What is Aggrenox
DipyridamoleThe Generic name of this drug
Treatment SummaryDipyridamole is a medication that blocks the absorption and breakdown of adenosine in red blood cells and in the cells that line blood vessels. It also makes prostacyclin, a drug that stops blood clots, work better.
Dipyridamoleis the brand name
Aggrenox Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dipyridamole
Dipyridamole
1980
98
Approved as Treatment by the FDA
Dipyridamole, also known as Dipyridamole, is approved by the FDA for 5 uses like Transient Ischemic Attack (TIA) and previous stroke .Transient Ischemic Attack (TIA)
Used to treat Transient Ischemic Attack in combination with Acetylsalicylic acid
previous stroke
Used to treat previous stroke in combination with Acetylsalicylic acid
Stroke
Used to treat Cerebrovascular Accident in combination with Acetylsalicylic acid
cardiac valve replacement
Postoperative Thromboembolism
Effectiveness
How Aggrenox Affects PatientsDipyridamole is a medicine used to widen the blood vessels, stop blood clots, and help prevent stroke. It is usually taken together with other anticoagulant drugs such as warfarin to prevent blood clots in patients with valve or vessel problems. It can also be used to take pictures of the heart, stop platelets from sticking together, and used with aspirin to lower the risk of stroke.
How Aggrenox works in the bodyDipyridamole works to stop platelets from clumping together and forming clots by preventing the breakdown of compounds that inhibit platelet function. It also increases the amount of a compound in the platelets that stops them from sticking together. Finally, Dipyridamole directly triggers the release of another compound which further raises the amount of the inhibitor compound inside the platelets.
When to interrupt dosage
The proposed portion of Aggrenox is contingent upon the diagnosed condition, such as Thrombosis, previous stroke and Stroke. The amount of dosage will depend on the technique for delivery (e.g. Tablet, coated or Capsule) highlighted in the table hereunder.Condition
Dosage
Administration
Thrombosis
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
previous stroke
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
Stroke
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
Heart Valve Prosthesis
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
Diagnostic Imaging
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
cardiac valve replacement
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
Myocardial Perfusion Imaging
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
Postoperative Thromboembolism
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
Transient Ischemic Attack (TIA)
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
Coronary Artery Disease (CAD)
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
Transient cerebral ischemia
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
Anti-platelet Therapy
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
Ischemic Stroke
200.0 mg, 75.0 mg, 100.0 mg, 25.0 mg, , 50.0 mg, 5.0 mg/mL, 150.0 mg
Tablet, coated, Capsule, Capsule - Oral, , Solution, Oral, Solution - Intravenous, Tablet - Oral, Tablet, extended release, Tablet, coated - Oral, Injection, Tablet, Tablet, film coated - Oral, Injection, solution - Intravenous, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Injection - Intravenous, Intravenous, Injection, solution, Tablet, extended release - Oral, Liquid, Liquid - Intravenous
Warnings
Aggrenox ContraindicationsCondition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
High Grade Atrioventricular Block
Do Not Combine
active wheezing
Do Not Combine
Common Aggrenox Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Dipyridamole is combined with Abrocitinib.
Acebutolol
Major
Dipyridamole may increase the bradycardic activities of Acebutolol.
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Dipyridamole.
Alprenolol
Major
Dipyridamole may increase the bradycardic activities of Alprenolol.
Amyl Nitrite
Major
The risk or severity of hypotension can be increased when Dipyridamole is combined with Amyl Nitrite.
Aggrenox Toxicity & Overdose RiskLow blood pressure may be a short-term side effect of this drug, but a medication to raise blood pressure may be prescribed if needed. The lowest toxic dose in rats was found to be greater than 6,000 mg/kg, while in dogs it was approximately 400 mg/kg. The lethal dose in rats is 8.4g/kg when taken orally.
Aggrenox Novel Uses: Which Conditions Have a Clinical Trial Featuring Aggrenox?
