Clonidine Hydrochloride

Hot Flashes, Smoke, clonidine suppression test + 15 more

Treatment

20 Active Studies for Clonidine Hydrochloride

What is Clonidine Hydrochloride

Clonidine

The Generic name of this drug

Treatment Summary

Clonidine is a medication used to treat high blood pressure, severe pain, and Attention Deficit Hyperactivity Disorder (ADHD). It is a derivative of the imidazole class and works by activating alpha-2 adrenoceptors in the body. Clonidine was approved by the FDA in 1974 and is typically prescribed as a tablet or patch.

Catapres

is the brand name

image of different drug pills on a surface

Clonidine Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Catapres

Clonidine

1974

447

Effectiveness

How Clonidine Hydrochloride Affects Patients

Clonidine works by stimulating certain receptors (alpha-2 adrenoceptors) in the body, which can lower blood pressure, make you sleepy, and help your nerves relax. It needs to be taken twice a day, and the recommended dosage is between 0.1mg and 2.4mg daily.

How Clonidine Hydrochloride works in the body

Clonidine is an alpha-2 adrenoceptor agonist, meaning it works by activating the alpha-2 adrenoceptor. This causes a number of physiological effects, such as decreasing blood pressure and heart rate, dampening pain signals at the spine, and promoting sleep. It works by activating G-proteins which, in turn, cause the alpha-2 adrenoceptor to bind to an effector and inhibit adenylyl cyclase, open potassium channels, and replace GDP with GTP. All these actions work together to produce the desired effects.

When to interrupt dosage

The suggested measure of Clonidine Hydrochloride relies upon the pinpointed condition, such as methadone, diabetic diarrhea and Hypertensive disease. The quantity of dosage fluctuates as indicated by the delivery system (e.g. Oral or Tablet) featured in the table beneath.

Condition

Dosage

Administration

Hypertensive disease

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Pheochromocytoma

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Tourette Syndrome

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Disease

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Attention Deficit and Disruptive Behavior Disorders

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Smoke

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

clonidine suppression test

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

clozapine

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

methadone

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Cancer Pain

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

growth hormone stimulation test

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

diabetic diarrhea

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Hot flashes

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Neuralgia, Postherpetic

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Human Growth Hormone Deficiency

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Attention Deficit Hyperactivity Disorder

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Smoking Cessation

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Hot Flashes

, 0.1 mg, 0.2 mg, 0.3 mg, 0.5 mg/mL, 0.1 mg/mL, 0.01 mg/hour, 0.02 mg/hour, 0.03 mg/hour, 0.09 mg/mL, 0.17 mg, 0.26 mg, 0.025 mg, 0.15 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Transdermal, Patch - Transdermal, Patch, Patch, extended release, Patch, extended release - Transdermal, For suspension, extended release - Oral, For suspension, extended release, Epidural, Injection, solution - Epidural, Kit, Kit - Oral, Suspension, extended release - Oral, Suspension, extended release

Warnings

Clonidine Hydrochloride has five contraindications, and it should not be taken simultaneously with any of the conditions cited in the table below.

Clonidine Hydrochloride Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

administration above the C4 dermatome

Do Not Combine

Communicable Diseases

Do Not Combine

bleeding diathesis

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Clonidine may interact with Pulse Frequency

There are 20 known major drug interactions with Clonidine Hydrochloride.

Common Clonidine Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The risk or severity of sedation can be increased when Clonidine is combined with 1,2-Benzodiazepine.

2,5-Dimethoxy-4-ethylthioamphetamine

Major

The risk or severity of sedation can be increased when Clonidine is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.

4-Bromo-2,5-dimethoxyamphetamine

Major

The risk or severity of sedation can be increased when Clonidine is combined with 4-Bromo-2,5-dimethoxyamphetamine.

4-Methoxyamphetamine

Major

The risk or severity of sedation can be increased when Clonidine is combined with 4-Methoxyamphetamine.

5-methoxy-N,N-dimethyltryptamine

Major

The risk or severity of sedation can be increased when Clonidine is combined with 5-methoxy-N,N-dimethyltryptamine.

