Azmacort

Macular Edema, Stomatitis, Denture, Ophthalmia, Sympathetic + 113 more

Treatment

16 FDA approvals

20 Active Studies for Azmacort

Treatment for

Macular Edema

What is Azmacort

Triamcinolone

The Generic name of this drug

Treatment Summary

Triamcinolone is a steroid used to treat inflammation in the body and various conditions such as allergic rhinitis, multiple sclerosis, and osteoarthritic knee pain. It is available in three forms: triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate. The FDA first approved triamcinolone in 1957 and in 2021, a suspension of triamcinolone acetonide was approved for suprachoroidal injection to treat macular edema associated with uveitis.

Aristocort

is the brand name

Azmacort Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Aristocort

Triamcinolone

1961

532

Approved as Treatment by the FDA

Triamcinolone, also called Aristocort, is approved by the FDA for 16 uses which include Lichen Planus and Ganglia .

Lichen Planus

Helps manage Lichen Planus (LP)

Ganglia

Helps manage cystic tumour of the ganglia

Granuloma Annulare

Helps manage granuloma annulare lesions

Psoriasis

Helps manage Psoriatic plaque

Neurodermatitis

Helps manage Lichen simplex chronicus

Lupus Erythematosus, Discoid

Helps manage Discoid Lupus Erythematosus (DLE)

granuloma annulare lesions

Helps manage granuloma annulare lesions

cystic tumour of the ganglia

Helps manage cystic tumour of the ganglia

Lichen simplex chronicus

Helps manage Lichen simplex chronicus

Lichen Planus (LP)

Helps manage Lichen Planus (LP)

Discoid Lupus Erythematosus (DLE)

Helps manage Discoid Lupus Erythematosus (DLE)

Alopecia Areata (AA)

Helps manage Alopecia Areata (AA)

Keloids Scars

Helps manage Keloids Scars

Necrobiosis Lipoidica

Helps manage Necrobiosis lipoidica diabeticorum

Alopecia Areata

Helps manage Alopecia Areata (AA)

Psoriatic plaque

Helps manage Psoriatic plaque

Effectiveness

How Azmacort Affects Patients

Triamcinolone is a type of medication with properties that can reduce inflammation. It is used to treat various inflammatory conditions in the organs and tissues, but should never be injected into the spine.

How Azmacort works in the body

Triamcinolone is a corticosteroid that helps reduce inflammation. It works by blocking cell membrane enzymes, which stops leukocytes from breaking down and forming arachidonic acid. This prevents the production of prostaglandins and leukotrienes, which cause inflammation. It also reduces the dilation of blood vessels and tightens permeability, stopping macrophage and leukocyte migration. Finally, it blocks nuclear factor kappa-B, which stops the production of inflammatory proteins like interleukin-6, interleukin-8, and monocyte chemoattractant protein-

When to interrupt dosage

The sum of Azmacort is contingent upon the determined affliction, including Mycosis Fungoides (MF), Mycoses and Alopecia Areata (AA). The measure of dosage can be found in the included table, dependent on the technique of delivery (e.g. Ointment or Injection, suspension - Intralesional; Parenteral).

Condition

Dosage

Administration

Neurodermatitis

, 40.0 mg/mL, 10.0 mg/mL, 0.055 mg, 0.001 mg/mg, 0.25 mg/mL, 1.0 mg/mL, 0.0005 mg/mg, 0.00025 mg/mg, 0.005 mg/mg, 5.0 mg/mL, 20.0 mg/mL, 0.000147 mg/mg, 0.5 mg/mL, 40.0 mg, 1.0 mg, 0.000025 mg/mg, 0.1 %, 0.025 %, 5.0 mg, 0.25 mg, 2.0 mg, 4.0 mg, 0.5 %, 15.0 mg/mL, 6.5 mg, 80.0 mg/mL, 0.075 mg, 200.0 mg/mL, 32.0 mg, 0.055 mg/dose, 0.5 mg, 0.2 mg/pump actuation, 0.1 mg/dose, 25.0 mg/mL, 0.055 mg/pump actuation, 2.0 mg/mL, 0.4 mg/mL

