Aztreonam

Osteomyelitis, Gonorrhea, Septicemia + 11 more

Treatment

7 FDA approvals

20 Active Studies for Aztreonam

Treatment for

Osteomyelitis

What is Aztreonam

AztreonamThe Generic name of this drug

Treatment SummaryViolacein is an antibiotic used to treat bacterial infections in the brain, bladder, and kidneys. It is effective against some types of bacteria that are resistant to other antibiotics. However, it can lead to a new infection caused by other types of bacteria.

Azactamis the brand name

image of different drug pills on a surface

Aztreonam Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Azactam

Aztreonam

2009

15

Approved as Treatment by the FDA

Aztreonam, commonly known as Azactam, is approved by the FDA for 7 uses which include Urinary Tract Infection and Communicable Diseases .

Urinary Tract Infection

Communicable Diseases

Skin Infections

Intraabdominal Infections

Gram-Negative Bacterial Infections

Septicemia

Lower Respiratory Tract Infection (LRTI)

Effectiveness

How Aztreonam Affects PatientsAztreonam is a type of antibiotic that is effective in fighting a wide range of bacteria, particularly gram-negative aerobic bacteria (including Pseudomonas aeruginosa). It is also known as the "magic bullet" due to its strong effect against these types of bacteria. Aztreonam is more resistant to certain types of enzymes that can break down other beta-lactam antibiotics and so it is often used when other antibiotics are not effective. This drug works over a wide range of pH levels and in the presence of human serum and without oxygen.

How Aztreonam works in the bodyAztreonam works by blocking the synthesis of the cell wall of bacteria. It does this by targeting a protein called penicillin binding protein 3 (PBP3). This blocks the last stage of cell wall synthesis, leading to the bacteria cell's destruction. Aztreonam may also interfere with an inhibitor of an enzyme called autolysins, which further weakens the cell wall and leads to the bacteria's death.

When to interrupt dosage

The measure of Aztreonam is contingent upon the diagnosed circumstance, including Intraabdominal Infections, Gram-Negative Bacterial Infections and Lower Respiratory Tract Infection (LRTI). The dose of dosage shifts, as per the delivery technique (e.g. Injection, powder, lyophilized, for solution - Intramuscular; Intravenous or Powder, for suspension - Respiratory (inhalation)) detailed in the table beneath.

Condition

Dosage

Administration

Urinary Tract Infection

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Pseudomonas Aeruginosa Infection

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Bone and Joint Infections

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Lower Respiratory Tract Infection (LRTI)

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Skin Infections

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Gram-Negative Bacterial Infections

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Cystic Fibrosis (CF)

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Osteomyelitis

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Gonorrhea

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Intraabdominal Infections

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Communicable Diseases

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Septicemia

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Febrile Neutropenia

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Septic Arthritis

100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg

Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution

Warnings

There are 20 known major drug interactions with Aztreonam.

Common Aztreonam Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Aztreonam.

Abacavir

Minor

Aztreonam may decrease the excretion rate of Abacavir which could result in a higher serum level.

Aclidinium

Minor

Aztreonam may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Acrivastine

Minor

Aztreonam may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Albutrepenonacog alfa

Minor

Aztreonam may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

image of a doctor in a lab doing drug, clinical research

Aztreonam Novel Uses: Which Conditions Have a Clinical Trial Featuring Aztreonam?

33 active investigations are analyzing the potential of Aztreonam to relieve Bone and Joint Infections, Cystic Fibrosis (CF) and Gram-Negative Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Bone and Joint Infections

0 Actively Recruiting

Septicemia

1 Actively Recruiting

Not Applicable

Gonorrhea

0 Actively Recruiting

Septic Arthritis

1 Actively Recruiting

Not Applicable

Gram-Negative Bacterial Infections

4 Actively Recruiting

Phase 2, Phase 3

Lower Respiratory Tract Infection (LRTI)

1 Actively Recruiting

Phase 3

Urinary Tract Infection

8 Actively Recruiting

Not Applicable, Phase 4, Phase 3

Febrile Neutropenia

2 Actively Recruiting

Phase 2, Phase 4

Communicable Diseases

0 Actively Recruiting

Pseudomonas Aeruginosa Infection

0 Actively Recruiting

Osteomyelitis

6 Actively Recruiting

Phase 4, Phase 2, Phase 3, Not Applicable

Cystic Fibrosis (CF)

0 Actively Recruiting

Intraabdominal Infections

4 Actively Recruiting

Not Applicable, Phase 4

Skin Infections

2 Actively Recruiting

Phase 2, Not Applicable

Aztreonam Reviews: What are patients saying about Aztreonam?

4.3Patient Review

5/26/2016

Aztreonam for Urinary Tract Infection

I had to take this treatment for a UTI, and it was every bit as annoying as you might expect. However, I'm glad to report that it was also quite effective. I saw no negative side effects whatsoever.

3Patient Review

3/1/2009

Aztreonam for Pneumonia caused by the Bacteria Pseudomonas Aeruginosa

This caused swelling in my knees and some pretty debilitating joint pain.

Patient Q&A Section about aztreonam

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of antibiotic is aztreonam?