Clonidine Hydrochloride Toxicity & Overdose Risk

The toxic dose of fentanyl in rats is 126mg/kg. In humans, the lowest toxic dose is 70µg/kg for children, 126µg/kg for women, and 69µg/kg for men. Signs of an overdose include high and low blood pressure, slower heart rate, shallow breathing, hypothermia, drowsiness, decreased reflexes, weakness, irritability, and constricted pupils. Severe overdoses can cause abnormal heartbeats, difficulty breathing, unconsciousness, seizures, and coma. Vomiting should not be induced due to the risk of further CNS depression; however,

image of a doctor in a lab doing drug, clinical research

Clonidine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Clonidine Hydrochloride?

231 active clinical trials are being conducted to assess the effectiveness of Clonidine Hydrochloride in aiding Smoking Cessation, Menopause symptoms and alleviating the severity of Cancer-related pain.

Condition

Clinical Trials

Trial Phases

Smoking Cessation

104 Actively Recruiting

Early Phase 1, Phase 4, Not Applicable, Phase 3, Phase 2, Phase 1

Attention Deficit Hyperactivity Disorder

63 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2

clonidine suppression test

0 Actively Recruiting

growth hormone stimulation test

0 Actively Recruiting

diabetic diarrhea

0 Actively Recruiting

Tourette Syndrome

0 Actively Recruiting

Neuralgia, Postherpetic

0 Actively Recruiting

Human Growth Hormone Deficiency

4 Actively Recruiting

Phase 2, Phase 4, Phase 3

Hot Flashes

6 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Cancer Pain

0 Actively Recruiting

Disease

6 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 1

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

methadone

0 Actively Recruiting

Attention Deficit and Disruptive Behavior Disorders

6 Actively Recruiting

Not Applicable, Phase 1, Phase 2

clozapine

0 Actively Recruiting

Hot flashes

19 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 3

Pheochromocytoma

0 Actively Recruiting

Smoke

0 Actively Recruiting

Clonidine Hydrochloride Reviews: What are patients saying about Clonidine Hydrochloride?

5

Patient Review

2/1/2019

Clonidine Hydrochloride for High Blood Pressure

This blood pressure medication is by far the best I've tried. Not only does it help keep my levels in check, but it also doesn't make me feel exhausted or groggy.

5

Patient Review

6/5/2021

Clonidine Hydrochloride for High Blood Pressure

I was taking this medication for my spiking blood pressure. I have also been taking Irbesartan (Avapro generic) 150 2 x daily. I have dropped the Amalodopine and started taking .1 clonidine in the evening every day. I feel better now and it also helps me sleep. My cardiologist said it was okay to take .2 if I needed to lower my extremely high spikes (which no doctirs can figure out).

5

Patient Review

2/1/2019

Clonidine Hydrochloride for High Blood Pressure

This is the best blood pressure medication I've ever taken. It's very effective in keeping my blood pressure levels under control, which is really important for me since I only have one kidney. I think it might cause a little bit of fatigue, but I take it early in the morning and then 12 hours later in the evening so it's not a big deal.

5

Patient Review

2/1/2019

Clonidine Hydrochloride for High Blood Pressure

This blood pressure medication is the best one I've tried so far. It's been very effective in keeping my levels stable, which is great considering I only have one kidney. The only downside is that it might cause fatigue, but if you take it at night before bed, it's not a problem.

5

Patient Review

6/5/2021

Clonidine Hydrochloride for High Blood Pressure

I was taking Amalodopine as an emergency medication for my spiking blood pressure. I also take Irbesartan (Avapro generic) 150 2 x daily. I have dropped the Amalodopine and started taking .1 clonidine in the evening every day. I feel better now and it also helps me sleep. My cardiologist said it was okay to do this.

