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What is Cardizem Cd
DiltiazemThe Generic name of this drug
Treatment SummaryDiltiazem is a medication used to treat high blood pressure and abnormal heart rhythms. It works by relaxing the blood vessels and decreasing the heart rate. It is usually prescribed in extended-release oral or intravenous forms, and is marketed under different brand names such as Cardizem and Tiazac. It is also sometimes used to treat anal fissures, migraines, pulmonary hypertension, and leg cramps. Diltiazem was approved by the FDA in 1982.
Cardizemis the brand name
Cardizem Cd Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cardizem
Diltiazem
1982
656
Approved as Treatment by the FDA
Diltiazem, commonly known as Cardizem, is approved by the FDA for 4 uses which include Chronic Stable Angina Pectoris and Hypertensive disease .Chronic Stable Angina Pectoris
Helps manage Chronic Stable Angina Pectoris
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Coronary Artery Vasospasm
Helps manage Coronary Artery Vasospasm
Anginal Pain
Helps manage Anginal Pain
Effectiveness
How Cardizem Cd Affects PatientsDiltiazem helps to reduce blood pressure by relaxing the muscles in blood vessels and slowing down the heart rate. It is mainly used to treat hypertension (high blood pressure), but can also be used to treat angina (chest pain). In studies, those taking diltiazem had a lower diastolic blood pressure compared to those taking a placebo, with the greatest decrease seen in those taking the highest dose. This drug may also help to protect against stroke in those with hypertension. Additionally, patients with chronic stable angina taking diltiazem at night have seen an increase in their exercise tolerance.
How Cardizem Cd works in the bodyDiltiazem works by blocking the influx of calcium ions into the muscles when they are excited. This stops cells from contracting and reduces the amount of calcium in the cell. This leads to increased relaxation of the heart and blood vessels, which lowers blood pressure and allows more oxygen to be delivered to the heart. It also reduces heart rate and total peripheral resistance, meaning that less energy is needed to pump blood. This helps to improve exercise tolerance in those with chronic stable angina.
When to interrupt dosage
The proposed dose of Cardizem Cd is contingent upon the diagnosed affliction, including prevention of migraine headaches, Fissure;Anal and Anginal Pain. The amount of dosage is dependent on the delivery method outlined in the table below.Condition
Dosage
Administration
Atrial Fibrillation
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Angina Pectoris, Variant
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Paroxysmal Supraventricular Tachycardia (PSVT)
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Dilated Cardiomyopathies, Idiopathic
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Proteinuria
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
prophylaxis of migraine headaches
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Diabetic Neuropathy
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Hypertensive disease
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Coronary Artery Vasospasm
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Anginal Pain
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Chronic Stable Angina Pectoris
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Pulmonary Hypertension
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Fissure;Anal
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
leg cramps
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Warnings
Cardizem Cd ContraindicationsCondition
Risk Level
Notes
Heart Attack
Do Not Combine
accessory bypass tract
Do Not Combine
accessory bypass tract
Do Not Combine
absence of a functioning ventricular pacemaker
Do Not Combine
Ventricular Tachycardia
Do Not Combine
absence of a functioning ventricular pacemaker
Do Not Combine
third degree AV block
Do Not Combine
Pulmonary Congestion
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Hypotension
Do Not Combine
Common Cardizem Cd Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Diltiazem.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Diltiazem.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Diltiazem.
Alfentanil
Major
The metabolism of Alfentanil can be decreased when combined with Diltiazem.
Amifostine
Major
Diltiazem may increase the hypotensive activities of Amifostine.
Cardizem Cd Toxicity & Overdose RiskDiltiazem is toxic when taken in large doses, with a lethal dose of 415-740 mg/kg for mice, 560-810 mg/kg for rats, and 360 mg/kg for monkeys. Overdoses of less than 1 gram to 18 grams have been reported and may cause slow heart rate, low blood pressure, abnormal heart rhythm, or heart failure. Treatment for overdose may include supportive care, vomiting, activated charcoal, and medications like atropine, isoproterenol, dopamine, or dobutamine. If taken in smaller doses, diltiazem has not been linked to cancer, mutations,
Cardizem Cd Novel Uses: Which Conditions Have a Clinical Trial Featuring Cardizem Cd?
228 active trials are presently investigating the capacity of Cardizem CD to provide relief from Atrial Fibrillation, Coronary Artery Spasm and Paroxysmal Supraventricular Tachycardia (PSVT).Condition
Clinical Trials
Trial Phases
Pulmonary Hypertension
26 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
Atrial Fibrillation
146 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Paroxysmal Supraventricular Tachycardia (PSVT)
2 Actively Recruiting
Phase 3, Phase 2
Anginal Pain
2 Actively Recruiting
Not Applicable, Phase 4
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable
prophylaxis of migraine headaches
0 Actively Recruiting
Dilated Cardiomyopathies, Idiopathic
1 Actively Recruiting
Not Applicable
Coronary Artery Vasospasm
0 Actively Recruiting
Fissure;Anal
0 Actively Recruiting
Angina Pectoris, Variant
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Neuropathy
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1
Proteinuria
5 Actively Recruiting
Phase 2, Phase 3, Phase 4
leg cramps
0 Actively Recruiting
Cardizem Cd Reviews: What are patients saying about Cardizem Cd?