"Aztreonam belongs to a class of medications called monobactam antibiotics. These drugs work by killing bacteria. However, they will not work against infections caused by viruses, such as colds and the flu."

Answered by AI

Is aztreonam a penicillin?

"Aztreonam is an antibiotic that can be given intravenously or intramuscularly. It was approved in 1986 for the treatment of Gram-negative bacterial infections. It is marketed as a safe alternative for patients with penicillin allergies."

Answered by AI

What bacteria does aztreonam treat?

"Aztreonam is an antibiotic usually used to treat infections caused by gram-negative bacteria, such as Pseudomonas aeruginosa. These infections might include bone infections, endometritis, intra abdominal infections, pneumonia, urinary tract infections, and sepsis."

Answered by AI

Is aztreonam a strong antibiotic?

"Aztreonam has been shown to be at least as effective as cefamandole or more effective in urinary tract infections, and similar in efficacy to tobramycin or gentamicin."

Answered by AI

Clinical Trials for Aztreonam

Image of Seattle Children's Hospital in Seattle, United States.

Education at the first follow up for Chronic Multifocal Osteomyelitis

This trial aims to understand how often children with CRMO at Seattle Children's Hospital do not take their medication as prescribed, and what factors might make it difficult for them to stick to their treatment plan.

Seattle Children's Hospital

Image of University of Utah in Salt Lake City, United States.

Antibiotic Stewardship at Discharge for Pneumonia

Salt Lake City, UT

This trial will test if an antibiotic stewardship approach tailored to a hospital's needs can reduce antibiotic overuse at discharge in hospitalized patients with CAP or UTI.

Waitlist Available

University of UtahValerie M Vaughn, MD

Image of Duke University in Durham, United States.

Cefiderocol for Bacterial Infections in Newborns and Infants

This trial studies the effectiveness of cefiderocol in treating bacterial infections in newborns & babies under 3 months.

Duke University (+1 Sites)Medical DirectorShionogi

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Tebipenem Pivoxil Hydrobromide +1 More for Urinary Tract Infection

This trial aims to compare how well an oral medication called TBP-PI-HBr works against a standard intravenous medication called imipenem-cilastatin in treating urinary tract or abdominal infections

Medical facilityKamal Hamed, MDGlaxoSmithKline

Have you considered Aztreonam clinical trials? We made a collection of clinical trials featuring Aztreonam, we think they might fit your search criteria.

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Image of St. Louis Children's Hospital in Saint Louis, United States.

Discharge Antibiotic Stewardship for Pediatric Infections

Saint Louis, MO

This trial tests if a discharge stewardship bundle can reduce inappropriate antibiotic prescribing for kids with 3 common infections. It will involve surveys, interviews and feedback reports.

Waitlist Available

St. Louis Children's Hospital (+4 Sites)Jeffrey S Gerber, MD, PhD

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Antimicrobial Therapy for Febrile Neutropenia

Winston-Salem, NC

This trial looks at how to best treat fevers in cancer patients on chemo, when antibiotics aren't working.

Wake Forest University Health SciencesJohn Williamson, PharmD

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Calcium Sulfate Antibiotic Depot for Open Tibia Fractures

Winston-Salem, NC

This trial is studying if a new treatment can better prevent infection in people with lower leg fractures.

Waitlist Available

Wake Forest University Health Sciences (+5 Sites)Jessica Rivera, MD

Image of Magee Women's Hospital of UPMC in Pittsburgh, United States.

Culture-Directed vs Empiric Antibiotics for Urinary Tract Infections

This trial will assess if a culture-based or empiric antibiotic strategy is best for treating UTI symptoms in older women, and their ability to follow the study plan.

Magee Women's Hospital of UPMC

Have you considered Aztreonam clinical trials? We made a collection of clinical trials featuring Aztreonam, we think they might fit your search criteria.

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Stimulan-VG + Antibiotics for Diabetic Foot Infection

This trial tests Stimulan-VG to treat diabetic foot osteomyelitis in the forefoot and evaluates its safety and effectiveness.

Perseverance Research Center, LLC (+3 Sites)MCRA

Image of Florida Orthopaedic Institute in Temple Terrace, United States.

Antibiotic Coated Nail for Preventing Infection in Broken Bones

Temple Terrace, FL

This trial will compare outcomes of patients treated with a prophylactic antibiotic coated nail vs. traditional IM nailing.

FDA Approved Drug

Florida Orthopaedic Institute (+14 Sites)Joseph Hsu, MD

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Phage Therapy for Diabetic Foot Osteomyelitis

This trial is testing whether a virus that kills bacteria can help treat diabetic foot osteomyelitis.

Senior-friendly

Futuro Clinical Trials, LLC (+21 Sites)Edward Fang, MDAdaptive Phage Therapeutics, Inc.

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Nutrition Ecosystem for Post-Abdominal Surgery

This trial will test whether a new method of providing nutrition to patients who have had abdominal surgery and require nutrition through their veins improves clinical outcomes.

Duke University Medical CenterPaul Wischmeyer

Have you considered Aztreonam clinical trials? We made a collection of clinical trials featuring Aztreonam, we think they might fit your search criteria.

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