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What is Aldactone
SpironolactoneThe Generic name of this drug
Treatment SummarySpironolactone is a medication used to treat high blood pressure, heart failure, and other conditions caused by too much aldosterone in the body. It works by preventing the body from reabsorbing too much sodium and water, while allowing the body to retain potassium. It was first developed in 1957 and approved by the FDA in 1960. Off-label uses of spironolactone include treating hirsutism, female pattern hair loss, adult acne, and aiding in medical gender transition.
Spironolactoneis the brand name
Aldactone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Spironolactone
Spironolactone
1960
288
Approved as Treatment by the FDA
Spironolactone, also known as Spironolactone, is approved by the FDA for 11 uses such as Hypesthesia and Hypokalemia .Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class III)
Hypokalemia
Swollen feet or ankles
Helps manage Edema
Hyperaldosteronism
Helps manage idiopathic hyperaldosteronism
Ascites
Helps manage Ascites
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Nephrotic Syndrome
Helps manage Nephrotic Syndrome
Congestive Heart Failure
Helps manage Congestive Heart Failure (CHF)
Primary Hyperaldosteronism
Helps manage Primary Hyperaldosteronism
Cirrhosis
Helps manage Cirrhosis of the Liver
Effectiveness
How Aldactone Affects PatientsSpironolactone was originally studied for the way it helps the body get rid of water without losing too much potassium. It does this by blocking certain receptors in the kidneys that help regulate sodium, water, and potassium levels. It is similar in structure to a hormone called progesterone, and as a result has some of the same effects, such as increased progesterone levels and anti-androgenic effects.
How Aldactone works in the bodySpironolactone works by blocking sodium and potassium channels in the kidneys. This causes more sodium and water to be released from the body, which is how the drug produces its diuretic and anti-hypertension effects. Potassium is the only ion that is not affected, and instead is retained in the body.
When to interrupt dosage
The endorsed dosage of Aldactone is contingent upon the diagnosed condition, such as Hypesthesia, Congestive Heart Failure and Cirrhosis. The measure of dosage fluctuates, depending on the method of administration specified in the accompanying table.Condition
Dosage
Administration
Primary Hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Secondary hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypertensive disease
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypesthesia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hirsutism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
nonresponsive to antihypertensive monotherapy
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypesthesia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Cirrhosis
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Nephrotic Syndrome
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Edema
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Acne
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Congestive Heart Failure
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Swollen feet or ankles
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Ascites
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypokalemia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
inadequate response to other therapeutic measures
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Warnings
Aldactone has six contra-indications. Any of the conditions given in the table below should preclude the utilization of Aldactone.Aldactone ContraindicationsCondition
Risk Level
Notes
significant impairment of renal excretory function
Do Not Combine
Anuria
Do Not Combine
Renal Insufficiency, Acute
Do Not Combine
Hyperkalemia
Do Not Combine
Pulse Frequency
Do Not Combine
Addison's Disease
Do Not Combine
Common Aldactone Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Spironolactone.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Spironolactone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Spironolactone.
Cyclosporine
Major
The risk or severity of hyperkalemia can be increased when Spironolactone is combined with Cyclosporine.
Dabrafenib
Major
The metabolism of Dabrafenib can be decreased when combined with Spironolactone.
Aldactone Toxicity & Overdose RiskPeople who overdose on spironolactone may feel drowsy, confused, have a rash, feel sick to their stomach, become dizzy, or have diarrhea. Treatment for overdose includes keeping hydrated and maintaining electrolyte balance and other vital functions. The toxic dose in mice, rats, and rabbits is greater than 1g/kg. Pregnant women should avoid spironolactone, as it has been reported to cause feminization of male fetuses in animal studies. Spironolactone is present in breast milk, but its long-term effects are still unknown. Animal studies have shown that spironol
Aldactone Novel Uses: Which Conditions Have a Clinical Trial Featuring Aldactone?
165 active clinical trials are currently underway to evaluate the utility of Aldactone in managing Hypokalemia, Hirsutism and Nephrotic Syndrome.Condition
Clinical Trials
Trial Phases
Hypesthesia
8 Actively Recruiting
Not Applicable, Phase 1
Acne
6 Actively Recruiting
Phase 4, Early Phase 1, Not Applicable, Phase 1, Phase 2
Hypokalemia
0 Actively Recruiting
Hyperaldosteronism
0 Actively Recruiting
Edema
0 Actively Recruiting
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
nonresponsive to antihypertensive monotherapy
0 Actively Recruiting
Primary Hyperaldosteronism
0 Actively Recruiting
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
inadequate response to other therapeutic measures
0 Actively Recruiting
Nephrotic Syndrome
11 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Secondary hyperaldosteronism
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Hypesthesia
5 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Hirsutism
0 Actively Recruiting
Aldactone Reviews: What are patients saying about Aldactone?
4.7Patient Review
4/16/2018 I've been taking this medication for six months to help with my high blood pressure. It's been great, but I started noticing some fatty tissue in my chest recently so I went to the doctor. He got an x-ray and diagnosed it as gynecomastia. Other than that, and a little potassium spike, I believe the benefits of this outweigh the harms.
4.3Patient Review
10/23/2015 I'm currently using this medication to treat my adult acne, under the guidance of a dermatologist. When I started the drug, my skin broke out pretty badly; however, it's since calmed down. I was supposed to take 50mg each day, but find that 25mg does the trick just fine. The only downside is that it makes me really tired, so I have to be careful about taking it at night. Otherwise, no real side effects to speak of other than an upset stomach on occasion.
3.7Patient Review
11/29/2015 I use this medication for adult acne as well as to help manage my borderline blood pressure. However, I would caution anyone taking this drug against consuming ginger before or while driving and/or operating machinery, as it can cause heart palpitations in large doses.
2.3Patient Review
4/7/2020 I'm an 84-year-old woman who had been taking this medication for three years to address heart problems and water retention. However, after about two and a half years, I started growing breasts. Six months ago, they started getting tender, so I notified my cardiologist. He took me off the medication and told me to check my blood pressure for a week before getting back in touch with him. My blood pressure was good, so I stopped taking the medication.
1.7Patient Review
1/27/20141.3Patient Review
9/21/2016 I had a really terrible reaction to this drug. I developed hives, breathing problems, and extreme dehydration. My blood sugar levels were all over the place, and I was in a lot of pain.
Patient Q&A Section about aldactone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Aldactone a steroid?
"Aldactone is not a steroid, but it does have some steroid-like effects on the hormones aldosterone and testosterone. Aldactone belongs to a class of drugs known as diuretics, which are potassium-sparing."
Answered by AI
What is a Aldactone used for?
"High blood pressure is a major problem because it can lead to strokes, heart attacks, and kidney problems. However, by lowering high blood pressure, these risks can be prevented. In addition, high blood pressure can also be treated by removing excess fluid and improving symptoms such as breathing problems."
Answered by AI
What is Aldactone used for and what are the side effects?
"Aldactone is a medication used to treat heart failure, high blood pressure, or low potassium levels in the blood. It can also be used to treat fluid retention in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome."
Answered by AI
What type of drug is Aldactone?
"Aldactone is a diuretic, meaning it helps your body get rid of water. It also helps your body retain potassium, which can raise the level of potassium in your blood to too high."
Answered by AI