Ativan

Alcohol Withdrawal Delirium, Delirium, Panic Disorder + 12 more

Treatment

20 Active Studies for Ativan

What is Ativan

Lorazepam

The Generic name of this drug

Treatment Summary

Lorazepam is a sedative and anti-anxiety medication that was first developed in 1977 by DJ Richards and was approved by the FDA in 1985. It is a type of benzodiazepine, meaning it acts quickly and is cleared from the body quickly. It is commonly used to help with anxiety and insomnia.

Lorazepam

is the brand name

image of different drug pills on a surface

Ativan Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Lorazepam

Lorazepam

1980

440

Effectiveness

How Ativan Affects Patients

Lorazepam works by increasing the activity of a certain type of brain cell (GABA-A receptors) which helps regulate nerve signals. This helps reduce seizures, as well as cause drowsiness and dizziness. The effects of lorazepam can be felt in different parts of the body, causing different levels of sleepiness and dizziness.

How Ativan works in the body

Lorazepam works by binding to receptors in the brain, specifically those related to GABA. Binding to these receptors increases the flow of chloride ions into the cell, making it more difficult for the cell to fire. Depending on which part of the brain lorazepam binds to, it can help with anxiety or seizure disorders.

When to interrupt dosage

The prescribed dosage of Ativan is based on the diagnosed affliction, including Anxiety Disorders, Generalized Anxiety Disorder and Insomnia. The dosage fluctuates based on the technique of delivery (e.g. Capsule, extended release - Oral or Liquid - Intramuscular; Intravenous) shown in the table beneath.

Condition

Dosage

Administration

Depression

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Preoperative

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Catatonia

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Pharmacotherapy

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Status Epilepticus

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Insomnia

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Generalized Anxiety Disorder

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Anesthetic premedication therapy

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Anxiety Disorders

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Syndrome

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Agitation

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Panic Disorder

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Spasm

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Alcohol Withdrawal Delirium

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Delirium

0.5 mg, , 2.0 mg, 1.0 mg, 2.0 mg/mL, 4.0 mg/mL, 2.5 mg, 3.0 mg, 1.5 mg

, Oral, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Sublingual, Tablet - Sublingual, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Intramuscular, Injection - Intramuscular, Capsule, extended release, Capsule, extended release - Oral

Warnings

Ativan has five contraindications, so it should not be taken in cooperation with the ailments listed in the following table.

Ativan Contraindications

Condition

Risk Level

Notes

Obstructive Sleep Apnea (OSA)

Do Not Combine

Respiratory Insufficiency

Do Not Combine

Glaucoma

Do Not Combine

intra-arterial route of administration

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Lorazepam may interact with Pulse Frequency

There are 20 known major drug interactions with Ativan.

Common Ativan Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Deutetrabenazine

Major

The risk or severity of sedation and somnolence can be increased when Lorazepam is combined with Deutetrabenazine.

Ethanol

Major

Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.

Methadone

Major

Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.

Olanzapine

Major

The risk or severity of adverse effects can be increased when Lorazepam is combined with Olanzapine.

Ativan Toxicity & Overdose Risk

A toxic dose of lorazepam in a mouse is 1850 mg/kg. Signs of a lorazepam overdose include deep sedation, slow breathing, loss of consciousness, and even death. In these cases, emergency medical care should be administered to help eliminate the drug from the body. There is no evidence that lorazepam causes cancer or mutations. Taking doses higher than 40 mg/kg during pregnancy can lead to fetal resorption and higher rates of fetal loss.

image of a doctor in a lab doing drug, clinical research

Ativan Novel Uses: Which Conditions Have a Clinical Trial Featuring Ativan?

1152 active clinical trials are being conducted to assess the potential of Ativan in providing relief from Anxiety Disorders, Generalized Anxiety Disorder and Insomnia.

