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What is Clobazam
ClobazamThe Generic name of this drug
Treatment SummaryClobazam is a medication used to treat anxiety and seizures. It belongs to a class of drugs known as benzodiazepines, which are thought to have fewer side effects than other types of benzodiazepines. It has been used to treat anxiety since 1975 and seizures since 1984. Clobazam was approved by the FDA in 2011, with an oral suspension expected to be available in 2013.
Onfiis the brand name
Clobazam Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Onfi
Clobazam
2011
64
Approved as Treatment by the FDA
Clobazam, also known as Onfi, is approved by the FDA for 4 uses including Lennox Gastaut Syndrome and Lennox Gastaut Syndrome (LGS) .Lennox Gastaut Syndrome
Used in combination with other therapies
Lennox Gastaut Syndrome (LGS)
Used in combination with other therapies
Seizures
Used in combination with other therapies
Epilepsy
Used in combination with other therapies
Effectiveness
How Clobazam Affects PatientsClobazam works similarly to other benzodiazepines by attaching to the GABA-A receptor in the brain. The difference is that it only partially attaches, which may cause less sedation than with other benzodiazepines. It works by increasing the frequency of the chloride channel opening and making it easier for chloride ions to pass through the brain's membrane. Taking clobazam over time may lead to decreased effectiveness.
How Clobazam works in the bodyClobazam helps make it easier for the brain to send signals that reduce activity. It does this by attaching to special binding sites next to chloride ion channels in the brain. This helps keep the channels open for longer, which allows the brain to send out more calming signals.
When to interrupt dosage
The measure of Clobazam is dependent upon the determined condition. The amount of dosage is contingent upon the method of administration described in the table beneath.Condition
Dosage
Administration
Epilepsy
5.0 mg, , 10.0 mg, 20.0 mg, 2.5 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Film - Oral, Film
Lennox Gastaut Syndrome
5.0 mg, , 10.0 mg, 20.0 mg, 2.5 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Film - Oral, Film
Warnings
There are 20 known major drug interactions with Clobazam.Common Clobazam Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Clobazam.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Clobazam.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Clobazam.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Clobazam.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Clobazam.
Clobazam Toxicity & Overdose RiskCommon side effects of this drug include drowsiness, fever, colds, and fatigue.
Clobazam Novel Uses: Which Conditions Have a Clinical Trial Featuring Clobazam?
57 active studies are presently assessing the potential of Clobazam to mitigate Epilepsy.Condition
Clinical Trials
Trial Phases
Epilepsy
16 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1
Lennox Gastaut Syndrome
3 Actively Recruiting
Phase 2, Phase 1, Phase 4
Clobazam Reviews: What are patients saying about Clobazam?
5Patient Review
7/23/2019 I've only been taking this medication for a short while, but it has helped my myoclonic jerks immensely!
5Patient Review
7/23/2019 This medication has helped my myoclonic jerks immensely in only a couple of weeks.
4Patient Review
5/27/2012 Clobazam has been a seizure-calming godsend for my son who suffers from Lennox Gastraut syndrome. He's been on it for over a year now, and we only had to order it from another country because it wasn't FDA approved in the US at that time. Thankfully, he's been switched over to Onfi now that it is available here. Fingers crossed there won't be any difference in his condition.
1Patient Review
9/6/2012 My son has a vns and is on 4 other kinds of seizure medication. The doctor wants to try clobazam, but Medicare and Tricare have rejected this medication. I don't have the money to see if this drug will work.
Patient Q&A Section about clobazam
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is clobazam a narcotic drug?
"Clobazam is a drug that is controlled by the government."
Answered by AI
Is clobazam a sleeping tablet?
"Clobazam is a medication that belongs to a group of drugs called benzodiazepines. It can only be obtained with a doctor's prescription. Clobazam is used for the treatment of anxiety (short-term only), sleep problems that are associated with anxiety, and controlling seizures (fits) in patients who have epilepsy."
Answered by AI
What type of drug is clobazam?
"Clobazam is a medication that can be used to help control seizure activity in children as young as two years old, and adults, who have a type of seizure that is often seen in people with Lennox-Gastaut Syndrome (LGS). There are many different types of seizures that are seen in people with LGS, which are listed under "Used to Treat.""
Answered by AI
What is the drug clobazam used for?
"Clobazam is used to help control seizures (convulsions) that occur with Lennox-Gastaut syndrome (LGS). It works in the brain to prevent seizures. This medicine will not cure LGS. Clobazam is a benzodiazepine."
Answered by AI
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