Amiloride Hydrochloride

Polyuria, Ascites, Hypokalemia + 7 more
Treatment
5 FDA approvals
20 Active Studies for Amiloride Hydrochloride

What is Amiloride Hydrochloride

AmilorideThe Generic name of this drug
Treatment SummaryAmiloride is a drug used to reduce the amount of sodium absorbed by the kidneys. When taken in conjunction with diuretics, it helps to prevent potassium loss in the body. Amiloride works by blocking sodium channels in renal epithelial cells, creating a negative potential in the luminal membranes of principal cells located in the distal convoluted tubule and collecting duct.
Amiloride Hydrochlorideis the brand name
image of different drug pills on a surface
Amiloride Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Amiloride Hydrochloride
Amiloride
1986
23

Approved as Treatment by the FDA

Amiloride, otherwise called Amiloride Hydrochloride, is approved by the FDA for 5 uses like Congestive Heart Failure (CHF) and Hypokalemia .
Congestive Heart Failure (CHF)
Used in combination with other therapies
Hypokalemia
Congestive Heart Failure
Used in combination with other therapies
kaliuretic diuretics
Hypertensive disease

Effectiveness

How Amiloride Hydrochloride Affects PatientsAmiloride is a drug used to treat high blood pressure and congestive heart failure. It helps reduce blood pressure and can be taken together with other diuretics. However, it can also cause levels of potassium in the blood to become too high, and so patients taking it should avoid taking extra potassium or salt replacements. Additionally, if patients are taking ACE inhibitors or spironolactone, the risk of hyperkalemia is increased.
How Amiloride Hydrochloride works in the bodyAmiloride helps the kidneys flush out sodium and water while preserving potassium levels. It targets the sodium channels in the distal convoluted tubules and collecting ducts of the kidneys, slowing down the reabsorption of sodium and allowing it to be excreted from the body. This process does not rely on aldosterone and can occur without it.

When to interrupt dosage

The recommended dosage of Amiloride Hydrochloride is dependent upon the diagnosed condition, such as Metabolic Alkalosis, Bartter's syndrome and Congestive Heart Failure. The measure of dosage fluctuates as per the technique of administration (e.g. Oral or Tablet) featured in the table beneath.
Condition
Dosage
Administration
Congestive Heart Failure
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Hypertensive disease
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Ascites
, 5.0 mg
, Oral, Tablet, Tablet - Oral
lithium
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Bartter Syndrome
, 5.0 mg
, Oral, Tablet, Tablet - Oral
kaliuretic diuretics
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Nephrolithiasis
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Hypokalemia
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Polyuria
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Metabolic Alkalosis
, 5.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Amiloride Hydrochloride Contraindications
Condition
Risk Level
Notes
Renal Insufficiency
Do Not Combine
Hyperkalemia
Do Not Combine
potassium supplementation
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Amiloride Hydrochloride.
Common Amiloride Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Amiloride.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Amiloride.
Cyclosporine
Major
The risk or severity of hyperkalemia can be increased when Amiloride is combined with Cyclosporine.
Dalfampridine
Major
The serum concentration of Dalfampridine can be increased when it is combined with Amiloride.
Gentamicin
Major
The serum concentration of Gentamicin can be increased when it is combined with Amiloride.
Amiloride Hydrochloride Toxicity & Overdose RiskThere is currently no information about overdosing on amiloride hydrochloride in humans. However, in mice, the lowest toxic dose is 56mg/kg, and in rats it is between 36-85mg/kg. Signs of overdosing on amiloride hydrochloride include dehydration and an imbalance of electrolytes.
image of a doctor in a lab doing drug, clinical research

Amiloride Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Amiloride Hydrochloride?

53 active clinical trials are currently examining the potential of Amiloride Hydrochloride to alleviate Hypokalemia, Bartter's syndrome and Congestive Heart Failure.
Condition
Clinical Trials
Trial Phases
Hypokalemia
0 Actively Recruiting
Congestive Heart Failure
12 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Nephrolithiasis
0 Actively Recruiting
kaliuretic diuretics
0 Actively Recruiting
Ascites
3 Actively Recruiting
Not Applicable, Phase 2
Polyuria
0 Actively Recruiting
Metabolic Alkalosis
0 Actively Recruiting
Bartter Syndrome
0 Actively Recruiting
lithium
0 Actively Recruiting

Amiloride Hydrochloride Reviews: What are patients saying about Amiloride Hydrochloride?

3.3Patient Review
9/26/2012
Amiloride Hydrochloride for High Blood Pressure
A common side effect of this treatment is needing to urinate more often than usual. Another is a dry throat.
3Patient Review
5/20/2012
Amiloride Hydrochloride for Visible Water Retention
This medication has helped to reduce the water retention, but unfortunately seems to come with some cold-like symptoms.
2.3Patient Review
7/26/2019
Amiloride Hydrochloride for High Blood Pressure
I didn't love this treatment because it caused cramps in my feet and legs.
2Patient Review
5/20/2010
Amiloride Hydrochloride for Visible Water Retention
I started taking this medication and within the first day, I began experiencing nausea and severe diarrhea. This always happens in the evenings, so I can't help but think it's connected to the drug.
1Patient Review
9/9/2008
Amiloride Hydrochloride for High Blood Pressure
This drug has caused me a lot of problems like fatigue, kidney issues, and cramps in my hands and feet. It was supposed to help with blood pressure but that hasn't been the case either.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about amiloride hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the best time to take amiloride?

"To use Amiloride HCL, take it by mouth with food, usually once daily or as directed by your doctor. If you take the drug too close to bedtime, you may need to wake up to urinate. To avoid this, take Amiloride HCL at least 4 hours before your bedtime."

Answered by AI

What are the side effects of hydrochlorothiazide and amiloride?

"You may experience a headache, dizziness, nausea, vomiting, loss of appetite, stomach/abdominal pain, gas, or diarrhea. If you experience any of these effects, please tell your doctor or pharmacist."

Answered by AI

What is another name for amiloride?

"Midamor is a drug that helps conserve potassium and has weak activity compared to thiazide diuretics in terms of being natriuretic, diuretic, and antihypertensive."

Answered by AI

What is amiloride hydrochloride used for?

"Amiloride is a diuretic that helps the body retain potassium andlower blood pressure by reducing the amount of water in the body. Aprescription from a doctor is required to obtain this medication."

Answered by AI

Clinical Trials for Amiloride Hydrochloride

Have you considered Amiloride Hydrochloride clinical trials? We made a collection of clinical trials featuring Amiloride Hydrochloride, we think they might fit your search criteria.
Have you considered Amiloride Hydrochloride clinical trials? We made a collection of clinical trials featuring Amiloride Hydrochloride, we think they might fit your search criteria.
Have you considered Amiloride Hydrochloride clinical trials? We made a collection of clinical trials featuring Amiloride Hydrochloride, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
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