Cisplatin

advanced Testicular cancer, Advance Directives, Neoplasm Metastasis + 3 more
Treatment
15 Active Studies for Cisplatin

What is Cisplatin

CisplatinThe Generic name of this drug
Treatment SummaryCisplatin is a chemotherapy drug used to treat different types of cancers, such as sarcomas, some carcinomas, lymphomas, and germ cell tumors. It was the first in its class of platinum-based cancer drugs, which now includes carboplatin and oxaliplatin. Cisplatin is used to treat small cell lung cancer and ovarian cancer, among other forms of cancer.
Cisplatinis the brand name
image of different drug pills on a surface
Cisplatin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cisplatin
Cisplatin
2000
28

Effectiveness

How Cisplatin Affects PatientsCisplatin is a medication used to treat cancer. It works by adding molecules to DNA strands that make it impossible for the strands to separate and replicate, preventing the cells from dividing. It also disrupts the correct utilization of molecules by base pairing, leading to the incorrect coding of DNA. Cisplatin affects cells in all stages of the cell cycle and works by three different mechanisms to cause cell death.
How Cisplatin works in the bodyAlkylating agents work to disrupt the normal functioning of cells by targeting DNA. They do this in three ways: 1) attaching alkyl groups to DNA bases, which stops enzymes from being able to fix the DNA, 2) creating bonds between atoms in the DNA, making it impossible for DNA to be copied, and 3) causing the wrong molecules to be matched up, resulting in mutations.

When to interrupt dosage

The suggested measure of Cisplatin is contingent upon the recognized condition, such as Refractory to Standard Therapies, Advanced Ovarian Cancer and Neoplasm Metastasis. The quantity of dose fluctuates, in agreement with the delivery system (e.g. Injection, solution or Solution) outlined in the table beneath.
Condition
Dosage
Administration
Refractory to Standard Therapies
1.0 mg/mL, , 5.0 mg/mL, 0.5 mg/mL
, Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intravenous, Solution, Liquid, Liquid - Intravenous
Neoplasm Metastasis
1.0 mg/mL, , 5.0 mg/mL, 0.5 mg/mL
, Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intravenous, Solution, Liquid, Liquid - Intravenous
advanced Testicular cancer
1.0 mg/mL, , 5.0 mg/mL, 0.5 mg/mL
, Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intravenous, Solution, Liquid, Liquid - Intravenous
Neoplasm Metastasis
1.0 mg/mL, , 5.0 mg/mL, 0.5 mg/mL
, Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intravenous, Solution, Liquid, Liquid - Intravenous
Advanced Ovarian Cancer
1.0 mg/mL, , 5.0 mg/mL, 0.5 mg/mL
, Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intravenous, Solution, Liquid, Liquid - Intravenous
Advance Directives
1.0 mg/mL, , 5.0 mg/mL, 0.5 mg/mL
, Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intravenous, Solution, Liquid, Liquid - Intravenous

Warnings

Cisplatin Contraindications
Condition
Risk Level
Notes
Bone Marrow
Do Not Combine
Pulse Frequency
Do Not Combine
hearing loss or impairment
Do Not Combine
There are 20 known major drug interactions with Cisplatin.
Common Cisplatin Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Cisplatin is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Cisplatin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Cisplatin is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Cisplatin is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Cisplatin is combined with Acteoside.
image of a doctor in a lab doing drug, clinical research

Cisplatin Novel Uses: Which Conditions Have a Clinical Trial Featuring Cisplatin?

13 active clinical trials are currently being conducted to assess the efficacy of Cisplatin in treating Advanced Ovarian Cancer, Neoplasm Metastasis and Metastatic Neoplasms.
Condition
Clinical Trials
Trial Phases
Advance Directives
0 Actively Recruiting
advanced Testicular cancer
0 Actively Recruiting
Neoplasm Metastasis
1 Actively Recruiting
Phase 2
Refractory to Standard Therapies
0 Actively Recruiting
Advanced Ovarian Cancer
14 Actively Recruiting
Phase 3, Early Phase 1, Phase 2, Phase 1, Not Applicable
Neoplasm Metastasis
0 Actively Recruiting

Cisplatin Reviews: What are patients saying about Cisplatin?