Condition

Clinical Trials

Trial Phases

Generalized Anxiety Disorder

181 Actively Recruiting

Not Applicable, Phase 2, Early Phase 1, Phase 4, Phase 1, Phase 3

Anxiety Disorders

55 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1

Preoperative

0 Actively Recruiting

Syndrome

4 Actively Recruiting

Phase 2, Phase 3, Not Applicable

Anesthetic premedication therapy

0 Actively Recruiting

Insomnia

0 Actively Recruiting

Panic Disorder

13 Actively Recruiting

Not Applicable

Alcohol Withdrawal Delirium

0 Actively Recruiting

Agitation

3 Actively Recruiting

Phase 2, Phase 3, Not Applicable

Delirium

26 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 4, Early Phase 1

Catatonia

0 Actively Recruiting

Status Epilepticus

0 Actively Recruiting

Depression

305 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3

Pharmacotherapy

1 Actively Recruiting

Not Applicable

Spasm

0 Actively Recruiting

Ativan Reviews: What are patients saying about Ativan?

5

Patient Review

6/3/2018

Ativan for Anxious

Ativan has been a game-changer for me. I was an absolute wreck after my husband was placed in a nursing home, but this medication has helped me to cope and get through each day.

5

Patient Review

8/27/2019

Ativan for Anxious

This pill is great. It has helped me calm down and sleep for many years. I only use it occasionally because it's hard to get from my doctor, but if it were up to me I would take one pill every day.

5

Patient Review

7/10/2020

Ativan for Chronic Trouble Sleeping

I take one tablet of Ativan about an hour or two before bedtime. It usually helps me sleep through the night, and I wake up feeling rested after 7-8 hours. I'm not too worried about addiction at my age (84 years old).

5

Patient Review

8/30/2020

Ativan for Anxious

This treatment has been really effective for my anxiety. Within an hour of taking it, I feel completely normal again. The only side effect I've experienced is feeling really tired once it wears off.

5

Patient Review

4/6/2021

Ativan for Anxious

On the days that I take this medication, I feel much more level-headed and calm. It's been a lifesaver for managing my anxiety. The only downside is that it can make me quite tired in the afternoon, but that just means I sleep better at night.

5

Patient Review

2/25/2022

Ativan for Chronic Trouble Sleeping

I tried this treatment on myself with CBD to see if it would help me fall asleep. I didn't experience any effects other than feeling very sleepy when I woke up. It was difficult to get out of bed in the morning.

5

Patient Review

9/23/2022

Ativan for A Feeling of Restlessness with Inability to Sit Still

Dr. Lynn, I'm proud to say that I'm no longer an alcoholic or drug addict. I only have a drink when I go out to dinner now. I do take prescribed drugs to help me sleep, though, because the pain from my cancer is excruciating. But I only take medication when I absolutely need it.

5

Patient Review

10/21/2021

Ativan for Muscle Spasm

This medication saved my life and I would recommend it to anyone.

5

Patient Review

10/27/2021

Ativan for Muscle Spasm

I liked this medication and would recommend it to others.

5

Patient Review

5/10/2019

Ativan for Anxious

This medication helped me a lot with stress, anxiety, and insomnia. I was also really pleased to find that it masked the ringing in my ears (tinnitus) which had been causing me a lot of anxiety.

5

Patient Review

10/27/2021

Ativan for Muscle Spasm

This was a great experience.

4.3

Patient Review

2/5/2018

Ativan for Anxious

I've used this medication for two decades now, and it's been a big help. I had (and sometimes still have) issues with my inner ear which caused vertigo spells. This was the only drug that helped me get any relief. And as an added bonus, it also calms my anxiety related to the vertigo.

4.3

Patient Review

11/6/2018

Ativan for Anxious

I had a really tough time withdrawing from this medication. It was honestly terrible and took me an entire year to get off of it.

4

Patient Review

6/6/2020

Ativan for Mania associated with Bipolar Disorder, Adjunct Treatment

I take one milligram of this medication whenever I start feeling anxious or before bed if insomnia is plaguing me. It's really effective and doesn't come with any nasty side effects like drowsiness the next day.

1

Patient Review

7/31/2022

Ativan for Anxious

Ineffective for panic attacks and generally made me feel pretty terrible. I'll never touch it again.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ativan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Xanax the same as Ativan?

"Ativan and Xanax are both effective benzodiazepines for treating anxiety. However, Xanax takes effect more quickly but doesn't last as long as Ativan (4 to 6 hours vs. 8 hours)."

Answered by AI

What exactly does Ativan do?

"This drug is used to treat anxiety by enhancing the effects of a natural chemical in the body called GABA."

