Calcium Acetate

Hyperphosphataemia, Communicable Diseases, Dialysis therapy + 4 more

Treatment

3 FDA approvals

3 Active Studies for Calcium Acetate

What is Calcium Acetate

Calcium acetate

The Generic name of this drug

Treatment Summary

Calcium acetate is a compound made from calcium and acetic acid (vinegar). It is usually sold as the monohydrate form, which absorbs water easily. It is also known as the acetate of lime.

ProcalAmine

is the brand name

Calcium Acetate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

ProcalAmine

Calcium acetate

1982

77

Approved as Treatment by the FDA

Calcium acetate, otherwise known as ProcalAmine, is approved by the FDA for 3 uses which include Kidney Failure, Chronic and End-stage Renal Failure (ESRF) .

Kidney Failure, Chronic

Helps manage End-stage Renal Failure (ESRF)

End-stage Renal Failure (ESRF)

Helps manage End-stage Renal Failure (ESRF)

Hyperphosphataemia

Helps manage Hyperphosphataemia

Effectiveness

How Calcium Acetate Affects Patients

For people with kidney problems, their body may not be able to get rid of phosphate properly. This can cause high levels of phosphate in the body which can lead to bone and tissue damage. To lower the amount of phosphate, people may need to reduce the amount they eat, use dialysis, or take a medicine called calcium acetate. Calcium acetate binds to phosphate in the gut and helps it pass out of the body in the feces. By taking calcium acetate, the amount of phosphate in the body can be kept below 6.0 mg/dl.

How Calcium Acetate works in the body

Calcium acetate helps to get rid of extra phosphorus in your body. It does this by binding with the phosphorus in the food you eat. This prevents it from being absorbed and instead causes it to be eliminated from the body.

When to interrupt dosage

The recommended dosage of Calcium Acetate is contingent upon the ascertained condition, such as Kidney, Hyperphosphataemia and Kidney Failure, Chronic. The required amount of dosage is delineated in the table beneath, with regards to the method of administration (e.g. Intravenous or Topical).

Condition

Dosage

Administration

Hyperphosphataemia

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Intravenous, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Tablet, coated - Oral, Solution - Intravenous, Injection, Tablet, coated

Kidney

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Intravenous, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Tablet, coated - Oral, Solution - Intravenous, Injection, Tablet, coated

high phosphate levels

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Intravenous, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Tablet, coated - Oral, Solution - Intravenous, Injection, Tablet, coated

Astringent

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Intravenous, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Tablet, coated - Oral, Solution - Intravenous, Injection, Tablet, coated

Communicable Diseases

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Intravenous, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Tablet, coated - Oral, Solution - Intravenous, Injection, Tablet, coated

Dialysis therapy

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Intravenous, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Tablet, coated - Oral, Solution - Intravenous, Injection, Tablet, coated

Kidney Failure, Chronic

667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL

, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Intravenous, Injection, solution, concentrate - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Tablet, coated - Oral, Solution - Intravenous, Injection, Tablet, coated

Warnings

Calcium Acetate has two restrictions, and it should not be taken in combination with any of the conditions in the following table.

Calcium Acetate Contraindications

Condition

Risk Level

Notes

Hypercalcemia

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Calcium Acetate.

Common Calcium Acetate Drug Interactions

Drug Name

Risk Level

Description

Technetium Tc-99m oxidronate

Major

Calcium acetate may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.

Dobutamine

Minor

The therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium acetate.

3-Aza-2,3-Dihydrogeranyl Diphosphate

Moderate

Calcium acetate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.

Acebutolol

Moderate

The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium acetate.

Acetyldigitoxin

Moderate

Calcium acetate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.

Calcium Acetate Toxicity & Overdose Risk

The lowest toxic dose of the drug in rats is 4280mg/kg. Mild signs of overdose include constipation, loss of appetite, and nausea and vomiting. In more severe cases, patients may show signs of confusion, unconsciousness, and difficulty speaking.

image of a doctor in a lab doing drug, clinical research

Calcium Acetate Novel Uses: Which Conditions Have a Clinical Trial Featuring Calcium Acetate?

Five active clinical trials are currently being conducted to assess the potential of Calcium Acetate in ameliorating Kidney, high phosphate levels and Hyperphosphataemia.

Condition

Clinical Trials

Trial Phases

high phosphate levels

0 Actively Recruiting

Kidney Failure, Chronic

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Hyperphosphataemia

0 Actively Recruiting

Dialysis therapy

3 Actively Recruiting

Not Applicable, Phase 3, Phase 4

Astringent

0 Actively Recruiting

Kidney

0 Actively Recruiting

Calcium Acetate Reviews: What are patients saying about Calcium Acetate?