5

Patient Review

6/5/2021

Clonidine Hydrochloride for High Blood Pressure

I was taking this as an emergency medication for my spiking blood pressure. I have also been taking Irbesartan (Avapro generic) 150 2 x daily. I have dropped the Amalodopine and started taking .1 clonidine in the evening every day. I feel better now and it also helps me sleep. My cardiologist said it was okay to take .2 if necessary in a BP emergency to lower extremely high spikes (which no doctors can figure out).

4.7

Patient Review

6/9/2018

Clonidine Hydrochloride for High Blood Pressure

Clonidine is, hands-down, the best medication I've tried for high blood pressure. And trust me when I say that I've tried a lot of different medications and Clonidine is by far the best one with the least amount of negative side effects.

4.7

Patient Review

6/9/2018

Clonidine Hydrochloride for High Blood Pressure

Clonidine is, by far, the best medication I've been on for high blood pressure. It doesn't come with the intense and uncomfortable side effects like other medications. When first taking it, you may feel tired; however, your body will adjust after some time. Clonidine also helps with hot flashes and excessive sweating - two things that have been bothering me for a while!

4.7

Patient Review

6/9/2018

Clonidine Hydrochloride for High Blood Pressure

Clonidine is by far the best medication I've tried for high blood pressure. No other meds gave me such great results without horrible side effects. And it's an added bonus that it helps with hot flashes and excessive sweating!

3

Patient Review

6/28/2022

Clonidine Hydrochloride for Excessive Sweating

This medication helped me a little bit with the sweating and anxiety I was experiencing from detoxing off of zipoclone. However, the constipation, weight gain, blurred vision, and fatigue were really terrible side effects that made me want to stop taking it.

3

Patient Review

6/28/2022

Clonidine Hydrochloride for Excessive Sweating

This medication helped me a little bit with my detox symptoms of excessive sweating and anxiety. However, the constipation, weight gain, blurred vision, and fatigue were all really bad side effects that I didn't enjoy. I'm going to stop taking this medication now and just tough out the sweats on my own. Good luck to everyone else who is taking this medication.

3

Patient Review

6/28/2022

Clonidine Hydrochloride for Excessive Sweating

This medication helped me a little with my excessive sweating and anxiety while I was detoxing from zipoclone. However, the constipation, weight gain, blurred vision, and fatigue were all terrible side effects. I'm stopping now and just going to tough out the sweats on my own. Good luck to everyone else who is taking this medication.

2.3

Patient Review

3/16/2018

Clonidine Hydrochloride for High Blood Pressure

I was warned by my GP not to take this medication, but my cardiologist put me on it anyway. I've been taking it for two months now and have experienced awful constipation, lack of sleep, and urinary incontinence. I am gradually stopping the medication and hope to be off of it entirely soon!

2.3

Patient Review

3/16/2018

Clonidine Hydrochloride for High Blood Pressure

My GP warned me about the potential side effects of this medication, but I decided to try it anyway under the care of my cardiologist. After two months of taking this medicine, I have experienced severe constipation, lack of sleep, and urinary incontinence. I am gradually stopping use of the medication and hope to be off it completely soon!

2.3

Patient Review

3/16/2018

Clonidine Hydrochloride for High Blood Pressure

I waswarned about this medication by my GP, but my cardiologist put me on it anyways. I've been taking it for two months now and have experienced severe constipation, lack of sleep, and urinary incontinence. I am gradually stopping this medication and will be off of it as soon as possible!

1

Patient Review

6/20/2020

Clonidine Hydrochloride for High Blood Pressure

Clonidine made me feel very ill; my blood pressure actually went up while taking it. I was on it for three weeks and had a hard time quitting because of how addictive it was. My side effects were terrible: hair loss, straw-like texture, awful taste in mouth, insomnia, vertigo, and fatigue. It's been a few weeks since I stopped taking it and most of the side effects have dissipated, but it was a scary experience overall.

1

Patient Review

2/11/2019

Clonidine Hydrochloride for Symptoms from Stopping Treatment with Opioid Drugs

I found this drug to be groggy and have caused me to sleep more. I was prescribed it to help with withdrawal symptoms from opioids, but it's had limited effects. Twice is enough for me; I'd rather deal with the withdrawal symptoms than take this again.

