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What is Clorpres
ChlorthalidoneThe Generic name of this drug
Treatment SummaryChlorthalidone is a drug used to treat high blood pressure and swelling caused by heart failure or kidney problems. It works by preventing the absorption of salt and water in the kidneys, which helps to reduce the pressure in the arteries and reduce swelling. Chlorthalidone is often used as the first treatment for uncomplicated hypertension because it has been shown to reduce the risk of stroke, heart attack, heart failure, and other cardiovascular issues. It has also been shown to have additional benefits, such as reducing platelet aggregation and vascular permeability, and promoting angiogenesis.
Chlorthalidoneis the brand name
Clorpres Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Chlorthalidone
Chlorthalidone
1981
193
Effectiveness
How Clorpres works in the bodyChlorthalidone works by preventing the reabsorption of sodium and chloride in the kidneys. This reduces the amount of fluid and salt in your blood, which causes your blood pressure to drop. It also helps reduce platelet aggregation and vascular permeability, as well as encouraging new blood vessel formation. These effects may help reduce your risk of cardiovascular disease.
When to interrupt dosage
The advised measure of Clorpres is contingent upon the determined condition, including Cirrhosis, probable necessity of multiple antihypertensive drugs, and Edema. The dosage fluctuates, depending on the technique of administration featured in the table below.Condition
Dosage
Administration
Congestive Heart Failure
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
multiple antihypertensive drugs likely required
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
not adequately controlled with monotherapy
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Cirrhosis
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Swollen feet or ankles
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Hypertensive disease
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Chronic Kidney Disease (CKD)
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Nephrolithiasis
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Clorpres has two contraindications and should not be ingested when experiencing any of the conditions displayed in the following table.Clorpres ContraindicationsCondition
Risk Level
Notes
Anuria
Do Not Combine
allergic reaction to sulfonamide derivatives
Do Not Combine
Common Clorpres Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Chlorthalidone may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Chlorthalidone is combined with Dofetilide.
Hexamethonium
Major
The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Hexamethonium.
Lithium carbonate
Major
Chlorthalidone may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Clorpres Novel Uses: Which Conditions Have a Clinical Trial Featuring Clorpres?
641 active trials are currently assessing the utility of Clorpres in treating Kidney Disease, Cirrhosis and Hypertensive Disease.Condition
Clinical Trials
Trial Phases
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Chronic Kidney Disease (CKD)
244 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
multiple antihypertensive drugs likely required
0 Actively Recruiting
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Nephrolithiasis
0 Actively Recruiting
not adequately controlled with monotherapy
0 Actively Recruiting
Clorpres Reviews: What are patients saying about Clorpres?
5Patient Review
12/21/2013 I haven't had to use it yet, but I'm glad it's there for when my blood pressure gets too high. It would be helpful if WebMD included more information about the pill along with its name.
5Patient Review
8/2/20134.7Patient Review
11/17/2013 I found that this medication made me more prone to anger, caused weight gain, and left me feeling dizzy when standing up.
4.7Patient Review
5/23/20134.3Patient Review
10/12/2013 I have experienced many negative side effects while taking this medication, such as needing to take laxatives nearly every night just to go to the bathroom. My mouth is always dry, my eyes are dry, and my vision gets blurry. I've spoken with my doctor about these problems, but they simply advised me to take a stool softener. In my opinion, I think this medication should be discontinued for me.
4.3Patient Review
11/4/2013 I felt nauseous all day.
4Patient Review
11/14/2013 I've been on clonidine for over a year to manage my high blood pressure. It worked great at first, but now I have to take it four times per day and it barely does anything. The side effects are also really awful-- dizziness, dry mouth and eyes, migraines, and vivid dreams. I can't wait to be taken off this medication.
4Patient Review
5/30/20134Patient Review
12/29/2013 Clonidine has been a great help for me. After trying out many different pills, this one worked the best by far. It's not perfect, but it does the job most of the time.
3.7Patient Review
12/30/2013 My doctor had me start with a low dose of this medication, and it did help lower my blood pressure. However, you have to be careful when stopping this drug as your blood pressure could spike if you're not weaned off of it properly.
3.7Patient Review
5/22/20133.3Patient Review
1/17/2014 I've been using this medication for about a month now. Some of the more bothersome side effects I've experienced are sweats at night, extreme dry mouth, and fatigue. My lips and tongue have also felt swollen at times. Hopefully these symptoms will dissipate as I continue to use the medication.
3.3Patient Review
7/23/20133Patient Review
1/10/2014 Clorpres was working great for me, but the price tag was a bit much so I decided to switch to Clonidine. Unfortunately, the change has resulted in some serious hair loss which is very annoying. I may have to go back to Clorpres even though it's expensive.
3Patient Review
1/4/2014 I experienced a lot of constipation, mouth dryness, and gum swelling while taking this medication. I also didn't see any improvements in my blood pressure, even when taking the recommended two tablets per day.
2.3Patient Review
9/5/2013 My blood pressure is lower since taking this medication, but it's still not in the normal range. I also have palpitations at night and dry mouth, but these side effects are worth the better readings I'm getting.
2Patient Review
10/31/2013 This drug is good for a number of things, including hypertension, opiate withdrawal, and mild pain. I take it for hypertension and opiod withdrawal, and it's pretty much saved my life.
Patient Q&A Section about clorpres
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is clonidine still available?
"Chlorthalidone/clonidine is no longer available in the United States."
Answered by AI
Is chlorthalidone the same as clonidine?
"This medication contains 2 medications: clonidine and chlorthalidone. Clonidine works by controlling nerve impulses along certain body nerve pathways. As a result, it relaxes blood vessels so that blood passes through them more easily. The chlorthalidone in this combination is a diuretic (water pill) that helps reduce the amount of water in the body by increasing the flow of urine."
Answered by AI
Why is clonidine used for ADHD?
"Clonidine affects the part of the brain that controls attention and impulsive behavior in people with ADHD, though its precise mechanism is not yet known."
Answered by AI