Answered by AI

Is Ativan a sleeping pill?

"Ativan is approved by the FDA to be used in the short term to treat insomnia that is caused by anxiety or stress. However, it is not the preferred medication to use for this purpose according to the American Academy of Sleep Medicine."

Answered by AI

Is Ativan a good drug for anxiety?

"Xanax and Ativan are effective for both emotional and physical symptoms of anxiety, as well as panic disorder. However, the risks associated with these medications mean that they are not always the first choice of treatment for either condition. Xanax and Ativan cause anti-anxiety effects quickly, usually within an hour or two of taking the medication."

Answered by AI

Clinical Trials for Ativan

Image of Cedars Sinai Medical Offices East Tower in Los Angeles, United States.

Active VR for Anxiety During ENT Procedures

18+
All Sexes
Los Angeles, CA

The purpose of this research is to evaluate whether active virtual reality reduces pain and anxiety more effectively than passive virtual reality during office-based ENT procedures. The main procedures include exposure to virtual reality (passive calming scenery or interactive puzzle game) via Paperplane Therapeutics software with VR headset or glasses during common in-office ENT procedures, participant self-report surveys (GAD-7, PHQ-9, PEG, VAS, SUDS, Likert, experience questions), and physician post-procedure survey. The study will enroll individuals 18 years or older who are scheduled to undergo common office-based ENT procedures (turbinate reduction, nasal debridement, balloon sinuplasty, radiofrequency ablation, nasal polypectomy, eustachian tube dilation, vocal fold injection, or subglottic steroid injection) at Cedars Sinai.

Waitlist Available
Has No Placebo

Cedars Sinai Medical Offices East Tower

Image of Washington University School of Medicine in St Louis, United States.

Psilocybin-Assisted Therapy for Depression

18+
All Sexes
St Louis, MO

Depression is the leading cause of disability worldwide, affecting an estimated 300 million people. Despite available treatments, response rates remain modest, and treatment resistance is common. Novel treatments are needed that act rapidly, produce lasting effects and work differently than existing antidepressants. In clinical trials, psilocybin has shown promise as a treatment for depression due to its rapid onset of antidepressant effects and sustained benefits. This study will use MRI scanning of the brain and other biological measures (biomarkers) to investigate how psilocybin affects brain activity and psychological flexibility before, during, and after receiving psilocybin in participants with depressive symptoms.

Phase 2
Waitlist Available

Washington University School of Medicine

Have you considered Ativan clinical trials?

We made a collection of clinical trials featuring Ativan, we think they might fit your search criteria.
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Cognitive Behavioral Therapy for Mental Health

18+
All Sexes
Imperial, CA

The goal of this study is to understand why certain treatments help people reduce repetitive negative thinking (RNT), which is common in many mental health problems. We want to: 1. Figure out what actually causes repetitive negative thinking to decrease when people use cognitive-behavioral therapy (CBT). 2. Find out which parts of RNT-focused CBT are the most important - the parts that truly make a difference in reducing RNT. The main result we will look at is how much a person's repetitive negative thought patterns change from the start of the study to the end of treatment (16 weeks). We will measure this using the Perseverative Thinking Questionnaire at baseline and week 16.

Waitlist Available
Has No Placebo

Imperial Valley College

Image of The Korean Association of West Florida in Tampa, United States.

Mobile App Mindfulness for Mental Health

18+
All Sexes
Tampa, FL

The goal of this clinical trial (single-arm pilot trial) is to learn whether a mobile application-based mindfulness intervention can improve mental health outcomes in older Korean immigrants aged 60 years and older. The main questions it aims to answer are whether the 8-week mobile app-based mindfulness intervention is feasible and acceptable, as indicated by recruitment, retention, and adherence rates, and whether participation in the intervention leads to improvements in positive psychological well-being (e.g., positive affect, optimism, life engagement, and mindfulness) and reductions in adverse mental health outcomes (e.g., anxiety, depressive symptoms, and perceived stress). Participants will complete baseline and post-intervention assessments, receive training on how to use the mobile mindfulness application, engage with the app for approximately 8 weeks (recommended 10-15 minutes per day), and participate in weekly check-ins to support engagement and address any challenges encountered during the intervention.

