to keep it in place. This has saved me a lot of money and hassle.

Patient Q&A Section about combipatch

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the CombiPatch used for?

"This medication is taken by women to help reduce menopause symptoms such as hot flashes and vaginal dryness. These symptoms are caused by the body producing less estrogen. The progestin in this medication helps lower the risk of cancer of the uterus, which can be caused by using estrogen."

Answered by AI

What is equivalent to CombiPatch?

"As of August 10th, 2022, there is no therapeutically equivalent version of CombiPatch available in the United States. It is important to note that there are many fraudulent online pharmacies that may try to sell an illegal generic version of CombiPatch. These medications can be counterfeit and potentially unsafe."

Answered by AI

Does CombiPatch make you gain weight?

"The use of progestin in addition to other treatments helps to prevent cancer of the uterus. It is important to discuss treatment options with a doctor to see what is best based on individual needs. There is no evidence to suggest that hormone therapy causes weight gain."

Answered by AI

How long does it take for CombiPatch to start working?

"COMBIPATCH is an effective combination hormone therapy that results in estrogen levels in your blood similar to what you would see in the early phase of your usual menstrual cycle during your premenopausal years. These levels are achieved within 12 to 24 hours after applying COMBIPATCH."

Answered by AI

Clinical Trials for Combipatch

Image of VA Greater Los Angeles Healthcare System, West Los Angeles, CA in West Los Angeles, United States.

EBQI Strategies for Women's Health

Any Age
All Sexes
West Los Angeles, CA

Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. Furthermore, few VA improvement efforts have focused on women Veterans' health and health care in midlife. The EMPOWER QUERI 3.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 18 VA facilities from 4 regions.

Waitlist Available
Has No Placebo

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Erin P Finley, PhD MPH

Image of UC San Diego in San Diego, United States.

Epione Device for Bone Conditions

18+
All Sexes
San Diego, CA

The goal of this investigational device exemption is to evaluate the Epione assistance for introducer placement during percutaneous procedures in musculo-skeletic (MSK) structures of the pelvis and the spine in adults. The main question is the determination of the rate of feasible procedures assisted by the Epione device Participants will undergo their procedure(s) as planned by their physician. If they accept to participate to the study, the differences with standard of care will be: * The use of the Epione device to place the introducer(s), instead of freehand placement if they do not participate * Additional CT or CBCT scans during the procedure.

Waitlist Available
Has No Placebo

UC San Diego (+2 Sites)

Sean Tutton, MD

Quantum Surgical

Image of University of Waterloo in Waterloo, Canada.

Virtual Chiropractic Intervention for Spinal Fracture

18+
All Sexes
Waterloo, Canada

This study will determine feasibility of a chiropractor delivered virtual intervention for individuals following osteoporotic vertebral fracture. This pilot trial will have two parallel groups with a 1:1 ratio. Participants will be randomized to: 1) immediate receipt; or 2) waitlist usual care control and delayed receipt of VIVA 10 weeks post-randomization. VIVA is an intervention for people with vertebral fractures that covers four areas: pain management, safe movement, exercise, and nutrition. It includes print and video resources, and a framework for goal setting, selecting exercises, and teaching body mechanics. A chiropractor (DC) completes a virtual assessment and then leads twelve 1:1 virtual sessions (via Zoom) over eight weeks. Sessions start with brief education on a topic (e.g., safe movement, pain management, exercise, nutrition), followed by training and modeling of exercise and safe movement strategies, then goal setting, and action planning. This trial will be considered feasible if a) we recruit 14 people in eight months; b) 80% of participants complete the trial; and c) exercise adherence is 75%.

Recruiting
Has No Placebo

University of Waterloo

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We made a collection of clinical trials featuring Combipatch, we think they might fit your search criteria.
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Image of Erevna Innovations Inc. in Montreal, Canada.

Sculptra + Restylane for Post-Menopausal Skin Concerns

40 - 65
Female
Montreal, Canada

The post-menopausal state is marked by a sharp decline in estrogen, leading to significant structural and functional changes in the skin, including collagen loss, dryness, thinning, and reduced elasticity. To address these concerns, aesthetic injectables products such as Sculptra® Aesthetic (poly-L-lactic-acid \[PLLA- SCA\]) and Restylane Skinboosters®\[HASBV\] (small-particle hyaluronic acid - SP-HA) can be used. PLLA-SCA stimulates collagen production via cellular activation (biostimulator), gradually improving dermal structure. HASBV enhances hydration, elasticity, and skin texture when injected under the skin. Considering that hydration and laxity represent the primary aesthetic concerns in this patient population. Targeted treatment with SP-HA (HASBV) to improve hydration and PLLA-SCA to address laxity have been shown to produce significant clinical outcomes by directly addressing these key dermal deficiencies. This approach forms the basis of the current study.

Phase 4
Recruiting

Erevna Innovations Inc.

Andreas Nikolis, MD, PhD

Image of University Hospitals Cleveland Medical Center in Cleveland, United States.

Ketamine for Pelvic Pain

18 - 89
Female
Cleveland, OH

The purpose of this research study is to see if ketamine infusion during surgery can decrease pain after surgery. Ketamine is a medication commonly used as part of anesthesia during surgery and is approved by the US FDA. Patients will be randomized to either receive standard anesthesia with OR without ketamine. The surgical procedure will be the same regardless of which group patients are randomized to. After surgery, patients will be asked to rate their pain in the post-operative observation unit and at their two-week post-operative visit. No additional visits are required for participation in this study. The investigators estimate the surveys will take approximately 10 minutes to complete.

Phase 4
Waitlist Available

University Hospitals Cleveland Medical Center

Morgan Cheeks, MD

Have you considered Combipatch clinical trials?

We made a collection of clinical trials featuring Combipatch, we think they might fit your search criteria.
Go to Trials

Have you considered Combipatch clinical trials?

We made a collection of clinical trials featuring Combipatch, we think they might fit your search criteria.
Go to Trials