1

Patient Review

1/1/2019

Clonidine Hydrochloride for Symptoms from Alcohol Withdrawal

I would not recommend this medication to anyone. It's dangerous and it killed my patient.

1

Patient Review

7/2/2020

Clonidine Hydrochloride for High Blood Pressure

I would not call this medication effective in any way, shape, or form. The side effects are incredibly severe and dangerous. Please avoid this "treatment" if at all possible.

1

Patient Review

2/11/2019

Clonidine Hydrochloride for Symptoms from Stopping Treatment with Opioid Drugs

This drug caused me to feel groggy and sleepy, and only had limited effects on my withdrawal symptoms. I was prescribed clonodine to reduce my dosage of opiods, but after taking it twice, I've decided that I would rather deal with the withdrawal symptoms than take this medication again.

1

Patient Review

1/1/2019

Clonidine Hydrochloride for Symptoms from Alcohol Withdrawal

I would not recommend this medication as it is toxic and has killed patients in the past.

1

Patient Review

6/22/2021

Clonidine Hydrochloride for Symptoms from Stopping Treatment with Opioid Drugs

My husband was on this for withdrawal and also high blood pressure. He would fall asleep mid sentence, eyes rolling back. It really freaked me out. One night he was confused and blood pressure dropped too low. He had vivid frightening Night terrors. Perhaps this drug helped him initially but as he recovered and no longer needed it for withdrawal, it only started to make his situation worse.

1

Patient Review

6/20/2020

Clonidine Hydrochloride for High Blood Pressure

I had a really terrible experience with this medication. It made me feel ill, my blood pressure went up, and I developed some nasty side effects that took weeks to recover from.

1

Patient Review

7/2/2020

Clonidine Hydrochloride for High Blood Pressure

I would not recommend this medication to anyone. It caused me severe blurred vision, high blood pressure spikes, and constipation. I felt terrible while taking it and it did nothing to improve my condition.

1

Patient Review

2/11/2019

Clonidine Hydrochloride for Symptoms from Stopping Treatment with Opioid Drugs

This drug has made me feel groggy and sleepy. It also hasn't done much to help with withdrawal symptoms. I'm supposed to take it to wean myself off of opioids, but I would rather just deal with the withdrawal symptoms than take this again.

1

Patient Review

6/22/2021

Clonidine Hydrochloride for Symptoms from Stopping Treatment with Opioid Drugs

My husband was prescribed this for withdrawal and high blood pressure. He would fall asleep mid sentence, eyes rolling back. It really freaked me out. One night he was confused and blood pressure dropped too low. He had vivid frightening Night terrors. Perhaps this drug helped him initially but as he recovered and no longer needed it for withdrawal, it only started to make his situation worse.

1

Patient Review

1/1/2019

Clonidine Hydrochloride for Symptoms from Alcohol Withdrawal

I would not recommend this medication as it is quite toxic and has killed patients in the past.

1

Patient Review

7/2/2020

Clonidine Hydrochloride for High Blood Pressure

This medication is absolutely terrible. It caused severe blurred vision, spikes and drops in blood pressure, and constipation. This medication is pure poison for your body.

1

Patient Review

6/20/2020

Clonidine Hydrochloride for High Blood Pressure

Clonidine made me nauseous, and my blood pressure actually increased while taking it. I was on it for three weeks before the side effects became too much to handle. Quitting was difficult because of the withdrawal symptoms. My hair became thin and straw-like, I had a constant metallic taste in my mouth, insomnia, vertigo, and extreme fatigue. The side effects have mostly dissipated now, but it was a very harrowing experience while they lasted.

1

Patient Review

6/22/2021

Clonidine Hydrochloride for Symptoms from Stopping Treatment with Opioid Drugs

My husband was prescribed this for withdrawal and high blood pressure. He would fall asleep in the middle of conversations, eyes rolling back. It was really concerning. One night he had a drop in blood pressure and started having vivid, frightening nightmares. Maybe this drug helped him at first, but as he no longer needed it for withdrawal, it only made things worse.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about clonidine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is clonidine hydrochloride a Xanax?

