Cefaclor

Tonsillitis, Bacteria, Otitis Media + 9 more

Treatment

2 FDA approvals

6 Active Studies for Cefaclor

What is Cefaclor

Cefaclor

The Generic name of this drug

Treatment Summary

Cephalexin is a semi-synthetic antibiotic that is effective against a broad range of bacteria.

Cefaclor

is the brand name

image of different drug pills on a surface

Cefaclor Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Cefaclor

Cefaclor

1995

47

Approved as Treatment by the FDA

Cefaclor, also known as Cefaclor, is approved by the FDA for 2 uses including Bacterial Infections and Urinary Tract Infection (UTI) .

Bacterial Infections

Urinary Tract Infection (UTI)

Effectiveness

How Cefaclor Affects Patients

Cefaclor is a type of antibiotic used to treat bacterial infections. Tests show that it works by stopping bacteria from making new cell walls, which prevents them from growing. Cefaclor has been shown to be effective in treating many types of bacteria, such as staphylococci, Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Haemophilus influenzae, Klebsiella sp., and Proteus mirabilis.

How Cefaclor works in the body

Cefaclor is an antibiotic similar to penicillin. It works by blocking certain proteins in bacterial cells that are used to build the bacterial cell wall. This prevents the wall from forming, leading to the destruction of the bacteria by its own enzymes. Cefaclor may also interact with an enzyme inhibitor to further enhance this process.

When to interrupt dosage

The proposed dosage of Cefaclor is contingent upon the specified affliction, including streptococcus pyogenes skin infection, Urinary Tract Infection (UTI) and Otitis Media. The amount of dosage is contingent upon the method of administration tabulated below.

Condition

Dosage

Administration

Urinary tract infection

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Tonsillitis

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

streptococcus pyogenes skin infection

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Staphylococcal Skin Infections

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Bacterial Infections

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Bacteria

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Streptococcal Pharyngitis

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Bronchitis, Chronic

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Moraxella catarrhalis

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Bronchitis

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Otitis Media

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Urinary Tract Infection (UTI)

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Warnings

There are 20 known major drug interactions with Cefaclor.

Common Cefaclor Drug Interactions

Drug Name

Risk Level

Description

Neomycin

Major

The risk or severity of nephrotoxicity can be increased when Cefaclor is combined with Neomycin.

Tenofovir

Major

Cefaclor may increase the nephrotoxic activities of Tenofovir.

Tenofovir alafenamide

Major

Cefaclor may increase the nephrotoxic activities of Tenofovir alafenamide.

Tenofovir disoproxil

Major

Cefaclor may increase the nephrotoxic activities of Tenofovir disoproxil.

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Cefaclor.

Cefaclor Toxicity & Overdose Risk

Signs of an overdose of this drug include diarrhea, nausea, stomach discomfort, and vomiting.

image of a doctor in a lab doing drug, clinical research

Cefaclor Novel Uses: Which Conditions Have a Clinical Trial Featuring Cefaclor?

29 active clinical trials are presently being conducted to ascertain the effectivity of Cefaclor in treating Streptococcal Pharyngitis, Acute Exacerbation of Chronic Bronchitis due to Streptococcus Pneumoniae and Moraxella catarrhalis.

Condition

Clinical Trials

Trial Phases

Bronchitis, Chronic

0 Actively Recruiting

Bacteria

0 Actively Recruiting

Urinary Tract Infection (UTI)

6 Actively Recruiting

Phase 1, Phase 3, Phase 4, Phase 2

Urinary tract infection

0 Actively Recruiting

Tonsillitis

0 Actively Recruiting

Bronchitis

0 Actively Recruiting

Moraxella catarrhalis

0 Actively Recruiting

streptococcus pyogenes skin infection

0 Actively Recruiting

Streptococcal Pharyngitis

0 Actively Recruiting

Otitis Media

0 Actively Recruiting

Bacterial Infections

0 Actively Recruiting

Staphylococcal Skin Infections

0 Actively Recruiting

Cefaclor Reviews: What are patients saying about Cefaclor?

