Abilify
Irritability, Schizophrenia, Agitation + 10 more
Treatment
1 FDA approval
20 Active Studies for Abilify
Treatment for
Irritability
What is Abilify
Aripiprazole
The Generic name of this drug
Treatment Summary
Aripiprazole is a medication used to treat mental health conditions like schizophrenia, bipolar disorder, major depression, irritability in people with autism, and Tourette's syndrome. It can be taken orally or given as an injection to treat agitation related to schizophrenia or bipolar mania. Aripiprazole works by stimulating dopamine and serotonin receptors while inhibiting alpha-adrenergic and serotonin receptors. This drug was approved by the FDA in 2002.
Abilify
is the brand name
Abilify Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Abilify
Aripiprazole
2002
454
Approved as Treatment by the FDA
Aripiprazole, also known as Abilify, is approved by the FDA for 1 uses such as Schizophrenia .
Schizophrenia
Used to treat Schizophrenia in combination with Aripiprazole lauroxil
Effectiveness
How Abilify Affects Patients
Aripiprazole binds strongly to various receptors in the brain, such as those for serotonin, dopamine, and adrenaline. It also has weaker effects on other receptors. It is not yet known exactly how this binding of aripiprazole to these receptors results in its clinical effects.
How Abilify works in the body
Aripiprazole works to treat psychosis by activating dopamine and serotonin receptors. It may also cause unwanted side effects by affecting other receptors, such as the adrenergic alpha1 receptor, which can cause low blood pressure when standing.
When to interrupt dosage
The recommended dosage of Abilify is contingent upon the diagnosed condition, including Agitation, Schizophrenia and Alzheimer's Disease. The quantity of dosage is dependent on the mode of delivery noted in the table below.
Condition
Dosage
Administration
Schizophrenia
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Irritability
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Bipolar Disorder
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Acute Coryza
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Alzheimer's Disease
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Psychotic Depression
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Schizophrenia
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Agitation
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Autism Spectrum Disorder (ASD)
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Tourette Syndrome
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Bipolar Disorder
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Bipolar Disorder
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Depression
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
Tablet - Oral, Tablet, , Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release; Kit, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution - Intramuscular, Injection, solution, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, Injection - Intramuscular
Warnings
Abilify Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Aripiprazole may interact with Pulse Frequency
There are 20 known major drug interactions with Abilify.
Common Abilify Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Aripiprazole may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Aripiprazole is combined with Aclidinium.
Alfuzosin
Major
Aripiprazole may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Aripiprazole may increase the antipsychotic activities of Amisulpride.
Aripiprazole lauroxil
Major
Aripiprazole may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Abilify Toxicity & Overdose Risk
There have been no studies done on the safety and effectiveness of taking aripiprazole while pregnant. However, a national pregnancy registry is tracking mothers who take it while pregnant. Studies of other antipsychotic medications during pregnancy have found that babies are at risk of developing symptoms like muscle stiffness or withdrawal. Animal studies of aripiprazole have linked it to birth defects and fetal death at higher doses than the recommended for humans. Aripiprazole should only be prescribed if the benefits outweigh the risks. Babies exposed to the drug in the third trimester may develop symptoms like muscle stiffness or withdrawal that can last from hours to
Abilify Novel Uses: Which Conditions Have a Clinical Trial Featuring Abilify?
Currently, 469 active clinical trials are underway to ascertain the potential of Abilify in treating Alzheimer's Disease, Early Infantile Autism and Irritability.
Condition
Clinical Trials
Trial Phases
Schizophrenia
97 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 1, Phase 2
Bipolar Disorder
0 Actively Recruiting
Bipolar Disorder
0 Actively Recruiting
Acute Coryza
1 Actively Recruiting
Not Applicable
Alzheimer's Disease
15 Actively Recruiting
Not Applicable, Phase 2, Phase 1
Psychotic Depression
0 Actively Recruiting
Irritability
8 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 4
Schizophrenia
31 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Agitation
3 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Bipolar Disorder
0 Actively Recruiting
Autism Spectrum Disorder (ASD)
60 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Depression
213 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1
Tourette Syndrome
3 Actively Recruiting
Not Applicable
Abilify Reviews: What are patients saying about Abilify?
5
Patient Review
6/18/2022
Abilify for Additional Medications to Treat Depression
5
Patient Review
6/30/2022
Abilify for Bipolar I Disorder with Most Recent Episode Mixed
4.7
Patient Review
9/15/2022
Abilify for Additional Medications to Treat Depression
4.7
Patient Review
9/9/2022
Abilify for Additional Medications to Treat Depression
3.3
Patient Review
11/6/2022
Abilify for Additional Medications to Treat Depression
1
Patient Review
7/22/2022
Abilify for Additional Medications to Treat Depression
1
Patient Review
9/1/2022
Abilify for Schizophrenia
1
Patient Review
9/16/2022
Abilify for Bipolar Disorder in Remission
Patient Q&A Section about abilify
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the drug Abilify used for?
"Aripiprazole is a medication that can be used to treat mental disorders such as bipolar I disorder, major depressive disorder, and schizophrenia. It can be used by itself or in combination with other medications."
Answered by AI
What are the negative side effects of Abilify?
"The following side effects may occur: dizziness, lightheadedness, drowsiness, nausea, vomiting, tiredness, excess saliva/drooling, blurred vision, weight gain, constipation, headache, and trouble sleeping. If you experience any of these effects, tell your doctor or pharmacist."
Answered by AI
Is Abilify an antipsychotic or mood stabilizer?
"Abilify is an antipsychotic medication that affects chemicals in the brain to treat the symptoms of psychotic conditions like schizophrenia in adults and children aged 13 and up."
Answered by AI
Is Abilify an antipsychotic or antidepressant?
"The medicine Abilify is used to treat a variety of mental disorders, such as schizophrenia, bipolar disorder, Tourette syndrome, and irritability associated with autism. It can be used in combination with an antidepressant to treat depression."
Answered by AI