Acetazolamide

Familial periodic paralysis, Calorimetry, Indirect, Hypercapnia + 12 more

Treatment

5 FDA approvals

20 Active Studies for Acetazolamide

What is Acetazolamide

Acetazolamide

The Generic name of this drug

Treatment Summary

Acetazolamide is a medication used to reduce the frequency of absence seizures. It can also be used to treat other types of seizures, like tonic-clonic, myoclonic, and atonic seizures, especially in women whose seizures are linked to their menstrual cycle. However, it may not be effective for long because some patients can become tolerant to its effects. Acetazolamide works by blocking brain carbonic anhydrase, which leads to an increased flow of chloride ions and increased inhibition in the brain.

AcetaZOLAMIDE

is the brand name

image of different drug pills on a surface

Acetazolamide Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

AcetaZOLAMIDE

Acetazolamide

1978

96

Approved as Treatment by the FDA

Acetazolamide, commonly known as AcetaZOLAMIDE, is approved by the FDA for 5 uses such as Open Angle Glaucoma (OAG) and Other and unspecified effects of high altitude .

Open Angle Glaucoma (OAG)

Other and unspecified effects of high altitude

Altitude Sickness

Open Angle Glaucoma

nonuveitic secondary glaucoma

Effectiveness

How Acetazolamide Affects Patients

Acetazolamide is a medication that helps control fluid production, treats certain types of seizures, and encourages urination when fluid builds up in the body. It is not related to mercury-based diuretics, but is instead a type of sulfonamide drug with a unique structure and effects.

How Acetazolamide works in the body

Acetazolamide helps with seizures and can also act as a diuretic. It works by inhibiting the carbonic anhydrase enzyme in the brain and kidneys. This reduces the amount of hydrogen ions present, which leads to less carbon dioxide in the lungs and more oxygen. In the kidneys, it reduces the number of hydrogen ions available for active transport, resulting in more bicarbonate, sodium, potassium, and water being excreted from the body.

When to interrupt dosage

The measure of Acetazolamide is contingent upon the diagnosed disorder, including Edema, Tonic - clonic seizures and Metabolic Alkalosis. The amount of dosage fluctuates, as per the administration technique (e.g. Injection, powder, lyophilized, for solution - Intravenous or Powder, for solution) presented in the table below.

Condition

Dosage

Administration

Respiration stimulated

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Urine alkalinization therapy

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Congestive Heart Failure

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Preoperative

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Metabolic Alkalosis

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Open Angle Glaucoma

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Hypercapnia

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

nonuveitic secondary glaucoma

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Swollen feet or ankles

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Familial periodic paralysis

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Calorimetry, Indirect

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Altitude Sickness

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Kidney Calculi

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

salicylate intoxication

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Edema

, 500.0 mg, 250.0 mg, 500.0 mg/mL, 125.0 mg

, Capsule, extended release, Oral, Capsule, extended release - Oral, Tablet, Tablet - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule - Oral, Capsule

Warnings

Acetazolamide has thirteen contraindications, hence it should be avoided if you have any of the conditions mentioned in the table below.

Acetazolamide Contraindications

Condition

Risk Level

Notes

Acidosis

Do Not Combine

Angle Closure Glaucoma

Do Not Combine

Disease

Do Not Combine

Cirrhosis

Do Not Combine

depressed sodium and/or potassium blood serum levels

Do Not Combine

Glaucoma

Do Not Combine

Sulfonamides

Do Not Combine

Chronic Kidney Disease (CKD)

Do Not Combine

hyperchloremic acidosis

Do Not Combine

Glaucoma

Do Not Combine

Chronic Kidney Disease (CKD)

Do Not Combine

Addison Disease

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Acetazolamide may interact with Pulse Frequency

There are 20 known major drug interactions with Acetazolamide.

Common Acetazolamide Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Acetazolamide.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Acetazolamide.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Acetazolamide.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Acetazolamide.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Acetazolamide.

image of a doctor in a lab doing drug, clinical research

Acetazolamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Acetazolamide?

Presently, 76 active studies are examining the applicability of Acetazolamide to alleviate Glaucoma, Preoperative Swelling and other related conditions.

