Amlodipine And Olmesartan Medoxomil

Diabetic Nephropathies, Hypertensive disease, multiple antihypertensive drugs likely required + 1 more
Treatment
2 FDA approvals
20 Active Studies for Amlodipine And Olmesartan Medoxomil

What is Amlodipine And Olmesartan Medoxomil

OlmesartanThe Generic name of this drug
Treatment SummaryOlmesartan is a medication used to lower high blood pressure. It belongs to a family of drugs called angiotensin II receptor blockers (ARBs) that work by blocking a protein called angiotensin II, which helps regulate blood pressure. Olmesartan can also help slow the progression of kidney damage caused by type 2 diabetes. It is generally well tolerated and can be used safely in adults and children. Olmesartan was developed by Daiichi Sankyo Pharmaceuticals and approved in 2002.
Benicaris the brand name
Amlodipine And Olmesartan Medoxomil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Benicar
Olmesartan
2002
340

Approved as Treatment by the FDA

Olmesartan, also called Benicar, is approved by the FDA for 2 uses which include Therapeutic procedure and Hypertensive disease .
Therapeutic procedure
Used to treat failed primary treatment in combination with Hydrochlorothiazide
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide

Effectiveness

How Amlodipine And Olmesartan Medoxomil Affects PatientsOlmesartan works by reducing blood pressure, decreasing aldosterone levels, and increasing the amount of sodium excreted in the body. It is important to be monitored closely by a doctor while taking olmesartan, as it may cause hypotension, especially in patients who are low on salt or volume. Those with aortic stenosis should be extra cautious, as there is a risk of decreased coronary perfusion. Olmesartan may also impair renal function and cause electrolyte imbalances. In some cases, prolonged use of olmesartan may cause severe diarrhea, weight loss, and villous atrophy
How Amlodipine And Olmesartan Medoxomil works in the bodyOlmesartan is a type of drug called an angiotensin II receptor blocker (ARB). It works by preventing the protein angiotensin II from causing blood vessels to become narrow. This helps keep blood pressure lower, reduces aldosterone levels, and makes the heart pump less. Olmesartan also affects the renin-angiotensin aldosterone system (RAAS), which helps regulate the body's blood pressure, kidney, and heart. Studies have shown that blocking RAAS with ARBs can help protect the heart from further damage caused by heart failure.

When to interrupt dosage

The dosage of Amlodipine And Olmesartan Medoxomil is contingent upon the diagnosed affliction, including Diabetic Nephropathy, Hypertensive illness and Therapeutic procedure. The measure of dosage is contingent on the approach of administration (e.g. Oral or Tablet, film coated) detailed in the following table.
Condition
Dosage
Administration
Diabetic Nephropathies
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
multiple antihypertensive drugs likely required
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Therapeutic procedure
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Amlodipine And Olmesartan Medoxomil Contraindications
Condition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
There are 20 known major drug interactions with Amlodipine And Olmesartan Medoxomil.
Common Amlodipine And Olmesartan Medoxomil Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Olmesartan may increase the hypotensive activities of Amifostine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Olmesartan.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Olmesartan.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Olmesartan.
Acebutolol
Minor
Olmesartan may increase the hypotensive activities of Acebutolol.
Amlodipine And Olmesartan Medoxomil Toxicity & Overdose RiskThe most toxic dose of olmesartan in dogs was found to be greater than 1500mg/kg. Overdosing on olmesartan can cause low blood pressure, a rapid heartbeat, or a slow heartbeat. Treatment for overdose includes supportive care. Olmesartan has not been shown to be carcinogenic or affect fertility in studies, but it has been shown to cause changes to chromosomes and to induce mutations in cells in laboratory studies.

Amlodipine And Olmesartan Medoxomil Novel Uses: Which Conditions Have a Clinical Trial Featuring Amlodipine And Olmesartan Medoxomil?

19 active studies are currently being conducted to evaluate the potential of Amlodipine And Olmesartan Medoxomil in providing Therapeutic Procedures, Hypertensive Disease Treatment and the likely requirement of Multiple Antihypertensive Drugs.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Nephropathies
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting

Patient Q&A Section about amlodipine and olmesartan medoxomil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can I take olmesartan and amlodipine together?

"The combination of amlodipine and olmesartan may be used to treat high blood pressure, which puts extra strain on the heart and arteries. If left untreated, high blood pressure can lead to long-term damage to the heart and arteries."

Answered by AI

How long does amlodipine and olmesartan take to work?

