Clorpres

Swollen feet or ankles, Chronic Kidney Disease (CKD), Congestive Heart Failure + 5 more
Treatment
20 Active Studies for Clorpres

What is Clorpres

ChlorthalidoneThe Generic name of this drug
Treatment SummaryChlorthalidone is a drug used to treat high blood pressure and swelling caused by heart failure or kidney problems. It works by preventing the absorption of salt and water in the kidneys, which helps to reduce the pressure in the arteries and reduce swelling. Chlorthalidone is often used as the first treatment for uncomplicated hypertension because it has been shown to reduce the risk of stroke, heart attack, heart failure, and other cardiovascular issues. It has also been shown to have additional benefits, such as reducing platelet aggregation and vascular permeability, and promoting angiogenesis.
Chlorthalidoneis the brand name
image of different drug pills on a surface
Clorpres Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Chlorthalidone
Chlorthalidone
1981
193

Effectiveness

How Clorpres works in the bodyChlorthalidone works by preventing the reabsorption of sodium and chloride in the kidneys. This reduces the amount of fluid and salt in your blood, which causes your blood pressure to drop. It also helps reduce platelet aggregation and vascular permeability, as well as encouraging new blood vessel formation. These effects may help reduce your risk of cardiovascular disease.

When to interrupt dosage

The advised measure of Clorpres is contingent upon the determined condition, including Cirrhosis, probable necessity of multiple antihypertensive drugs, and Edema. The dosage fluctuates, depending on the technique of administration featured in the table below.
Condition
Dosage
Administration
Hypertensive disease
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Swollen feet or ankles
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Chronic Kidney Disease (CKD)
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
multiple antihypertensive drugs likely required
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Congestive Heart Failure
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
not adequately controlled with monotherapy
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Cirrhosis
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Nephrolithiasis
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Clorpres has two contraindications and should not be ingested when experiencing any of the conditions displayed in the following table.Clorpres Contraindications
Condition
Risk Level
Notes
Anuria
Do Not Combine
allergic reaction to sulfonamide derivatives
Do Not Combine
There are 20 known major drug interactions with Clorpres.
Common Clorpres Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Chlorthalidone may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Chlorthalidone is combined with Dofetilide.
Hexamethonium
Major
The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Hexamethonium.
Lithium carbonate
Major
Chlorthalidone may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
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Clorpres Novel Uses: Which Conditions Have a Clinical Trial Featuring Clorpres?

641 active trials are currently assessing the utility of Clorpres in treating Kidney Disease, Cirrhosis and Hypertensive Disease.
Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease (CKD)
26 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
not adequately controlled with monotherapy
0 Actively Recruiting
Cirrhosis
56 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1
multiple antihypertensive drugs likely required
0 Actively Recruiting
Congestive Heart Failure
176 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Swollen feet or ankles
7 Actively Recruiting
Phase 2, Not Applicable
Nephrolithiasis
0 Actively Recruiting

Clorpres Reviews: What are patients saying about Clorpres?

5Patient Review
12/21/2013
Clorpres for Extremely High Blood Pressure
I haven't had to use it yet, but I'm glad it's there for when my blood pressure gets too high. It would be helpful if WebMD included more information about the pill along with its name.
5Patient Review
8/2/2013
Clorpres for Extremely High Blood Pressure
4.7Patient Review
11/17/2013
Clorpres for High Blood Pressure
I found that this medication made me more prone to anger, caused weight gain, and left me feeling dizzy when standing up.
4.7Patient Review
5/23/2013
Clorpres for High Blood Pressure
4.3Patient Review
10/12/2013
Clorpres for High Blood Pressure
I have experienced many negative side effects while taking this medication, such as needing to take laxatives nearly every night just to go to the bathroom. My mouth is always dry, my eyes are dry, and my vision gets blurry. I've spoken with my doctor about these problems, but they simply advised me to take a stool softener. In my opinion, I think this medication should be discontinued for me.
View All Reviews
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Patient Q&A Section about clorpres

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is clonidine still available?

"Chlorthalidone/clonidine is no longer available in the United States."

Answered by AI

Is chlorthalidone the same as clonidine?

"This medication contains 2 medications: clonidine and chlorthalidone. Clonidine works by controlling nerve impulses along certain body nerve pathways. As a result, it relaxes blood vessels so that blood passes through them more easily. The chlorthalidone in this combination is a diuretic (water pill) that helps reduce the amount of water in the body by increasing the flow of urine."

Answered by AI

Why is clonidine used for ADHD?

"Clonidine affects the part of the brain that controls attention and impulsive behavior in people with ADHD, though its precise mechanism is not yet known."

Answered by AI

What is the side effects of clonidine?

"Signs of an impending heart attack include anxiety, chest pain, confusion, decreased urine output, dilated neck veins, a fast heartbeat, and general discomfort."

Answered by AI

Clinical Trials for Clorpres

Have you considered Clorpres clinical trials? We made a collection of clinical trials featuring Clorpres, we think they might fit your search criteria.
Have you considered Clorpres clinical trials? We made a collection of clinical trials featuring Clorpres, we think they might fit your search criteria.
Have you considered Clorpres clinical trials? We made a collection of clinical trials featuring Clorpres, we think they might fit your search criteria.
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