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What is Brisdelle
ParoxetineThe Generic name of this drug
Treatment SummaryParoxetine (brand name Paxil) is a type of medication called a selective serotonin reuptake inhibitor (SSRI). It is used to treat anxiety, depression, posttraumatic stress disorder, and menopause symptoms. Paroxetine was approved by the FDA in the 1990s and is more powerful than other SSRIs, making it more likely to cause withdrawal symptoms when stopped. It is generally well-tolerated with a similar side effect profile to other SSRIs. The controlled release version was designed to reduce the risk of nausea.
Paxilis the brand name
Brisdelle Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Paxil
Paroxetine
1993
429
Approved as Treatment by the FDA
Paroxetine, also known as Paxil, is approved by the FDA for 2 uses which include Vasomotor Symptoms Associated With Menopause and Hot flashes .Vasomotor Symptoms Associated With Menopause
Helps manage Vasomotor Symptoms Associated With Menopause
Hot flashes
Helps manage Menopause
Effectiveness
How Brisdelle Affects PatientsParoxetine is used to treat symptoms of depression, anxiety, posttraumatic stress disorder, obsessive-compulsive disorder, and menopause. It works by blocking the absorption of serotonin in the brain. It usually takes 6 weeks for it to start working. Paroxetine should not be taken with monoamine oxidase inhibitors as it increases the risk of serotonin syndrome. If you have been taking MAO inhibitors, you should wait 2 weeks before taking paroxetine.
How Brisdelle works in the bodyParoxetine helps to increase serotonin levels in the brain by blocking its reabsorption. It does this more effectively than other drugs in its class, such as citalopram and fluvoxamine. While the exact way it relieves the symptoms of menopause is unknown, it may be related to its effects on temperature regulation. Paroxetine also has a weak effect on certain receptors in the brain, such as adrenergic, dopamine, histamine, and serotonin receptors. The delayed effect of paroxetine may be due to its initial action on serotonin neurons, which temporarily inhibit the release of serotonin.
When to interrupt dosage
The instructed measure of Brisdelle is contingent upon the determined condition, such as Post Traumatic Stress Disorder, Depression and Irritable Bowel Syndrome (IBS). The amount of dosage deviates, in accordance with the delivery procedure (e.g. Oral or Capsule - Oral) listed in the table below.Condition
Dosage
Administration
Premature Ejaculation
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Irritable Bowel Syndrome (IBS)
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Obsessive-Compulsive Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Social Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Post Traumatic Stress Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Panic Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Vasomotor Symptoms Associated With Menopause
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Hot flashes
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Generalized Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Depression
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Warnings
Brisdelle has five contraindications, therefore it should not be employed together with the conditions specified in the following table.Brisdelle ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Paroxetine may interact with Pulse Frequency
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Serotonin Syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
Common Brisdelle Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Paroxetine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Paroxetine.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Paroxetine.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Paroxetine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Paroxetine is combined with Aclidinium.
Brisdelle Toxicity & Overdose RiskThe toxic dose of paroxetine in mice and rats is 350 mg/kg. The minimum amount of paroxetine that has been reported to cause a fatal outcome is 400 mg, and the most that has been reported for a patient to survive is 2000 mg. Symptoms of an overdose on paroxetine can include fatigue, fever, elevated blood pressure, rapid heartbeat, nausea, vomiting, drowsiness, trembling, dizziness, restlessness, anxiety, headache, sweating, dilated pupils, seizures, tingling sensations, serotonin syndrome, involuntary muscle contractions, and changes in mental status. In some
Brisdelle Novel Uses: Which Conditions Have a Clinical Trial Featuring Brisdelle?
539 active clinical trials are presently being conducted to assess the potential of Brisdelle in managing Post Traumatic Stress Disorder, Premature Ejaculation and Menopausal symptoms.Condition
Clinical Trials
Trial Phases
Depression
199 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Post Traumatic Stress Disorder
258 Actively Recruiting
Phase 4, Phase 1, Not Applicable, Early Phase 1, Phase 2, Phase 3
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Social Anxiety Disorder
22 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 3
Premature Ejaculation
0 Actively Recruiting
Obsessive-Compulsive Disorder
17 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Generalized Anxiety Disorder
32 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4
Vasomotor Symptoms Associated With Menopause
1 Actively Recruiting
Phase 3
Panic Disorder
17 Actively Recruiting
Not Applicable, Phase 2
Irritable Bowel Syndrome (IBS)
9 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Brisdelle Reviews: What are patients saying about Brisdelle?
