What is Caduet
AmlodipineThe Generic name of this drug
Treatment SummaryAmlodipine is a medication used to treat high blood pressure and chest pain (angina). It was approved by the FDA in 1987 and belongs to a class of drugs called dihydropyridine calcium channel blockers. These types of drugs are known for having a lower risk of heart-related side effects than other calcium channel blockers. Amlodipine has antioxidant properties and can increase the production of nitric oxide, which helps to relax the blood vessels and lower blood pressure. It is also convenient because it only needs to be taken once a day.
Norvascis the brand name
Caduet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norvasc
Amlodipine
1992
1199
Approved as Treatment by the FDA
Amlodipine, also known as Norvasc, is approved by the FDA for 4 uses like Chronic Stable Angina Pectoris and Coronary Artery Disease (CAD) .Chronic Stable Angina Pectoris
Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin
Coronary Artery Disease (CAD)
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Vasospastic Angina
Used to treat Vasospastic Angina in combination with Atorvastatin
angiographically documented disease
Used to treat angiographically documented disease in combination with Atorvastatin
Effectiveness
How Caduet Affects PatientsAmlodipine is a drug that works by blocking certain calcium channels in cells, causing the blood vessels to relax and widen. This helps to lower blood pressure and relieve symptoms of chest pain associated with angina. The effects of amlodipine last for at least 24 hours after taking it once a day, and it does not significantly affect heart rate or blood pressure. Taking amlodipine with other medications like beta-blockers has not resulted in any noticeable changes to electrocardiogram readings. Studies have shown that daily administration of amlodipine can improve exercise time, reduce the frequency of
How Caduet works in the bodyAmlodipine is a drug that lowers blood pressure by widening the blood vessels. It works by blocking calcium ions from entering the cells of the heart and blood vessels, which helps relax the vessels and reduce the pressure. In addition to reducing blood pressure, amlodipine can also reduce the work of the heart, making it use less energy and oxygen. It can also widen the main coronary arteries and arterioles, allowing for more oxygen delivery to the heart in those with coronary artery spasm.
When to interrupt dosage
The suggested dosage of Caduet is contingent upon the determined condition, for example inadequate response to diet, High Cardiovascular Risk and Lifestyle Modification. The amount of dosage fluctuates, depending on the technique of delivery (e.g. Tablet, film coated or Tablet) featured in the table beneath.Condition
Dosage
Administration
Hypertensive disease
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Vasospastic Angina
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Anginal Pain
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Homozygous Familial Hypercholesterolemia
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Cardiovascular Events
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
angiographically documented disease
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
inadequate response to diet
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Primary Hypercholesterolemia
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Pharmacotherapy
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Heart failure
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
High Cardiovascular Risk
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Hypertensive disease
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Mixed Dyslipidaemia
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Lifestyle Modification
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
inadequate control on monotherapy
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Dyslipidemias
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Chronic Stable Angina Pectoris
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Coronary Artery Disease (CAD)
, 5.0 mg, 10.0 mg, 2.5 mg, 1.0 mg/mL
Tablet, film coated, Tablet, , Tablet - Oral, Oral, Capsule, Tablet, film coated - Oral, Tablet, coated, Tablet, multilayer - Oral, Capsule - Oral, Kit, Suspension - Oral, Solution, Tablet, coated - Oral, Suspension, Tablet, multilayer, Solution - Oral
Warnings
Caduet ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amlodipine may interact with Toxoplasma Infections
Common Caduet Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Amlodipine.
Amifostine
Major
Amlodipine may increase the hypotensive activities of Amifostine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Amlodipine.
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Amlodipine.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Amlodipine.
Caduet Toxicity & Overdose RiskThe toxic dose of amlodipine in mice is 37mg/kg. An overdose of amlodipine can cause peripheral vasodilation, an irregular heartbeat, and low blood pressure, which may be fatal. Studies on rats and mice showed no evidence that amlodipine is carcinogenic, mutagenic, or affects fertility. Amlodipine has not been proven safe for pregnant or nursing women, so it should only be used if the benefits outweigh the risks. Nursing mothers should discontinue use of amlodipine.
Caduet Novel Uses: Which Conditions Have a Clinical Trial Featuring Caduet?
