Clobazam

Epilepsy, Lennox Gastaut Syndrome
Treatment
4 FDA approvals
20 Active Studies for Clobazam

What is Clobazam

ClobazamThe Generic name of this drug
Treatment SummaryClobazam is a medication used to treat anxiety and seizures. It belongs to a class of drugs known as benzodiazepines, which are thought to have fewer side effects than other types of benzodiazepines. It has been used to treat anxiety since 1975 and seizures since 1984. Clobazam was approved by the FDA in 2011, with an oral suspension expected to be available in 2013.
Onfiis the brand name
image of different drug pills on a surface
Clobazam Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Onfi
Clobazam
2011
64

Approved as Treatment by the FDA

Clobazam, also known as Onfi, is approved by the FDA for 4 uses including Lennox Gastaut Syndrome and Lennox Gastaut Syndrome (LGS) .
Lennox Gastaut Syndrome
Used in combination with other therapies
Lennox Gastaut Syndrome (LGS)
Used in combination with other therapies
Seizures
Used in combination with other therapies
Epilepsy
Used in combination with other therapies

Effectiveness

How Clobazam Affects PatientsClobazam works similarly to other benzodiazepines by attaching to the GABA-A receptor in the brain. The difference is that it only partially attaches, which may cause less sedation than with other benzodiazepines. It works by increasing the frequency of the chloride channel opening and making it easier for chloride ions to pass through the brain's membrane. Taking clobazam over time may lead to decreased effectiveness.
How Clobazam works in the bodyClobazam helps make it easier for the brain to send signals that reduce activity. It does this by attaching to special binding sites next to chloride ion channels in the brain. This helps keep the channels open for longer, which allows the brain to send out more calming signals.

When to interrupt dosage

The measure of Clobazam is dependent upon the determined condition. The amount of dosage is contingent upon the method of administration described in the table beneath.
Condition
Dosage
Administration
Epilepsy
5.0 mg, , 10.0 mg, 20.0 mg, 2.5 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Film - Oral, Film
Lennox Gastaut Syndrome
5.0 mg, , 10.0 mg, 20.0 mg, 2.5 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Film - Oral, Film

Warnings

There are 20 known major drug interactions with Clobazam.
Common Clobazam Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Clobazam.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Clobazam.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Clobazam.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Clobazam.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Clobazam.
Clobazam Toxicity & Overdose RiskCommon side effects of this drug include drowsiness, fever, colds, and fatigue.
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Clobazam Novel Uses: Which Conditions Have a Clinical Trial Featuring Clobazam?

57 active studies are presently assessing the potential of Clobazam to mitigate Epilepsy.
Condition
Clinical Trials
Trial Phases
Epilepsy
19 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4, Phase 1
Lennox Gastaut Syndrome
2 Actively Recruiting
Phase 1, Phase 2, Phase 4

Clobazam Reviews: What are patients saying about Clobazam?

5Patient Review
7/23/2019
Clobazam for Additional Medication for Myoclonic Epilepsy
I've only been taking this medication for a short while, but it has helped my myoclonic jerks immensely!
5Patient Review
7/23/2019
Clobazam for Additional Medication for Myoclonic Epilepsy
This medication has helped my myoclonic jerks immensely in only a couple of weeks.
4Patient Review
5/27/2012
Clobazam for Lennox-Gastaut Syndrome Treatment Adjunct
Clobazam has been a seizure-calming godsend for my son who suffers from Lennox Gastraut syndrome. He's been on it for over a year now, and we only had to order it from another country because it wasn't FDA approved in the US at that time. Thankfully, he's been switched over to Onfi now that it is available here. Fingers crossed there won't be any difference in his condition.
1Patient Review
9/6/2012
Clobazam for Lennox-Gastaut Syndrome Treatment Adjunct
My son has a vns and is on 4 other kinds of seizure medication. The doctor wants to try clobazam, but Medicare and Tricare have rejected this medication. I don't have the money to see if this drug will work.
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Patient Q&A Section about clobazam

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is clobazam a narcotic drug?

"Clobazam is a drug that is controlled by the government."