38 active trials are being conducted to assess the potential of Aggrenox in Postoperative Thromboembolism, Stroke and Thrombotic Disorders management.Condition
Clinical Trials
Trial Phases
Ischemic Stroke
1 Actively Recruiting
Not Applicable
Postoperative Thromboembolism
0 Actively Recruiting
Stroke
14 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Thrombosis
0 Actively Recruiting
Anti-platelet Therapy
0 Actively Recruiting
Transient Ischemic Attack (TIA)
8 Actively Recruiting
Not Applicable, Phase 4
previous stroke
0 Actively Recruiting
cardiac valve replacement
0 Actively Recruiting
Heart Valve Prosthesis
0 Actively Recruiting
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
Myocardial Perfusion Imaging
1 Actively Recruiting
Phase 1
Transient cerebral ischemia
0 Actively Recruiting
Diagnostic Imaging
0 Actively Recruiting
Aggrenox Reviews: What are patients saying about Aggrenox?
5Patient Review
10/14/2016 I had a TIA three years ago and was put on Clopidogrel. However, I developed mild numbness in my face after just fifteen days. So, I changed neurologists and he suggested Aggrenox. I had a headache for the first two days but then nothing else. I continued taking Aggrenox and now it's been three years with no further TIAs or side effects (besides mild acidity).
5Patient Review
7/30/2013 My doctor prescribed this in order to lower my HDL levels. It was successful, and I experienced some side effects; however, they eventually went away with continued use of the drug.
5Patient Review
1/9/2014 I had an ischemic stroke when I was 51, and Aggrenox has been a lifesaver. Not only have I not had any more strokes or TIA's, but I also haven't experienced any headaches. The only downside is that I sometimes bleed from my anus, but it's not too bad.
5Patient Review
1/27/2014 I've been on Aggrenox for six years now, and it has prevented any further mini-strokes (TSA) since I started taking it. I'm very pleased with the results and have experienced no negative side effects whatsoever.
5Patient Review
4/1/20134.3Patient Review
5/20/2014 I had two strokes in 2002 and my carotid artery was 100% blocked. I've been taking Aggrenox for 12 years now, and the only problem I've had was after 5 years when I started having stomach problems. I went on omeprazole and that fixed the issue. My only concern now is that I need knee replacement surgery and no orthopedic surgeons know anything about this drug or how long I can stop taking it for safety. Does anyone know the answer?
4.3Patient Review
11/30/2013 The side effects were unfortunately quite debilitating. I couldn't really function at all while taking this medication.
4Patient Review
6/17/2015 I've been taking aspirin for years per my doctor's recommendation, but recently he prescribed Aggrenox because I had a TIA about 10 years ago with no recurrence. I have met my donut hole, and the stuff costs a fortune. I've called the doc to find out if I can resume taking just aspirin, as I had for years. Before he gets back to me, can anyone tell me if they have noticed a perceptable difference between Aggrenox and 81 mg aspirin? Is it worth the outrageous price vs. $3 for a year's worth of aspirins?
2Patient Review
7/11/2014 I have found that Aggrenox has caused me to lose my appetite, constantly feel nauseous, and experience a bad taste in my mouth. I've also lost weight since taking this medication. I'm hoping to explore other options with my doctor soon.
1Patient Review
2/17/2015 My father experienced a brain embolism and was prescribed Aggrenox. One week later, he had a major cerebral bleed and died. This is not a good drug!
1Patient Review
9/5/2013 I've been taking this medication for 15 years with no problems. However, I have recently started experiencing pain and wonder if it would be okay to take Advil or Aleve
Patient Q&A Section about aggrenox
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Aggrenox the same as aspirin?
"Aggrenox consists of aspirin and dipyridamole, which is another medication. Those who have had a stroke or TIA in the past generally take either aspirin or Aggrenox, but not both."
Answered by AI
What is the generic name for Aggrenox?
"The FDA approved the generic version of Aggrenox, aspirin/extended-release dipyridamole, on July 1, 2015. This medication is used to help prevent stroke in people who have had a previous "mini-stroke" or an actual ischemic stroke."
Answered by AI
What is the difference between Aggrenox and Plavix?
"Plavix protects you from blood clots after you have had a heart attack or surgery. It is a cheap, generic drug that is just as effective as more expensive options. Aggrenox prevents blood clots and stroke, but there are cheaper drugs available that work just as well."
Answered by AI
What is the medication Aggrenox used for?
"This medication is mean to prevent another stroke from happening to patients who have already had mini strokes or a single full stroke. The medication works by thinning the blood so that clots are less likely to form and cause another stroke."
Answered by AI