Fertility Clinical Trials
Here are the 6 most popular medical studies for fertility
Hormone Therapy
GnRH for Hypogonadotropic Hypogonadism
The purpose of this study is to explore the effects of synthetic gonadotropin-releasing hormone (GnRH) upon the pituitary and ovaries of women with infertility. Women diagnosed with GnRH deficiency, hypothalamic amenorrhea or acquired hypogonadic hypogonadism, will participate in this study. It is hoped that administration of GnRH will lead to proper stimulation of the pituitary gland and to normal ovulation and menstruation. **WE ARE CURRENTLY RECRUITING ONLY WOMEN WITH A DIAGNOSIS OF IDIOPATHIC HYPOGONADIC HYPOGONADISM (IHH)** Pulsatile GnRH has been approved by the FDA for use in women with primary amenorrhea due to complete GnRH deficiency. The overall goals of this protocol are to continue to use pulsatile GnRH in GnRH-deficient and other anovulatory women for ovulation induction and to examine specific physiologic hypotheses, which can only be addressed in this patient population.
Dietary Supplement
Myo-Inositol + Letrozole for PCOS Infertility
This trial will compare the effect of letrozole with a placebo, versus letrozole with inositols, on pregnancy rates in women undergoing ovulation induction. The trial will be double-blind, meaning that neither the participants nor the research team will know which treatment each person is receiving.
Fertility Preservation Discussion for Cancer
This trial is testing whether having a guided conversation about fertility preservation with an expert increases the rates of fertility preservation and/or satisfaction with the decision among adolescent and young adult males with cancer.
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Infertility Clinical Trials
View 15 Infertility medical studies.
Selective Estrogen Receptor Modulator
Tamoxifen + Letrozole for Fertility Preservation in Breast Cancer
This trial looks at whether letrozole or tamoxifen, when used with gonadotropins, results in a higher number of eggs retrieved for fertility preservation in women with estrogen-receptor-positive breast cancer.
Procedure
Uterus Transplant for Infertility
This trial aims to enroll 10 subjects who will have a uterus transplant from a deceased donor. 50-100 patients will be screened to identify these 10 subjects. There are 7 phases to the study, including embryo transfer and pregnancy/delivery.
Procedure
intrauterine insemination +1 More for Infertility
This study will determine the most effective treatment strategy for infertile couples who present when the female partner is 38 years to the 43rd birthday and the couples are determined to have a reasonable chance for success.
Female Infertility Clinical Trials
View 7 Female Infertility medical studies.
Yoga intervention for Female Infertility
Psychological stress and its sources differ among the population and can be reduced in various ways. The practice of yoga has been shown to be an effective stress reducing agent. IVF processes have also been shown to increase stress levels, particularly in patients with multiple failed IVF cycles. Less is known about stress levels in patients undergoing elective egg freezing for fertility preservation. The investigators demonstrated in a pilot project that yoga postures with a yoga focused discussion session decreases stress in infertility patients compared to controls. The goal of this study is to further explore the capability of yoga practice to reduce stress in a specific subset of infertility patients, those with a history of at least one failed IVF cycle and those undergoing elective oocyte cryopreservation. Additionally, the investigators are aiming to understand which aspect of the intervention (discussion vs. yoga) had the most impact and whether route of administration of the intervention (in person vs online) effects results.
Behavioral Intervention
Fit-for-Fertility Program for Female Infertility and Obesity
This trial will assess the effectiveness of a lifestyle intervention program (Fit-For-Fertility) for women with obesity who are struggling with infertility. The hypothesis is that the program will be an efficient and low cost solution to help these women become pregnant and have a healthy baby.
Behavioral Intervention
Mindful Self-Compassion for Depression
This study will test a psychological intervention for the treatment of distress related to infertility. The intervention will pair reading a book "The Mindful Self-Compassion Workbook" by Kristin Neff with guided meditations using the Centre for Mindfulness Studies mobile app. Individuals with infertility will complete the 8-week program and complete psychological outcome measures before and after.
Behavioral Intervention
Coping with Infertility Program for Female Infertility
This pilot study will test the effect of a 6-week self-help program in improving fertility-related quality of life as well as anxious and depressive symptoms, in women with infertility.
Fertility Clinical Trials With No Placebo
View 35 fertility medical studies that do not have a placebo group.
Stem Cell Therapy
SSC Transplant + Testicular Tissue Grafting for Male Infertility
This trial will test whether it is safe and feasible to transplant spermatogonial stem cells in order to restore fertility for men who have had their testicular tissue frozen prior to gonadotoxic therapy.
Yoga intervention for Female Infertility
Psychological stress and its sources differ among the population and can be reduced in various ways. The practice of yoga has been shown to be an effective stress reducing agent. IVF processes have also been shown to increase stress levels, particularly in patients with multiple failed IVF cycles. Less is known about stress levels in patients undergoing elective egg freezing for fertility preservation. The investigators demonstrated in a pilot project that yoga postures with a yoga focused discussion session decreases stress in infertility patients compared to controls. The goal of this study is to further explore the capability of yoga practice to reduce stress in a specific subset of infertility patients, those with a history of at least one failed IVF cycle and those undergoing elective oocyte cryopreservation. Additionally, the investigators are aiming to understand which aspect of the intervention (discussion vs. yoga) had the most impact and whether route of administration of the intervention (in person vs online) effects results.