Condition

Clinical Trials

Trial Phases

Hypercapnia

0 Actively Recruiting

Familial periodic paralysis

0 Actively Recruiting

Metabolic Alkalosis

0 Actively Recruiting

Edema

0 Actively Recruiting

Preoperative

0 Actively Recruiting

Calorimetry, Indirect

0 Actively Recruiting

Respiration stimulated

0 Actively Recruiting

Congestive Heart Failure

11 Actively Recruiting

Not Applicable, Phase 1, Phase 2

salicylate intoxication

0 Actively Recruiting

nonuveitic secondary glaucoma

0 Actively Recruiting

Urine alkalinization therapy

0 Actively Recruiting

Altitude Sickness

0 Actively Recruiting

Open Angle Glaucoma

10 Actively Recruiting

Phase 3, Not Applicable, Phase 4

Kidney Calculi

0 Actively Recruiting

Swollen feet or ankles

5 Actively Recruiting

Phase 2, Not Applicable, Phase 4

Acetazolamide Reviews: What are patients saying about Acetazolamide?

5

Patient Review

4/1/2010

Acetazolamide for Pseudotumor Cerebri

This treatment has been great for me. It's helped with my headaches and neck tension, and I've even lost 16 pounds in 2 1/2 weeks. The only downside is that soda now tastes like metal to me, but that's not really a bad thing!

4.3

Patient Review

1/19/2011

Acetazolamide for Pseudotumor Cerebri

I've been taking Acetazpolamide for over two and a half years, and I couldn't be more grateful. Before this medication, I had papilloedema; now, I'm able to live my life normally. Coca-Cola still tastes great to me, too!

4

Patient Review

10/9/2010

Acetazolamide for Pseudotumor Cerebri

I had issues with constipation and rectal pain, but this medication cleared that right up. I also experienced less pain overall.

3.3

Patient Review

2/3/2010

Acetazolamide for Pseudotumor Cerebri

I had some initial nausea but that went away after a little while. I still have numbness in my hands and feet, though.

3.3

Patient Review

5/15/2010

Acetazolamide for Closed Angle Glaucoma

I currently take this medication twice a day, and while it has helped with some symptoms, others (like headaches) are still present. It's an improvement, but not ideal by any means.

3.3

Patient Review

3/12/2011

Acetazolamide for Pseudotumor Cerebri

While the side effects are very unpleasant, they have helped to decrease the pressure in my eyes. I'm grateful for that, even though it's not a perfect solution.

2.3

Patient Review

11/4/2009

Acetazolamide for Pseudotumor Cerebri

I had an incredibly severe reaction to this medication, to the point where I had to go to the ER instead of going on vacation. If you are sensitive to drugs, I would recommend talking to your doctor about side effects before taking this medication.

2

Patient Review

7/1/2009

Acetazolamide for Pseudotumor Cerebri

1.3

Patient Review

11/30/2009

Acetazolamide for Pseudotumor Cerebri

I've been on this medication for a decade and, in my opinion, it has saved my vision. The only notable side effect I have experienced is the occasional numbness in my heel.

1.3

Patient Review

3/24/2011

Acetazolamide for Pseudotumor Cerebri

I was extremely tired and could not get out of bed. I was put on a high dose because my vision was getting bad quickly, but it was too much too fast. Now I have to get a shunt put in.

1

Patient Review

8/7/2009

Acetazolamide for Altitude Sickness

I was taking this medication for a few months and then suddenly started experiencing bruises all over my body for no reason, as well as a sunburn-like rash. My doctor is now trying a new treatment plan with me.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about acetazolamide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is acetazolamide?

"The drug acetazolamide falls into the category of anticonvulsants and carbonic anhydrase inhibitors, which are used to treat conditions like glaucoma."

Answered by AI

What are acetazolamide side effects?

"If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

The side effects of the medication may include dizziness, lightheadedness, increased urination, blurred vision, dry mouth, drowsiness, loss of appetite, nausea, vomiting, diarrhea, or changes in taste. These side effects may occur during the first few days as your body adjusts to the medication. If any of these side effects persist or worsen, you should notify your doctor or pharmacist promptly."

