Colestid

Primary Hypercholesterolemia, Diet

Treatment

2 FDA approvals

15 Active Studies for Colestid

Treatment for

Primary Hypercholesterolemia

What is Colestid

ColestipolThe Generic name of this drug

Treatment SummaryColestipol is a medication used to reduce high cholesterol. It works by decreasing the absorption of cholesterol and bile acids in the gut. It does not enter the bloodstream, so it typically does not cause side effects in the body. It is generally used as an adjunct therapy and may not be suitable for people on complex drug regimens, those with constipation or biliary obstruction, or those who are pregnant or breastfeeding.

Colestipol Hydrochlorideis the brand name

image of different drug pills on a surface

Colestid Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Colestipol Hydrochloride

Colestipol

1977

Approved as Treatment by the FDA

Colestipol, also known as Colestipol Hydrochloride, is approved by the FDA for 2 uses like Primary Hypercholesterolemia and Diet .

Primary Hypercholesterolemia

Used in combination with other therapies

Diet

Used in combination with other therapies

Effectiveness

How Colestid Affects PatientsCholesterol is the main ingredient used to make bile acids which help break down fat in food and aid in digestion. Most of the bile acids are reabsorbed back into the liver, but a small amount shows up in the bloodstream. Colestipol hydrochloride binds with bile acids in the intestines and prevents them from being reabsorbed, which causes them to be excreted in the feces instead. Colestipol hydrochloride is an anion exchange resin, meaning it can swap out its chloride ions for other anions that have a stronger attraction to the resin.

How Colestid works in the bodyColestipol is a medication that helps lower cholesterol. It works by binding to bile acids in the intestine, preventing them from being reabsorbed. This causes an increase in the oxidation of cholesterol and an increase in the number of LDL receptors in the liver. This results in more LDL being taken up by the liver and a reduction in total and LDL cholesterol levels in the blood.

When to interrupt dosage

The proposed amount of Colestid is contingent upon the diagnosed condition. The dosage fluctuates as indicated by the delivery procedure (e.g. Granule - Oral or Granule, for suspension) featured in the table beneath.

Condition

Dosage

Administration

Primary Hypercholesterolemia

, 1000.0 mg, 5000.0 mg, 5.0 mg/mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral

Diet

, 1000.0 mg, 5000.0 mg, 5.0 mg/mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral

Warnings

Colestid Contraindications

Condition

Risk Level

Notes

complete biliary obstruction

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Colestipol may interact with Pulse Frequency

There are 20 known major drug interactions with Colestid.

Common Colestid Drug Interactions

Drug Name

Risk Level

Description

Mycophenolate mofetil

Major

Colestipol can cause a decrease in the absorption of Mycophenolate mofetil resulting in a reduced serum concentration and potentially a decrease in efficacy.

Mycophenolic acid

Major

Colestipol can cause a decrease in the absorption of Mycophenolic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.

Raloxifene

Major

Colestipol can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.

(R)-warfarin

Minor

Colestipol can cause a decrease in the absorption of (R)-warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.

(S)-Warfarin

Minor

Colestipol can cause a decrease in the absorption of (S)-Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.

Colestid Toxicity & Overdose RiskThere have been no reports of overdosing on colestipol, but potential harm could be caused by an obstruction of the gastrointestinal tract. The use of colestipol during pregnancy, lactation, or by women who could become pregnant should be done with caution. There is also limited data on the use of colestipol in children and no data on its effects on fertility in humans. The elderly may be more likely to experience gastrointestinal side effects and adverse nutritional effects. The toxic dose of colestipol in rats has been found to be greater than 1000mg/kg.

image of a doctor in a lab doing drug, clinical research

Colestid Novel Uses: Which Conditions Have a Clinical Trial Featuring Colestid?

12 active studies are currently being conducted to examine the potential of Colestid in managing Primary Hypercholesterolemia.

Condition

Clinical Trials

Trial Phases

Diet

5 Actively Recruiting

Not Applicable, Phase 1

Primary Hypercholesterolemia

10 Actively Recruiting

Phase 3, Phase 2, Not Applicable

Colestid Reviews: What are patients saying about Colestid?

4.7Patient Review

5/17/2009

Colestid for Itching Associated with Blockage of a Bile Duct

I've been taking this medicine for years with few issues. The only problem I sometimes have is remembering to allow the necessary time to pass before taking other medications. I took the powdered form for a bit, and found it ineffective and frankly, gross. However, the pills (though huge!!) work just fine and have never given me any problems with side effects.

4.7Patient Review

6/1/2013

Colestid for High Cholesterol

I saw a significant decrease in my cholesterol levels after just two months of taking this medication.

2.3Patient Review

12/8/2009

Colestid for High Cholesterol

I didn't enjoy taking this medication because the dosage is high and it made me constipated.

2Patient Review

10/21/2010

Colestid for High Cholesterol

I was given this medication to lower my cholesterol, but it actually had the opposite effect. My cholesterol increased from 214 to 256. From what I can tell from reading other reviews, this drug is best used for intestinal/gall bladder problems; something I do not have.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about colestid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is Colestid?

"This lowers the level of bile acid in your body.

Colestipol is a bile acid sequestrant. It works by binding to bile acid in your intestines and lowering the level of bile acid in your body."

Answered by AI

Is colestipol used to treat diarrhea?

"Your doctor may prescribe Colestid to treat diarrhea caused by excess bile acids. Colestid may cause constipation, burping, nausea, vomiting, flatulence, diarrhea, anxiety, or fatigue."

Answered by AI

What are the side effects of the drug colestipol?

"The following effects may occur: constipation, stomach/abdominal pain, gas, nausea, and vomiting. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To prevent constipation, eat dietary fiber, drink enough water, and exercise."

Answered by AI

What is the drug Colestid used for?

"This medication is designed to remove bile acids from the body. In individuals with high cholesterol, this prompts the liver to produce more bile acids using the cholesterol present in the blood. This, in turn, helps to lower the overall cholesterol levels."

Answered by AI

Clinical Trials for Colestid

Have you considered Colestid clinical trials? We made a collection of clinical trials featuring Colestid, we think they might fit your search criteria.

Have you considered Colestid clinical trials? We made a collection of clinical trials featuring Colestid, we think they might fit your search criteria.