"Catapres and Xanax are both used to treat anxiety, but Catapres is mainly used to treat high blood pressure while Xanax is used to treat panic attacks. They belong to different drug classes."

Answered by AI

What is clonidine hydrochloride used for?

"This can damage the blood vessels of the brain, heart, and kidneys, and can lead to a stroke, heart failure, or kidney failure.

Clonidine is used to treat high blood pressure by lowering the amount of blood going through the arteries and veins. This lowers the workload of the heart and arteries, and reduces the risk of stroke, heart failure, and kidney failure."

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Does clonidine hydrochloride make you high?

"Clonidine does not get you high. Clonidine works by helping to reduce nervous system over-excitation, which can occur during withdrawal from opioids, alcohol, and nicotine."

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How does clonidine make you feel?

"Anxiety, hallucinations, depression, and sleep disorders are some of the potentially severe and dangerous side effects of clonidine. If you experience any of these side effects, you should seek medical help immediately. Long-term use of clonidine can also cause gastrointestinal problems."

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Clinical Trials for Clonidine Hydrochloride

Image of VA Greater Los Angeles Healthcare System, West Los Angeles, CA in West Los Angeles, United States.

EBQI Strategies for Women's Health

Any Age
All Sexes
West Los Angeles, CA

Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. Furthermore, few VA improvement efforts have focused on women Veterans' health and health care in midlife. The EMPOWER QUERI 3.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 18 VA facilities from 4 regions.

Waitlist Available
Has No Placebo

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Erin P Finley, PhD MPH

Image of Inova Schar Cancer Institute in Fairfax, United States.

Acupuncture for Prostate Cancer

18+
Male
Fairfax, VA

Prostate cancer is the most common cancer among men in the United States. Many men with prostate cancer are treated with hormone therapy, also called androgen deprivation therapy (ADT). While this treatment is effective, it often causes bothersome side effects such as hot flashes, poor sleep, fatigue, and other physical and emotional symptoms. There is currently no standard treatment to help manage these side effects in men. Acupuncture is a non-drug treatment that has been shown to help reduce hot flashes and related symptoms in women receiving hormone therapy for breast cancer. However, much less is known about whether acupuncture is helpful for men receiving hormone therapy for prostate cancer. This study will test whether an acupuncture program, combined with usual lifestyle education, is feasible and acceptable for men undergoing ADT. The study will also explore whether acupuncture may help reduce hot flashes and improve related symptoms. A total of 24 men with prostate cancer receiving ADT will be randomly assigned to one of two groups: one group will begin acupuncture right away, and the other group will begin acupuncture after a delay, with regular check-ins during the waiting period. All participants will receive standard lifestyle education. Participants will be followed for about five months and will be asked to complete daily hot flash diaries, questionnaires about their symptoms and quality of life, and wear a Fitbit to track sleep. The results of this pilot study will help determine whether a larger study should be conducted to better understand the role of acupuncture in managing hormone therapy side effects in men with prostate cancer.

Waitlist Available
Has No Placebo

Inova Schar Cancer Institute

Jeanny Aragon-Ching, MD

Image of Miles Square Health Center Chicago in Chicago, United States.

Food is Medicine for High Blood Pressure and Obesity

Any Age
All Sexes
Chicago, IL

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leverages existing partnerships with community-based organizations for home food delivery and culinary skill-skill building. The main questions it aims to answer are: (1) What is the effect of FIM+DASH vs. usual care control on blood pressure? (2) What is the effect of FIM+DASH vs. usual care control on DASH diet adherence (diet quality), body weight, and waist circumference? (3) How to identify factors associated with the sustainability and scalability of FIM+DASH in real-world settings?

Phase 2
Waitlist Available

Miles Square Health Center Chicago (+3 Sites)

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Image of Seattle Children's Hospital in Seattle, United States.