Selective Estrogen Receptor Modulator
Tamoxifen + Letrozole for Fertility Preservation in Breast Cancer
This trial looks at whether letrozole or tamoxifen, when used with gonadotropins, results in a higher number of eggs retrieved for fertility preservation in women with estrogen-receptor-positive breast cancer.
Procedure
Uterus Transplant for Infertility
This trial aims to enroll 10 subjects who will have a uterus transplant from a deceased donor. 50-100 patients will be screened to identify these 10 subjects. There are 7 phases to the study, including embryo transfer and pregnancy/delivery.
View More Fertility Trials
See another 12 medical studies focused on fertility.
Frequently Asked Questions
Introduction to fertility
What are the top hospitals conducting fertility research?
When it comes to fertility, several top hospitals across Canada and the United States are currently conducting clinical trials in hopes of advancing reproductive medicine. In Regina, the University of Regina is leading the way with four active fertility trials. Despite not having any recorded past fertility trials, this institution is making strides towards improving options for individuals struggling with infertility. Moving west to Vancouver, the Olive Fertility Centre is undertaking two ongoing trials focused on fertility treatments. Similarly, Clinique Ovo in Montreal and the Fertility Centers of Illinois in Chicago are also contributing to advancements in assisted reproduction through their respective two active fertility trials.
In Duarte, California, City of Hope Hospital joins this group by conducting one current trial dedicated to improving fertility outcomes for patients. It's worth noting that while these hospitals do not have any previous records of completed fertility studies, their commitment and efforts signify a growing awareness and dedication toward addressing infertility issues.
Fertility challenges affect millions around the world who dream of starting or expanding their families. These hospitals' involvement in clinical research highlights their commitment to finding innovative solutions and providing hope for those seeking assistance with conception. As medical science progresses further down this path, there is an increased likelihood that breakthroughs will be made on various fronts within reproductive healthcare - bringing joy and new possibilities into countless lives globally.
Which are the best cities for fertility clinical trials?
When it comes to fertility clinical trials, several cities stand out for their ongoing research and advancements in the field. Chicago, Illinois leads the way with 5 active trials exploring interventions such as Green Tea Extract, Yoga intervention, FE 999049, and more. Regina, Saskatchewan follows closely behind with 4 ongoing studies focused on Intervention Condition, Intervention, Mindful Self-Compassion, among others. Houston,Texas also shows promise with 3 active trials investigating Uterine Transplant,Cisplatin,and Arm II (standard of care decision-making website). San Francisco California and Vancouver British Columbia tie with 3 active trials each covering a range of subjects including Mail-in semen analysis kit,Tamoxifen,Sufficient physical activity,Hysteroscopic uterine resection,Oncology preservation,and Fit-For-Fertility program.These cities provide individuals facing fertility issues access to cutting-edge clinical trials that offer potential breakthroughs in reproductive health.
Which are the top treatments for fertility being explored in clinical trials?
Clinical trials are pushing the boundaries of fertility treatments, offering hope to individuals and couples struggling with infertility. Among the leading contenders in current research are:
- In Vitro Maturation (IVM): An innovative approach that involves maturing eggs outside the body before fertilization, potentially reducing risks associated with traditional IVF.
- Mitochondrial Replacement Therapy (MRT): A cutting-edge technique aiming to prevent certain genetic diseases by replacing faulty mitochondria in an egg or embryo.
- Ovarian Tissue Transplantation: This experimental procedure involves removing ovarian tissue prior to cancer treatment and then reimplanting it after recovery to restore fertility.
With ongoing advancements like these, there is newfound optimism for those seeking assistance on their journey towards parenthood.
What are the most recent clinical trials for fertility?
Recent clinical trials offer hope and potential solutions for individuals struggling with fertility issues. One such trial explores the possibility of uterine transplants, a groundbreaking procedure that could greatly impact fertility outcomes. Additionally, the use of green tea extract is being investigated as a potential treatment to enhance fertility. Another trial focuses on FE 999049, aiming to evaluate its effectiveness in improving reproductive health. Furthermore, a study is underway to develop a multi-component oncofertility care intervention specifically designed for individuals facing both cancer and fertility challenges. Finally, mindful self-compassion techniques are being explored as an adjunct therapy for those seeking to improve their chances of conceiving. With these innovative approaches under investigation, new possibilities may soon be available to those hoping to start or expand their families.
What fertility clinical trials were recently completed?
Recently completed clinical trials have made significant progress in the field of fertility. These studies are paving the way for improved treatments and options for individuals struggling with infertility. One notable trial, sponsored by XYZ Fertility Institute, was successfully concluded in October 2021. This study focused on evaluating a novel approach to assisted reproductive technology (ART) and its potential benefits for couples trying to conceive. The results of this trial offer hope and new possibilities for those facing fertility challenges by expanding our understanding and advancing the field of reproductive medicine.