Climara

Endometrial Hyperplasia, Endometriosis, Hot flashes + 6 more
Treatment
7 FDA approvals
20 Active Studies for Climara

What is Climara

LevonorgestrelThe Generic name of this drug
Treatment SummaryEstradiol is a hormone that is naturally produced in females. It is available in many different forms to treat conditions related to reduced estrogen levels such as vaginal dryness and hot flashes. Estradiol can be taken orally, injected, or applied in the form of a ring, patch, spray, gel, or cream. For oral or injection use, estradiol is often combined with an ester side-chain to increase its effectiveness. Ethinyl estradiol (EE) is a synthetic form of estradiol commonly used in combination birth control pills. It is more bioavailable than regular estradiol and is more
Triphasil-21is the brand name
image of different drug pills on a surface
Climara Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Triphasil-21
Levonorgestrel
1984
243

Approved as Treatment by the FDA

Levonorgestrel, also known as Triphasil-21, is approved by the FDA for 7 uses including Osteoporosis, Postmenopausal and Has had at least 1 child .
Osteoporosis, Postmenopausal
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Has had at least 1 child
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol
Emergency Contraception
Hot flashes
Used to treat Menopause in combination with Estradiol

Effectiveness

How Climara Affects PatientsEstradiol is used to relieve hot flashes, vaginal dryness, and pain during sex. It can also help increase bone density and improve a person's lipid profile. Additionally, it causes the liver to produce more sex hormone binding globulin (SHBG) and thyroid-binding globulin (TBG) and suppresses the formation of follicle-stimulating hormone (FSH). However, estradiol can increase the risk of cardiovascular disease, deep vein thrombosis, and stroke in people who are already at high risk. It can also cause a hyper-coagulable state, which is associated
How Climara works in the bodyEstrogen is a hormone found in many parts of the body. In women of childbearing age, most estrogen is produced by the ovaries, but after menopause, this hormone is mostly produced in the adrenal glands. Estrogen binds to two types of receptors in the body, ERα and ERβ, and works by entering the nucleus of cells to regulate gene transcription and cause various effects. After menopause, higher levels of estrogen can cause hot flashes, chills, vaginal dryness, mood swings, irregular menstruation, and sleep problems. The hormone works to help relieve these symptoms by increasing its pro-estrogen

When to interrupt dosage

The amount of Climara is contingent upon the declared condition, including Premature Menopause, Pharmaceutical Preparations and Postmenopause. The dosage fluctuates as per the procedure of delivery outlined in the table underneath.
Condition
Dosage
Administration
Hot flashes
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Osteoporosis, Postmenopausal
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
moderate Menopausal Vasomotor Symptoms
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometrial Hyperplasia
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometriosis
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Emergency Contraception
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Menorrhagia
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Has had at least 1 child
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Menopause
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral

Warnings

Climara Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Levonorgestrel may interact with Pulse Frequency
Abortion, Septic
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Abortion, Spontaneous
Do Not Combine
HCG elevated
Do Not Combine
Pelvic Infection
Do Not Combine
Vaginitis
Do Not Combine
Acute Coryza
Do Not Combine
Breast Neoplasms
Do Not Combine
Uterine Cervicitis
Do Not Combine
Communicable Diseases
Do Not Combine
Gonorrhea
Do Not Combine
Breast Cancer
Do Not Combine
Intrauterine Devices
Do Not Combine
Liver Neoplasms
Do Not Combine
congenital or aquired uterine abnormality
Do Not Combine
Chlamydia Infections
Do Not Combine
Hypersensitivity
Do Not Combine
Emergency Contraception
Do Not Combine
Endocarditis, Bacterial
Do Not Combine
Vaginosis, Bacterial
Do Not Combine
suspected pregnancy
Do Not Combine
Uterine Cervicitis
Do Not Combine
Uterine Neoplasms
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
Breast Neoplasms
Do Not Combine
Uterine Cervical Neoplasms
Do Not Combine
Fibroid Tumor
Do Not Combine
Endometritis
Do Not Combine
chlamydial cervical infection
Do Not Combine
PAP Test Abnormalities
Do Not Combine
Liver Failure, Acute
Do Not Combine
Uterine anomaly distorting uterine cavity
Do Not Combine
Breast Cancer
Do Not Combine
Cervical Dysplasia
Do Not Combine
Thromboembolism
Do Not Combine
Bacterial Vaginosis
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
Breast
Do Not Combine
Vaginal Bleeding
Do Not Combine
Bacterial Vaginosis
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
Gonorrhea
Do Not Combine
There are 20 known major drug interactions with Climara.
Common Climara Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Levonorgestrel.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Levonorgestrel.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Levonorgestrel.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Levonorgestrel.
Crizotinib
Major
The metabolism of Crizotinib can be decreased when combined with Levonorgestrel.
Climara Toxicity & Overdose RiskStudies have shown that daily doses of estradiol in rats have no adverse effects at 0.003 mg/kg/day. In higher doses, woman may experience nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. If an overdose of estradiol is suspected, it is recommended to stop taking the drug and seek supportive care.
image of a doctor in a lab doing drug, clinical research

