Bepreve

Itching, Allergic Conjunctivitis (AC)

Treatment

3 FDA approvals

3 Active Studies for Bepreve

What is Bepreve

Bepotastine

The Generic name of this drug

Treatment Summary

Bepotastine is a medication used to treat allergic rhinitis and itching/rash. It works by blocking histamine, a chemical released by the body during an allergic reaction. Bepotastine was approved in Japan in 2000 and 2002, and is sold under the brand name Talion. It is available as an oral and eye drop solution, with the eye drop version being sold in the U.S. under the brand name Bepreve since 2009.

Bepreve

is the brand name

image of different drug pills on a surface

Bepreve Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bepreve

Bepotastine

2009

7

Approved as Treatment by the FDA

Bepotastine, otherwise called Bepreve, is approved by the FDA for 3 uses which include Pruritus and Allergic Conjunctivitis (AC) .

Pruritus

Allergic Conjunctivitis (AC)

Itching

Effectiveness

How Bepreve Affects Patients

Bepotastine is a medication that blocks the effects of histamine, a chemical that affects your body's immune system. It is a type of drug called a mast cell stabilizer and helps reduce inflammation and eosinophil movement in the body. Bepotastine does not cause the same side effects as other medications, such as dry mouth or drowsiness. It takes about a quarter of an hour to start working, and lasts up to 24 hours.

How Bepreve works in the body

Bepotastine treats itchy eyes caused by allergies. It works by blocking histamine, which is released when an allergen is present, from triggering an allergic reaction. It also helps to stabilize the cells which release histamine, and prevent additional cells from coming to the site of the allergic reaction, thus reducing inflammation and irritation.

When to interrupt dosage

The suggested measure of Bepreve is contingent on the determined condition. The amount likewise fluctuates with the mode of delivery (e.g. Solution or Solution / drops - Ophthalmic) noted in the table underneath.

Condition

Dosage

Administration

Itching

, 15.0 mg/mL, 1.5 %

, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic

Allergic Conjunctivitis (AC)

, 15.0 mg/mL, 1.5 %

, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic

Warnings

Bepreve has one contraindication and ought not to be taken while experiencing any of the conditions in the following table.

Bepreve Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Bepotastine may interact with Pulse Frequency

There are 20 known major drug interactions with Bepreve.

Common Bepreve Drug Interactions

Drug Name

Risk Level

Description

Pitolisant

Major

The therapeutic efficacy of Pitolisant can be decreased when used in combination with Bepotastine.

Aclidinium

Minor

Bepotastine may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Acrivastine

Minor

Bepotastine may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Albutrepenonacog alfa

Minor

Bepotastine may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Almasilate

Minor

Bepotastine may decrease the excretion rate of Almasilate which could result in a higher serum level.

image of a doctor in a lab doing drug, clinical research

Bepreve Novel Uses: Which Conditions Have a Clinical Trial Featuring Bepreve?

19 trials are presently being conducted to examine the potential of Bepreve to alleviate Itch symptoms.

Condition

Clinical Trials

Trial Phases

Allergic Conjunctivitis (AC)

1 Actively Recruiting

Phase 2

Itching

2 Actively Recruiting

Phase 3, Not Applicable

Bepreve Reviews: What are patients saying about Bepreve?

5

Patient Review

3/21/2011

Bepreve for Allergic Conjunctivitis

This drop is the only thing that has worked for my crazy itchy eyes this weekend ! Get the big bottle as my insurance company was charging me the same for a bottle half the size. Hope this stuff works just as good as the allergy season rolls in !

5

Patient Review

12/17/2012

Bepreve for Allergic Conjunctivitis

Though very costly, this medication is like magic for me. It immediately relieves my allergies and I don't need to take other medications as frequently.

5

Patient Review

7/15/2011

Bepreve for Allergic Conjunctivitis

This stuff is really great! By 8 PM, my vision was significantly improved. I only wish it wasn't so expensive.

5

Patient Review

9/5/2015

Bepreve for Allergic Conjunctivitis

Bepreve cleared up my eyes within a week and I had no side effects!

