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What is Zyfrel
HydrocodoneThe Generic name of this drug
Treatment SummaryHydrocodone is a pain medication derived from codeine. It is usually combined with acetaminophen to treat moderate to severe pain. In the past, it was often used as a cough suppressant, but it has been mostly replaced by dextromethorphan in current cough and cold medications. Hydrocodone's more powerful form, hydromorphone, is used for more severe pain and was approved by the FDA in 1943.
Hycodanis the brand name
Zyfrel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hycodan
Hydrocodone
1943
1122
Approved as Treatment by the FDA
Hydrocodone, otherwise called Hycodan, is approved by the FDA for 2 uses including Pain and Pain .Pain
Used to treat Severe Pain in combination with Acetaminophen
Pain
Helps manage moderate Pain
Effectiveness
How Zyfrel Affects PatientsHydrocodone is a drug that blocks pain signals from being sent to the brain and spine, which reduces pain. It can also cause feelings of pleasure, shallow breathing, and drowsiness.
How Zyfrel works in the bodyHydrocodone works by attaching to two types of opioid receptors in the body. The first is the mu opioid receptor, and the second is the delta opioid receptor. When the receptors are activated, it causes a reaction in the body that reduces pain signals and suppresses the cough reflex. It also releases dopamine in the brain, which produces a feeling of pleasure. This can lead to addiction. Hydrocodone also reduces the GABAergic tone in certain parts of the brain, which can lead to sedation and respiratory depression. Finally, it can also activate inhibitory neurons in the spinal cord, further reducing pain signals.
When to interrupt dosage
The measure of Zyfrel is contingent upon the diagnosed condition, such as Coughing, Coughing and Chronic Pain. The amount of dosage changes, in accordance with the approach of delivery (e.g. Tablet, extended release - Oral or Tablet - Oral) specified in the table beneath.Condition
Dosage
Administration
Nasal Congestion caused by Common Cold
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Nasal Congestion caused by Allergic Rhinitis
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Allergic rhinitis (disorder)
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
upper respiratory symptoms caused by Common Cold
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Rhinitis
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Coughing
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Acute Bronchitis
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Chronic Pain
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Inflammation
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Acute Pain
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Coughing
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Pain
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Pain
7.5 mg, , 5.0 mg, 10.0 mg, 1.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.75 mg/mL, 0.075 mg/mL, 2.5 mg, 10.0 mg/mL, 15.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 50.0 mg, 60.0 mg, 80.0 mg, 100.0 mg, 120.0 mg, 0.5 mg/mL, 90.0 mg, 750.0 mg, 45.0 mg, 3.0 mg/mL, 0.33 mg/mL, 1.65 mg/mL, 1.7 mg/mL, 1.667 mg/mL, 1.8 mg/mL, 1.67 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Syrup - Oral, Syrup, Solution, Solution - Oral, Tablet, Tablet - Oral, Suspension, extended release, Suspension, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Kit, Suspension, Suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Liquid, Liquid - Oral, Topical, Cream - Topical, Cream, Elixir, Elixir - Oral, Capsule, Capsule - Oral
Warnings
Zyfrel has twenty-one contraindications and should not be deployed for the conditions specified in the below table.Zyfrel ContraindicationsCondition
Risk Level
Notes
Paralytic Ileus
Do Not Combine
Asthma
Do Not Combine
Intracranial Hypertension
Do Not Combine
Status Asthmaticus
Do Not Combine
in the absence of resuscitative equipment acute bronchial asthma
Do Not Combine
increased cerebrospinal pressure
Do Not Combine
Mental Depression
Do Not Combine
Cor Pulmonale
Do Not Combine
Abdomen
Do Not Combine
convulsive disorders
Do Not Combine
chronic obstructive airway
Do Not Combine
ethanol
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Alcohol Withdrawal Delirium
Do Not Combine
Asthma
Do Not Combine
Hypercarbia
Do Not Combine
Asthma
Do Not Combine
severe CNS depression
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Hydrocodone may interact with Pulse Frequency
Common Zyfrel Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Hydrocodone.
Azelastine
Major
Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Hydrocodone.
Eluxadoline
Major
The risk or severity of constipation can be increased when Hydrocodone is combined with Eluxadoline.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Hydrocodone.
Zyfrel Toxicity & Overdose RiskTaking too much hydrocodone can lead to serious side effects, such as trouble breathing, extreme drowsiness, low muscle tone, cold and clammy skin, small pupils, fluid in the lungs, slow heartbeat, low blood pressure, blocked airways, abnormal snoring, and death. If this happens, medical attention is necessary. Treatment may include giving oxygen and fluids through an IV, using drugs to maintain circulation, and using naloxone, an opioid antagonist, to reverse the drug's effects. Monitoring is still necessary after naloxone is administered as the opioid effects may return. In patients who are already opioid
Zyfrel Novel Uses: Which Conditions Have a Clinical Trial Featuring Zyfrel?
50 active studies are currently being conducted to assess the potential of Zyfrel in alleviating Chronic Pain, Nasal Congestion due to Common Cold and Acute Bronchitis.Condition
Clinical Trials
Trial Phases
Acute Bronchitis
12 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3, Phase 1
Coughing
0 Actively Recruiting
Allergic rhinitis (disorder)
0 Actively Recruiting
Pain
0 Actively Recruiting
Pain
0 Actively Recruiting
Rhinitis
0 Actively Recruiting
Nasal Congestion caused by Allergic Rhinitis
0 Actively Recruiting
Coughing
0 Actively Recruiting
Chronic Pain
30 Actively Recruiting
Phase 2, Not Applicable, Phase 3
upper respiratory symptoms caused by Common Cold
0 Actively Recruiting
Nasal Congestion caused by Common Cold
0 Actively Recruiting
Inflammation
0 Actively Recruiting
Acute Pain
21 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4, Phase 2, Phase 1
Zyfrel Reviews: What are patients saying about Zyfrel?
4.3Patient Review
2/20/2008 This medication quickly and effectively stopped my cough from a cold.