Caduet

Congestive Heart Failure, Primary Hypercholesterolemia, Coronary Disease + 13 more
Treatment
5 FDA approvals
20 Active Studies for Caduet

What is Caduet

AmlodipineThe Generic name of this drug
Treatment SummaryAmlodipine is a medication used to treat high blood pressure and chest pain (angina). It was approved by the FDA in 1987 and belongs to a class of drugs called dihydropyridine calcium channel blockers. These types of drugs are known for having a lower risk of heart-related side effects than other calcium channel blockers. Amlodipine has antioxidant properties and can increase the production of nitric oxide, which helps to relax the blood vessels and lower blood pressure. It is also convenient because it only needs to be taken once a day.
Norvascis the brand name
image of different drug pills on a surface
Caduet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norvasc
Amlodipine
1992
1199

Approved as Treatment by the FDA

Amlodipine, also known as Norvasc, is approved by the FDA for 5 uses like Coronary Disease and Coronary Artery Disease (CAD) .
Coronary Disease
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Coronary Artery Disease (CAD)
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Coronary Artery Disease
Used to treat angiographically documented disease in combination with Atorvastatin
Angina, Stable
Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin
Vasospastic Angina
Used to treat Vasospastic Angina in combination with Atorvastatin

Effectiveness

How Caduet Affects PatientsAmlodipine is a drug that works by blocking certain calcium channels in cells, causing the blood vessels to relax and widen. This helps to lower blood pressure and relieve symptoms of chest pain associated with angina. The effects of amlodipine last for at least 24 hours after taking it once a day, and it does not significantly affect heart rate or blood pressure. Taking amlodipine with other medications like beta-blockers has not resulted in any noticeable changes to electrocardiogram readings. Studies have shown that daily administration of amlodipine can improve exercise time, reduce the frequency of
How Caduet works in the bodyAmlodipine is a drug that lowers blood pressure by widening the blood vessels. It works by blocking calcium ions from entering the cells of the heart and blood vessels, which helps relax the vessels and reduce the pressure. In addition to reducing blood pressure, amlodipine can also reduce the work of the heart, making it use less energy and oxygen. It can also widen the main coronary arteries and arterioles, allowing for more oxygen delivery to the heart in those with coronary artery spasm.

When to interrupt dosage

The suggested dosage of Caduet is contingent upon the determined condition, for example inadequate response to diet, High Cardiovascular Risk and Lifestyle Modification. The amount of dosage fluctuates, depending on the technique of delivery (e.g. Tablet, film coated or Tablet) featured in the table beneath.
Condition
Dosage
Administration
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
High Cardiovascular Risk
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Pharmacotherapy
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Homozygous Familial Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Vasospastic Angina
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
inadequate response to diet
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Congestive Heart Failure
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Primary Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Cardiovascular Events
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Lifestyle Modification
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Angina, Stable
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Artery Disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension

Warnings

Caduet Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amlodipine may interact with Pulse Frequency
There are 20 known major drug interactions with Caduet.
Common Caduet Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Amlodipine may increase the hypotensive activities of Amifostine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Ziprasidone.
Abafungin
Minor
The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.
Caduet Toxicity & Overdose RiskThe toxic dose of amlodipine in mice is 37mg/kg. An overdose of amlodipine can cause peripheral vasodilation, an irregular heartbeat, and low blood pressure, which may be fatal. Studies on rats and mice showed no evidence that amlodipine is carcinogenic, mutagenic, or affects fertility. Amlodipine has not been proven safe for pregnant or nursing women, so it should only be used if the benefits outweigh the risks. Nursing mothers should discontinue use of amlodipine.
image of a doctor in a lab doing drug, clinical research

Caduet Novel Uses: Which Conditions Have a Clinical Trial Featuring Caduet?

Presently, 46 active clinical trials are assessing the potential of Caduet to reduce High Cardiovascular Risk, alleviate Vasospastic Angina and treat Coronary Artery Disease (CAD).
Condition
Clinical Trials
Trial Phases
Dyslipidemias
1 Actively Recruiting
Phase 2
inadequate response to diet
0 Actively Recruiting
Homozygous Familial Hypercholesterolemia
1 Actively Recruiting
Phase 3
Congestive Heart Failure
173 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Hypertensive disease
3 Actively Recruiting
Not Applicable
Vasospastic Angina
1 Actively Recruiting
Phase 2, Phase 3
Dyslipidemias
0 Actively Recruiting
Primary Hypercholesterolemia
10 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Coronary Disease
1 Actively Recruiting
Not Applicable
Lifestyle Modification
2 Actively Recruiting
Not Applicable
Angina, Stable
1 Actively Recruiting
Not Applicable
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Coronary Artery Disease
0 Actively Recruiting
High Cardiovascular Risk
1 Actively Recruiting
Phase 2
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Pharmacotherapy
0 Actively Recruiting

Caduet Reviews: What are patients saying about Caduet?

5Patient Review
4/25/2011
Caduet for High Blood Pressure
I have high blood pressure and cholesterol, and this medication has been working well for me. I was previously taking two separate medications to manage each problem, but my doctor suggested trying this combination product instead. So far I'm very happy with it and haven't experienced any side effects. Thankful for doctors who are willing to work with patients!
5Patient Review
6/22/2009
Caduet for Combined High Blood Cholesterol and Triglyceride Level
5Patient Review
6/30/2009
Caduet for Primary Prevention of Heart Attack
5Patient Review
10/6/2009
Caduet for Combined High Blood Cholesterol and Triglyceride Level
I'm very pleased with this medication. It's been a year and my blood pressure and cholesterol have both decreased significantly with no negative side effects.
4.7Patient Review
10/5/2010
Caduet for Homozygous Inherited High Blood Cholesterol
I found that this medication caused my ankles and legs to swell. Additionally, I had a very quick reaction/swelling after just one drink of alcohol.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about caduet

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name for Caduet?

"Although the brand version of Caduet may be more expensive, the generic form of the medication may be a more affordable option."

Answered by AI

What are the side effects of Caduet?

"Itchy skin, rashes, or hives

If you experience any of the following side effects, call your doctor immediately: swelling of the hands, ankles, or feet; tiredness; flushing (warmth or redness in your face); headache; muscle pain; diarrhea; nausea; stomach pain; itchy skin, rashes, or hives."

Answered by AI

When is the best time to take Caduet?

"You should take your Caduet medication once a day, at around the same time each day, either in the morning or the evening. Taking it at the same time each day will help the medicine work better, and it will also help you remember when to take it. You can take Caduet with or without food."

Answered by AI

What is the drug Caduet used for?

"Norvasc is used to lower blood pressure.

CADUET is a prescription drug that combines two drugs, Norvasc and Lipitor, in one pill. CADUET is used in adults who need both of these drugs. Lipitor lowers the levels of bad cholesterol and triglycerides in the blood while Norvasc lowers blood pressure."

Answered by AI

Clinical Trials for Caduet

Have you considered Caduet clinical trials? We made a collection of clinical trials featuring Caduet, we think they might fit your search criteria.
Have you considered Caduet clinical trials? We made a collection of clinical trials featuring Caduet, we think they might fit your search criteria.
Have you considered Caduet clinical trials? We made a collection of clinical trials featuring Caduet, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top