4.3

Patient Review

10/24/2012

Bepreve for Allergic Conjunctivitis

My allergy doctor told me these were good, but he should have told me they were MAGIC. I have had terrible eye allergies the past 6 weeks with intense itching and burning pain. I used two other drops that did nothing. I have used this for 3 days and it's like I have a new set of eyeballs. No more itching, burning, or pain. I'm a fan. Even though the drops are outrageously priced, ask your doctor for samples and a coupon before you buy them--I got both of which really helped financially.

4.3

Patient Review

5/7/2019

Bepreve for Allergic Conjunctivitis

Works great, but unfortunately leaves an unpleasant taste in your mouth.

3.7

Patient Review

3/20/2010

Bepreve for Allergic Conjunctivitis

The cost of this medication is quite high, but it has been effective in treating my eye condition.

2.3

Patient Review

12/31/2010

Bepreve for Allergic Conjunctivitis

The drops were effective at reducing my itching, but I had to stop taking them because I started tasting a metallic flavor in my mouth after a few minutes. It was really unpleasant.

2.3

Patient Review

7/19/2014

Bepreve for Allergic Conjunctivitis

I got a headache, taste buds went off, sore throat, chronic cough, itching, face swelled up, and blood pressure went up.

2

Patient Review

8/26/2015

Bepreve for Allergic Conjunctivitis

My doctor gave me this eye drops and after the first drop, my blood pressure soared. I'm so glad I take my BP regularly or it could have been much worse.

1.7

Patient Review

4/28/2011

Bepreve for Allergic Conjunctivitis

I tried this on my 8 year old son this week, and it was totally ineffective. His eyes are still red as anything and he's complaining they are burning and running. Called the allergist to see if we can try something else. Poor kid, I wish it would have worked for him, he's miserable!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about bepreve

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is bepreve used for?

"Bepreve is a medication used to treat itching associated with allergic conjunctivitis. It works by blocking histamine receptors."

Answered by AI

What are the side effects of Bepreve eye drops?

"Unusual or unpleasant taste in the mouth, headache, eye irritation, stuffy nose, and sore throat are all symptoms of allergies."

Answered by AI

How many times a day do you use Bepreve eye drops?

"For the ophthalmic dosage form (eye drops):

For itching of the eyes:

Adults, teenagers, and children 2 years of age and older—Use one drop in the affected eye two times a day.

Children younger than 2 years of age—Use and dose must be determined by your doctor."

Answered by AI

Can you buy bepreve over the counter?

"Bepotastine (Bepreve) is not available over the counter and requires a prescription. If you are looking for an over the counter option, you may want to try Pataday (olopatadine) or Zaditor (ketotifen) which work similarly."

Answered by AI

Clinical Trials for Bepreve

Image of Johns Hopkins Bayview Medical Center in Baltimore, United States.

VR-Enhanced PMR for Post-Burn Symptoms

18+
All Sexes
Baltimore, MD

The goal of this clinical trial is to learn whether progressive muscle relaxation (PMR), delivered either alone or enhanced with virtual reality (VR), can help treat chronic symptom, such as pain, itch, anxiety, sleep disturbances, and fatigue, in adult burn survivors. The main questions it aims to answer are: * Does VR-enhanced PMR (VR-PMR) reduce chronic pain, anxiety, itch, sleep disturbances, and fatigue more effectively than standard PMR? * Is VR-PMR a feasible and acceptable self-administered home-based intervention for burn survivors? Researchers will compare two self-administered intervention conditions, VR-enhanced PMR and standard PMR, using a randomized to sequence crossover design to see if VR technology enhances the therapeutic effects of PMR on chronic symptom management in burn survivors. Participants will: * Complete home-based sessions of VR-enhanced PMR * Complete home-based sessions of standard PMR * Report symptoms such as pain, itch, anxiety, sleep disturbances, and fatigue throughout the study * Use VR equipment provided for the intervention period (during the VR-PMR arm)

Recruiting
Has No Placebo

Johns Hopkins Bayview Medical Center

Sheera Lerman Zohar, PhD