Answered by AI

Is clobazam a sleeping tablet?

"Clobazam is a medication that belongs to a group of drugs called benzodiazepines. It can only be obtained with a doctor's prescription. Clobazam is used for the treatment of anxiety (short-term only), sleep problems that are associated with anxiety, and controlling seizures (fits) in patients who have epilepsy."

Answered by AI

What type of drug is clobazam?

"Clobazam is a medication that can be used to help control seizure activity in children as young as two years old, and adults, who have a type of seizure that is often seen in people with Lennox-Gastaut Syndrome (LGS). There are many different types of seizures that are seen in people with LGS, which are listed under "Used to Treat.""

Answered by AI

What is the drug clobazam used for?

"Clobazam is used to help control seizures (convulsions) that occur with Lennox-Gastaut syndrome (LGS). It works in the brain to prevent seizures. This medicine will not cure LGS. Clobazam is a benzodiazepine."

Answered by AI

Clinical Trials for Clobazam

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Cobenfy KarXT for Memory Loss

18 - 75
All Sexes
Dallas, TX
The goal of this study is to learn about the effects of Cobenfy KarXT (xanomeline and trospium chloride) on episodic memory processing, including specific effects on areas of the brain involved in memory and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure monitoring, and measuring the activity from the brain areas being assessed. The main questions it aims to answer are 1) whether Cobenfy KarXT changes memory activity based on its agonist effect on muscarinic receptors and acetylcholine, and 2) what the nature of these brain activity changes are. This work builds on previous experiments evaluating cholinergic antagonists. Participants will complete two treatment arms. One of these will be with the drug, and the other will be with a placebo pill, so that the participants are unaware which session the actual drug has been received. Patients will complete a verbal serial recall and/or associative recognition task each of the two days. An anesthesiologist or patient nurse will administer either the drug or the placebo at a critical point which addresses both of the research questions. Researchers will compare the brain activity between the two treatment arms to determine what brain activity changes, and whether there is an additional behavioral effect on memory.
Phase < 1
Waitlist Available
University of Texas Southwestern Medical CenterBradley C Lega, MD
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BHV-7000 for Epilepsy

18 - 75
All Sexes
New Haven, CT
This is an open label study to assess the biological effect of BHV-7000 on abnormal activity recorded by the RNS System in patients with focal epilepsy implanted with the RNS System. BHV-7000 is a potassium channel activator being evaluated for use in epilepsy. Participants are offered the drug for 4 weeks. Activity during that treatment period is compared to a 90-day retrospective baseline period in which other medications and device settings were stable, and also to a 4-week withdrawal period after treatment is discontinued. The study is open to patients with RNS regardless of whether they report clinical seizures, as long as the device recordings continue to show epileptiform activity.
Phase 1
Recruiting
Yale Comprehensive Epilepsy CenterImran Quraishi, MD, PhDBiohaven Pharmaceuticals, Inc.
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Epidiolex for Epilepsy

2 - 18
All Sexes
Toronto, Canada
The goal of this clinical trial is to learn the best way to switch children with Lennox-Gastaut Syndrome (LGS) or Dravet Syndrome (DS) taking 'artisanal' (non pharmaceutical-grade) cannabidiol (CBD) to Epidiolex for treatment of seizures. The main questions it aims to answer are: * How well does a gradual switch from 'artisanal' CBD to Epidiolex work? * Does the same dose of Epidiolex as 'artisanal' CBD work best? * What side-effects or medical problems do participants have when switching from 'artisanal' CBD to Epidiolex? Researchers will examine how successful switching from 'artisanal' CBD to Epidiolex is. Participants will: * Gradually increase their dose of Epidiolex and reduce their dose of 'artisanal' CBD until they are taking just Epidiolex * Visit the clinic five times over 20 weeks for checkups and tests * Keep a diary of their seizures, symptoms and the number of times they use a rescue seizure medication
Phase 4
Waitlist Available
The Hospital for Sick ChildrenElizabeth Donner, MDJazz Pharmaceuticals
Have you considered Clobazam clinical trials? We made a collection of clinical trials featuring Clobazam, we think they might fit your search criteria.Go to Trials
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Tranexamic Acid Timing for Postoperative Bleeding

