Dermaprazole Cream for Radiation Dermatitis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing a new cream called Dermaprazole on patients with head and neck cancer. The cream is a special version of a medicine that usually reduces stomach acid. Researchers want to see if it is safe and effective for these patients.
Will I have to stop taking my current medications?
If you are currently taking proton pump inhibitors, you will need to stop them with your doctor's approval to participate in the trial. The protocol does not specify about other medications.
How is Dermaprazole Cream different from other treatments for radiation dermatitis?
Dermaprazole Cream is unique because it uses a topical form of esomeprazole, which is typically an oral medication for acid reflux, to reduce skin inflammation and fibrosis caused by radiation. It works by activating protective pathways in the skin, offering a novel approach compared to traditional treatments that may not effectively address these issues.12345
What data supports the effectiveness of the drug Dermaprazole Cream for treating radiation dermatitis?
Who Is on the Research Team?
Shraddha Dalwadi, MD
Principal Investigator
The University of Texas Health Science Center - Mays Cancer Center
Are You a Good Fit for This Trial?
This trial is for adults over 18 with head and neck cancer, excluding brain malignancies, who are set to receive at least 66Gy of chemoradiation. They should have a performance status that allows daily activities (ECOG 0-2) and no prior treatments like head and neck radiotherapy or neoadjuvant chemotherapy. Those taking proton pump inhibitors must stop with their doctor's approval.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Dermaprazole cream or Aquaphor for 7 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Dermaprazole Cream
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mohamad Hassan Fakhreddine
Lead Sponsor
The University of Texas Health Science Center at San Antonio
Lead Sponsor