Cardizem Cd

Angina Pectoris, Variant, Atrial Fibrillation, Proteinuria + 11 more
Treatment
6 FDA approvals
20 Active Studies for Cardizem Cd

What is Cardizem Cd

DiltiazemThe Generic name of this drug
Treatment SummaryDiltiazem is a medication used to treat high blood pressure and abnormal heart rhythms. It works by relaxing the blood vessels and decreasing the heart rate. It is usually prescribed in extended-release oral or intravenous forms, and is marketed under different brand names such as Cardizem and Tiazac. It is also sometimes used to treat anal fissures, migraines, pulmonary hypertension, and leg cramps. Diltiazem was approved by the FDA in 1982.
Cardizemis the brand name
image of different drug pills on a surface
Cardizem Cd Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cardizem
Diltiazem
1982
656

Approved as Treatment by the FDA

Diltiazem, commonly known as Cardizem, is approved by the FDA for 6 uses which include Coronary Vasospasm and Coronary Artery Vasospasm .
Coronary Vasospasm
Helps manage Coronary Artery Vasospasm
Coronary Artery Vasospasm
Helps manage Coronary Artery Vasospasm
Anginal Pain
Helps manage Anginal Pain
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Angina, Stable
Helps manage Chronic Stable Angina Pectoris
Angina Pectoris
Helps manage Anginal Pain

Effectiveness

How Cardizem Cd Affects PatientsDiltiazem helps to reduce blood pressure by relaxing the muscles in blood vessels and slowing down the heart rate. It is mainly used to treat hypertension (high blood pressure), but can also be used to treat angina (chest pain). In studies, those taking diltiazem had a lower diastolic blood pressure compared to those taking a placebo, with the greatest decrease seen in those taking the highest dose. This drug may also help to protect against stroke in those with hypertension. Additionally, patients with chronic stable angina taking diltiazem at night have seen an increase in their exercise tolerance.
How Cardizem Cd works in the bodyDiltiazem works by blocking the influx of calcium ions into the muscles when they are excited. This stops cells from contracting and reduces the amount of calcium in the cell. This leads to increased relaxation of the heart and blood vessels, which lowers blood pressure and allows more oxygen to be delivered to the heart. It also reduces heart rate and total peripheral resistance, meaning that less energy is needed to pump blood. This helps to improve exercise tolerance in those with chronic stable angina.

When to interrupt dosage

The proposed dose of Cardizem Cd is contingent upon the diagnosed affliction, including prevention of migraine headaches, Fissure;Anal and Anginal Pain. The amount of dosage is dependent on the delivery method outlined in the table below.
Condition
Dosage
Administration
Angina Pectoris, Variant
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Migraine Disorders
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Angina, Stable
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Cardiomyopathy, Dilated
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Muscle Cramp
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Atrial Fibrillation
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Angina Pectoris
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Hypertensive disease
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Fissure in Ano
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Tachycardia, Supraventricular
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Proteinuria
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Diabetic Neuropathy
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Pulmonary Hypertension
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Coronary Vasospasm
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous

Warnings

Cardizem Cd Contraindications
Condition
Risk Level
Notes
Heart Attack
Do Not Combine
accessory bypass tract
Do Not Combine
accessory bypass tract
Do Not Combine
Bradycardia
Do Not Combine
Ventricular Tachycardia
Do Not Combine
Bradycardia
Do Not Combine
Atrioventricular Block
Do Not Combine
Pulmonary Congestion
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Hypotension
Do Not Combine
There are 20 known major drug interactions with Cardizem Cd.
Common Cardizem Cd Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Diltiazem.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Diltiazem.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Diltiazem.
Alfentanil
Major
The metabolism of Alfentanil can be decreased when combined with Diltiazem.
Amifostine
Major
Diltiazem may increase the hypotensive activities of Amifostine.
Cardizem Cd Toxicity & Overdose RiskDiltiazem is toxic when taken in large doses, with a lethal dose of 415-740 mg/kg for mice, 560-810 mg/kg for rats, and 360 mg/kg for monkeys. Overdoses of less than 1 gram to 18 grams have been reported and may cause slow heart rate, low blood pressure, abnormal heart rhythm, or heart failure. Treatment for overdose may include supportive care, vomiting, activated charcoal, and medications like atropine, isoproterenol, dopamine, or dobutamine. If taken in smaller doses, diltiazem has not been linked to cancer, mutations,
image of a doctor in a lab doing drug, clinical research

Cardizem Cd Novel Uses: Which Conditions Have a Clinical Trial Featuring Cardizem Cd?

