Arimidex

BRCA1 gene, Breast, Metastatic Breast Cancer + 5 more
Treatment
20 Active Studies for Arimidex

What is Arimidex

AnastrozoleThe Generic name of this drug
Treatment SummaryAnastrozole is a non-steroidal drug used to lower the amount of estrogen in postmenopausal women with estrogen-sensitive breast cancer. Unlike other aromatase inhibitors, Anastrozole does not come with steroid-related side effects such as weight gain and acne. Anastrozole is preferred to earlier drugs such as tamoxifen due to its superior effectiveness and fewer side effects. The drug was approved by the FDA in 1995.
Arimidexis the brand name
image of different drug pills on a surface
Arimidex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Arimidex
Anastrozole
1996
74

Effectiveness

How Arimidex Affects PatientsAnastrozole helps to treat breast cancer by reducing the levels of estrogen in the body. It is taken once daily and works quickly, with effects lasting up to 6 days. However, anastrozole has been linked to increased risk of heart disease and decreased bone mineral density. Therefore, it is important to consider the risks as well as the benefits before beginning anastrozole therapy.
How Arimidex works in the bodyAnastrazole blocks the body's ability to make estrogen. This is important for hormone receptor-positive cancers, which are cancers that need estrogen to grow. Anastrazole works by competing with the aromatase enzyme, which is found in the adrenal glands, liver, and fat tissues. It blocks the enzyme from converting androgens into estrogens, reducing the amount of estrogen present in the body and slowing the growth of hormone receptor-positive tumors.

When to interrupt dosage

The advised dosage of Arimidex is contingent upon the determined circumstance, such as BRCA1 gene, Invasive Early Breast Cancer and hormone receptor obscure. The measure of dosage vacillates, as per the delivery technique (e.g. Oral or Pellet, implantable - Subcutaneous) featured in the table underneath.
Condition
Dosage
Administration
Invasive Early Breast Cancer
, 1.0 mg, 20.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Pellet, Pellet - Oral, Pellet, implantable - Subcutaneous, Subcutaneous, Pellet, implantable
disease progression with tamoxifen therapy
, 1.0 mg, 20.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Pellet, Pellet - Oral, Pellet, implantable - Subcutaneous, Subcutaneous, Pellet, implantable
Breast
, 1.0 mg, 20.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Pellet, Pellet - Oral, Pellet, implantable - Subcutaneous, Subcutaneous, Pellet, implantable
BRCA1 gene
, 1.0 mg, 20.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Pellet, Pellet - Oral, Pellet, implantable - Subcutaneous, Subcutaneous, Pellet, implantable
Breast
, 1.0 mg, 20.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Pellet, Pellet - Oral, Pellet, implantable - Subcutaneous, Subcutaneous, Pellet, implantable
Metastatic Breast Cancer
, 1.0 mg, 20.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Pellet, Pellet - Oral, Pellet, implantable - Subcutaneous, Subcutaneous, Pellet, implantable
hormone receptor unknown
, 1.0 mg, 20.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Pellet, Pellet - Oral, Pellet, implantable - Subcutaneous, Subcutaneous, Pellet, implantable
2-3 years of tamoxifen therapy
, 1.0 mg, 20.0 mg, 4.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Pellet, Pellet - Oral, Pellet, implantable - Subcutaneous, Subcutaneous, Pellet, implantable

Warnings

Arimidex Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Anastrozole may interact with Pulse Frequency
Breast Milk Production
Do Not Combine
There are 20 known major drug interactions with Arimidex.
Common Arimidex Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Anastrozole.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Anastrozole.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Anastrozole.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Anastrozole.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Anastrozole.
Arimidex Toxicity & Overdose RiskThe most toxic dose of anastrozole that has been reported in a human female is 1.68mg/kg, administered over 12 weeks. There is limited information on the effects of overdosing on anastrozole as no one has ever taken more than 60mg, which was given to a healthy male volunteer with no serious side effects. Treatment should focus on managing the symptoms and monitoring the patient's vital signs. Since anastrozole does not bind to protein, dialysis may be used in some cases to help remove the drug from the body.
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Arimidex Novel Uses: Which Conditions Have a Clinical Trial Featuring Arimidex?