Injection, suspension, Intra-articular; Intramuscular, Injection, suspension - Intra-articular; Intramuscular, , Injection, suspension - Intra-articular; Intralesional, Intra-articular; Intralesional, Nasal, Spray, metered, Spray, metered - Nasal, Cream - Topical, Topical, Ointment - Topical, Lotion - Topical, Lotion, Cream, Ointment, Intralesional; Parenteral, Injection, suspension - Intralesional; Parenteral, Intra-articular; Parenteral, Injection, suspension - Intra-articular; Parenteral, Aerosol, spray, Aerosol, spray - Topical, Paste - Topical, Paste, Intramuscular, Injection, suspension - Intramuscular, Dental, Paste - Dental, Suspension - Intra-articular; Intramuscular, Suspension - Intra-articular; Intrabursal; Intradermal; Intrasynovial, Suspension, Suspension - Intra-articular; Intrabursal; Intramuscular, Intra-articular; Intrabursal; Intramuscular, Aerosol, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Respiratory (inhalation), Oral, Tablet, Tablet - Oral, Intra-articular; Intramuscular; Intrasynovial, Liquid - Intra-articular; Intramuscular; Intrasynovial, Intra-articular; Intradermal; Intramuscular, Syrup - Oral, Syrup, Suspension - Intramuscular, Liquid - Intra-articular; Intradermal; Intramuscular, Kit, Intra-articular; Intradermal; Intralesional; Intramuscular, Suspension - Intra-articular; Intradermal; Intralesional; Intramuscular, Spray, suspension - Nasal, Injection, solution, Injection, solution - Intra-articular; Intramuscular, Ophthalmic, Injection, suspension - Ophthalmic, Intravitreal, Suspension - Intra-articular, Spray - Topical, Intra-articular; Intrabursal; Intradermal; Intralesional, Injection, suspension - Intra-articular; Intrabursal; Intradermal; Intralesional, Intra-articular; Intrabursal; Intradermal; Intrasynovial, Intralesional, Suspension - Intralesional, Intra-articular, Liquid, Kit - Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Suspension - Intravitreal, Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical, Kit - Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical, Spray, Suspension - Ophthalmic, Subcutaneous, Implant - Subcutaneous, Injection, suspension - Intra-articular; Intramuscular; Intravitreal, Intra-articular; Intramuscular; Intravitreal, Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Intra-articular; Intramuscular; Topical, Epidural; Intra-articular; Intramuscular; Topical, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral, Epidural; Infiltration; Intra-articular; Intralesional, Kit - Epidural; Infiltration; Intra-articular; Intralesional, Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral, Kit - Intra-articular, Paste, dentifrice - Dental, Paste, dentifrice, Kit - Infiltration; Soft tissue; Topical, Infiltration; Soft tissue; Topical, Ointment - Buccal, Buccal, Emulsion, Gel - Topical, Gel, Intra-articular; Intrasynovial; Periarticular, Suspension - Intra-articular; Intrasynovial; Periarticular, Kit - Intra-articular; Intramuscular, Implant, Emulsion - Topical, Intra-articular; Intramuscular; Topical, Kit - Topical, Injection, suspension - Intra-articular, Infiltration; Intra-articular; Intramuscular; Topical, Kit - Infiltration; Intra-articular; Intramuscular; Topical

Proteinuria

cutaneous candidiasis

Ganglia

Atopic Dermatitis

Skin Diseases

Granuloma Annulare

Sarcoidosis

Stomatitis, Denture

Stomatitis, Aphthous

Multiple Sclerosis

Inflammation

induction of Diuresis

Hypercalcemia

Hives

Berylliosis

Intertrigo

Adrenal Insufficiency

Uveitis

Neurodermatitis

Warnings

Azmacort has four contraindications. It should not be taken when facing any of the conditions mentioned in the table below.

Azmacort Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Triamcinolone may interact with Pulse Frequency

Mycoses

Do Not Combine

active periocular infections

Do Not Combine

Eye Infections

Do Not Combine

There are 20 known major drug interactions with Azmacort.

Common Azmacort Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Triamcinolone.

Abetimus

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with Abetimus.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Triamcinolone.

Azmacort Toxicity & Overdose Risk

The lowest toxic dose of triamcinolone acetonide in rats is 13,100µg/kg and 132mg/kg in mice. The lethal dose in rats is 1451mg/kg and 2168mg/kg in mice. When overdosing on triamcinolone acetonide, patients may develop Cushing's syndrome, which can be treated with supportive therapy and a medication called mifepristone.

image of a doctor in a lab doing drug, clinical research

Azmacort Novel Uses: Which Conditions Have a Clinical Trial Featuring Azmacort?