Organizational Skills Training vs Mindfulness for ADHD

13 - 17
All Sexes
Seattle, WA

This randomized control trial comparing Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI) among adolescents with a pre-existing ADHD diagnosis presenting to the Duke ADHD Program. Both treatments are eight 90 minute sessions. The research component will involve a pre-treatment assessment and post-treatment assessment. Both assessments will involve adolescents and one caregiver to complete questionnaires over REDCap. Rating scales will include ADHD symptom severity (Conners 3: self and parent report), functional impairment (IRS: self and parent report), executive functioning (BRIEF-2: parent report), emotion dysregulation (DERS: self and parent report), trait mindfulness (FFMQ: self report), organizational skills (BRIEF-2: parent report), treatment satisfaction (self report and parent report) and credibility (self report and parent report). Post-treatment assessments for feasibility will include attendance (measured over the course of treatment) and homework completion rates on a scale of 1 to 5 in which 5 indicates higher homework completion. We will also assess acceptability via individual items on a Likert scale (self report): overall satisfaction, how much was learned about ADHD, usefulness of information learned, content relevance to individual experience, comprehension of strategies, confidence about using strategies, likelihood of using strategies, helpfulness to share with the group, benefits from hearing from other group members, willingness to recommend the same treatment to others, and whether or not treatment was beneficial.

Recruiting
Has No Placebo

Seattle Children's Hospital

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL

This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.

Waitlist Available
Has No Placebo

U Health (+1 Sites)

Ziad Zoghby, M.D., M.B.A.

Biobeat Technologies Ltd.

Image of St. Jude Children's Research Hospital in Memphis, United States.

Methylphenidate for Sickle Cell Disease

8 - 17
All Sexes
Memphis, TN

The purpose of this study is to determine if patients with sickle cell disease (SCD) can consistently take a drug called Methylphenidate (MPH) daily, once a day for 4 weeks to help with any thinking, attention or schoolwork problems and if they have any side effects. The study will assess any thinking or attention problems participants may have both before taking this drug and after. Additionally, the study will assess the decision-making process of the caregiver that may influence using this drug or not. Primary Objective: • Assess the feasibility, acceptability, and adherence to MPH treatment in children with SCD and EF deficits. Secondary Objective: • Evaluate neurobehavioral and safety outcomes following MPH treatment. Exploratory Objective: • Evaluate decision-making and determinants influencing methylphenidate utilization among parents.

Phase 1
Recruiting

St. Jude Children's Research Hospital

Andrew Heitzer, PhD

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Image of The University of Iowa in Iowa City, United States.

fMRI for Cognitive Flexibility

18 - 35
All Sexes
Iowa City, IA

The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, involve difficulties with cognitive flexibility and control. The primary research questions are: Does the MD thalamus represent the context that organizes how working memory guides task selection? Does the MD thalamus signal when context needs to be updated after a change in task demands? Do these thalamic representations support generalization to new situations or rules? Participants will complete cognitive tasks while undergoing high-resolution brain imaging using 7-Tesla MRI. The investigators will combine behavioral data, computational modeling, and advanced neuroimaging analyses to examine how the thalamus interacts with the cortex during flexible decision-making.

Waitlist Available
Has No Placebo

The University of Iowa

Image of UCSF Nancy Friend Pritzker Psychiatry Building in San Francisco, United States.

Trigeminal Nerve Stimulation for ADHD in Children with Autism

7 - 14
All Sexes
San Francisco, CA

The goal of this clinical trial is to learn if external trigeminal nerve stimulation (eTNS) works to treat ADHD symptoms in children on the autism spectrum (ASD). It will also learn about the efficacy and tolerability of the eTNS device. The main questions it aims to answer are: * Does eTNS reduce ADHD symptoms? * Does eTNS improve core and associated features of ASD? Participation spans 8-12 weeks and includes: * 4-5 in-person visits * 4 brief virtual check-ins * Nightly use of the eTNS device with a small sticky patch applied to child's forehead * Randomized assignment (those who start with the sham device may try the active device later)

Recruiting
Device

UCSF Nancy Friend Pritzker Psychiatry Building

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