Alphagan

Open-angle glaucoma, Rosacea, Glaucoma + 4 more
Treatment
6 FDA approvals
20 Active Studies for Alphagan

What is Alphagan

BrimonidineThe Generic name of this drug
Treatment SummaryBrimonidine is a drug used to treat glaucoma, a condition that can lead to blindness if not managed properly. It is used to reduce the pressure in the eye by decreasing the amount of fluid and increasing the natural drainage from the eye. Brimonidine is approved for long-term use and is considered safe because it does not cause cardiovascular side effects like some other glaucoma medications. It is also available in combination with other medications to treat rosacea, a skin condition causing redness on the face.
Alphagan Pis the brand name
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Alphagan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Alphagan P
Brimonidine
2001
43

Approved as Treatment by the FDA

Brimonidine, commonly known as Alphagan P, is approved by the FDA for 6 uses including Open Angle Glaucoma and Glaucoma .
Open Angle Glaucoma
Helps manage Open Angle Glaucoma (OAG)
Glaucoma
Helps manage Increased Intra Ocular Pressure (IOP)
Open Angle Glaucoma (OAG)
Helps manage Open Angle Glaucoma (OAG)
Increased Intra Ocular Pressure (IOP)
Helps manage Increased Intra Ocular Pressure (IOP)
Ocular Hypertension
Helps manage Ocular Hypertension
Ocular Hypertension
Helps manage Ocular Hypertension

Effectiveness

How Alphagan Affects PatientsBrimonidine is a medication used to treat certain eye conditions. It works by targeting certain receptors in the body to reduce pressure and inflammation in the eyes. After taking brimonidine, the effects can be seen in two hours, with a 23% reduction in eye pressure. Studies have also shown that it may reduce facial redness in those with moderate to severe rosacea. When used systemically, brimonidine can cause a decrease in blood pressure, heart rate, and respiration rate. There is also evidence that it may have neuroprotective effects on the eyes and optic nerves, but more research is needed to confirm
How Alphagan works in the bodyBrimonidine is used to reduce the pressure in the eye, which can help prevent vision loss caused by glaucoma. It works by activating a receptor in the eye that reduces the amount of fluid being produced, and increases the fluid leaving the eye. When applied to the skin, brimonidine causes direct vasoconstriction of small arteries and veins, leading to reduced redness and inflammation. This makes it useful in treating rosacea, which is caused by abnormal dilation of facial blood vessels.

When to interrupt dosage

The proposed measure of Alphagan is contingent upon the determined condition, such as Open Angle Glaucoma, facial erythema and Ocular Hypertension. The magnitude of dosage shifts, in line with the technique of application featured in the table below.
Condition
Dosage
Administration
Glaucoma
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Open Angle Glaucoma
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Ocular Hypertension
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Open-angle glaucoma
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Rosacea
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Glaucoma
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
facial erythema
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension

Warnings

Alphagan Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Brimonidine may interact with Pulse Frequency
There are 20 known major drug interactions with Alphagan.
Common Alphagan Drug Interactions
Drug Name
Risk Level
Description
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Brimonidine is combined with Oliceridine.
Acebutolol
Minor
Brimonidine may increase the antihypertensive activities of Acebutolol.
Aliskiren
Minor
Brimonidine may increase the antihypertensive activities of Aliskiren.
Alprenolol
Minor
Brimonidine may increase the antihypertensive activities of Alprenolol.
Ambrisentan
Minor
Brimonidine may increase the antihypertensive activities of Ambrisentan.
Alphagan Toxicity & Overdose RiskThe toxic dose of brimonidine in mice is 50mg/kg and 100mg/kg in rats. Symptoms of an overdose in adults may include low blood pressure, weakness, vomiting, sleepiness, slow heartbeat, abnormal heart rhythms, constricted pupils, difficulty breathing, low body temperature, and seizures. Treatment for an overdose includes providing supportive care and symptomatic therapy. Cases of brimonidine overdose have been reported in infants and children. In pregnant animals, brimonidine was not found to cause birth defects. Studies also did not show any mutagenic or clastogenic potential of the drug. Brimonidine should not be
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Alphagan Novel Uses: Which Conditions Have a Clinical Trial Featuring Alphagan?

114 active trials are assessing the use of Alphagan in managing Open Angle Glaucoma, inadequately controlled intraocular pressure, and other Open Angle Glaucoma conditions.
Condition
Clinical Trials
Trial Phases
Open-angle glaucoma
41 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Early Phase 1, Phase 1
Glaucoma
0 Actively Recruiting
facial erythema
0 Actively Recruiting
Rosacea
0 Actively Recruiting
Glaucoma
0 Actively Recruiting
Ocular Hypertension
11 Actively Recruiting
Phase 3, Phase 4, Phase 1, Phase 2, Not Applicable
Open Angle Glaucoma
12 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1

Alphagan Reviews: What are patients saying about Alphagan?

5Patient Review
10/30/2011
Alphagan for Increased Pressure in the Eye
I used this for about 18 months, during which time I got six eye infections. I was diagnosed with allergic conjunctivitis in 2011 and found out that Alphagan is extremely toxic; apparently, 30% of patients have this side effect.
5Patient Review
8/22/2011
Alphagan for Wide-Angle Glaucoma
This medication has not helped me at all. If anything, it's made my blood pressure and eye pressure worse.
5Patient Review
8/22/2011
Alphagan for Wide-Angle Glaucoma
This medication unfortunately has not helped me at all. If anything, it's made my symptoms worse.
5Patient Review
10/30/2011
Alphagan for Increased Pressure in the Eye
I used this treatment for about eighteen months, during which time I had six eye infections. I was diagnosed with allergic conjunctivitis in 2011 due to the use of Alphagan. Unfortunately, this medication is quite toxic; 30% of people who take it experience side effects like mine.
4.7Patient Review
9/13/2016
Alphagan for Increased Pressure in the Eye
The only complaint I have is that it's a bit pricey. Other than that, it seems to work well. It was prescribed to me to help with the itchiness caused by my other medication (Prednisone drops) which I needed after my corneal transplant.
View All Reviews
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Patient Q&A Section about alphagan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are alphagan and brimonidine the same thing?

"Brimonidine is available in two forms: Alphagan P and Qoliana. Alphagan P is available in three strengths: 0.1%, 0.15%, and 0.2%. Qoliana is available in one strength: prescription-only."

Answered by AI

Is alphagan good for glaucoma?

"Alphagan is a drug used to treat open angle glaucoma and ocular hypertension. It works by reducing the production of aqueous humor and increasing uveoscleral outflow."

Answered by AI

What is the generic drug for Alphagan?

"Falcon Pharmaceuticals, an affiliate of Alcon Inc., has recieved U.S. regulatory approval to market brimonidine tartrate ophthalmic solution 0.2%. This generic drug is therapeutically equivalent to Alphagan (brimonidine tartrate, Allergan), according to an Alcon press release."

Answered by AI

What is alphagan used for?

"This medication is used to treat open-angle glaucoma, which is when there is high fluid pressure in the eye. Lowering the fluid pressure can reduce the risk of vision loss, nerve damage, or blindness."

Answered by AI

Clinical Trials for Alphagan

Have you considered Alphagan clinical trials? We made a collection of clinical trials featuring Alphagan, we think they might fit your search criteria.
Have you considered Alphagan clinical trials? We made a collection of clinical trials featuring Alphagan, we think they might fit your search criteria.
Have you considered Alphagan clinical trials? We made a collection of clinical trials featuring Alphagan, we think they might fit your search criteria.
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