A total of 1076 active studies are analyzing the effectiveness of Azmacort in relieving symptoms of Lupus, Atopic Dermatitis and Brain Metastases.

Condition

Clinical Trials

Trial Phases

Macular Edema

1 Actively Recruiting

Phase 2

Inflammation

57 Actively Recruiting

Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4

Asthma

91 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3

Anemia, Hemolytic, Autoimmune

0 Actively Recruiting

Rheumatoid Arthritis

56 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Vitrectomy therapy

0 Actively Recruiting

Dermatitis, Seborrheic

0 Actively Recruiting

Thyroiditis

0 Actively Recruiting

Brain

0 Actively Recruiting

Stomatitis

0 Actively Recruiting

Dermatitis

0 Actively Recruiting

Crohn's Disease

54 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1

Tinea

0 Actively Recruiting

Conjunctivitis, Bacterial

0 Actively Recruiting

Tenosynovitis

0 Actively Recruiting

Mycoses

0 Actively Recruiting

Synovitis

1 Actively Recruiting

Phase 4

Dermatitis, Allergic Contact

0 Actively Recruiting

Keloids Scars

0 Actively Recruiting

Ulcer

0 Actively Recruiting

Azmacort Reviews: What are patients saying about Azmacort?

Patient Review

5/27/2008

Azmacort for Asthma

Azmacort was highly effective for me when I first started taking it in 1992. However, my disease has progressed since then and it is no longer as effective as it once was.

Patient Review

1/17/2014

Azmacort for Asthma

I had used Azmacort for many years with great results. Asthma controlled in conjunction with Serevent. Suddenly, it is no longer available. I have tried several steroid inhalers since & have been plagued with recurrent bouts of oral thrush despite faithfully rinsing after use. HELP!

Patient Review

5/19/2010

Azmacort for Asthma

I've been using azmacort for a while now and it's really helped me. I haven't found anything else that works as well, so I'm pretty bummed that it's being discontinued.

Patient Review

2/15/2010

Azmacort for Asthma

This drug was really helpful for me and controlled my asthma very well for over 14 years. I'm sorry it's no longer being manufactured.

Patient Review

8/27/2010

Azmacort for Asthma

I've used Azmacort for a long time and it's always done a great job of keeping my asthma under control. I'm really upset that it's being discontinued because there is no generic alternative.

4.7

Patient Review

3/15/2010

Azmacort for Asthma

Azmacort was highly effective for me, and I never experienced any lung irritation. It's a shame that it's no longer being manufactured.

4.3

Patient Review

1/28/2008

Azmacort for Asthma

I had to increase the dosage, which resulted in me gaining weight. I also experienced dryness of mouth and sinus passage, as well as an increase in mucus in the throat. In the end, I had to stop using this medication.

Patient Review

4/26/2010

Azmacort for Asthma

This medication really helped me.

Patient Review

10/13/2007

Azmacort for Asthma

3.7

Patient Review

11/5/2008

Azmacort for Asthma

This medication definitely does something. I use it daily, and when I have a cold I up the dosage to six or eight puffs per day.

3.3

Patient Review

10/13/2007

Azmacort for Asthma

Patient Review

8/9/2008

Azmacort for Asthma

I've been using this medication for half a year and it's done wonders for my asthma. The cost is pretty high, but to me it's worth every penny. I used to use Singulair, but after a while it stopped working as well. This was the replacement, and I haven't had any problems since.

2.3

Patient Review

11/13/2007

Azmacort for Asthma

The treatment is effective, but the cost stops me from being able to use it as prescribed.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about azmacort

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Azmacort a steroid?

"Azmacort is a drug that contains the active ingredient triamcinolone, a steroid. It works by preventing the release of substances in the body that cause inflammation. Azmacort is used to prevent asthma attacks."

Answered by AI

Is Azmacort still available?

"The Azmacort brand name will no longer be used in the U.S. Generic versions of this product that have been approved by the FDA may be available."

Answered by AI

What type of inhaler is Azmacort?

"Azmacort is a prescription medicine used to treat the symptoms of Asthma. It may be used alone or with other medications. It belongs to a class of drugs called Glucocorticoids."

Answered by AI

What is Azmacort used to treat?

"Azmacort Inhalation Aerosol can be used for the maintenance treatment of asthma or for asthma patients who require systemic corticosteroid administration. Adding Azmacort may reduce or eliminate the need for the systemic corticosteroids."

Answered by AI

Clinical Trials for Azmacort

Have you considered Azmacort clinical trials?

