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What is Adrucil
FluorouracilThe Generic name of this drug
Treatment SummaryFluorouracil (5-FU) is an anti-cancer medication that works by blocking the ability of cells to make DNA. It does this by preventing the conversion of a substance called deoxyuridylic acid to thymidylic acid.
Efudexis the brand name
Adrucil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Efudex
Fluorouracil
1970
62
Approved as Treatment by the FDA
Fluorouracil, also known as Efudex, is approved by the FDA for 1 uses like Actinic keratosis .Actinic keratosis
Used to treat hyperkeratotic actinic keratosis in combination with Salicylic acid
Effectiveness
How Adrucil Affects PatientsFluorouracil is an antineoplastic drug that works by blocking the formation of DNA. It does this by stopping the building blocks of DNA (purines and pyrimidines) from being properly incorporated into the DNA strands. Fluorouracil also blocks an enzyme that converts one type of nucleotide (cytosine) into a different type, and prevents another type of nucleotide (thymidine) from being added to the DNA.
How Adrucil works in the bodyFluorouracil works by stopping cancer cells from replicating. It binds to a protein called thymidylate synthase, which prevents the formation of thymidylate from uracil. This blocks DNA and RNA synthesis, which halts cell growth. Fluorouracil can also be incorporated into RNA instead of the usual uridine triphosphate, interfering with RNA processing and protein synthesis.
When to interrupt dosage
The prescribed dosage of Adrucil is contingent upon the diagnosed condition, like Actinic Keratosis, Verruca (Warts) and non-immunocompromised. The volume of drug is contingent on the technique of delivery (e.g. Solution - Topical or Injection, solution) described in the table beneath.Condition
Dosage
Administration
Superficial Basal Cell Carcinoma
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Breast Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Colon Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Rectal Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Verruca (Warts)
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Stomach Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Actinic keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Actinic Keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Pancreatic Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Warnings
Adrucil has a single contraindication and should not be utilized in combination with the conditions shown in the following table.Adrucil ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Adrucil Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Abetimus.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fluorouracil.
Acteoside
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Acteoside.
Adrucil Toxicity & Overdose RiskTests in mice have found that the lowest toxic dose of the drug is 230mg/kg when taken orally.
Adrucil Novel Uses: Which Conditions Have a Clinical Trial Featuring Adrucil?
1138 active clinical trials are currently assessing the potential of Adrucil to reduce the symptoms of Stomach Cancer, Colon Cancer and Rectal Cancer.Condition
Clinical Trials
Trial Phases
Breast Cancer
714 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Colon Cancer
64 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Pancreatic Cancer
228 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Actinic keratosis
0 Actively Recruiting
Verruca (Warts)
0 Actively Recruiting
Actinic Keratosis
11 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Stomach Cancer
124 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable
Rectal Cancer
51 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Superficial Basal Cell Carcinoma
4 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Adrucil Reviews: What are patients saying about Adrucil?
2.3Patient Review
10/28/2017 The pump was not easy to deal with for the 49 hours it was in use.
Patient Q&A Section about adrucil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How is Adrucil given?
"Adrucil is given as an intravenous infusion. A healthcare provider will give you this injection. You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects."
Answered by AI
What type of drug is Adrucil?
"Adrucil is a prescription medicine used to treat the symptoms of Cancer of the Colon and Rectum, Breast, Gastric, and Pancreatic. Adrucil may be used alone or with other medications. Adrucil belongs to a class of drugs called Antineoplastics and Antimetabolites. It is not known if Adrucil is safe and effective in children."
Answered by AI
Is Adrucil a chemo drug?
"Fluorouracil, sold under the brand name Adrucil among others, is a medication used to treat cancer. Specifically, it is used for the treatment of breast cancer, colorectal cancer, pancreatic cancer, and stomach cancer."
Answered by AI
What is Adrucil used for?
"This medication is used to treat various types of cancer. These cancers include colon cancer, rectal cancer, breast cancer, stomach cancer, and pancreatic cancer. Your doctor may also prescribe this medication to treat other types of cancer."
Answered by AI