Antithymocyte globulin (ATG) for Blood Cancers

Memorial Sloan Kettering Cancer Center, New York, NY
Blood CancersAntithymocyte globulin (ATG) - Drug
Eligibility
18+
All Sexes

Study Summary

This trial will test a new, shorter chemotherapy regimen for people with blood cancers before a transplant. Researchers want to know if the new regimen has the same or fewer side effects as the current one.

Eligible Conditions
  • Blood Cancers

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase 1

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Busulfan
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Participants with Sickle Cell Disease or β-Thalassemia

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: in the first 30 days post-HCT

Day 30
the number of grade 4 toxicities

Trial Safety

Phase-Based Safety

1 of 3

Similar Trials

1
Busulfan
2
Thiotepa
2
Participants with Sickle Cell Disease or β-Thalassemia

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.

Trial Design

2 Treatment Groups

patients hematologic malignancies other than multiple myeloma
1 of 2
patients with multiple myeloma
1 of 2

Experimental Treatment

45 Total Participants · 2 Treatment Groups

Primary Treatment: Antithymocyte globulin (ATG) · No Placebo Group · Phase 1

patients hematologic malignancies other than multiple myelomaExperimental Group · 5 Interventions: Fludarabine, Allogeneic hematopoietic cell transplantation (Allo-HCT), Antithymocyte globulin (ATG), Melphalan, Busulfan 3.2 mg/kg/day · Intervention Types: Drug, Procedure, Drug, Drug, Drug
patients with multiple myelomaExperimental Group · 5 Interventions: Fludarabine, Busulfan 0.8 mg/kg, Allogeneic hematopoietic cell transplantation (Allo-HCT), Antithymocyte globulin (ATG), Melphalan · Intervention Types: Drug, Drug, Procedure, Drug, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Fludarabine
FDA approved
Melphalan
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: in the first 30 days post-hct

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor
1,865 Previous Clinical Trials
591,599 Total Patients Enrolled
1 Trials studying Blood Cancers
25 Patients Enrolled for Blood Cancers
Michael Scordo, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center
1 Previous Clinical Trials
62 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 0 Total Inclusion Criteria

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References

Frequently Asked Questions

How many participants are currently enrolled in this research trial?

"Affirmative. According to clinicaltrials.gov, this research project is presently recruiting participants and was first posted on September 18th2019 with the most recent update taking place on October 3rd 2022. 45 patients are needed from one medical facility." - Anonymous Online Contributor

Unverified Answer

In what circumstances is Antithymocyte globulin (ATG) typically administered?

"Antithymocyte globulin (ATG) is often employed to treat severe hodgkin lymphoma. More broadly, it can be utilized as a palliative measure for conditions like [chronic lymphocytic leukemia](https://www.withpower.com/clinical-trials/chronic-lymphocytic-leukemia), allogeneic hematopoietic stem cell transplantation, chronic myelogenous leukemia and stem cell transplants." - Anonymous Online Contributor

Unverified Answer

What risks come with the use of Antithymocyte globulin (ATG)?

"Our team has attributed a score of 1 to the safety profile of antithymocyte globulin (ATG) due to its limited evidence in clinical trials." - Anonymous Online Contributor

Unverified Answer

Is it still possible to volunteer for this experiment?

"Affirmative. The clinicaltrials.gov database indicates that this medical trial, initially posted on September 18th 2019, is still looking for volunteers. Researchers are hoping to enroll 45 patients from a single location." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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