We made a collection of clinical trials featuring Azmacort, we think they might fit your search criteria.

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SALI-10 Oral Probiotics for Gum Disease

18 - 70

All Sexes

Toronto, Canada

Gingivitis is among the most prevalent oral diseases worldwide, affecting an estimated 50-90% of adults. It is a reversible condition primarily caused by microbial plaque accumulation on teeth and gingival surfaces, which triggers inflammation. Standard care emphasizes plaque reduction through oral hygiene, and research shows gingivitis can be reversed once hygiene resumes. The classic experimental gingivitis (EG) model developed in 1965 by Löe and Silness demonstrated the direct link between plaque buildup and gingival inflammation, further confirming that gingival health can be restored after resuming proper care. Microbial ecology shifts are central to gingivitis pathogenesis. In health, the oral microbiome is dominated by gram-positive Streptococcus species. With plaque accumulation, microbial communities transition to gram-negative periopathogens such as Porphyromonas, Tannerella, Treponema, and Prevotella. This dysbiosis provokes heightened inflammation, tissue damage, and, in susceptible individuals, progression to periodontitis. Individual variability in the inflammatory response has been associated with differences in the presence and activity of beneficial streptococci. Certain strains of Streptococcus salivarius produce lantibiotics called salivaricins-polycyclic antimicrobial peptides containing lanthionine residues. Salivaricins inhibit oral pathogens and have been investigated for their antimicrobial and probiotic properties, particularly in the context of rising antibiotic resistance. Probiotic S. salivarius strains isolated from healthy individuals have demonstrated safety and antimicrobial potential in previous studies, supporting their use in preventing oral and respiratory infections. A strain of S. salivarius designated SALI-10 produces a lantibiotic, Salivaricin 10, and is being evaluated as a candidate for gingivitis prevention. This strain is hypothesized to (1) help stabilize populations of beneficial streptococci during plaque accumulation, (2) competitively inhibit periopathogens such as Porphyromonas and Prevotella, and (3) suppress the dysbiotic shift toward gram-negative dominance. By contributing to microbial balance and reducing inflammatory triggers, SALI-10 may support resilient host-microbe interactions associated with gingival health. This approach may offer a dual antimicrobial and microbiome-stabilizing strategy with relevance to gingivitis management and longer-term periodontal health.

Phase 2

Recruiting

Has No Placebo

University of Toronto

Dr. Michael Goldberg, MDM

Ostia Sciences

Have you considered Azmacort clinical trials?

We made a collection of clinical trials featuring Azmacort, we think they might fit your search criteria.

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Steroids for Rheumatoid Arthritis

18+

All Sexes

Toronto, Canada

People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improving symptoms reported by patients? 2. How do the two treatments compare in terms of symptom relief, ability to function, and patient satisfaction? 3. What do patients think and feel about using GCs to treat RA flares? What the Investigators Think: The investigators believe that a one-time GC injection is just as good as taking pills for a few weeks when it comes to managing RA flares. In fact, the injection might even be safer and preferred by patients. What the Investigators are Doing: The investigators will study 220 adults with RA who are currently having a flare (with at least 3 swollen and tender joints). These patients will be recruited from rheumatology clinics at the University of Toronto and must not have used GCs in the past month. They will be randomly assigned to receive either: A single injection (Methylprednisolone 120 mg), or Oral pills (Prednisone starting at 15 mg daily and tapering down over 3 weeks). The main thing the investigators will look at is how much better patients feel after 6 weeks, based on a questionnaire designed to measure RA flares. The investigators will also look at how well they function, how satisfied they are with the treatment, and whether they had any side effects. In addition, 20 patients (10 from each group) will be interviewed to understand their experiences and opinions about flare treatment in more detail. Why This Is Possible: The investigators have already surveyed University of Toronto rheumatologists who support the idea and provided input on study design. The investigators have also partnered with experts in research methods, national arthritis organizations, and patient groups to make sure the study is relevant and meaningful. Ethics approval has been obtained. Why It Matters: RA flares can have a major impact on people's lives. While current treatments help control inflammation, the investigators need to better understand how these treatments affect people from their own perspective. This study will shift the focus to what matters most to patients, helping doctors and patients choose the best treatment based not only on medical results but also on the patient's experience. This could lead to more effective and personalized care for people living with RA.

Phase 4

Waitlist Available

Has No Placebo

Sunnybrook Health Sciences Centre (+4 Sites)