8-Mop

Vitiligo, Vitiligo, Psoriasis + 3 more
Treatment
19 Active Studies for 8-Mop

What is 8-Mop

MethoxsalenThe Generic name of this drug
Treatment SummaryBergapten is a natural compound found in certain plants, like Psoralea corylifolia. When exposed to UV light, it can form chemical bonds with DNA.
Oxsoralenis the brand name
image of different drug pills on a surface
8-Mop Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Oxsoralen
Methoxsalen
1954
7

Effectiveness

How 8-Mop Affects PatientsMethoxsalen stops the body from making DNA. It also alters the amount of guanine and cytosine present in cells. If a large amount of this drug is taken, it can also block cells from making proteins and RNA.
How 8-Mop works in the bodyAfter being activated, this drug targets the guanine and cytosine molecules in DNA, which then links the molecules together and stops DNA from functioning properly.

When to interrupt dosage

The sum of 8-Mop is contingent upon the identified condition, including Palliative Care, Vitiligo and Psoriasis. The amount of dosage also varies, conforming to the technique of delivery (e.g. Solution - Extracorporeal or Topical) featured in the table underneath.
Condition
Dosage
Administration
Vitiligo
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Vitiligo
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Psoriasis
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Lymphoma, T-Cell, Cutaneous
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Palliative Treatment
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
CTAGE1 protein, human
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical

Warnings

8-Mop has five contraindications, thus it should not be taken when encountering the conditions enumerated in the following table.8-Mop Contraindications
Condition
Risk Level
Notes
Aphakia
Do Not Combine
melanoma
Do Not Combine
Squamous cell carcinoma
Do Not Combine
Photophobia
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with 8-Mop.
Common 8-Mop Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Methoxsalen.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Methoxsalen.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Methoxsalen.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Methoxsalen.
Bendamustine
Major
The metabolism of Bendamustine can be decreased when combined with Methoxsalen.
image of a doctor in a lab doing drug, clinical research

8-Mop Novel Uses: Which Conditions Have a Clinical Trial Featuring 8-Mop?

40 active studies are presently exploring the potential of 8-Mop to ameliorate Lymphoma, Cutaneous T-Cell, CTAGE1 protein, human and Palliative Care.
Condition
Clinical Trials
Trial Phases
Vitiligo
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Lymphoma, T-Cell, Cutaneous
0 Actively Recruiting
Vitiligo
7 Actively Recruiting
Phase 2, Phase 3, Phase 1
Palliative Treatment
1 Actively Recruiting
Not Applicable
CTAGE1 protein, human
11 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Early Phase 1, Phase 3

8-Mop Reviews: What are patients saying about 8-Mop?

1Patient Review
1/18/2013
8-Mop for Severe Psoriasis that is Resistant to Treatment
After years of struggling to control my diarrhea, this medication was finally able to help me.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about 8-mop

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How do you take methoxsalen tablets?

"Adults and children over 12 should take 20mg of methoxsalen two to four hours before exposure to ultraviolet light A. This treatment should be given two or three times a week, with at least 48 hours in between treatments."

Answered by AI

Is methoxsalen natural?

"Methoxsalen is a naturally occurring photoactive substance found in the seed of the Ammi majus plant. It is part of a class of compounds known as psoralens."

Answered by AI

What is Methoxsalen used to treat?

"Methoxsalen is a medicine that belongs to the group of medicines called psoralens. PUVA is a treatment that uses methoxsalen along with ultraviolet light from sunlight or special lamps to treat vitiligo and psoriasis."

Answered by AI

What is Methoxypsoralen?

"5-Methoxypsoralen is thought to increase the risk of skin cancer, as there is a clear correlation between the number of PUVA treatments and the number of basal cell carcinomas.

5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo. In patients and volunteers, PUVA 5-methoxypsoralen causes a dose-related increase in cutaneous photosensitivity. 5-Methoxypsoralen is thought to increase the risk of skin cancer, as there is a clear correlation between the number of PUVA treatments and the number of basal cell carcinomas."

Answered by AI

Clinical Trials for 8-Mop

Have you considered 8-Mop clinical trials? We made a collection of clinical trials featuring 8-Mop, we think they might fit your search criteria.
Have you considered 8-Mop clinical trials? We made a collection of clinical trials featuring 8-Mop, we think they might fit your search criteria.
Have you considered 8-Mop clinical trials? We made a collection of clinical trials featuring 8-Mop, we think they might fit your search criteria.
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