5Patient Review
2/17/2012 I unfortunately saw negative results from this treatment. Both my blood pressure and heart rate increased, which led me to have to go to the doctor.
4Patient Review
1/13/20124Patient Review
1/23/2013 I have been struggling with feet and ankle swelling as well as fatigue.
3.7Patient Review
9/2/2012 This medication has been successful in lowering my blood pressure and I have not had any more episodes of racing heart. However, the swelling of my feet is now severe and very uncomfortable. This side effect has really changed my life for the worse and I am worried about it.
3.7Patient Review
4/12/2013 The medication did a good job of controlling the rate, but I developed severe swelling and itching in my feet, throat, and lips on day four. I also had difficulty breathing. So, I stopped taking the medication.
3.3Patient Review
3/13/2013 I was on 120 mg for 6 weeks and doing great, but then the doctor increased my dosage to 240mg. Now I am experiencing unbearable constipation and will be calling the doctor tomorrow to ask for a change.
3Patient Review
1/1/2014 Cardizem was great at first, but now I'm feeling really lousy. Dizzy, nauseated, exhausted, and my urine is a weird green color. Not sure if I can continue on this medication.
3Patient Review
5/9/2012 This has helped with my SVT, but my blood pressure is now worse.
3Patient Review
6/11/2012 I have fast heartbeat and high blood pressure, for which I was originally prescribed a beta blocker. However, I was switched to this drug instead and frankly, I can't tell the difference.
2.7Patient Review
1/18/2014 Recently, my doctor prescribed this medication for A-Fib. I have been feeling incredibly fatigued and also have had sever stomach pain and sometimes lack of control over bowel movements--both of which are new issues since taking the medication. Additionally, I've been short of breath. I'm going to contact my doctor early next week, but as of now, I am not a fan of this treatment.
2.3Patient Review
2/9/2012 I saw a rise in my blood pressure after taking this medication for just one week. Additionally, it caused an elevation in my heart rate which made it difficult to sleep. My resting heart rate was in the mid-80s.
2.3Patient Review
2/7/2012 I was prescribed too high of a dose by my second doctor- 240mg. My first doctor only had me on 120 mg and I didn't have any issues with swelling. Now, my ankles and feet are swollen and I also have Atrial Fibillation.
2Patient Review
2/17/2014 I'm undecided on this treatment. I think it lowers blood pressure too much and I've been having burning sensations in my muscles.
1.7Patient Review
12/2/2012 I started out taking two pills per day, 30 mg each. I began experiencing palpitations, which have since stopped. However, I constantly felt dizzy and lightheaded. I made three trips to the ER before they doubled my medication dosage. Now I think I'm overmedicated; whenever I cut back to just one pill, I feel incredibly dizzy for a few days straight.
1Patient Review
7/18/2013 I had a terrible allergic reaction to this medication. I developed a red, itchy rash all over my body within one week of taking the drug. The rash lasted for one week, even while taking 50mg of Benadryl 4 times per day.
Patient Q&A Section about cardizem cd
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Cardizem CD once daily?
"-Cardizem CD or equivalent (Cartia XT) generic extended-release capsules are to be taken once a day, with or without meals. -Cardizem LA extended-release tablets are to be taken once a day as well, either in the morning or evening, with or without meals."
Answered by AI
What are the side effects of diltiazem CD?
"If you experience any of the following side effects, stop using the cream or ointment and seek medical advice:
swollen hands, ankles or feet, headaches, feeling dizzy and lightheaded, feeling tired, weak and generally unwell, feeling hot (flushing) and redness of the skin, itching or burning on the skin where you use the cream or ointment, stomach pain, indigestion and constipation."
Answered by AI
What does the CD stand for in Cardizem?
"Cardizem and Cardizem CD are both medications that contain the active ingredient diltiazem hydrochloride. The difference between the two is that Cardizem CD is designed to release the active ingredient slowly so that it works over the course of 24 hours and can be taken once a day. The acronym "CD" stands for "controlled delivery.""
Answered by AI
Is diltiazem ER and CD the same?
"DILTIAZEM/Tiazac (dil TYE a zem) is a medication used to treat high blood pressure and prevent chest pain (angina). It works by relaxing the blood vessels, which decreases the workload of the heart. It is classified as a calcium channel blocker."
Answered by AI