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What is Bretylium Tosylate
BretyliumThe Generic name of this drug
Treatment SummaryBretylium is a drug used to treat abnormally fast heart rhythms, such as ventricular tachycardia and ventricular fibrillation. It works by blocking the release of a neurotransmitter called noradrenaline from the peripheral nervous system. Bretylium also interferes with the electrical signals in the heart by blocking potassium channels and inhibiting the enzyme Na,K-ATPase.
Bretylium Tosylateis the brand name
Bretylium Tosylate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Bretylium Tosylate
Bretylium
2019
2
Approved as Treatment by the FDA
Bretylium, also known as Bretylium Tosylate, is approved by the FDA for 2 uses such as Ventricular Fibrillation and Ventricular Tachycardia .Ventricular Fibrillation
Ventricular Tachycardia
Effectiveness
How Bretylium Tosylate Affects PatientsBretylium is a medication that is attracted to the nerves in the body responsible for controlling blood pressure. It helps to reduce the amount of norepinephrine released, which helps prevent irregular heart rhythms and ventricular fibrillation.
How Bretylium Tosylate works in the bodyBretylium helps prevent irregular heartbeats, like ventricular fibrillation. It does this by making it harder for the heart to send out electrical signals. Bretylium also increases the time it takes the heart's electrical signals to reach the ventricles, which helps the heart beat more regularly. It can also help restore the natural rhythm of pacemaker tissue and increase the speed at which electrical signals travel through the heart.
When to interrupt dosage
The preferred dose of Bretylium Tosylate is contingent upon the specified condition. The measure of dosage fluctuates as per the technique of delivery (e.g. Solution - Intravenous or Intramuscular; Intravenous) featured in the table beneath.Condition
Dosage
Administration
Ventricular Fibrillation
, 50.0 mg/mL, 4.0 mg/mL, 2.0 mg/mL
Intramuscular; Intravenous, , Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Intravenous, Solution - Intravenous, Injection, Injection - Intramuscular; Intravenous
Ventricular Tachycardia
, 50.0 mg/mL, 4.0 mg/mL, 2.0 mg/mL
Intramuscular; Intravenous, , Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Intravenous, Solution - Intravenous, Injection, Injection - Intramuscular; Intravenous
Warnings
There are 20 known major drug interactions with Bretylium Tosylate.Common Bretylium Tosylate Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Bretylium may increase the hypotensive activities of Amifostine.
Dronedarone
Major
Bretylium may increase the QTc-prolonging activities of Dronedarone.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Bretylium is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Bretylium is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Bretylium is combined with Ziprasidone.
Bretylium Tosylate Toxicity & Overdose RiskIn mice, the fatal dose of bretylium is 400 mg/kg. Accidental overdosing has been reported, in which a patient was given 30 mg/kg instead of the intended 10 mg/kg dose. This caused a rapid increase in blood pressure, followed by dangerously low blood pressure, and the patient died 18 hours later due to renal failure and pneumonia. The bretylium levels in the patient's blood were 8000 ng/mL.
Bretylium Tosylate Novel Uses: Which Conditions Have a Clinical Trial Featuring Bretylium Tosylate?
19 active trials are exploring the potential of Bretylium Tosylate to address Ventricular Fibrillation.Condition
Clinical Trials
Trial Phases
Ventricular Fibrillation
3 Actively Recruiting
Phase 3, Phase 4, Not Applicable
Ventricular Tachycardia
14 Actively Recruiting
Phase 3, Phase 4, Not Applicable, Phase 2, Early Phase 1
Patient Q&A Section about bretylium tosylate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What class is procainamide?
"Procainamide is an anti-arrhythmic medication that affects the speed of electrical conduction in the heart. It also prolongs the heart's electrical activity and reduces the speed of impulse conduction."
Answered by AI
What is bretylium tosylate injection used for?
"Bretylium is an antiarrhythmic drug used to treat ventricular fibrillation (a type of irregular heart beat) and tachycardia (a fast heart rate). It is given as an injection and is used in emergency medicine and other medical specialty areas."
Answered by AI
Is bretylium still used?
"Since the drug bretylium has not been available since 1999, it has been forgotten because of shortages in supplies of the chemical substance."
Answered by AI
What kind of drug is bretylium?
"Bretylium is a drug that prevents or treats ventricular fibrillation, a life-threatening type of irregular heart rhythm."
Answered by AI