5

Patient Review

5/25/2013

Cefaclor for Urinary Tract Infection

On the final day of the ten-day course, I broke out in hives all over my body. The itching was unbearable and antihistamines provided little relief. Aveeno baths helped a bit, but I still wouldn't recommend this medication to anyone.

5

Patient Review

7/31/2017

Cefaclor for Skin Infection

I had no issues with this treatment whatsoever. No allergies, no side effects- the infection was gone within a week. I couldn't be happier.

4

Patient Review

12/28/2011

Cefaclor for Acute Infection of the Nose, Throat or Sinus

I was given this medication for my inflamed tonsils, but it didn't provide any pain relief after three days. I had to go back to the doctor for something else.

4

Patient Review

6/11/2020

Cefaclor for Bacterial Infection with Bronchitis

It's effective, but I got a mild rash and some itchiness.

4

Patient Review

2/19/2022

Cefaclor for Urinary Tract Infection

I'm about halfway through the treatment, and it's going well. I've experienced some normal side effects, but nothing too bad.

4

Patient Review

2/19/2022

Cefaclor for Urinary Tract Infection

I haven't had any negative effects from this treatment so far, which is great. I'm about halfway through the course and am hopeful that it will continue to be effective.

3.7

Patient Review

3/20/2012

Cefaclor for Middle Ear Infection

On the 7th day of taking this medication, I broke out in hives on my palms, feet, neck and other areas. It's been really uncomfortable and itchy, and I would never take this medication again.

3.7

Patient Review

11/3/2008

Cefaclor for Acute Infection of the Nose, Throat or Sinus

3.7

Patient Review

4/15/2010

Cefaclor for Acute Infection of the Nose, Throat or Sinus

I started experiencing extreme itchiness on my hands and feet about 45 minutes after taking this medication. I stopped taking it once I realized that was the cause.

2.7

Patient Review

8/27/2016

Cefaclor for Urinary Tract Infection

Cefaclor helped with my UTI symptoms, but then I developed hives and had to stop taking it.

2

Patient Review

3/14/2009

Cefaclor for Acute Infection of the Nose, Throat or Sinus

I had a severe allergic reaction to this medication, characterized by hives all over my body and incessant itching.

1.7

Patient Review

2/11/2011

Cefaclor for Inflammation of the Tonsils

I had to take this for more than ten days in order to see any results, and even then it was only marginal. I got a yeast infection from the medication, which is apparently pretty common. All in all, not worth it.

1.7

Patient Review

3/1/2014

Cefaclor for Bacterial Urinary Tract Infection

I had to take this medication three times per day for ten days. I didn't start seeing any improvement until I was nearly out of the medicine. Two weeks later, my symptoms are back again. Unfortunately, this wasn't effective for me.

1

Patient Review

3/10/2009

Cefaclor for Acute Infection of the Nose, Throat or Sinus

This treatment really helped me. I'm grateful for modern medicine.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cefaclor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is cefaclor?

"This medication is an antibiotic that is used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria."

Answered by AI

What is the drug cefaclor used for?

"Cefaclor is an antibiotic used to treat various bacterial infections, including pneumonia, skin infections, and urinary tract infections."

Answered by AI

Is cefaclor and amoxicillin the same?

"Cefaclor, found in Cefaclor Oral Suspension, is not as effective as amoxicillin-clavulanate in treating acute otitis media, but is prescribed less than amoxicillin based drugs."

Answered by AI

Is cefaclor a penicillin?

"Both penicillin and cephalosporin antibiotics work by inhibiting the ability of bacteria to make cell walls, causing the bacteria to eventually die.

No, Ceclor (cefaclor) is not a penicillin. Ceclor (cefaclor) is a cephalosporin, which is a class of antibiotics that are related to penicillin. Both penicillin and cephalosporin antibiotics work by inhibiting the ability of bacteria to make cell walls, causing the bacteria to eventually die."

Answered by AI

Clinical Trials for Cefaclor

Image of Harbor UCLA Medical Center - Medicine - Infectious Diseases in Torrance, United States.