113 active studies are presently underway to assess the potential of Arimidex for the treatment of Invasive Early Breast Cancer, 2-3 years of tamoxifen therapy and Hormone Receptor Unknown Disorders.
Condition
Clinical Trials
Trial Phases
2-3 years of tamoxifen therapy
0 Actively Recruiting
BRCA1 gene
11 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1
Breast
12 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
Metastatic Breast Cancer
95 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Phase 4, Early Phase 1
disease progression with tamoxifen therapy
0 Actively Recruiting
Breast
19 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
Invasive Early Breast Cancer
0 Actively Recruiting
hormone receptor unknown
0 Actively Recruiting

Arimidex Reviews: What are patients saying about Arimidex?

5Patient Review
3/19/2022
Arimidex for malignant tumor or cancer
I've tried a lot of different steroids over the years, and this is by far the best one I've found for dealing with high estrogen levels. No pain, no joint problems, no fatigue, just great results in the gym.
4.3Patient Review
8/12/2020
Arimidex for Breast Cancer that has Spread to Another Part of the Body
I've been on this medication for eight years and, up until recently, it's been going great. I never got over hot flashes, but that was never a big deal to me. However, my feet and ankles have started swelling and I've gained a lot of weight. My primary care physician keeps telling me to lose weight, but it seems impossible with this medication.
3.7Patient Review
3/13/2020
Arimidex for Breast Cancer
In 2005, I had a lumpectomy for an invasive ductal carcinoma. I received 35 treatments of radiation and was started on Arimidex for 5 years. The only side effect I experienced was crying, so my primary care physician put me on an antidepressant. Now, I have neuropathy in my feet that neurologist said is more commonly seen in people who had received chemotherapy.
3.7Patient Review
6/2/2017
Arimidex for Breast Cancer
2.3Patient Review
9/27/2017
Arimidex for Breast Cancer
1.7Patient Review
4/5/2019
Arimidex for Hormone Receptor Positive Breast Cancer
My bone pain increased and I even fractured my spine after using this treatment for six months.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about arimidex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Arimidex a form of chemotherapy?

"No, ARIMIDEX is not a type of cytotoxic chemotherapy. It is a hormonal treatment that works by reducing the amount of estrogen produced by your body."

Answered by AI

Does Arimidex cause weight gain?

"Some people who use Arimidex may gain weight during treatment, 9% of those taking Arimidex in a study had weight gain, as well as 9% of women who took a different cancer drug, tamoxifen, for 5 years."

Answered by AI

What does Arimidex do to the body?

"Arimidex works by blocking the enzyme aromatase, which turns the hormone androgen into estrogen in the body. This means less estrogen is available to stimulate the growth of hormone receptor-positive breast cancer cells. Arimidex will not work on hormone receptor-negative breast cancer."

Answered by AI

What are the most common side effects of Arimidex?

"hot flashes, night sweats, vaginal dryness or changes in sexual appetite

The possible side effects of menopause are constipation, diarrhea, nausea, vomiting, upset stomach, loss of appetite, body aches and pains (back pain, bone pain, joint pain or stiffness), breast swelling/tenderness/pain, hot flashes, night sweats, vaginal dryness or changes in sexual appetite."

Answered by AI

Clinical Trials for Arimidex

Have you considered Arimidex clinical trials? We made a collection of clinical trials featuring Arimidex, we think they might fit your search criteria.
Have you considered Arimidex clinical trials? We made a collection of clinical trials featuring Arimidex, we think they might fit your search criteria.
Have you considered Arimidex clinical trials? We made a collection of clinical trials featuring Arimidex, we think they might fit your search criteria.
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Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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