5Patient Review
9/28/2017 I found huge relief from hot flashes after switching to Brisdell from Combipatch. I also experienced decreased appetite, which is a welcomed change from the ravenous hunger I had on Combipatch.
5Patient Review
5/12/2017 Brisdelle has been a life-saver for me. I had such bad hot flashes and insomnia that I was never able to get a good night's sleep. This medication really helped within the first week, and the nausea went away after a few weeks. I haven't had many hot flashes since starting this medication, but I have put on 40 pounds; however, I think that is more due to quitting smoking around the same time as starting the medication.
5Patient Review
6/29/2017 I've been taking this medication for almost a year and it's been great. All my menopause symptoms have disappeared. I'm very grateful.
4.7Patient Review
6/14/2016 Brisdelle has been a total game-changer for me when it comes to night sweats and my mood swings.
4.7Patient Review
1/8/2017 I was having hot flashes and they disappeared within the first week of taking this medication. I'm also now able to sleep through the night, which has been amazing. On top of that, it's helped with my anxiety and mild depression. I take the pill five hours before bedtime and have no problem getting up in the morning for work. The only downside is that I feel tired with this med, but I'm maintaining my exercise regime so my weight hasn't changed.
3.7Patient Review
3/10/2017 I only took the medication for a month. While it did stop the hot flashes (and no weight gain), it made me extremely anxious, irritated all of the time, and almost aggressive. When I discovered it's a low dose of Paxil, I stopped it immediately.
3.3Patient Review
3/6/2019 Brisdelle was great for my hot flashes and mood in the beginning, but the hot flashes came back with a vengeance. I also gained about 10 pounds because I can't seem to get myself to exercise. I stopped taking it as directed by my OB and within 2 days started having dizziness and muscle spasms in my head.
3.3Patient Review
10/4/2019 Brisdelle did help with hot flashes, though I experienced some side effects. Hormone replacement ended up being a better solution for me as it addressed more issues.
3Patient Review
2/13/2017 I first tried this medication a couple years ago and it helped for a while, but then the hot flashes came back. I just started taking it again recently, and they've come back with a vengeance. On top of that, I'm constantly exhausted and have lost interest in many things. I think I'll stop taking it again and see if I can manage the hot flashes through diet. Also, the packaging is really difficult to open.
3Patient Review
8/21/2016 This treatment initially worked well for me in reducing hot flashes and night sweats. However, over time they have started to become worse again. I have also experienced many days of feeling lethargic and tired while taking this medication, which has led me to discontinue use. So far I haven't had any bad withdrawal symptoms, and I'm hoping that continues.
3Patient Review
12/16/2016 The packaging of this product is really not up to par.
2Patient Review
4/10/2016 Brisdelle worked for me for a couple months, but then the hot flashes came back. Additionally, I had some pretty severe side effects while taking it; sweating, nausea, weight gain. But as soon as I switched to Lexapro 5mg, all those problems went away and my hot flashes stopped too. Plus, it's way cheaper--I was paying $60 copayment for Brisdelle but only $2.50 for Lexapro.
1.7Patient Review
8/4/2017 I've been taking this medication for about a month now, and my hot flashes have actually increased (I'm getting about one an hour). I'm also feeling more agitated than before. I'll try it for a little while longer and see if there's any improvement.
Patient Q&A Section about brisdelle
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Brisdelle the same as Paxil?
"Brisdelle and Paxil are both drugs that contain paroxetine as their active ingredient. Paroxetine is a medication that belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). However, the amount of paroxetine in Brisdelle is lower than the amount in Paxil because Brisdelle and Paxil are used to treat different conditions."
Answered by AI
Does Brisdelle help with anxiety?
"Brisdelle (paroxetine) is not an effective treatment for anxiety. The medication only contains a small amount of paroxetine, which is not enough to treat anxiety."
Answered by AI
What is Brisdelle used for?
"This medication is used to treat hot flashes that occur with menopause by blocking the reuptake of serotonin, a neurotransmitter."
Answered by AI
Does Brisdelle help with sleep?
"Last year, the FDA approved the first non-hormonal treatment for hot flashes – a 7.5-mg formulation of the selective serotonin reuptake inhibitor (SSRI) paroxetine. This drug is marketed under the name of Brisdelle."
Answered by AI