Azulfidine

Proctitis, Colitis, Ulcerative, Arthritis, Juvenile + 4 more

Treatment

20 Active Studies for Azulfidine

Treatment for

Proctitis

What is Azulfidine

SulfasalazineThe Generic name of this drug

Treatment SummarySulfasalazine is a drug used to treat inflammation in the intestines, such as in inflammatory bowel disease. It works by breaking down into a chemical called 5-aminosalicylic acid (mesalamine) which helps reduce inflammation in the colon.

Azulfidineis the brand name

image of different drug pills on a surface

Azulfidine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Azulfidine

Sulfasalazine

1950

Effectiveness

How Azulfidine Affects PatientsThe exact way sulfasalazine works is still being studied, but it is believed to reduce inflammation and affect the immune system. It is also thought to stick to connective tissue and to be absorbed in large amounts when taken by mouth. In people with ulcerative colitis, studies have shown that the main therapeutic effect comes from 5-aminosalicylic acid, a metabolite of sulfasalazine. It is not known how sulfasalazine and its metabolites contribute to treating rheumatoid arthritis.

How Azulfidine works in the bodySulfasalazine works to reduce inflammation, likely by blocking chemicals that cause it. It is thought to do this by stopping some enzymes from working, like phospholipase A2, cyclooxygenase-1, cyclooxygenase-2, and arachidonate 5-lipoxygenase. These enzymes create chemicals that cause inflammation, so when sulfasalazine blocks them, the inflammation is reduced.

When to interrupt dosage

The recommended dosage of Azulfidine is contingent upon the diagnosed condition, such as moderate Ulcerative colitis, Rheumatoid Arthritis and Ulcerative Colitis. The dose varies, in regard to the administration technique (e.g. Tablet or Enema - Rectal) listed in the table below.

Condition

Dosage

Administration

Arthritis, Juvenile

, 500.0 mg, 30.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Suspension, Rectal, Suspension - Rectal, Enema, Enema - Rectal, Suppository - Rectal, Tablet, film coated, Tablet, film coated - Oral

Proctitis

, 500.0 mg, 30.0 mg/mL

Colitis, Ulcerative

, 500.0 mg, 30.0 mg/mL

Ulcerative Colitis

, 500.0 mg, 30.0 mg/mL

Rheumatoid Arthritis

, 500.0 mg, 30.0 mg/mL

Crohn's Disease

, 500.0 mg, 30.0 mg/mL

Ulcerative Colitis

, 500.0 mg, 30.0 mg/mL

Warnings

Azulfidine has seven contraindications and should not be taken while encountering any of the circumstances outlined in the following table.Azulfidine Contraindications

Condition

Risk Level

Notes

Porphyrias

Do Not Combine

Intestines

Do Not Combine

There are 20 known major drug interactions with Azulfidine.

Common Azulfidine Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Sulfasalazine is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Sulfasalazine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Abatacept.

Abetimus

Major

The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Abetimus.

Acteoside

Major

The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Acteoside.

Azulfidine Toxicity & Overdose RiskStudies in rats and mice showed that taking high doses of sulfasalazine can cause tumors in the bladder and kidney of male rats, and liver tumors in male and female mice. It also caused infertility in male rats. In humans, it has been linked to an increased risk of birth defects such as neural tube defects. Pregnant women should only take sulfasalazine if it is absolutely necessary. There is not enough data to know if it affects the growth or development of children whose mothers took it during pregnancy.

image of a doctor in a lab doing drug, clinical research

Azulfidine Novel Uses: Which Conditions Have a Clinical Trial Featuring Azulfidine?

Currently, 114 active trials are investigating the potential of Azulfidine to provide relief from Polyarticular juvenile rheumatoid arthritis, chronic or unspecified, Ulcerative Colitis and Crohn's Disease.

Condition

Clinical Trials

Trial Phases

Colitis, Ulcerative

0 Actively Recruiting

Proctitis

0 Actively Recruiting

Ulcerative Colitis

0 Actively Recruiting

Rheumatoid Arthritis

53 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Crohn's Disease

43 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4

Arthritis, Juvenile

0 Actively Recruiting

Ulcerative Colitis

0 Actively Recruiting

Azulfidine Reviews: What are patients saying about Azulfidine?

5Patient Review

2/5/2011

Azulfidine for Crohn's Disease

I know someone who developed lung disease from this medication. They're now on Flolan and having a lot of trouble.

5Patient Review

4/8/2012

Azulfidine for Crohn's Disease

I'm really struggling since I started this medication a month ago. I'm exhausted all the time, my pain has gotten worse, and my veins are bulging and painful to the touch. My heart feels like it's fluttering in my chest.

5Patient Review

2/8/2013

Azulfidine for Rheumatoid Arthritis

I've had no issues with this treatment.

5Patient Review

2/23/2014

Azulfidine for Rheumatoid Arthritis

I have seronegative arthritis and my doctor prescribed this to me. I am afraid of the side effects, as I have high blood pressure and a history of slow heart rate. Will this medication result in my blood pressure getting higher and my heart rate slowing down? If so, I stop taking it because I don't want to experience any more negative health effects.

5Patient Review

9/2/2013

Azulfidine for Ulcerative Colitis currently Without Symptoms

Aloe Vera Juice is an affordable and accessible treatment for Ulcerative Colitis that really works! I highly recommend it to anyone suffering from this condition.

View All Reviews

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Patient Q&A Section about azulfidine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Azulfidine an immunosuppressant?

"The drug Azulfidine EN-tabs is used to treat moderate to severe ulcerative colitis.Azulfidine belongs to a different drug class than Imuran. Imuran is an immunosuppressive antimetabolite and Azulfidine is an anti-inflammatory agent and immunomodulatory agent."

Answered by AI

Is Azulfidine a sulfa drug?

"Sulfasalazine (Azulfidine) is a drug used to treat the symptoms of arthritis. It can also help prevent joint damage and reduce the risk of long-term disability."

Answered by AI

Is Azulfidine a steroid?

"No, sulfasalazine is not a steroid. It is actually considered a "steroid-sparing" medication. "Steroid-sparing" medications aim to lower the amount of corticosteroids you need by treating your condition and symptoms."

Answered by AI

What is Azulfidine used for?

"This medication is used to treat conditions such as ulcerative colitis and rheumatoid arthritis. It works by reducing irritation and swelling in the intestines and by reducing joint pain, stiffness, and swelling."

Answered by AI

Clinical Trials for Azulfidine

Have you considered Azulfidine clinical trials? We made a collection of clinical trials featuring Azulfidine, we think they might fit your search criteria.

Have you considered Azulfidine clinical trials? We made a collection of clinical trials featuring Azulfidine, we think they might fit your search criteria.