228 active trials are presently investigating the capacity of Cardizem CD to provide relief from Atrial Fibrillation, Coronary Artery Spasm and Paroxysmal Supraventricular Tachycardia (PSVT).
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Pulmonary Hypertension
30 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 1, Early Phase 1
Tachycardia, Supraventricular
2 Actively Recruiting
Phase 3, Phase 2
Angina, Stable
1 Actively Recruiting
Not Applicable
Diabetic Neuropathy
6 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Angina Pectoris, Variant
0 Actively Recruiting
Angina Pectoris
2 Actively Recruiting
Not Applicable, Phase 4
Cardiomyopathy, Dilated
0 Actively Recruiting
Proteinuria
3 Actively Recruiting
Phase 2, Phase 3
Muscle Cramp
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Coronary Vasospasm
0 Actively Recruiting
Migraine Disorders
1 Actively Recruiting
Phase 3
Fissure in Ano
0 Actively Recruiting

Cardizem Cd Reviews: What are patients saying about Cardizem Cd?

5Patient Review
2/17/2012
Cardizem Cd for Ventricular Rate Control in Atrial Fibrillation
I unfortunately saw negative results from this treatment. Both my blood pressure and heart rate increased, which led me to have to go to the doctor.
4Patient Review
1/13/2012
Cardizem Cd for Ventricular Rate Control in Atrial Fibrillation
4Patient Review
1/23/2013
Cardizem Cd for Ventricular Rate Control in Atrial Fibrillation
I have been struggling with feet and ankle swelling as well as fatigue.
3.7Patient Review
9/2/2012
Cardizem Cd for High Blood Pressure
This medication has been successful in lowering my blood pressure and I have not had any more episodes of racing heart. However, the swelling of my feet is now severe and very uncomfortable. This side effect has really changed my life for the worse and I am worried about it.
3.7Patient Review
4/12/2013
Cardizem Cd for Ventricular Rate Control in Atrial Fibrillation
The medication did a good job of controlling the rate, but I developed severe swelling and itching in my feet, throat, and lips on day four. I also had difficulty breathing. So, I stopped taking the medication.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cardizem cd

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Cardizem CD once daily?

"-Cardizem CD or equivalent (Cartia XT) generic extended-release capsules are to be taken once a day, with or without meals. -Cardizem LA extended-release tablets are to be taken once a day as well, either in the morning or evening, with or without meals."

Answered by AI

What are the side effects of diltiazem CD?

"If you experience any of the following side effects, stop using the cream or ointment and seek medical advice:

swollen hands, ankles or feet, headaches, feeling dizzy and lightheaded, feeling tired, weak and generally unwell, feeling hot (flushing) and redness of the skin, itching or burning on the skin where you use the cream or ointment, stomach pain, indigestion and constipation."

Answered by AI

What does the CD stand for in Cardizem?

"Cardizem and Cardizem CD are both medications that contain the active ingredient diltiazem hydrochloride. The difference between the two is that Cardizem CD is designed to release the active ingredient slowly so that it works over the course of 24 hours and can be taken once a day. The acronym "CD" stands for "controlled delivery.""

Answered by AI

Is diltiazem ER and CD the same?

"DILTIAZEM/Tiazac (dil TYE a zem) is a medication used to treat high blood pressure and prevent chest pain (angina). It works by relaxing the blood vessels, which decreases the workload of the heart. It is classified as a calcium channel blocker."

Answered by AI

Clinical Trials for Cardizem Cd

Have you considered Cardizem Cd clinical trials? We made a collection of clinical trials featuring Cardizem Cd, we think they might fit your search criteria.
Have you considered Cardizem Cd clinical trials? We made a collection of clinical trials featuring Cardizem Cd, we think they might fit your search criteria.
Have you considered Cardizem Cd clinical trials? We made a collection of clinical trials featuring Cardizem Cd, we think they might fit your search criteria.
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