Answered by AI

Who should not use acetazolamide?

"Do not use acetazolamide if you are allergic, have severe liver disease, cirrhosis, severe kidney disease, or an electrolyte imbalance"

Answered by AI

What does acetazolamide do to urine?

"Acetazolamide causes an increase in the amount of sodium that is excreted in urine, with only a small, if any, effect on calcium excretion. Acetazolamide has a similar effect of reducing sodium and calcium absorption in the proximal tubule."

Answered by AI

Clinical Trials for Acetazolamide

Image of Mumford Professional Centre in Halifax, Canada.

Remote Monitoring for Cardiovascular Disease

18+
All Sexes
Halifax, Canada

The goal of this interventional study is to evaluate the implementation, usability, and clinical outcomes of a wearable medical-grade device in a virtual Cardiac Rehabilitation (CR) program, titled HEARTS in Sync. The question guiding this study is: Do patient clinical outcomes differ between those who use the CardioWatch 287-2 during the HEARTS in Sync program as compared to those who participate without using the CardioWatch 287-2? The comparison will happen between two non-randomized groups of patients who are enrolled in the HEARTS in Sync virtual CR program. The wearable device (CardioWatch 287-2), worn on patient's wrists, will provide clinicians with physiological information to better mirror the clinical oversight provided to an in-person CR program. Participants who choose to use the device will be asked to wear it daily. The clinical team will review weekly summary reports to help guide participant progress through the 13-week program. The primary objectives of this study are to: 1. Characterize participants (e.g., demographic health history, patient feedback) between those who choose to use the CardioWatch 287-2 device and those who do not. 2. Compare clinical outcomes between users and non-users of the device within the HEARTS in Sync program, by: 1. Tracking patient enrollment, attendance in virtual education sessions, and program completion rates, 2. Evaluating change in patient bloodwork outcomes, 3. Measuring change is physical ability, 4. Analyzing changes in eating behaviours, and 5. Examining quality of life using validated tools. 3. Asses the feasibility of the CardioWatch 287-2 for the HEARTS in Sync virtual CR program by: 1. Assessing device adherence 2. Reviewing patient feedback survey, and 3. Determining if clinician team were able to access and interpret data collected throughout the program The secondary objective of this study is to compare clinical outcomes of device users during the HEARTS in Sync program with patients who completed the on-site CR program. This research aims to better understand how a medical-grade device may improve virtual CR programming to extend clinical care to the community. As a result, this could lead to a more personalized care and better results for patients.

Waitlist Available
Has No Placebo

Mumford Professional Centre

Nicholas B Giacomantonio, Medical Doctor

Corsano Health B.V.

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Image of Virginia Commonwealth University in Richmond, United States.

Endovascular Treatment for Stroke

18+
All Sexes
Richmond, VA

Endovascular therapy (EVT) has proven to be more beneficial for patients with AIS caused by large vessel occlusions (LVO) than medical management alone. A recent meta-analysis of 5 RCTs showed that EVT significantly reduced disability at 90 days compared to medical management \[1\]. Despite its obvious benefits, patients may have neurological deterioration despite successful thrombectomy due to ischemia progression, intracranial hemorrhage, re-occlusion, or vasogenic edema. The incidence of early neurological deterioration (END) following EVT for acute stroke has been reported to be ranging from 14.1-35.2% with some studies defining END up to 7 days and some restricting the definition between 6-72 hours post thrombectomy. A small proportion of these patients, approximately 5.9-10.5%, experienced sICH following EVT. Whether END occurs due to ischemic or hemorrhagic it leads to worse outcomes.

Waitlist Available
Has No Placebo

Virginia Commonwealth University

Aarti Sarwal

Have you considered Acetazolamide clinical trials?

We made a collection of clinical trials featuring Acetazolamide, we think they might fit your search criteria.
Go to Trials

Have you considered Acetazolamide clinical trials?

We made a collection of clinical trials featuring Acetazolamide, we think they might fit your search criteria.
Go to Trials