Fertility Supplement for Male Infertility
(FertEnhancer Trial)
Trial Summary
What is the purpose of this trial?
Old age, obesity, physical inactivity, environmental factors and genetics may contribute negatively to fertility in both males and females. In males, specifically, certain supplements, such as single antioxidants and trace minerals, have previously been shown to improve sperm function marginally. One hypothesis is that sperm function can be improved even further by combining several different types of supplements (e.g., amino acids, energy carriers, vitamins, antioxidants, and trace minerals) to target several age-related cell pathways, for example, oxidative stress, mitochondrial dysfunction, inflammation and cell energetics. This 3-month placebo-controlled, randomized clinical trial, aims to test the effects of a novel multi-ingredient supplement (Fertility Enhancer) that targets several age-related cell pathways on sperm function in overweight or obese and subfertile males.
Do I need to stop taking my current medications for the trial?
You may need to stop taking certain supplements that contain the ingredients being tested, but only after a 1-month period without them. The protocol does not specify stopping other medications, but some exclusions apply, such as cytotoxic drugs, immunosuppressants, and certain other medications.
What data supports the effectiveness of the treatment Fertility Enhancer for male infertility?
Is the fertility supplement for male infertility safe for humans?
How is the Fertility Enhancer treatment different from other treatments for male infertility?
Fertility Enhancer is unique because it is a dietary supplement that combines various nutrients, potentially improving sperm parameters. Unlike some treatments that may not have proven efficacy, this supplement focuses on ingredients like zinc, selenium, and coenzyme Q, which have shown potential benefits, although the effectiveness of such supplements is still debated.1291011
Eligibility Criteria
Men aged 25-50 with diagnosed subfertility can join this trial. They must meet WHO criteria for sperm health but cannot have genital diseases, recent reproductive surgeries, or be using certain medications like immunosuppressants. Smokers and those with a BMI over 30 aren't eligible.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive daily supplementation of either the Fertility Enhancer or placebo for 3 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Fertility Enhancer
Find a Clinic Near You
Who Is Running the Clinical Trial?
Hamilton Health Sciences Corporation
Lead Sponsor
One Fertility
Collaborator