"It may take a couple of weeks to start feeling the full effects of this medication. If your condition doesn't improve or gets worse (your blood pressure readings stay high or go up), let your doctor know."

Answered by AI

What are the side effects of olmesartan amlodipine?

"If you experience any of the following symptoms, you should contact your doctor immediately as they may be signs of a liver problem: dark urine, decreased urine output, itching, skin rash, large hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, light-colored stools, muscle pain or stiffness, stomach pain, or upper right abdominal or stomach pain."

Answered by AI

What is the difference between olmesartan medoxomil and amlodipine?

"Amlodipine and olmesartan is a combination medicine used to treat high blood pressure (hypertension). Amlodipine is a calcium channel blocker and olmesartan is an angiotensin II receptor blocker (sometimes called an ARB)."

Answered by AI

Clinical Trials for Amlodipine And Olmesartan Medoxomil

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Have you considered Amlodipine And Olmesartan Medoxomil clinical trials? We made a collection of clinical trials featuring Amlodipine And Olmesartan Medoxomil, we think they might fit your search criteria.Go to Trials
Have you considered Amlodipine And Olmesartan Medoxomil clinical trials? We made a collection of clinical trials featuring Amlodipine And Olmesartan Medoxomil, we think they might fit your search criteria.Go to Trials
Image of University of Alberta in Edmonton, Canada.

Egg White Powder for High Blood Sugar and High Blood Pressure

18 - 70
All Sexes
Edmonton, Canada
Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides is namely IRW made from egg white hydrolysate and composed of three peptides. This is a feasibility study to assess the acute effect of IRW in egg white hydrolysate for the management of high sugar and blood pressure. Participants at high risk of type 2 diabetes (T2D) or having T2D will undergo 4 consecutive treatments of 1 day each (randomly), during which they will consume a standardized breakfast with a smoothie containing different protein powders. Each treatment will be separated by a minimum of 1-week. Participants in the healthy control group will undergo 1 treatment only (one day).
Phase 1
Waitlist Available
University of AlbertaJianping Wu, PhD
Image of Northern Arizona University in Flagstaff, United States.

CardioCare Quest for High Blood Pressure

18+
All Sexes
Flagstaff, AZ
This project aims to address healthcare disparities among Navaho people diagnosed with hypertension or prehypertension through three main objectives. Firstly, it identifies and shares insights on healthcare access disparities affecting Navaho individuals experiencing nonadherence to hypertension treatment. Secondly, the proposal develops a telehealth solution based on factors identified as knowledge gaps caused by healthcare access disparities in hypertension management; we will use the factors to design a series of engaging minigames that can be incorporated into the larger CardioCare Quest. These minigames will be co-designed with end users and clinicians. Finally, the proposal conducts comprehensive qualitative and quantitative assessments of user experiences, perceptions, and challenges with CardioCare Quest.
Recruiting
Has No Placebo
Northern Arizona University (+1 Sites)Tochukwu Ikwunne, PhD
Image of Tufts University in Boston, United States.

Food as Medicine for Cardiometabolic Health

18+
All Sexes
Boston, MA
Though the Mississippi Delta has a rich agricultural history and some of the nation's most fertile soil, residents have experienced the legacy of slavery and economic exploitation through food insecurity and poverty for generations. This project focuses on Bolivar, Washington, and Sunflower, contiguous counties in the Delta that are designated as health disparity populations. Over 65% of the 100,000 residents are Black/African American and \~30% live at or below the poverty level. Obesity rates are high and the rate of diabetes is almost double the national average. Tufts University received a grant from the National Institute of Minority Health and Health Disparities to develop, test, and evaluate a Food is Medicine program in Mississippi. The Delta Growing a Resilient, Enriching, Equitable, Nourishing food System (GREENS) Food is Medicine (FIM) Project, is a collaborative project in Bolivar, Washington, and Sunflower counties in Mississippi. The intervention involves regularly distributed fruit and vegetable produce boxes as well as nutrition education materials to the intervention group. The control group will receive produce boxes later, after they complete study activities. The project's primary goal is to improve health outcomes by creating a FIM intervention. The Delta GREENS FIM Project aims to become a model for promoting nutrition security and management of chronic conditions in varied communities nationwide.
Recruiting
Has No Placebo
Tufts UniversityChristina D Economos, PhD
Have you considered Amlodipine And Olmesartan Medoxomil clinical trials? We made a collection of clinical trials featuring Amlodipine And Olmesartan Medoxomil, we think they might fit your search criteria.Go to Trials
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