This trial is evaluating whether Tamoxifen will improve 1 primary outcome and 9 secondary outcomes in patients with Infertility. Measurement will happen over the course of Up to 2 weeks.
This trial requires 144 total participants across 3 different treatment groups
This trial involves 3 different treatments. Tamoxifen is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 3 and have had some early promising results.
"Infertility may be a symptom of a health problem that can be corrected with surgery. About 5% of all couples report that the major problem with their infertility is lack of male/female sexual intercourse.\n" - Anonymous Online Contributor
"Female reproductive medicine involves different treatment options. Female infertility can be treated through gynecological surgery, reproductive endocrinology, or ovarian stimulation (often a combination of these). It's important that men and patients are aware of the risks and benefits of each treatment option before agreeing to treatment.\n" - Anonymous Online Contributor
"Around 7 million American women are now having difficulty conceiving. In an effort to improve contraceptive supplies and accessibility, efforts have been made in recent years to increase contraceptive use and educate individuals about contraception. Despite these efforts, rates of use remain low because of the inconvenience and the lack of access to family planning clinics." - Anonymous Online Contributor
"Recent findings provided results that could be helpful to patients with male infertility. For those using the infertility treatments, and those with spontaneous pregnancies, there was no statistically significant difference in the number of pregnancies or the birth rate from the control group. Therefore, the effect of IVF treatment and the pregnancy rate were lower than the fertility clinic where the patients were followed. The only one parameter that was statistically significant was the number of babies born with full-term (more than 37 weeks gestation)." - Anonymous Online Contributor
"This article examines the signs of infertility in men. A variety of tests can provide the clues that can be used to rule out specific causes. However, for many infertility symptoms there are no known causes. The first step in determining the cause of infertility is to rule out a common cause." - Anonymous Online Contributor
"A variety of infertility is not linked to a specific cause. Most infertility cases are related to the men, and have a multifactorial cause. Factors such as age, lifestyle, body mass, body image and sexual desire may all play a role in how fertility is affected.\n\nEndometriosis is a chronic inflammatory disorder that arises from a metaplasia of endometrial tissue. Endometriosis usually presents in women in their reproductive years, and rarely affects men.\n\nEndometriosis often presents with vague or non-specific abdominal, painful symptoms that may include pelvic pain, bloating and pelvic or abdominal distention." - Anonymous Online Contributor
"The most common common side effects are breast tenderness (68%), joint pain (62%), headache (56%), and gastrointestinal disorders (53%). Most of these side effects are mild (severity scores 6 and below), but several side effects of tamoxifen are severe in nature, thus warranting immediate medical attention." - Anonymous Online Contributor
"Tamoxifen has proven to be a successful therapeutic agent for the treatment of ER-positive breast cancer in women; however, additional studies are required to determine the ultimate clinical effectiveness of tamoxifen for the treatment of breast cancer in women of all ages." - Anonymous Online Contributor
"Consideration of clinical endpoints should be provided to all patients who seek fertility treatments. As our present knowledge about the effects of infertility treatments improves, consideration of clinical endpoints should be increased for patients." - Anonymous Online Contributor
"The primary cause of infertility is in many ways an incorrect idea, which is in itself an unwarranted assumption. In this paper, we discuss the reasons for the widespread adoption of such unfounded ideas. We conclude that more serious and comprehensive and more research is needed before settling the question of primary causes of infertility." - Anonymous Online Contributor
"Although there is no good medical reason to refrain from intercourse, the emotional consequences of the news of ininfertility must be a challenge to health professionals. If a man becomes infertile, it means his life and future are put into jeopardy and might jeopardize his partner's as well. The woman may experience similar emotions and this may lead to other problems. It can be very hard to accept that a man can no longer have children of his own." - Anonymous Online Contributor
"We can recommend to treat patients with tamoxifen for a short duration (6 or 12 months) for moderate to pronounced ovarian suppression which was associated with good ovarian response." - Anonymous Online Contributor