5Patient Review
1/16/2020
Cisplatin for Cancer of the Cervix
According to my PET scan, there was significant shrinkage of the tumor. I would consider this treatment effective because of that. I did have some vomiting, but I had medication to help with that. One side effect was that one of the veins in my forearm seemed to harden, but it felt normal again a few weeks after treatment was completed.
4.7Patient Review
9/14/2009
Cisplatin for Testicular Germ Cell Cancer
I took cisplatin and etoposide for testicular cancer and it was very effective. However, I did suffer from some short-term memory loss as a side effect. So far my short-term memory has returned, but I hope this review helps others who are considering this treatment.
4.3Patient Review
5/9/2016
Cisplatin for Cancer Involving the Head or Neck
Though the side effects were incredibly harsh, this treatment did save my life. A year later and I'm cancer free; though I still have neuropathy in my feet and lost some hearing, I would rather be alive and dealing with those problems than dead.
4.3Patient Review
2/15/2018
Cisplatin for Cancer Involving the Head or Neck
At 57 years old, I had a tumor located above my tonsils that made surgery not an option. I underwent six cycles of chemo and 25 rounds of radiation over the course of three years. Now in remission, I still suffer from bad headaches and back pain occasionally. Additionally, my sense of taste is only at 50% now. On the bright side, I didn't lose any hair during treatment!
4Patient Review
4/20/2010
Cisplatin for Osteosarcoma of Bone
I began to lose my hair within two weeks of starting this treatment. It also made my stomach hurt pretty badly.
3.7Patient Review
11/10/2015
Cisplatin for Cancer Involving the Head or Neck
I got sick about three days after the infusions, but it only lasted for five days.
3.7Patient Review
9/13/2012
Cisplatin for Small Cell Cancer of the Lung
If you can handle the intensity, this treatment is more than effective. It might not be pleasant, but it's worth it.
3.7Patient Review
6/12/2010
Cisplatin for Small Cell Cancer of the Lung
I didn't notice any side effects from this treatment.
3.7Patient Review
12/17/2013
Cisplatin for Non-Small Cell Lung Cancer
I was diagnosed with Poorly Differentiated Neuroendocrine Carcinoma of the Lung in May 2012. I didn't get sick or lose my hair. This drug was paired with Navelbine, Emend, Nulasta and an ulcer med. I did however develop neuropathy in one of my legs after treatment. It is now 12/13 and my cancer is back and has spread to the other lung and lymphnodes. I'm not sure if they will use this drug again or not, but since it worked the first time, I'm not opposed to trying it again.
2.7Patient Review
2/3/2010
Cisplatin for Small Cell Cancer of the Lung
My dad was left with autonomic neuropathy after taking this drug. He's incontinent, can't walk, has blood pressure issues, and so many more problems. The cisplatin got rid of the cancer but at what cost? His quality of life is now very poor.
2.7Patient Review
11/27/2011
Cisplatin for Cancer Involving the Head or Neck
I just completed this treatment, so I can't speak to its effectiveness yet. I have to wait a bit and get another PET scan. The main issue I'm having right now is a constant metallic taste in my mouth and really bad ringing in my ears. I'm hoping my hearing will clear up soon.
2.7Patient Review
1/23/2012
Cisplatin for Non-Small Cell Lung Cancer
I ended up having kidney problems and severe dehydration after taking this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cisplatin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of cisplatin?

"The following are symptoms of medical emergencies that require immediate medical attention: black, tarry stools; blood in urine or stools; burning, numbness, tingling, or painful sensations; change in frequency of urination or amount of urine; cough or hoarseness; difficulty in breathing; feeling of fullness in the ears; fever or chills."

Answered by AI

What cancer is cisplatin used for?

"A chemotherapy drug called cisplatin is most effective in treating testicular cancer. It can also be used to treat other types of cancer, including lung, bladder, cervical, and ovarian cancer. Cisplatin and other drugs that contain platinum were developed with support from the National Cancer Institute (NCI)."

Answered by AI

Is cisplatin a strong chemo drug?

"Currently, cisplatin is one of the most potent chemotherapeutic drugs used to treat ovarian cancer, even though resistance is typical [20]. In ovarian germ cell cancer, cisplatin use results in high response rates [21]."

Answered by AI

Why is cisplatin so toxic?

"Cisplatin leads to mitochondrial and non-mitochondrial cell death pathways by damaging DNA and causing the production of ROS. Additionally, cisplatin disrupts mitochondrial energetics, which may cause nephrotoxicity."

Answered by AI

Clinical Trials for Cisplatin

Have you considered Cisplatin clinical trials? We made a collection of clinical trials featuring Cisplatin, we think they might fit your search criteria.
Have you considered Cisplatin clinical trials? We made a collection of clinical trials featuring Cisplatin, we think they might fit your search criteria.
Have you considered Cisplatin clinical trials? We made a collection of clinical trials featuring Cisplatin, we think they might fit your search criteria.