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What is Cerebyx
FosphenytoinThe Generic name of this drug
Treatment SummaryFosphenytoin is a drug used in hospitals to treat epileptic seizures. It works by slowing down signals in the brain that cause seizures. It does this by blocking certain sodium channels in the neurons, which helps stop the continuous firing of nerve signals that cause seizures.
Cerebyxis the brand name
Cerebyx Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cerebyx
Fosphenytoin
1996
38
Effectiveness
How Cerebyx Affects PatientsFosphenytoin is a medication used to control epileptic seizures. After it is given, it is changed into the active ingredient phenytoin by the body. The dose of fosphenytoin should be calculated carefully as 1.5 mg of fosphenytoin is equal to 1.0mg of phenytoin. Severe side effects such as skin rashes, blisters, and blood problems may happen, and a different seizure medication should be used if these occur. When stopping fosphenytoin, it should be done gradually as this may cause seizures.
How Cerebyx works in the bodyFosphenytoin is a form of phenytoin, which is a drug used to treat seizures. It works by stabilizing the electrical activity in the brain, preventing it from becoming too active and causing seizures. This is accomplished by blocking sodium channels on the neurons, which helps stop the spread of seizure activity. By reducing sodium levels, it can also prevent seizures that are triggered by changes in the environment.
When to interrupt dosage
The amount of Cerebyx is contingent upon the diagnosed affliction, including prophylaxis of Seizures, Status Epilepticus (Convulsive) and Neurosurgery. The dosage also fluctuates in relation to the delivery technique (e.g. Liquid or Solution) specified in the table beneath.Condition
Dosage
Administration
prophylaxis of Seizures
, 50.0 mg/mL, 75.0 mg/mL, 100.0 mg/mL
, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Injection - Intravenous, Injection, solution - Intravenous
Epilepsy
, 50.0 mg/mL, 75.0 mg/mL, 100.0 mg/mL
, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Injection - Intravenous, Injection, solution - Intravenous
Status Epilepticus (Convulsive)
, 50.0 mg/mL, 75.0 mg/mL, 100.0 mg/mL
, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Injection - Intravenous, Injection, solution - Intravenous
Therapeutic procedure
, 50.0 mg/mL, 75.0 mg/mL, 100.0 mg/mL
, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Injection - Intravenous, Injection, solution - Intravenous
Neurosurgery
, 50.0 mg/mL, 75.0 mg/mL, 100.0 mg/mL
, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Injection - Intravenous, Injection, solution - Intravenous
generalized tonic-clonic status epilepticus
, 50.0 mg/mL, 75.0 mg/mL, 100.0 mg/mL
, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Injection - Intravenous, Injection, solution - Intravenous
Warnings
Cerebyx has seven contraindications, so it should not be administered when experiencing any of the conditions in the following table.Cerebyx ContraindicationsCondition
Risk Level
Notes
Adams-Stokes Syndrome
Do Not Combine
phenytoin
Do Not Combine
Sinoatrial Block
Do Not Combine
third degree AV block
Do Not Combine
Sinus Bradycardia
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fosphenytoin may interact with Pulse Frequency
Common Cerebyx Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be increased when combined with Fosphenytoin.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Fosphenytoin.
5-androstenedione
Major
The metabolism of 5-androstenedione can be increased when combined with Fosphenytoin.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be increased when combined with Fosphenytoin.
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Fosphenytoin.
Cerebyx Toxicity & Overdose RiskOverdosing on fosphenytoin may cause nausea, vomiting, fatigue, rapid heartbeat, slow heartbeat, heart stoppage, low blood pressure, fainting, low calcium levels, acidosis in the blood, and even death. In animal studies, the median lethal dose was found to be 156mg/kg in mice and 250mg/kg in rats, which is about 0.6 to 2 times the maximum human loading dose. Signs of toxicity in animals included difficulty walking, heavy breathing, drooping eyelids, and lack of activity.
Cerebyx Novel Uses: Which Conditions Have a Clinical Trial Featuring Cerebyx?
54 active clinical studies are in progress to ascertain the effectiveness of Cerebyx in treating Epilepsy, Neurosurgery and Generalized Tonic-Clonic Status Epilepticus.Condition
Clinical Trials
Trial Phases
Epilepsy
54 Actively Recruiting
Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4, Early Phase 1
Therapeutic procedure
0 Actively Recruiting
generalized tonic-clonic status epilepticus
0 Actively Recruiting
Neurosurgery
1 Actively Recruiting
Early Phase 1
Status Epilepticus (Convulsive)
0 Actively Recruiting
prophylaxis of Seizures
0 Actively Recruiting
Cerebyx Reviews: What are patients saying about Cerebyx?
1Patient Review
3/10/2014 I had a seizure and was given this treatment at the ER. Almost immediately, I began to twitch on one side of my body, then I threw up. For the past two days, I've been dealing with numbness and severe twitching on the left side. Do not take this; it's dangerous.
1Patient Review
11/15/2007 The emergency room gave me this medication intravenously, but I started itching all over my body almost immediately. The nurse had to stop the IV and give me a dose of Benadryl to calm down the reaction.
Patient Q&A Section about cerebyx
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is fosphenytoin the same as Dilantin?
"Fosphenytoin is a pro-drug of Phenytoin. The main difference between the two is that fosphenytoin is more water soluble."
Answered by AI
How long does Cerebyx last?
"Fosphenytoin is quickly converted to phenytoin following IV or IM administration, with a half-life of around 15 minutes. Plasma total phenytoin concentrations peak in about 3 hours after IM administration."
Answered by AI
What is Cerebyx used for?
"Cerebyx is a drug used to prevent or control seizures that is only meant to be used for a short time when other forms of phenytoin cannot be given."
Answered by AI
Can Cerebyx be given IV push?
"The highest concentration of CEREBYX that should be used in any solution is 25 mg PE/mL. When CEREBYX is given as an IV infusion, it needs to be diluted and should not be given at a rate higher than 150 mg PE/min."
Answered by AI