Waitlist Available
Has No Placebo

The Korean Association of West Florida (+1 Sites)

Soonhyung Kwon

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We made a collection of clinical trials featuring Ativan, we think they might fit your search criteria.
Go to Trials
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Behavioral Activation-Guided Self-Help for Depression

18+
All Sexes
Houston, TX

Symptoms of depression are highly prevalent among Veterans. However, fewer than 30% of individuals with these symptoms receive any psychotherapy in the Veterans Health Administration (VHA). This is due to many factors, which may include provider availability and patient preferences. Guided self-help (GSH), which involves coaching sessions with patients who are following a fully developed self-help program, has the potential to increase access to care for these Veterans, particularly if implemented within a stepped care model of mental health treatment delivery and if delivered by a diverse set of providers. The VHA's primary care-mental health integration (PCMHI) service, which focuses on short courses of care for mild to moderate symptoms, may be an ideal place in which to deploy GSH. The current project seeks conduct a pilot randomized trial of a GSH program for depression adapted for PCMHI based on behavioral activation.

Waitlist Available
Has No Placebo

Michael E. DeBakey VA Medical Center, Houston, TX

Maribel Plasencia, BA MS PhD

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Cognitive Training + tDCS for Depression

18+
All Sexes
Nashville, TN

The goal of this clinical trial is to learn if a combination of non-drug treatments works to benefit memory, thinking, and brain functioning in older individuals with recurrent depression. The non-drug approaches the investigators are studying include transcranial direct current stimulation (tDCS) and computerized cognitive training. tDCS uses small currents of electricity on the forehead to potentially stimulate your brain's ability to process and learn. Computerized cognitive training uses tablet games to improve memory and thinking. In this study, two different cognitive training programs are being investigated, both of which are stimulating and designed to engage brain activity. One that is believed to be a specific treatment for depression, while the other provides extra stimulation for the brain that is non-specific. Two different tDCS parameters - active stimulation and sham (or placebo) stimulation - are also being investigated. Participants will be randomized to one of three study groups: 1. Depression cognitive training treatment with active brain stimulation 2. Depression cognitive training treatment with sham brain stimulation 3. Non-specific cognitive training treatment with sham brain stimulation The main questions this clinical trial aims to answer are: * Does "depression cognitive training treatment with active brain stimulation" benefit thinking and memory more so than the other treatments? * Does "depression cognitive training treatment with active brain stimulation" benefit brain functioning more so than the other treatments? Participants will: * Complete several baseline and post-intervention visits at the research center for checkups and tests over the course of 3-4 months. * Visit the research center daily for 4 weeks to complete their assigned treatment.

Waitlist Available
Has No Placebo

Vanderbilt University Medical Center

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Medi-TBS for Depression

18 - 65
All Sexes
San Diego, CA

Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of \~30%. Additionally, rTMS has not been shown to improve cognitive functioning that may be an independent factor predicting treatment success. This study will develop a novel multimodal treatment, which combines intermittent theta burst stimulation (iTBS) - a type of rTMS with digital mindfulness training to engage brain plasticity, enhance cognition and alleviate depression symptoms in individuals with TRD.

Phase 2
Recruiting

UC San Diego Health Psychiatry

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ONE-D TMS + D-Cycloserine for Depression and Concussion

18 - 65
Female
Ocala, FL

Concussion and depression have long been recognized to be intertwined pathologies.1-3 Although female athletes are more likely to suffer from mental health symptoms than males athletes following a concussion,2 research in this area has been largely biased toward males.4 Recently functional MRI (fMRI) studies5 in concussed athletes have established that there are patterns of local alterations in neural connectivity in the frontal cortex that demonstrate anatomic congruency with transcranial magnetic stimulation (TMS) studies that mapped alternations in neural connectivity to functional and somatic symptoms.6 Thus, there is potential that TMS treatment could decrease both symptom profiles, revolutionizing comorbid treatment options. Possible Benefits: Previous studies have showed a 70% remission rate for depression symptoms. It is possible that participants could have improvement in depressive or concussive symptoms after the ONE-D TMS treatment.

Phase 2 & 3
Waitlist Available

UF World Equestrian Center

Sara Gould, MD

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We made a collection of clinical trials featuring Ativan, we think they might fit your search criteria.
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