4.7

Patient Review

4/14/2010

Calcium Acetate for Renal Osteodystrophy with Hyperphosphatemia

This treatment is great. I'm grateful for modern medicine.

4

Patient Review

9/23/2018

Calcium Acetate for High Amount of Phosphate in the Blood

I saw a significant drop in my phosphorus levels after just two weeks of using this treatment. It was easy to use and didn't require any dietary changes, which was great. The only downside is that I have to remember to take it every time I eat, but it's worth it for the relief from itching.

4

Patient Review

3/7/2010

Calcium Acetate for High Amount of Phosphate in the Blood

This medication unfortunately caused me a lot of discomfort, including nausea, stomach pain, chest pain, and dizziness. Blurry vision was also an issue. Overall, not a great experience.

3.3

Patient Review

11/21/2009

Calcium Acetate for High Amount of Phosphate in the Blood

3

Patient Review

11/16/2009

Calcium Acetate for High Amount of Phosphate in the Blood

3

Patient Review

3/15/2010

Calcium Acetate for Osteoporosis

I'm not sure if this caused my ruptured blood vessel in the colon, but I would be careful before taking this treatment.

2.7

Patient Review

3/14/2012

Calcium Acetate for High Amount of Phosphate in the Blood

I was instructed by my doctor to take this medication 3 or more times a day with each meal. I experienced severe itching and cramping in both hands every night, about 30 minutes after eating. The heaviest dose I took was at dinner time.

2.3

Patient Review

5/30/2009

Calcium Acetate for High Amount of Phosphate in the Blood

1

Patient Review

12/17/2018

Calcium Acetate for High Amount of Phosphate in the Blood

My father had a severe allergic reaction to one of the inactive ingredients in this drug, which caused anaphylaxis. He died less than an hour after taking it. Do not take this medication if you have any allergies to other medications. Always consult with your doctor before taking any new medication.

1

Patient Review

9/7/2010

Calcium Acetate for High Amount of Phosphate in the Blood

I started taking this medication for high blood pressure, but it caused me a lot of problems. I would get very short of breath and my whole body would start shaking. It also brought my blood sugar down pretty low. The shakiness was not hypoglycemia. I have stopped taking this medication, and the shortness of breath and the shakiness has stopped. Would not recommend to anyone.

1

Patient Review

1/14/2018

Calcium Acetate for High Amount of Phosphate in the Blood

The itching was unbearable, and the coughing fits made me feel like I was going to vomit. This went on for two months straight with no relief.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about calcium acetate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who should not take calcium acetate?

"Do not use calcium acetate if you are allergic to it or have high levels of calcium in your blood. Let your doctor know if: your kidney disease gets worse; or you are also taking digoxin (digitalis, Lanoxin)."

Answered by AI

What is another name for calcium acetate?

"There are different brands of calcium acetate, which is a calcium supplement used to control the level of phosphate in the blood for patients on dialysis due to severe kidney disease."

Answered by AI

What is the side effects of calcium acetate?

"The following are symptoms of poisoning: abdominal or stomach pain, full or partial loss of consciousness, headache, incoherent speech, increased urination, metallic taste, muscle weakness, nausea or vomiting."

Answered by AI

When should you take calcium acetate?

"Calcium acetate is a supplement that comes in the form of capsules, tablets, or a liquid solution. It is typically taken with each meal, and people are advised to take it at the same time each day."

Answered by AI

Clinical Trials for Calcium Acetate

Image of Rocky Mountain Kidney Care - Lone Tree in Lone Tree, United States.

AP301 for High Phosphate Levels

Any Age
All Sexes
Lone Tree, CO

The goal of this clinical trial is to learn if AP301 could work in the patients receiving maintenance dialysis with elevated blood phosphate. The main questions it aims to answer are: * Does AP301 lower blood phosphate levels? * Does AP301 works on serum calcium level, calcium times phosphate level, and intact parathyroid hormone level? * What discomfort or medical problem do the patients have when taking AP301? * Does AP301 improve quality of life in Chinese patients? The researchers will compare AP301 to an ineffective comparator (a look-alike substance that contains low dose AP301) to see if AP301 works to treat elevated blood phosphate. In the study, the patients will experience the following stages in a chronicle order: * Stop all using blood phosphate-lowering drugs, * Take AP301 or the comparator three times a day for 8 weeks, * Take AP301 three times a day for 24 weeks, and * Take AP301 or the comparator three times a day for 3 weeks. In the first 32 weeks, the dose of AP301 will be adjusted upwards or downwards based on the patient's blood phosphate level and the study doctor's judgment. If the participant has a blood phosphate level above or below a certain level, they may receive additional treatment to lower the blood phosphate level.

Phase 3
Recruiting

Rocky Mountain Kidney Care - Lone Tree (+18 Sites)

Alebund Pharmaceuticals