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What is Cabergoline
CabergolineThe Generic name of this drug
Treatment SummaryCabergoline is a medication derived from a type of fungus that works to reduce prolactin levels in the body. It is mainly used to treat disorders caused by too much prolactin in the blood, such as hyperprolactinemic disorders and Parkinson's Syndrome. Cabergoline works by activating dopamine receptors, which can help regulate the body's hormone levels.
Dostinexis the brand name
Cabergoline Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dostinex
Cabergoline
1996
16
Approved as Treatment by the FDA
Cabergoline, also known as Dostinex, is approved by the FDA for 7 uses which include Hyperprolactinemia and Pituitary Adenomas .Hyperprolactinemia
Pituitary Adenomas
Inhibition of physiological lactation therapy
Hyperprolactinemia
Pituitary Adenoma
Inhibition of physiological lactation
Hyperprolactinemia
Effectiveness
How Cabergoline Affects PatientsCabergoline is a semisynthetic ergot derivative that works on certain dopamine receptors in the brain. It is used to treat Parkinson's syndrome, which is caused by a lack of activity in an area of the brain called the nigrostriatal pathway. This can cause symptoms such as difficulty with movement, tremor, and reduced facial expression. Cabergoline also acts on a pathway called the mesolimbic pathway, which can cause hallucinations and delusions if too much dopamine is present. Finally, cabergoline works on the tuberoinfundibular pathway to reduce levels of the hormone prolactin.
How Cabergoline works in the bodyThe dopamine D2 receptor is a protein in the body that is linked to certain G proteins. When stimulated, it reduces the activity of certain enzymes, interrupts calcium entering the cell, and blocks certain proteins from being phosphorylated. This can help regulate growth hormone release, muscle activity, and other important functions. Cabergoline is a drug with a high affinity to the dopamine D2 receptor, which helps stimulate it. Cabergoline does not interact with other receptors in the body, like D1 receptors, adrenergic receptors, or serotonin receptors.
When to interrupt dosage
The suggested amount of Cabergoline is based upon the diagnosed affliction, including idiopathic hyperprolactinemic disorder, Hyperprolactinemia and Pituitary Adenoma. The dosage is contingent upon the method of delivery (e.g. Oral or Tablet) displayed in the table beneath.Condition
Dosage
Administration
Inhibition of physiological lactation
0.5 mg,
, Oral, Tablet, Tablet - Oral
Pituitary Adenoma
0.5 mg,
, Oral, Tablet, Tablet - Oral
Inhibition of physiological lactation therapy
0.5 mg,
, Oral, Tablet, Tablet - Oral
Hyperprolactinemia
0.5 mg,
, Oral, Tablet, Tablet - Oral
Hyperprolactinemia
0.5 mg,
, Oral, Tablet, Tablet - Oral
Warnings
Cabergoline ContraindicationsCondition
Risk Level
Notes
history of pericardial fibrosis
Do Not Combine
Retroperitoneal fibrosis
Do Not Combine
Heart Valve Diseases
Do Not Combine
Pulmonary Fibrosis
Do Not Combine
Hypertensive disease
Do Not Combine
Common Cabergoline Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
4-Methoxyamphetamine
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
Cabergoline may increase the vasoconstricting activities of 5-methoxy-N,N-dimethyltryptamine.
Abediterol
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of Abediterol.
Adrafinil
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of Adrafinil.
Cabergoline Toxicity & Overdose RiskTaking too much of this drug may cause stuffiness in the nose, passing out, or hallucinations.
Cabergoline Novel Uses: Which Conditions Have a Clinical Trial Featuring Cabergoline?
Five active clinical trials are being conducted to evaluate the potential of Cabergoline in managing idiopathic hyperprolactinemic disorder, Hyperprolactinemia, and the Inhibition of physiological lactation.Condition
Clinical Trials
Trial Phases
Inhibition of physiological lactation therapy
1 Actively Recruiting
Phase 2
Pituitary Adenoma
2 Actively Recruiting
Phase 1, Not Applicable
Hyperprolactinemia
0 Actively Recruiting
Inhibition of physiological lactation
0 Actively Recruiting
Hyperprolactinemia
0 Actively Recruiting
Cabergoline Reviews: What are patients saying about Cabergoline?
5Patient Review
3/28/2022 If you've been struggling to conceive, this medication might be a great option for you. I was trying to get pregnant for 8 years before taking this medication for two months. Now I have an healthy 8-month-old boy!
5Patient Review
2/7/2016 I was really blown away by how well this drug worked for me. Not only did it quickly lower my blood prolactin levels to normal, but it also increased my energy, restarted my periods, stopped my lactation, and improved both my depression and sexual function. The only downside is that I got more headaches while taking the medication; however, these were manageable as long as I took the drug right before bed.
5Patient Review
2/27/2016 Cabergoline has been an effective medication for me with no negative side effects. I've had irregular cycles and no period since December 2015, but after being on cabergoline for only a week my period came back!
5Patient Review
7/16/2016 I was diagnosed with low testosterone due to high prolactin levels in my blood. This treatment really helped turn things around for me and my sex life - my wife can't even keep up with me now! I've been using it for about a year with no negative side effects, other than an increased libido.
5Patient Review
6/5/2016 I stuck with this medication for a few weeks even though the side effects were really tough at first. I'm glad I did because it eventually helped me recover my menstrual cycle and lower my prolactin levels
Patient Q&A Section about cabergoline
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does cabergoline do to dopamine?
"The drug cabergoline is used to treat Parkinson's disease. This drug is different from levodopa in that it directly stimulates dopamine receptors."
Answered by AI
When should cabergoline be taken?
"It is generally recommended to take this medication twice a week, with or without food. Be sure to follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. It is important to take cabergoline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor."
Answered by AI
Does cabergoline make you fertile?
"Approximately 85% of women who take cabergoline will ovulate and can become pregnant if no other causes of infertility are present."
Answered by AI
What type of drug is cabergoline?
"If a man has high levels of prolactin, it can cause enlarged breasts and decreased sexual ability/desire. Cabergoline is a medication that blocks the release of prolactin from the pituitary gland."
Answered by AI
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