Optimized Beta-lactam Dosing for Bacterial Infections

18+
All Sexes
Torrance, CA

The purpose of this study is to evaluate the abilities of Cystatin C (CysC) and CysC-based estimated Glomerular Filtration Rate (eGFR) equations to characterize the pharmacokinetics (PK) profiles of meropenem and cefepime relative to Serum Creatinine (SCR), Serum Creatinine based Equation (SCRE)and iohexol at the population and individual levels in critically ill adult patients with suspected or documented AMR Gram-negative infections. We hypothesize that CysC and CysC-based eGFR equations will characterize the PK profiles of meropenem and cefepime at the population and individual levels with greater accuracy and precision than SCR and SCREs. Iohexol will be administered to patients enrolled in the study and serve as the reference indicator of measured Glomerular Filtration Rate (mGFR), which is the gold standard assessment of kidney function. We hypothesize that the predictive performances of CysC and CysC-based eGFR equations in estimating the PK profiles of meropenem and cefepime at the population and individual levels will be comparable to iohexol. The information obtained in this study will be used to develop PK/pharmacodynamics (PD) optimized meropenem and cefepime dosing schemes based on the renal function biomarker population PK (PopPK) model with the best predictive performance for clinical use in the treatment of critically ill adult patients with suspected or documented AMR Gram-negative infections and varying degrees of renal function. The primary objective of this study is to compare the abilities of renal function biomarkers (CysC, CysC-based eGFR equations, SCR, SCREs) relative to iohexol to characterize the PK profiles of meropenem and cefepime in critically ill adult patients with suspected or documented AMR Gram-negative infections.

Phase 4
Recruiting

Harbor UCLA Medical Center - Medicine - Infectious Diseases (+9 Sites)

Image of University of Missouri in Columbia, United States.

Antibiotics for Cat Bite Injuries

18+
All Sexes
Columbia, MO

Cat bites are puncture wounds that have the potential to seed bacteria deep within the joint capsule, periosteum, and bone. The hand is the most common site of bite injuries. Pasteurella multocida is the is the most common organism isolated from the mouths of cats that can cause infections after a bite. Prophylactic antibiotics are often recommended with amoxicillin-clavulanate for 3-5 days to decrease the incidence of developing an infection. However, only one randomized controlled clinical trial consisting of 12 patients has been performed to justify this course of treatment, raising the possibility that the use of antibiotics could be reduced or even eliminated. Investigators will compare different durations of prophylactic antibiotics and a placebo control for cat bites to the hand/forearm presenting to the Emergency Department, Urgent Care, Plastic Surgery Clinic using a randomized, controlled, double-blind clinical trial. Participants presenting to the University of Missouri Hospital Emergency Department, Missouri University (MU) Healthcare Urgent Care, Plastic Surgery Clinic over the next year will be offered the chance to enroll if they meet the inclusion/exclusion criteria. For inclusion, participants will be \>18 years of age, have cat bites to the hand or distal to elbow, and present within 24 hours of the cat bite injury. Participants must not present with active local or systemic infections, have received antibiotics within the past 30 days, or be immunocompromised (primary and secondary immunodeficiencies). Participants will be randomized to one of three treatment arms (placebo; amoxicillin-clavulanate 1 day; amoxicillin-clavulanate 5 days). Outcomes are the development of an infection at the location of the cat bite and/or systemic infection, adverse effects of interventions, disability assessed by Quick Disabilities of Arm, Shoulder and Hand (QuickDASH) scores, and quality of life (QOL) assessed by HAND Questionnaire (HAND-Q) scores. Infection will be assessed at day 0, day 2, day 7+/-2, day 14+/-2, and day 30+/-2 by vital signs, laboratory values, physical examination and with an infrared and digital camera. All measures will be within the standard of care, apart from the infrared camera, QuickDASH, and HAND-Q scores. The anatomic locations of cat bites to the hand/forearm will be assessed for correlations with infections.

Phase 4
Recruiting

University of Missouri

Kevin M Klifto, DO, PharmD

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