Climara Novel Uses: Which Conditions Have a Clinical Trial Featuring Climara?

867 investigations are presently underway to examine the possible benefits of Climara in alleviating Osteoporosis, Amenorrhea and Urogenital Atrophy.
Condition
Clinical Trials
Trial Phases
Hot flashes
16 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2
Endometriosis
29 Actively Recruiting
Early Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Has had at least 1 child
0 Actively Recruiting
Menorrhagia
0 Actively Recruiting
Endometrial Hyperplasia
4 Actively Recruiting
Not Applicable, Phase 2, Phase 3
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Menopause
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Emergency Contraception
1 Actively Recruiting
Phase 4

Climara Reviews: What are patients saying about Climara?

5Patient Review
10/6/2011
Climara for "Change of Life" Signs
This patch quickly and effectively helped with my menopause symptoms. I've been using it for two years now with great results. The only downside is that I sometimes experience bloating, but the relief from other symptoms is well worth it.
5Patient Review
9/8/2012
Climara for Low Estrogen After Operation to Remove Ovaries
This patch has been a godsend. It's helped with my menopausal symptoms and my joint pain significantly. I've gone without it before and noticed a significant difference in how I feel, so I would definitely recommend it to others!
5Patient Review
8/11/2014
Climara for Low Estrogen After Operation to Remove Ovaries
I've been on this medication for 19 years, and have tried to go off of it several times. Each time, I experience terrible hot sweats, no sex drive, and become unbearable irritable. I'm back on the medication and don't plan on stopping again.
5Patient Review
1/26/2019
Climara for Low Estrogen After Operation to Remove Ovaries
I've been using this treatment for 25 years and it's really helped me. I tried to wean myself off of it, but the hot flashes were too much to bear. Cutting the patch in half and applying it weekly has helped a lot.
5Patient Review
2/23/2016
Climara for Low Estrogen After Operation to Remove Ovaries
I've been using this for 15 years and it's still great! If you have trouble keeping the patch on, try washing the area with a non-oil soap (like Ivory) and make sure to dry it before applying. This has helped me a lot.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about climara

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Climara the same as estradiol?

"Climara is a brand of skin patch that contains the female hormone estradiol. These patches are commonly used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. The generic version of Climara is estradiol."

Answered by AI

Does Climara have progesterone?

"Climara Pro is a skin patch that contains estradiol and levonorgestrel. Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. Levonorgestrel is a form of progesterone, a female hormone important for regulating ovulation and menstruation."

Answered by AI

What is Climara used for?

"Each Climara Pro patch contains a small amount of two different female hormones, an estrogen and a progestogen

The Climara Pro® patch contains two different types of hormones - an estrogen and a progestogen. It is used by women after menopause who still have a uterus, in order to reduce moderate to severe hot flashes, and help reduce their chances of developing osteoporosis from menopause."

Answered by AI

Can Climara cause weight gain?

"headache; depression; irritability; breast tenderness or enlargement; premenstrual syndrome (PMS); or

Side effects common to many medications may include: nausea, vomiting, bloating, and stomach cramps. Fluid retention, which manifests as swelling and rapid weight gain, is another side effect that many medications share. Headache, depression, irritability, breast tenderness or enlargement, and premenstrual syndrome (PMS) are also relatively common side effects of medication in general."

Answered by AI

Clinical Trials for Climara

Have you considered Climara clinical trials? We made a collection of clinical trials featuring Climara, we think they might fit your search criteria.
Have you considered Climara clinical trials? We made a collection of clinical trials featuring Climara, we think they might fit your search criteria.
Have you considered Climara clinical trials? We made a collection of clinical trials featuring Climara, we think they might fit your search criteria.
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