18 - 100
All Sexes
Hamilton, Canada
The goal of this clinical trial is to establish the feasibility of conducting a large trial to determine the optimal timing of intravenous tranexamic acid administration in cardiac surgery. The main questions it aims to answer are: * Is it feasible to conduct a larger definitive trial? * Can we measure the systemic tranexamic acid concentration and fibrinolytic potential in the blood samples? Researchers will compare intravenous tranexamic acid administered before cardiopulmonary bypass versus after cardiopulmonary bypass to see if the systemic tranexamic acid concentration and fibrinolytic potential are similar or better. Participants will: * Provide written informed consent * Receive tranexamic acid during surgery * Provide blood samples at 5 time points: before surgery, on arrival in intensive care unit, 3 hours after arrival, 6 hours after arrival, and on the next morning.
Phase 3
Waitlist Available
Hamilton Health Sciences - General HospitalAndre Lamy, MD
Have you considered Clobazam clinical trials? We made a collection of clinical trials featuring Clobazam, we think they might fit your search criteria.Go to Trials
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Focused Ultrasound for Seizures

19 - 85
All Sexes
New Haven, CT
In this study, the investigators propose Pulsed Low-Intensity Focused Ultrasound (PLIFU) stimulation of brain regions that modulate (thalamus) or generate focal motor seizures (primary motor cortex), with the goal of ameliorating seizure activity in subjects in non-convulsive or focal motor status epilepticus. The course of treatment will consist of an initial 10 minute PLIFU treatment session with an option for a 2nd session if necessary. The primary objective of this study is to determine whether PLIFU reduces or suppresses epileptic activity in patients with Non-Convulsive Status Epilepticus (NCSE)/Focal Motor Status Epilepticus (FMSE) that have not responded to standard of care.
Recruiting
Has No Placebo
Yale New Haven HospitalImran Quraishi, MD
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Factors Affecting Oxygen Toxicity

18 - 45
All Sexes
Durham, NC
The goal of this clinical trial is to learn about the mechanisms of oxygen toxicity in scuba divers. The main questions it aims to answer are: * How does the training of respiratory muscles affect oxygen toxicity? * How do environmental factors, such as sleep deprivation, the ingestion of commonly utilized medications, and chronic exposure to carbon dioxide, impact the risk of oxygen toxicity? * How does immersion in water affect the development of oxygen toxicity? Participants will be asked to do the following: * Undergo a basic screening exam composed of health history, vital signs, and some respiratory function tests * Train their respiratory muscles at regular intervals * Exercise on a cycle ergometer both in dry conditions and underwater/under pressure in the context of medication, sleep deprivation, or carbon dioxide exposure Researchers will compare the performance of each subject before and after the possible interventions described above to see if there are changes in exercise performance, respiratory function, cerebral blood flow, and levels of gene expression.
Recruiting
Has No Placebo
Duke University Health SustemDerek B Covington, MD
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Scopolamine for Memory Loss

18 - 55
All Sexes
Dallas, TX
The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure monitoring, and measuring the activity from the brain areas being assessed. The main questions it aims to answer are 1) whether scopolamine changes memory activity solely at encoding (the time when the person perceives and determines to remember an item or event) as has previously been found, or if it also can selectively impact retrieval (when the item or event which has been processed is recalled or remembered), and 2) what the nature of the brain activity changes is. Participants will complete two treatment arms. One of these will be with the drug, and the other will be with a saline solution, so that the participants are unaware which session the actual drug has been received. Patients will complete a verbal and/or spatial task each of the two days. An anesthesiologist will administer either the drug or the saline at a critical point which addresses both of the research questions. Researchers will compare the brain activity between the two treatment arms to determine what brain activity changes, and at what time point during memory formation.
Phase < 1
Recruiting
University of Texas Southwestern Medical CenterBradley C Lega, MD
Have you considered Clobazam clinical trials? We made a collection of clinical trials featuring Clobazam, we think they might fit your search criteria.Go to Trials
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