Presently, 46 active clinical trials are assessing the potential of Caduet to reduce High Cardiovascular Risk, alleviate Vasospastic Angina and treat Coronary Artery Disease (CAD).Condition
Clinical Trials
Trial Phases
Vasospastic Angina
0 Actively Recruiting
High Cardiovascular Risk
0 Actively Recruiting
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
Primary Hypercholesterolemia
13 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Hypertensive disease
20 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4
inadequate control on monotherapy
0 Actively Recruiting
Homozygous Familial Hypercholesterolemia
4 Actively Recruiting
Phase 3, Phase 2
Dyslipidemias
2 Actively Recruiting
Phase 2
inadequate response to diet
0 Actively Recruiting
Mixed Dyslipidaemia
0 Actively Recruiting
Hypertensive disease
3 Actively Recruiting
Phase 1, Not Applicable
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Chronic Stable Angina Pectoris
3 Actively Recruiting
Phase 3, Not Applicable
Pharmacotherapy
0 Actively Recruiting
Heart failure
0 Actively Recruiting
Lifestyle Modification
0 Actively Recruiting
angiographically documented disease
0 Actively Recruiting
Anginal Pain
2 Actively Recruiting
Not Applicable, Phase 4
Caduet Reviews: What are patients saying about Caduet?
5Patient Review
4/25/2011 I have high blood pressure and cholesterol, and this medication has been working well for me. I was previously taking two separate medications to manage each problem, but my doctor suggested trying this combination product instead. So far I'm very happy with it and haven't experienced any side effects. Thankful for doctors who are willing to work with patients!
5Patient Review
6/22/20095Patient Review
6/30/20095Patient Review
10/6/2009 I'm very pleased with this medication. It's been a year and my blood pressure and cholesterol have both decreased significantly with no negative side effects.
4.7Patient Review
10/5/2010 I found that this medication caused my ankles and legs to swell. Additionally, I had a very quick reaction/swelling after just one drink of alcohol.
4.7Patient Review
7/12/20094.3Patient Review
8/24/2009 I've been taking this drug for a little over four years now. It's helped to lower my diastolic blood pressure, but not systolic. I don't experience any pain while taking this medication, though I have noticed myself feeling sleepier than usual during the day.
4Patient Review
2/4/2010 I experienced some severe muscle pain in my calves while taking this medication, so I stopped. Thankfully, the pain went away after I ceased use of the treatment.
3.7Patient Review
6/20/20093.3Patient Review
11/5/2009 Out of all the different medications I've tried, this one has finally worked for me. My average blood pressure was 160/100, but now it's down to a much healthier 130/70 after only a month of taking this medicine. The only side effect I've noticed is some occasional dizziness, but it's not too bad.
3.3Patient Review
1/5/2014 I have to urinate several times throughout the night, which makes me feel nauseous in the morning. I've been checked out by two different doctors and they say there's nothing wrong-- it's just a natural part of aging. However, I've also developed bladder issues and cysts on my scrotum. My blood pressure is now all over the place, and I'm more anxious than ever before.
3.3Patient Review
7/22/2010 This drug is okay for me. It works well enough, but I've had better results with other treatments.
2.7Patient Review
3/10/2011 The pill is easy to take, only needing to be taken once a day.
2.7Patient Review
4/6/2010 I've been taking this medication for a year now to help with my high blood pressure. It hasn't been too effective so far, so my doctor suggested I double the dosage. Not sure if the aches and pains in my legs are from this medication or not.
2.7Patient Review
6/26/2010 I was on this medication for a year and saw some benefits like lower cholesterol and blood pressure. However, about a month ago I started having severe leg pains that made it hard to walk or sleep. Once I switched medications the pain pretty much went away.
1.7Patient Review
11/14/2009 The only side effect I've experienced is having to wake up in the middle of the night to urinate.
1.3Patient Review
6/18/2011 I haven't had any problems with this medication. I actually prefer it to taking two different medications for high blood pressure and high cholesterol.
Patient Q&A Section about caduet
What is the generic name for Caduet?
"Although the brand version of Caduet may be more expensive, the generic form of the medication may be a more affordable option." - Anonymous Online Contributor
Unverified Answer
What are the side effects of Caduet?
If you experience any of the following side effects, call your doctor immediately: swelling of the hands, ankles, or feet; tiredness; flushing (warmth or redness in your face); headache; muscle pain; diarrhea; nausea; stomach pain; itchy skin, rashes, or hives." - Anonymous Online Contributor
Unverified Answer
When is the best time to take Caduet?
"You should take your Caduet medication once a day, at around the same time each day, either in the morning or the evening. Taking it at the same time each day will help the medicine work better, and it will also help you remember when to take it. You can take Caduet with or without food." - Anonymous Online Contributor
Unverified Answer
What is the drug Caduet used for?
"Norvasc is used to lower blood pressure.
CADUET is a prescription drug that combines two drugs, Norvasc and Lipitor, in one pill. CADUET is used in adults who need both of these drugs. Lipitor lowers the levels of bad cholesterol and triglycerides in the blood while Norvasc lowers blood pressure." - Anonymous Online Contributor
Unverified Answer