Amlodipine And Olmesartan Medoxomil

Diabetic Nephropathies, Hypertensive disease, multiple antihypertensive drugs likely required + 1 more

Treatment

2 FDA approvals

20 Active Studies for Amlodipine And Olmesartan Medoxomil

Treatment for

Diabetic Nephropathies

What is Amlodipine And Olmesartan Medoxomil

OlmesartanThe Generic name of this drug

Treatment SummaryOlmesartan is a medication used to lower high blood pressure. It belongs to a family of drugs called angiotensin II receptor blockers (ARBs) that work by blocking a protein called angiotensin II, which helps regulate blood pressure. Olmesartan can also help slow the progression of kidney damage caused by type 2 diabetes. It is generally well tolerated and can be used safely in adults and children. Olmesartan was developed by Daiichi Sankyo Pharmaceuticals and approved in 2002.

Benicaris the brand name

Amlodipine And Olmesartan Medoxomil Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Benicar

Olmesartan

2002

340

Approved as Treatment by the FDA

Olmesartan, also called Benicar, is approved by the FDA for 2 uses which include Therapeutic procedure and Hypertensive disease .

Therapeutic procedure

Used to treat failed primary treatment in combination with Hydrochlorothiazide

Hypertensive disease

Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide

Effectiveness

How Amlodipine And Olmesartan Medoxomil Affects PatientsOlmesartan works by reducing blood pressure, decreasing aldosterone levels, and increasing the amount of sodium excreted in the body. It is important to be monitored closely by a doctor while taking olmesartan, as it may cause hypotension, especially in patients who are low on salt or volume. Those with aortic stenosis should be extra cautious, as there is a risk of decreased coronary perfusion. Olmesartan may also impair renal function and cause electrolyte imbalances. In some cases, prolonged use of olmesartan may cause severe diarrhea, weight loss, and villous atrophy

How Amlodipine And Olmesartan Medoxomil works in the bodyOlmesartan is a type of drug called an angiotensin II receptor blocker (ARB). It works by preventing the protein angiotensin II from causing blood vessels to become narrow. This helps keep blood pressure lower, reduces aldosterone levels, and makes the heart pump less. Olmesartan also affects the renin-angiotensin aldosterone system (RAAS), which helps regulate the body's blood pressure, kidney, and heart. Studies have shown that blocking RAAS with ARBs can help protect the heart from further damage caused by heart failure.

When to interrupt dosage

The dosage of Amlodipine And Olmesartan Medoxomil is contingent upon the diagnosed affliction, including Diabetic Nephropathy, Hypertensive illness and Therapeutic procedure. The measure of dosage is contingent on the approach of administration (e.g. Oral or Tablet, film coated) detailed in the following table.

Condition

Dosage

Administration

Diabetic Nephropathies

40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Hypertensive disease

40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

multiple antihypertensive drugs likely required

40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Therapeutic procedure

40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Amlodipine And Olmesartan Medoxomil Contraindications

Condition

Risk Level

Notes

Type 2 Diabetes

Do Not Combine

There are 20 known major drug interactions with Amlodipine And Olmesartan Medoxomil.

Common Amlodipine And Olmesartan Medoxomil Drug Interactions

Drug Name

Risk Level

Description

Amifostine

Major

Olmesartan may increase the hypotensive activities of Amifostine.

Lithium carbonate

Major

The serum concentration of Lithium carbonate can be increased when it is combined with Olmesartan.

Lithium citrate

Major

The serum concentration of Lithium citrate can be increased when it is combined with Olmesartan.

Lithium hydroxide

Major

The serum concentration of Lithium hydroxide can be increased when it is combined with Olmesartan.

Acebutolol

Minor

Olmesartan may increase the hypotensive activities of Acebutolol.

Amlodipine And Olmesartan Medoxomil Toxicity & Overdose RiskThe most toxic dose of olmesartan in dogs was found to be greater than 1500mg/kg. Overdosing on olmesartan can cause low blood pressure, a rapid heartbeat, or a slow heartbeat. Treatment for overdose includes supportive care. Olmesartan has not been shown to be carcinogenic or affect fertility in studies, but it has been shown to cause changes to chromosomes and to induce mutations in cells in laboratory studies.

Amlodipine And Olmesartan Medoxomil Novel Uses: Which Conditions Have a Clinical Trial Featuring Amlodipine And Olmesartan Medoxomil?

19 active studies are currently being conducted to evaluate the potential of Amlodipine And Olmesartan Medoxomil in providing Therapeutic Procedures, Hypertensive Disease Treatment and the likely requirement of Multiple Antihypertensive Drugs.

Condition

Clinical Trials

Trial Phases

Hypertensive disease

22 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Diabetic Nephropathies

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

multiple antihypertensive drugs likely required

0 Actively Recruiting

Patient Q&A Section about amlodipine and olmesartan medoxomil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can I take olmesartan and amlodipine together?

"The combination of amlodipine and olmesartan may be used to treat high blood pressure, which puts extra strain on the heart and arteries. If left untreated, high blood pressure can lead to long-term damage to the heart and arteries."

Answered by AI

How long does amlodipine and olmesartan take to work?

"It may take a couple of weeks to start feeling the full effects of this medication. If your condition doesn't improve or gets worse (your blood pressure readings stay high or go up), let your doctor know."

Answered by AI

What are the side effects of olmesartan amlodipine?

"If you experience any of the following symptoms, you should contact your doctor immediately as they may be signs of a liver problem: dark urine, decreased urine output, itching, skin rash, large hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, light-colored stools, muscle pain or stiffness, stomach pain, or upper right abdominal or stomach pain."

Answered by AI

What is the difference between olmesartan medoxomil and amlodipine?

"Amlodipine and olmesartan is a combination medicine used to treat high blood pressure (hypertension). Amlodipine is a calcium channel blocker and olmesartan is an angiotensin II receptor blocker (sometimes called an ARB)."

Answered by AI

Clinical Trials for Amlodipine And Olmesartan Medoxomil

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